DE69014653T2 - Verfahren und vorrichtung zur iontophoretischen abgabe von medikamenten. - Google Patents

Verfahren und vorrichtung zur iontophoretischen abgabe von medikamenten.

Info

Publication number
DE69014653T2
DE69014653T2 DE69014653T DE69014653T DE69014653T2 DE 69014653 T2 DE69014653 T2 DE 69014653T2 DE 69014653 T DE69014653 T DE 69014653T DE 69014653 T DE69014653 T DE 69014653T DE 69014653 T2 DE69014653 T2 DE 69014653T2
Authority
DE
Germany
Prior art keywords
medicines
iontophoretic delivery
delivery
isolates
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69014653T
Other languages
English (en)
Other versions
DE69014653D1 (de
Inventor
Ronald Haak
J Gyory
Felix Theeuwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26781412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69014653(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE69014653D1 publication Critical patent/DE69014653D1/de
Publication of DE69014653T2 publication Critical patent/DE69014653T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444Membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/0436Material of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir
DE69014653T 1988-10-03 1990-04-30 Verfahren und vorrichtung zur iontophoretischen abgabe von medikamenten. Revoked DE69014653T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/252,463 US4927408A (en) 1988-10-03 1988-10-03 Electrotransport transdermal system
PCT/US1990/002414 WO1991016943A1 (en) 1988-10-03 1990-04-30 Device and method of iontophoretic drug delivery

Publications (2)

Publication Number Publication Date
DE69014653D1 DE69014653D1 (de) 1995-01-12
DE69014653T2 true DE69014653T2 (de) 1995-04-06

Family

ID=26781412

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69014653T Revoked DE69014653T2 (de) 1988-10-03 1990-04-30 Verfahren und vorrichtung zur iontophoretischen abgabe von medikamenten.

Country Status (10)

Country Link
US (1) US4927408A (de)
EP (1) EP0528789B1 (de)
AT (1) ATE114486T1 (de)
AU (1) AU644792B2 (de)
DE (1) DE69014653T2 (de)
DK (1) DK0528789T3 (de)
ES (1) ES2067743T3 (de)
FI (1) FI924918A0 (de)
NO (1) NO924127L (de)
WO (1) WO1991016943A1 (de)

