JPWO2007010900A1 - 貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置 - Google Patents
貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置 Download PDFInfo
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- JPWO2007010900A1 JPWO2007010900A1 JP2007526015A JP2007526015A JPWO2007010900A1 JP WO2007010900 A1 JPWO2007010900 A1 JP WO2007010900A1 JP 2007526015 A JP2007526015 A JP 2007526015A JP 2007526015 A JP2007526015 A JP 2007526015A JP WO2007010900 A1 JPWO2007010900 A1 JP WO2007010900A1
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- Prior art keywords
- patch
- drug
- holding part
- living body
- marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
- A61F13/0213—Adhesive plasters or dressings having a fluid handling member the fluid handling member being a layer of hydrocoloid, gel forming material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
バッキング層20は、パッチ10の一次構造要素として機能し、パッチ10にその柔軟性、被覆性を与えている。バッキング層に使用される材料は、不活性で、パッチ10内に含まれた薬剤組成物の薬物、安定剤等のその他の成分を吸収し得るべきではない。バッキング層20は好ましくは保護カバーの役目を果たす軟質材料の1層以上のシート又はフィルムから作られ、パッチ10が皮膚の外形に追従することを許容する。又、通気性(即ち空気及び蒸気等の透過性)を有していることが更に好ましい。通気性を有するバッキング層20により、皮膚貼付部位の呼吸(酸素と二酸化炭素の交換)が可能となり、且つ皮膚表面からの水蒸気を透過させることができる。より具体的に好適なバッキング層20の材料例としては、コポリエステル、ポリエーテル/ポリアミドコポリマー、ポリウレタン及びポリエチレン誘導体等が挙げられる。勿論これらに限定されるものではない。好適なポリエーテル/ポリアミドコポリマーの例としては、PEBAX(登録商標)が挙げられる。好適なポリウレタンの例としては、ESTANEが挙げられる。好適なポリエチレン誘導体の例としては、SKYCARE AND SCYAIRフィルムが挙げられる。
本実施形態における薬剤保持部(層)18は例えばヒドロゲル等が好ましい。このヒドロゲルはγ線滅菌が可能であって、且つ、局所麻酔薬を含浸可能なヒドロゲルであれば全て本実施形態のパッチ10に用いるのに好適である。ヒドロゲルは、適用部位にパッチ10を付着させるために十分な粘着性を有するだけでなく、刺激又は創傷にダメージを与えることなく取り除くことができることが好ましい。
経皮吸収用パッチ10の使用に際しては、薬剤として、患者に貼付して治療効果を上げたり、医療効果を上げたりすることが可能なあらゆる経皮吸収性薬剤を用いることが可能であるが、いくつかの具体例を挙げ、以下に列挙する。勿論以下のものに限定される趣旨のものではない。
本実施形態で用いられるマーカーは、生体内へと投入する薬剤(特定の物質)と化学的な反応を起さないものであること、及び、生体に何らかの異常を起こすものでないことが必要である。逆に、この条件を満たし得る物質であれば、種々のものが考えられる。油性染料や水性染料、水性顔料等の視覚的に捉えることが可能なものは勿論、紫外線の照射により可視化する蛍光色素や、ルシフェラーゼ等の特定の酵素を働かせることによって酸素と結合し、蛍光発光するルシフェリン等の物質でもよい。更には、臭いや味のように、視覚以外で特定するものであってもよい。
Claims (7)
- 薬剤保持部とバッキング層とを有し、生体に貼付した状態で、前記薬剤保持部の表面又は前記薬剤保持部に接する膜を介して、薬剤を経皮吸収により生体内へと導入するための経皮吸収用パッチであって、
前記バッキング層の表面、前記薬剤保持部及び前記薬剤保持部に接する膜のうち少なくとも一つには、貼付した際に生体側へと移行することによって、前記パッチを剥がした後においても貼付位置を表示可能なマーカーが含まれている
ことを特徴とする経皮吸収用パッチ。 - 請求項1において、前記マーカーは、前記薬剤保持部中に、前記薬剤と混合されて封入されていることを特徴とする経皮吸収用パッチ。
- 請求項1において、
前記マーカーは、前記パッチを剥がした後においても、前記バッキング層及び前記薬剤保持部の表面及び前記薬剤保持部に接する膜の少なくとも一部が生体側に残存した残存部である
ことを特徴とする経皮吸収用パッチ。 - 請求項1において、
前記薬剤保持部を収容するとともに前記バッキング層を兼ねる容器を設け、この容器の生体との接触面に凹部を設けるとともに、この凹部内に前記マーカーを配置したことを特徴とする経皮吸収用パッチ。 - 請求項1、2又は4において、
前記マーカーは、食用色素又は錠剤印刷用インクで構成されている
ことを特徴とする経皮吸収用パッチ。 - 請求項1乃至5のいずれかにおいて、
更に、電源に接続される電極を少なくとも備え、該電極に電気を印加することによって前記薬剤保持部の薬剤を生体内へと積極的に導入する
ことを特徴とする経皮吸収用パッチ。 - 薬剤を保持する薬剤保持部を有する作用側パッチとこの対極として非作用側パッチとを備え、両パッチを皮膚に当接させた状態で、作用側パッチに薬剤保持部中の薬剤イオンと同一導電型の電圧を作用させることで薬剤イオンを電気的に駆動して生体内に移行させるイオントフォレーシス装置であって、前記作用側パッチ及び非作用側パッチの少なくとも一方を、前記請求項5に記載の経皮吸収用パッチにより構成したことを特徴とするイオントフォレーシス装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005207675 | 2005-07-15 | ||
JP2005207675 | 2005-07-15 | ||
PCT/JP2006/314183 WO2007010900A1 (ja) | 2005-07-15 | 2006-07-18 | 貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPWO2007010900A1 true JPWO2007010900A1 (ja) | 2009-01-29 |
Family
ID=37668779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007526015A Abandoned JPWO2007010900A1 (ja) | 2005-07-15 | 2006-07-18 | 貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20090214625A1 (ja) |
EP (1) | EP1905433A1 (ja) |
JP (1) | JPWO2007010900A1 (ja) |
WO (1) | WO2007010900A1 (ja) |
Families Citing this family (9)
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CA2671069A1 (en) | 2006-12-01 | 2008-06-12 | Tti Ellebeau, Inc. | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
WO2008087884A1 (ja) | 2007-01-16 | 2008-07-24 | Tti Ellebeau, Inc. | 薬物投与量の予測方法及びそのプログラム |
US10387613B2 (en) * | 2015-08-03 | 2019-08-20 | Drägerwerk AG & Co. KGaA | Displaying status of medical lines |
US10821297B2 (en) * | 2016-09-30 | 2020-11-03 | Johnson & Johnson Consumer Inc. | Kit and method for topical delivery of benefits |
CN111885992B (zh) * | 2018-05-17 | 2023-12-08 | 松下知识产权经营株式会社 | 生物体贴附用选择性透过膜、透皮吸收套件和美容方法 |
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-
2006
- 2006-07-18 JP JP2007526015A patent/JPWO2007010900A1/ja not_active Abandoned
- 2006-07-18 US US11/995,796 patent/US20090214625A1/en not_active Abandoned
- 2006-07-18 WO PCT/JP2006/314183 patent/WO2007010900A1/ja active Application Filing
- 2006-07-18 EP EP06781196A patent/EP1905433A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20090214625A1 (en) | 2009-08-27 |
WO2007010900A1 (ja) | 2007-01-25 |
EP1905433A1 (en) | 2008-04-02 |
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