ES2195190T3 - Dispositivo y metodo para mejorar el flujo de agente transdermico. - Google Patents

Dispositivo y metodo para mejorar el flujo de agente transdermico.

Info

Publication number
ES2195190T3
ES2195190T3 ES97951729T ES97951729T ES2195190T3 ES 2195190 T3 ES2195190 T3 ES 2195190T3 ES 97951729 T ES97951729 T ES 97951729T ES 97951729 T ES97951729 T ES 97951729T ES 2195190 T3 ES2195190 T3 ES 2195190T3
Authority
ES
Spain
Prior art keywords
improving
agent flow
transdermal agent
skin
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97951729T
Other languages
English (en)
Inventor
Felix Theeuwes
Armand P Neukermans
Michel J N Cormier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2195190T3 publication Critical patent/ES2195190T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN DISPOSITIVO DE ADMINISTRACION O MUESTREO (2) DE UN AGENTE, QUE COMPRENDE UN ELEMENTO (6) QUE TIENE VARIAS LAMINAS (4) PARA PERFORAR LA PIEL Y UN MEDIO DE CONEXION (65) QUE CUBRE, POR LO MENOS, UNA PARTE DEL LADO QUE ESTA EN CONTACTO CON LA PIEL (48) DEL ELEMENTO (6) PARA INCREMENTAR EL FLUJO TRANSDERMICO DE UN AGENTE.
ES97951729T 1996-12-20 1997-12-16 Dispositivo y metodo para mejorar el flujo de agente transdermico. Expired - Lifetime ES2195190T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3344096P 1996-12-20 1996-12-20

Publications (1)

Publication Number Publication Date
ES2195190T3 true ES2195190T3 (es) 2003-12-01

Family

ID=21870407

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97951729T Expired - Lifetime ES2195190T3 (es) 1996-12-20 1997-12-16 Dispositivo y metodo para mejorar el flujo de agente transdermico.

Country Status (11)