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250022A (en) * 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5162042A (en) * 1988-07-05 1992-11-10 Alza Corporation Electrotransport transdermal system
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5057072A (en) * 1988-10-28 1991-10-15 Medtronic, Inc. Iontophoresis electrode
US5006108A (en) * 1988-11-16 1991-04-09 Noven Pharmaceuticals, Inc. Apparatus for iontophoretic drug delivery
US5236412A (en) * 1989-07-21 1993-08-17 Iomed, Inc. Rehydratable product and method of preparation thereof
ES2095929T3 (es) * 1989-10-23 1997-03-01 Theratech Inc Dispositivo iontoforetico que emplea un regulador del regimen.
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5084008A (en) * 1989-12-22 1992-01-28 Medtronic, Inc. Iontophoresis electrode
US5088978A (en) * 1990-01-26 1992-02-18 Gensia Pharmaceuticals, Inc. Apparatus and method for iontophoretic transfer
JP2816886B2 (ja) * 1990-03-05 1998-10-27 興和株式会社 生体通電装置
US5084006A (en) * 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5162043A (en) * 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US6004309A (en) * 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
DE69115471T2 (de) * 1990-03-30 1996-05-02 Alza Corp Gerät zur iontophoretischen verabreichung von medikamenten
US5147297A (en) * 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
US5362308A (en) * 1990-09-25 1994-11-08 Rutgers, The State University Of New Jersey Disposable dosage unit for iontophoresis-facilitated transdermal delivery, related devices and processes
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5405317A (en) * 1991-05-03 1995-04-11 Alza Corporation Iontophoretic delivery device
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
ES2114569T3 (es) * 1991-10-16 1998-06-01 Richardson Vicks Inc Sistema mejorado de penetracion en la piel para la administracion topica mejorada de farmacos.
FR2687321B1 (fr) * 1992-02-14 1999-04-16 Elf Aquitaine Dispositif d'ionophorese pour l'administration transcutanee d'une quantite totale donnee d'un principe actif a un sujet.
IL105073A0 (en) 1992-03-17 1993-07-08 Becton Dickinson Co User activated iontophoretic device and method for using same
ATE160510T1 (de) * 1992-06-02 1997-12-15 Alza Corp Abgabevorrichtung zur elektrischen übertragung von arzneimitteln
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
JP2542792B2 (ja) * 1992-11-05 1996-10-09 ベクトン・ディッキンソン・アンド・カンパニー ユ―ザ作動型のイオン導入式装置
US5298017A (en) * 1992-12-29 1994-03-29 Alza Corporation Layered electrotransport drug delivery system
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
CA2126487C (en) * 1993-06-23 2001-05-29 Keiichiro Okabe Iontophoresis device
US5540669A (en) * 1993-09-30 1996-07-30 Becton, Dickinson And Company Iontophoretic drug delivery system and method for using same
US20050159699A1 (en) * 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
WO1995009032A1 (en) * 1993-09-30 1995-04-06 Becton, Dickinson And Company Iontophoretic drug delivery system and method
US6377847B1 (en) * 1993-09-30 2002-04-23 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US5505200A (en) * 1994-01-28 1996-04-09 Minnesota Mining And Manufacturing Biomedical conductor containing inorganic oxides and biomedical electrodes prepared therefrom
JP3549540B2 (ja) * 1994-03-30 2004-08-04 アルザ・コーポレーション 電気的移送式投与中の皮膚刺激状態の軽減
AU2286995A (en) * 1994-04-08 1995-10-30 Alza Corporation Electrotransport system with ion exchange competitive ion capture
US5871460A (en) * 1994-04-08 1999-02-16 Alza Corporation Electrotransport system with ion exchange material providing enhanced drug delivery
ATE258452T1 (de) * 1994-06-17 2004-02-15 Hisamitsu Pharmaceutical Co Elektrode für iontophorese und vorrichtung dafür
US5795321A (en) * 1994-09-30 1998-08-18 Becton Dickinson And Company Iontophoretic drug delivery system, including removable controller
DK0783301T3 (da) * 1994-09-30 1999-08-02 Becton Dickinson Co Fremgangsmåde til udformning og pakning af iontoforetiske medikamentleveringsplastre og lignende med henblik på forøgelse a
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
JPH08155041A (ja) * 1994-12-05 1996-06-18 Advance Co Ltd イオントフォレシス用新規高能率電極システム
US5843014A (en) * 1995-03-24 1998-12-01 Alza Corporation Display for an electrotransport delivery device
US5990179A (en) * 1995-04-28 1999-11-23 Alza Corporation Composition and method of enhancing electrotransport agent delivery
IE960312A1 (en) 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
CA2218369C (en) * 1995-06-05 2010-02-09 Alza Corporation Transdermal electrotransport delivery of fentanyl and sufentanil
IE960375A1 (en) * 1995-06-05 1996-12-11 Alza Corp Device for transdermal electrotransport delivery of fentanyl¹and sufentanil
DE69629628T2 (de) * 1995-06-14 2004-06-17 Hisamitsu Pharmaceutical Co., Inc., Tosu Schnittstelle für Iontophorese
US5788666A (en) * 1995-06-15 1998-08-04 Empi, Inc. Iontophoresis electrode
US5840056A (en) * 1995-06-15 1998-11-24 Empi, Inc. Iontophoresis electrode
US5738774A (en) * 1995-07-28 1998-04-14 The Governors Of The University Of Alberta Eva containing ion selective membranes and methods of making same
EP1762268A1 (de) * 1995-09-29 2007-03-14 Vyteris, Inc. Preisgünstige Elektroden für ein Iontophoresegerät
WO1997012644A1 (en) * 1995-09-29 1997-04-10 Becton Dickinson And Company Improved iontophoretic reservoir apparatus
US5961483A (en) * 1996-06-19 1999-10-05 Sage; Burton H. Iontophoretic delivery of cell adhesion inhibitors
EP0813887A3 (de) * 1996-06-20 1999-11-03 Hisamitsu Pharmaceutical Co. Inc. Iontophoretische Vorrichtung
US5941843A (en) * 1996-07-12 1999-08-24 Empi, Inc. Iontophoresis electrode
US5871461A (en) * 1996-07-12 1999-02-16 Empi, Inc. Method of making an iontophoresis electrode
US5857993A (en) * 1996-07-12 1999-01-12 Empi, Inc. Process of making an iontophoresis electrode
US5797867A (en) 1996-09-27 1998-08-25 Becton Dickinson And Company Iontophoretic drug delivery system, including method for activating same for attachment to patient
US5919156A (en) 1996-09-27 1999-07-06 Becton, Dickinson And Company Iontophoretic drug delivery system, including unit for dispensing patches
US5713846A (en) 1996-09-27 1998-02-03 Becton Dickinson And Company Iontophoretic drug delivery system, including method for activating same for attachment to patient
US5693024A (en) 1996-09-27 1997-12-02 Becton Dickinson And Company Iontophoretic drug delivery system, including method for determining hydration of patch
US5738647A (en) 1996-09-27 1998-04-14 Becton Dickinson And Company User activated iontophoretic device and method for activating same
US6350259B1 (en) 1996-09-30 2002-02-26 Vyteris, Inc. Selected drug delivery profiles using competing ions
IL119417A (en) * 1996-10-13 2003-02-12 Moshe Kushnir Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease
FR2755372B1 (fr) * 1996-11-07 1998-12-24 Elf Aquitaine Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet
US6246904B1 (en) * 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
US6148233A (en) 1997-03-07 2000-11-14 Cardiac Science, Inc. Defibrillation system having segmented electrodes
US5976547A (en) * 1997-04-22 1999-11-02 Niblick Pharmaceuticals, Inc. Analgesic and antiphlogistic compositions and therapeutic wrap for topical delivery
CA2244332C (en) 1997-07-30 2002-04-02 Becton, Dickinson And Company Bonding agent and method of bonding electrode to printed conductive trace
US6004577A (en) * 1997-08-12 1999-12-21 Murdock; Thomas O. Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions
US5882677A (en) * 1997-09-30 1999-03-16 Becton Dickinson And Company Iontophoretic patch with hydrogel reservoir
CN1278737A (zh) * 1997-11-12 2001-01-03 阿尔萨公司 减少多肽自结合的方法