Country Link
EP (1) EP0957972B1 (es)
JP (1) JP4153999B2 (es)
KR (1) KR100453132B1 (es)
CN (1) CN1133472C (es)
AT (1) ATE234649T1 (es)
AU (1) AU722574B2 (es)
CA (1) CA2271167C (es)
DE (1) DE69720057T2 (es)
DK (1) DK0957972T3 (es)
ES (1) ES2195190T3 (es)
WO (1) WO1998028037A1 (es)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2212826C (en) 1995-12-28 2002-02-19 Cygnus, Inc. Methods for monitoring a physiological analyte
ES2244106T3 (es) * 1997-12-11 2005-12-01 Alza Corporation Dispositivo para mejorar el flujo transdermico de agentes.
JP2001525227A (ja) * 1997-12-11 2001-12-11 アルザ・コーポレーション 経皮的薬剤流量を高めるための装置
EP1911488A3 (en) 1997-12-11 2008-12-03 Alza Corporation Device for enhancing transdermal agent flux
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
EP1109594B1 (en) * 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
TR200103018T2 (tr) 1999-04-19 2002-02-21 Beecham Biologicals S.A. Smithkline İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri.
AU5461300A (en) * 1999-06-04 2000-12-28 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
DE60027720T2 (de) * 1999-06-08 2007-04-26 Altea Therapeutics Corp. Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
DK1239916T3 (da) 1999-12-10 2006-04-03 Alza Corp Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring
DE60020159T2 (de) * 1999-12-10 2005-10-06 Alza Corp., Mountain View Hautbehandlungsvorrichtung zur verlängerten transdermalen verabreichung von medikamenten
US6622035B1 (en) * 2000-01-21 2003-09-16 Instrumentarium Corp. Electrode for measurement of weak bioelectrical signals
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
AU8346901A (en) * 2000-08-24 2002-03-04 Alza Corp Method for transdermal nucleic acid sampling
DE60129585T2 (de) 2000-09-08 2008-04-17 Alza Corp., Mountain View Transdermale vorrichtung
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
EP1341442B1 (en) 2000-10-13 2005-06-29 Alza Corporation Microblade array impact applicator
BR0114628A (pt) 2000-10-13 2004-01-20 Alza Corp Membro de retenção em microprojeção para aplicador de impacto
CZ20031037A3 (cs) * 2000-10-13 2003-10-15 Alza Corporation Zařízení a způsob probodnutí kůže mikrovýčnělky
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
ES2377077T3 (es) 2000-10-18 2012-03-22 Glaxosmithkline Biologicals S.A. Vacunas que comprenden al antígeno MAGE unido a un fragmento de proteína D
JP4659336B2 (ja) 2000-10-26 2011-03-30 アルザ・コーポレーシヨン 被覆された微細突出物を有する経皮的薬剤配達装置
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US6855372B2 (en) 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
CN101129327A (zh) 2001-04-20 2008-02-27 阿尔扎公司 具有包含有益药剂的涂层的微小突出物阵列
EP3251722B1 (en) 2001-04-20 2020-06-17 ALZA Corporation Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
US8361037B2 (en) 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CA2499838C (en) 2001-09-21 2012-12-18 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
WO2003101507A2 (en) * 2002-03-11 2003-12-11 Altea Therapeutics Corporation Transdermal drug delivery device, method and use
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
ES2437565T3 (es) 2003-06-30 2014-01-13 Alza Corporation Formulaciones para microproyecciones revestidas que contienen contraiones no volátiles
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1675539A4 (en) * 2003-10-24 2007-09-12 Alza Corp METHOD AND SYSTEM FOR PRETREATMENT FOR IMPROVING TRANSDERMAL DRUG DELIVERY
BRPI0415986A (pt) 2003-10-28 2007-01-23 Alza Corp método e aparelho para reduzir a incidência do uso de tabaco
KR20060099523A (ko) 2003-10-31 2006-09-19 알자 코포레이션 미세 돌출부 어레이를 위한 자가 작동 어플리케이터
WO2005051476A1 (en) * 2003-11-28 2005-06-09 Acrux Dds Pty Ltd Method and system for rapid transdermal administration
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
MX2007001667A (es) * 2004-08-11 2007-10-02 Johnson & Johnson Aparato y metodo para el suministro transdermico de peptidos natriureticos.
NZ553776A (en) 2004-09-22 2010-05-28 Glaxosmithkline Biolog Sa Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide.
TW200738252A (en) * 2005-02-16 2007-10-16 Alza Corp Apparatus and method for transdermal delivery of Epoetin-based agents
JP2008534151A (ja) * 2005-03-28 2008-08-28 アルザ コーポレイション 毛管作用制御特徴部を有するマイクロプロジェクション及び方法
ATE477833T1 (de) 2005-06-27 2010-09-15 3M Innovative Properties Co Mikronadelkartuschenanordnung
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
EP3020411A1 (en) 2005-12-22 2016-05-18 GlaxoSmithKline Biologicals s.a. Vaccine
EP1981547B1 (en) 2005-12-28 2015-09-30 Alza Corporation Stable therapeutic formulations
EP1998802A2 (en) 2006-03-30 2008-12-10 GlaxoSmithKline Biologicals S.A. Immunogenic composition
EP2076312A4 (en) * 2006-04-20 2013-09-04 3M Innovative Properties Co SHAPED ITEMS WITH MICRONADEL ARRANGEMENTS
DE102006028987A1 (de) * 2006-06-24 2007-12-27 Lts Lohmann Therapie-Systeme Ag Ultraschallverstärktes transdermales therapeutisches System
CA2664619C (en) 2006-10-12 2012-12-11 Glaxosmithkline Biologicals S.A. Immunogenic compositions comprising an oil-in-water emulsion adjuvant containing a reduced amount of squalene, tocol and an emulsifying agent
EP2433648A3 (en) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
NZ580997A (en) 2007-04-27 2011-08-26 Echo Therapeutics Inc Dermal abrasion device with feedback electrode to deliver data on skin thickness and removable abrasion heads