KR100247558B1 (ko) 1997-11-24 2000-05-01 김충섭 사이클로덱스트린을 이용한 이온토포레시스 개선방법
US6163720A (en) * 1997-12-18 2000-12-19 Alza Corporation Layered rate controlling membranes for use in an electrotransport device
US6374136B1 (en) * 1997-12-22 2002-04-16 Alza Corporation Anhydrous drug reservoir for electrolytic transdermal delivery device
EP1115454B1 (de) * 1998-08-31 2006-10-25 Travanti Pharma Inc Gesteuerte medikamentdosierungsvorrichtung
EP1109594B1 (de) 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
WO2000062857A1 (en) 1999-04-16 2000-10-26 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
EP1106681A4 (de) * 1999-06-10 2005-03-23 Matsushita Electric Ind Co Ltd Elektrochemische vorrichtung zur bewegung von mit proteinen bedeckten partikeln
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US6421561B1 (en) * 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
US6522918B1 (en) 2000-02-09 2003-02-18 William E. Crisp Electrolytic device
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US6690959B2 (en) * 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
US6546284B2 (en) * 2001-01-25 2003-04-08 Iomed, Inc. Fluid retention assembly for an iontophoretic delivery device and associated method for preparing the same
EP1385571B1 (de) * 2001-04-04 2008-07-30 Alza Corporation Transdermales verabreichungsgerät mittels elektrotransport mit einer kompatiblen antimikrobiellen reservoir-lösung
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) * 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
ATE438418T1 (de) 2001-05-01 2009-08-15 Av Topchiev Inst Petrochemical Hydrogel-zusammensetzungen
US6803420B2 (en) * 2001-05-01 2004-10-12 Corium International Two-phase, water-absorbent bioadhesive composition
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US20030027833A1 (en) * 2001-05-07 2003-02-06 Cleary Gary W. Compositions and delivery systems for administration of a local anesthetic agent
US6653014B2 (en) 2001-05-30 2003-11-25 Birch Point Medical, Inc. Power sources for iontophoretic drug delivery systems
DE10136403B4 (de) * 2001-07-26 2006-04-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Elektrisch aktive Pflaster und ihre Anwendung
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US7643874B2 (en) * 2001-10-24 2010-01-05 Power Paper Ltd. Dermal patch
EP1440707A4 (de) * 2001-10-31 2006-05-24 Transcutaneous Tech Inc Iontophorese-vorrichtung
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
WO2003047689A1 (en) * 2001-11-29 2003-06-12 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
DE10205373B4 (de) * 2002-02-09 2007-07-19 Aloys Wobben Brandschutz
AU2003221770A1 (en) * 2002-04-29 2003-11-17 Stephen T. Flock Controlled release transdermal drug delivery
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US7834147B2 (en) 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
MXPA05013213A (es) * 2003-06-11 2006-03-09 Procter & Gamble Dispositivo para preparar un producto en el momento de usarlo que comprende un producto de hidrogel preformado.
DK1644076T3 (da) * 2003-06-30 2014-02-03 Johnson & Johnson Consumer Topisk sammensætning til behandling af akne og rosacea med galvanisk genereret elektricitet
WO2005074894A1 (en) 2004-01-30 2005-08-18 Corium International Rapidly dissolving film for delivery of an active agent
US20050220439A1 (en) * 2004-03-19 2005-10-06 Carton Owen A Interactive multimedia system and method
US20050228335A1 (en) 2004-04-07 2005-10-13 Reddy Vilambi N Physical, structural, mechanical, electrical and electromechanical features for use in association with electrically assisted delivery devices and systems
US20050228336A1 (en) 2004-04-07 2005-10-13 Preston Keusch Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability
CN103497713B (zh) * 2004-08-05 2018-07-17 考里安国际公司 粘合剂组合物
JP2008510987A (ja) * 2004-08-24 2008-04-10 スカイラド エルティーディー. 温度感知製品の指示装置
US20060095001A1 (en) * 2004-10-29 2006-05-04 Transcutaneous Technologies Inc. Electrode and iontophoresis device
WO2006055729A1 (en) * 2004-11-16 2006-05-26 Transcutaneous Technologies Inc. Iontophoretic device and method for administering immune response-enhancing agents and compositions
JP4728631B2 (ja) * 2004-11-30 2011-07-20 Tti・エルビュー株式会社 イオントフォレーシス装置
US7590444B2 (en) * 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
JP4731931B2 (ja) * 2005-02-03 2011-07-27 Tti・エルビュー株式会社 イオントフォレーシス装置
CA2595990A1 (en) * 2005-02-03 2006-08-10 Transcutaneous Technologies Inc. Iontophoresis device
US8386029B2 (en) 2005-03-31 2013-02-26 Encore Medical Asset Corporation Apparatus for electrotherapy drug delivery with added impurities
JP2006296511A (ja) * 2005-04-15 2006-11-02 Transcutaneous Technologies Inc 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
JP2006334164A (ja) * 2005-06-02 2006-12-14 Transcutaneous Technologies Inc イオントフォレーシス装置及びその制御方法
JP2007000342A (ja) * 2005-06-23 2007-01-11 Transcutaneous Technologies Inc 複数薬剤の投与量および投与時期を制御するイオントフォレーシス装置
US20070027426A1 (en) * 2005-06-24 2007-02-01 Transcutaneous Technologies Inc. Iontophoresis device to deliver active agents to biological interfaces
JPWO2007010900A1 (ja) * 2005-07-15 2009-01-29 Tti・エルビュー株式会社 貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
US8295922B2 (en) 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US8386030B2 (en) 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
JPWO2007023907A1 (ja) * 2005-08-24 2009-02-26 Tti・エルビュー株式会社 冷凍型イオントフォレーシス用電極構造体
WO2007026671A1 (ja) * 2005-08-29 2007-03-08 Transcu Ltd. センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
US20070048362A1 (en) * 2005-08-29 2007-03-01 Transcutaneous Technologies Inc. General purpose electrolyte solution composition for iontophoresis
JPWO2007029611A1 (ja) * 2005-09-06 2009-03-19 Tti・エルビュー株式会社 イオントフォレーシス装置
US20070112294A1 (en) * 2005-09-14 2007-05-17 Transcutaneous Technologies Inc. Iontophoresis device
RU2008114490A (ru) 2005-09-15 2009-10-20 ТиТиАй ЭЛЛЕБО, ИНК. (JP) Устройство ионтофореза стержневого типа
JPWO2007037324A1 (ja) * 2005-09-28 2009-04-09 Tti・エルビュー株式会社 乾燥型イオントフォレーシス用電極構造体
US20070078372A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia
WO2007041300A2 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoresis method and apparatus for systemic delivery of active agents
EP1928539A1 (de) * 2005-09-30 2008-06-11 Tti Ellebeau, Inc. Transdermale funktionalisierte mikronadel-arzneiabgabesysteme, vorrichtungen und verfahren
US20070232983A1 (en) * 2005-09-30 2007-10-04 Smith Gregory A Handheld apparatus to deliver active agents to biological interfaces
US20070093743A1 (en) * 2005-09-30 2007-04-26 Vyteris, Inc. Iontophoresis Drug Delivery Device Providing Acceptable Depth and Duration of Dermal Anesthesia
US20070135754A1 (en) * 2005-09-30 2007-06-14 Hidero Akiyama Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same
US20070078445A1 (en) * 2005-09-30 2007-04-05 Curt Malloy Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces
JP2009509659A (ja) * 2005-09-30 2009-03-12 Tti・エルビュー株式会社 生体界面への活性物質の送達のイオントフォレーシス装置及び方法
JP2009509682A (ja) 2005-09-30 2009-03-12 バイテリス,インコーポレイテッド 予め充填された結合電気搬送パッチからの性腺刺激ホルモン放出ホルモンのパルス状搬送
US20090187134A1 (en) * 2005-09-30 2009-07-23 Hidero Akiyama Iontophoresis Device Controlling Amounts of a Sleep-Inducing Agent and a Stimulant to be Administered and Time at Which the Drugs are Administered
WO2007041115A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau Inc. Method and system to detect malfunctions in an iontophoresis device that delivers active agents to biological interfaces
KR20080066712A (ko) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
US20070078434A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices
CN101432042A (zh) * 2005-09-30 2009-05-13 Tti优而美株式会社 用于包封在纳米颗粒中的药物给药的离子电渗疗法的电极组件和使用该组件的离子电渗装置