EP2152304B1 (en) 2007-05-02 2018-08-22 The Regents of the University of Michigan Nanoemulsion therapeutic compositions and methods of using the same
EP2153863B1 (en) 2007-05-15 2022-03-16 Hisamitsu Pharmaceutical Co., Inc. Method of coating microneedle
PT2167121E (pt) 2007-06-26 2015-12-02 Glaxosmithkline Biolog Sa Vacina compreendendo conjugados de polissacáridos capsulares de streptococcus pneumoniae
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
EP2247527A4 (en) 2008-02-07 2014-10-29 Univ Queensland PATCH PRODUCTION
GB0802447D0 (en) 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
PT2271360E (pt) 2008-04-16 2015-12-07 Glaxosmithkline Biolog Sa Vacina
WO2009140735A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
JP5722782B2 (ja) 2008-09-26 2015-05-27 ナノバイオ コーポレーション ナノエマルジョン治療用組成物及びその使用方法
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
KR101634836B1 (ko) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스
SG173160A1 (en) 2009-01-30 2011-08-29 Hisamitsu Pharmaceutical Co Microneedle device
EP2441437B1 (en) 2009-06-10 2018-08-08 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
CN102596243B (zh) 2009-06-16 2015-10-21 密执安大学评议会 纳米乳剂疫苗
WO2011010605A1 (ja) 2009-07-23 2011-01-27 久光製薬株式会社 マイクロニードルアレイ
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
CN102770176B (zh) 2010-02-24 2015-11-25 久光制药株式会社 微针装置及其制造方法
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
KR101759370B1 (ko) 2010-05-28 2017-07-18 히사미쓰 세이야꾸 가부시키가이샤 미소 돌기가 형성된 어레이
KR101741294B1 (ko) 2010-05-28 2017-05-29 히사미쓰 세이야꾸 가부시키가이샤 미소 돌기가 형성된 어레이를 갖는 디바이스
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
EP2679270B1 (en) 2011-02-24 2016-11-09 Hisamitsu Pharmaceutical Co., Inc. Glp-1 analogue composition for microneedle devices
US8696637B2 (en) * 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
SG194733A1 (en) 2011-05-17 2013-12-30 Glaxosmithkline Biolog Sa Vaccine against streptococcus pneumoniae
CA2851606C (en) 2011-10-12 2020-08-04 3M Innovative Properties Company Integrated microneedle array delivery system
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
JP2013153959A (ja) * 2012-01-30 2013-08-15 Toppan Printing Co Ltd 針状体の構造
CN103356243A (zh) * 2012-03-27 2013-10-23 马广 新型皮肤采样器
PL2912186T3 (pl) 2012-10-24 2021-06-14 Platelet Targeted Therapeutics Llc Leczenie ukierunkowane na płytki krwi
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
WO2015063611A2 (en) 2013-11-01 2015-05-07 University Of Oslo Albumin variants and uses thereof
EP3068426B1 (en) 2013-11-13 2020-02-12 University Of Oslo Outer membrane vesicles and uses thereof
DK3069138T3 (en) 2013-11-15 2019-04-08 Univ Oslo Hf CTL PEPTID EPITOPES AND ANTIGEN-SPECIFIC T-CELLS, METHODS OF RECOGNITION THEREOF, AND APPLICATIONS THEREOF
EP4112076A1 (en) 2014-10-10 2023-01-04 The Regents of The University of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
EP4218892A1 (en) 2015-02-02 2023-08-02 Vaxxas Pty Limited Microprojection array applicator
EP4226937A3 (en) 2015-03-05 2023-09-27 Northwestern University Non-neuroinvasive viruses and uses thereof
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
WO2017054040A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
EP3454891A4 (en) 2016-05-10 2019-12-25 The Regents of The University of Michigan EMULSION ADDITIVE FOR INTRAMUSCULAR, INTRADERMAL AND SUBCUTANEOUS ADMINISTRATION
WO2017201390A1 (en) 2016-05-19 2017-11-23 The Regents Of The University Of Michigan Novel adjuvant compositions
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
US20190350840A1 (en) 2016-12-26 2019-11-21 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
WO2018155431A1 (ja) 2017-02-24 2018-08-30 久光製薬株式会社 マイクロニードルデバイス
DK3606760T3 (da) 2017-03-31 2023-11-06 Vaxxas Pty Ltd Indretning og fremgangsmåde til belægning af overflader
WO2018227246A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
SG11201912601RA (en) 2017-06-23 2020-01-30 Nosocomial Vaccine Corp Immunogenic compositions
CA3071680A1 (en) 2017-08-04 2019-02-07 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
JP2020533338A (ja) 2017-09-07 2020-11-19 ユニバーシティ オブ オスロＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｏｓｌｏ ワクチン分子
EP3678699A1 (en) 2017-09-07 2020-07-15 University Of Oslo Vaccine molecules
AU2018359556B2 (en) 2017-11-03 2021-12-02 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
WO2021206294A1 (ko) * 2020-04-06 2021-10-14 (주)일론 화장품 흡수 유도용 미세바늘이 장착된 화장품 주입기 및 이의 제작방법
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
CA2079315C (en) 1990-03-30 2003-04-15 Joseph Bradley Phipps Device and method for iontophoretic drug delivery
ZA918528B (en) 1990-10-29 1992-08-26 Alza Corp Iontophoretic delivery device and method of hydrating same
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
DE59505328D1 (de) * 1994-12-09 1999-04-15 Novartis Ag Transdermales system
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem

Also Published As

Publication number Publication date
CA2271167A1 (en) 1998-07-02
KR20000053006A (ko) 2000-08-25
EP0957972B1 (en) 2003-03-19
EP0957972A1 (en) 1999-11-24
JP2001506904A (ja) 2001-05-29
JP4153999B2 (ja) 2008-09-24
CA2271167C (en) 2007-01-09
AU722574B2 (en) 2000-08-10
KR100453132B1 (ko) 2004-10-15
AU5529498A (en) 1998-07-17
DE69720057D1 (de) 2003-04-24
CN1133472C (zh) 2004-01-07
DE69720057T2 (de) 2003-09-25
CN1233967A (zh) 1999-11-03
WO1998028037A1 (en) 1998-07-02
DK0957972T3 (da) 2003-07-21
ATE234649T1 (de) 2003-04-15

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