JP2009509657A (ja) * 2005-09-30 2009-03-12 Tti・エルビュー株式会社 生体界面への活性物質の送達のイオントフォレーシス装置及び方法
US20090299265A1 (en) * 2005-09-30 2009-12-03 Tti Ellebeau, Inc. Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same
US20090221985A1 (en) * 2005-10-19 2009-09-03 Shmuel Bukshpan System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof
US20080033398A1 (en) * 2005-12-29 2008-02-07 Transcutaneous Technologies Inc. Device and method for enhancing immune response by electrical stimulation
US7848801B2 (en) * 2005-12-30 2010-12-07 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
WO2007079189A2 (en) * 2005-12-30 2007-07-12 Tti Ellebeau, Inc. System and method for remote based control of an iontophoresis device
CA2642338A1 (en) * 2006-02-13 2007-08-23 Aveva Drug Delivery Systems Adhesive preparation comprising sufentanil and methods of using the same
US8036738B2 (en) 2006-03-14 2011-10-11 New Jersey Institute Of Technology Iontophoretic transdermal drug delivery system based on conductive polyaniline membrane
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
CA2935569A1 (en) * 2006-04-13 2007-10-25 Teva Pharmaceuticals International Gmbh Transdermal methods and systems for the delivery of anti-migraine compounds
WO2007127439A2 (en) 2006-04-28 2007-11-08 Children's Hospital Medical Center Compositions comprising fusogenic proteins or polypeptides derived from prosaposin for application in transmembrane drug delivery systems
CN101495105A (zh) * 2006-07-05 2009-07-29 Tti优而美株式会社 具有自组装树枝状聚合物的输送装置及其使用方法
US20080077076A1 (en) * 2006-08-29 2008-03-27 Transcutaneous Technologies Inc. Iontophoresis device and method for operation with a usb (universal serial bus) power source
EP2059298A2 (de) * 2006-09-05 2009-05-20 Tti Ellebeau, Inc. Systeme zur transdermalen wirkstoffverabreichung sowie vorrichtungen und verfahren unter nutzung induktiver netzteile
US7904146B2 (en) * 2006-11-13 2011-03-08 Travanti Pharma Inc. Transdermal systems for the delivery of ionic agents directly to open wounds and surgically repaired incisions
BRPI0719353A2 (pt) * 2006-12-01 2014-01-07 Titi Ellebeau Inc Sistemas, dispositivos e métodos para dispositivos de energização e/ou controle, por exemplo, dispositivos de distribuição transdérmicos
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
RU2482841C2 (ru) * 2007-05-18 2013-05-27 ТиТиАй Эллебо, Инк. Устройства для трансдермальной доставки, обеспечивающие улучшенное высвобождение действующего начала через биологическую поверхность
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
EP2644228A1 (de) * 2007-06-27 2013-10-02 The General Hospital Corporation Verfahren und Vorrichtung zur optischen Unterdrückung der photodynamischen Therapie
WO2009074156A1 (en) * 2007-12-12 2009-06-18 Aarhus Universitet (University Of Aarhus) Crystal structure of a plasma membrane proton pump
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
KR100950584B1 (ko) * 2008-04-07 2010-04-01 주식회사로케트전기 전지 일체형 이온토포레시스 패치
ES2680222T3 (es) 2008-05-22 2018-09-05 H. Lundbeck A/S Modulación de los receptores con dominio Vps10p para el tratamiento de la enfermedad cardiovascular
US8155737B2 (en) * 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
EP2307042B1 (de) 2008-06-25 2014-03-26 H. Lundbeck A/S Modulierung des trpv : vps10p domänen-rezeptorsystems zur behandlung von schmerzen
TW201026347A (en) * 2008-09-10 2010-07-16 Transcu Ltd Apparatus and method to dispense HPC-based viscous liquids into porous substrates, e. g., continuous web-based process
US8637075B2 (en) 2008-09-12 2014-01-28 Pharma Gp Aps Colostrum composition
CN102439041B (zh) 2008-12-19 2016-05-04 H.隆德贝克有限公司 用于治疗精神和行为障碍的对Vps10p-结构域受体家族的调节
ES2612830T3 (es) 2008-12-30 2017-05-18 Teva Pharmaceuticals International Gmbh Control electrónico de sistema de administración de fármacos
AU2010204986B2 (en) 2009-01-14 2016-06-02 Corium International, Inc. Transdermal administration of tamsulosin
WO2010144424A2 (en) * 2009-06-09 2010-12-16 Tti Ellebeau, Inc. Long life high capacity electrode, device, and method of manufacture
CN102573489A (zh) 2009-08-10 2012-07-11 纽帕特公司 用离子电渗疗法治疗恶心和偏头痛的方法
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
WO2011054359A2 (en) 2009-11-06 2011-05-12 University Of Copenhagen Method for early detection of cancer
WO2011095174A1 (en) 2010-02-08 2011-08-11 Aarhus Universitet Human herpes virus 6 and 7 u20 polypeptide and polynucleotides for use as a medicament or diagnosticum
WO2011107100A1 (en) 2010-03-03 2011-09-09 Aarhus Universitet Methods and compositions for regulation of herv4
AU2011239636A1 (en) 2010-04-13 2012-11-22 Najib Babul Dermal pharmaceutical compositions of 1-Methyl-2',6'-pipecoloxylidide and method of use
JP2013532144A (ja) 2010-06-14 2013-08-15 ハー・ルンドベック・アクチエゼルスカベット SorLAとGDNFファミリーリガンド受容体の間の相互作用の調節
CA2817824A1 (en) 2010-11-23 2012-05-31 Nupathe, Inc. User-activated self-contained co-packaged iontophoretic drug delivery system
MX357655B (es) 2011-11-15 2018-07-18 Walter & Eliza Hall Inst Medical Res Mediador soluble.
WO2013167750A2 (en) 2012-05-11 2013-11-14 Prorec Bio Ab Method for diagnosis and treatment of prolactin associated disorders
EP2919759A4 (de) 2012-11-14 2016-07-20 Ohio State Innovation Foundation Materialien und methoden zur behandlung von glioblastomen
WO2014122627A1 (en) 2013-02-11 2014-08-14 Glycanova As Basidiomycete-derived cream for treatment of skin diseases
MX2016001318A (es) 2013-07-29 2016-08-03 Kural Corp Transferencia terapeutica de iones y electrones a traves de una semi-celda.
JP2016536326A (ja) 2013-08-29 2016-11-24 ユニバーシティ オブ コペンハーゲン 癌治療用抗adam12抗体
FI127226B (en) 2013-12-20 2018-01-31 Teknologian Tutkimuskeskus Vtt Oy PROCEDURE AND DEVICE FOR SKIN TREATMENT
SE545752C2 (en) * 2019-12-20 2023-12-27 Oboe Ipr Ab Selective drug delivery in an ion pump through proton entrapment
WO2022026720A1 (en) * 2020-07-31 2022-02-03 Board Of Regents Of The University Of Nebraska Hydrogel ionic circuit based devices for electrical stimulation and drug therapy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4767401A (en) * 1975-04-22 1988-08-30 Maurice Seiderman Iontophoretic administration of ionizable or polar medicaments to a mammalian body
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4274420A (en) * 1975-11-25 1981-06-23 Lectec Corporation Monitoring and stimulation electrode
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus
CA1153427A (en) * 1978-12-11 1983-09-06 Patrick T. Cahalan Tape electrode
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US4419092A (en) * 1981-11-06 1983-12-06 Motion Control, Inc. Iontophoretic electrode structure
US4457748A (en) * 1982-01-11 1984-07-03 Medtronic, Inc. Non-invasive diagnosis method
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
DE3337668C2 (de) * 1983-10-17 1985-12-05 Carl Schleicher & Schuell Gmbh & Co Kg, 3352 Einbeck Verfahren zur Elektroelution elektrisch geladener Makromoleküle
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
ATE80048T1 (de) * 1985-06-10 1992-09-15 Drug Delivery Systems Inc Programmierbare kontrolle und bausystem eines verabreichungsgeraetes fuer transdermische arzneien.
JPS6222662A (ja) * 1985-07-19 1987-01-30 林原 健 イオン導入電子治療器
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery

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DK0528789T3 (da) 1995-05-01
ES2067743T3 (es) 1995-04-01
WO1991016943A1 (en) 1991-11-14
EP0528789A1 (de) 1993-03-03
US4927408A (en) 1990-05-22
FI924918A0 (fi) 1992-10-29
AU5634090A (en) 1991-11-27
NO924127D0 (no) 1992-10-26
NO924127L (no) 1992-10-26
EP0528789B1 (de) 1994-11-30
DE69014653D1 (de) 1995-01-12
AU644792B2 (en) 1993-12-23
ATE114486T1 (de) 1994-12-15

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