DE69713499T3 - Verfahren zur inhibierung der immunreaktion durch blockierung der gp39/cd40 und ctla4/cd28/b7 routen und zusammensetzung zu deren verwendung - Google Patents
Verfahren zur inhibierung der immunreaktion durch blockierung der gp39/cd40 und ctla4/cd28/b7 routen und zusammensetzung zu deren verwendung Download PDFInfo
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- DE69713499T3 DE69713499T3 DE69713499T DE69713499T DE69713499T3 DE 69713499 T3 DE69713499 T3 DE 69713499T3 DE 69713499 T DE69713499 T DE 69713499T DE 69713499 T DE69713499 T DE 69713499T DE 69713499 T3 DE69713499 T3 DE 69713499T3
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US13751P | 1996-03-20 | ||
| PCT/US1997/004248 WO1997034633A1 (en) | 1996-03-20 | 1997-03-20 | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
Publications (3)
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| DE69713499D1 DE69713499D1 (de) | 2002-07-25 |
| DE69713499T2 DE69713499T2 (de) | 2003-01-30 |
| DE69713499T3 true DE69713499T3 (de) | 2010-05-06 |
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| JP (1) | JP4751493B2 (enExample) |
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| DE (1) | DE69713499T3 (enExample) |
| DK (1) | DK0892643T4 (enExample) |
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| IL (1) | IL125928A (enExample) |
| NO (1) | NO326922B1 (enExample) |
| PT (1) | PT892643E (enExample) |
| WO (1) | WO1997034633A1 (enExample) |
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| ATE401909T1 (de) * | 2000-07-03 | 2008-08-15 | Bristol Myers Squibb Co | Verwendung von löslichen ctla4-mutanten zur behandlung von rheumatoider arthritis |
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| WO2002083162A1 (en) * | 2001-04-13 | 2002-10-24 | University Of Chicago | Use of a cd8+ t cell inhibitory agent in the presence of a cd4+ t cell inhibitory agent for inhibition of transplant rejection |
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| ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
| US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| MXPA02012157A (es) * | 2000-06-09 | 2003-06-06 | Bristol Myers Squibb Co | Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos. |
| ATE401909T1 (de) * | 2000-07-03 | 2008-08-15 | Bristol Myers Squibb Co | Verwendung von löslichen ctla4-mutanten zur behandlung von rheumatoider arthritis |
| US20040022787A1 (en) * | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| HUP0303930A3 (en) * | 2001-01-26 | 2012-09-28 | Univ Emory | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
| ATE390931T1 (de) * | 2001-05-23 | 2008-04-15 | Bristol Myers Squibb Co | Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4- mutationsmolekülen |
-
1997
- 1997-03-20 IL IL12592897A patent/IL125928A/en not_active IP Right Cessation
- 1997-03-20 DK DK97916037T patent/DK0892643T4/da active
- 1997-03-20 ES ES97916037T patent/ES2177967T5/es not_active Expired - Lifetime
- 1997-03-20 JP JP53360197A patent/JP4751493B2/ja not_active Expired - Lifetime
- 1997-03-20 PT PT97916037T patent/PT892643E/pt unknown
- 1997-03-20 WO PCT/US1997/004248 patent/WO1997034633A1/en not_active Ceased
- 1997-03-20 EP EP97916037A patent/EP0892643B2/en not_active Expired - Lifetime
- 1997-03-20 AU AU23310/97A patent/AU710998B2/en not_active Ceased
- 1997-03-20 CA CA2246352A patent/CA2246352C/en not_active Expired - Lifetime
- 1997-03-20 US US08/821,400 patent/US5916560A/en not_active Expired - Lifetime
- 1997-03-20 AT AT97916037T patent/ATE219376T1/de active
- 1997-03-20 DE DE69713499T patent/DE69713499T3/de not_active Expired - Lifetime
-
1998
- 1998-09-18 NO NO19984369A patent/NO326922B1/no not_active IP Right Cessation
-
2001
- 2001-05-22 US US09/862,255 patent/US20020031510A1/en not_active Abandoned
-
2005
- 2005-01-04 US US11/028,793 patent/US20050202011A1/en not_active Abandoned
-
2008
- 2008-09-10 US US12/207,997 patent/US20090186037A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0892643B2 (en) | 2009-09-02 |
| AU710998B2 (en) | 1999-10-07 |
| US20020031510A1 (en) | 2002-03-14 |
| DE69713499T2 (de) | 2003-01-30 |
| NO984369D0 (no) | 1998-09-18 |
| IL125928A (en) | 2002-11-10 |
| PT892643E (pt) | 2002-09-30 |
| NO984369L (no) | 1998-11-18 |
| CA2246352A1 (en) | 1997-09-25 |
| DK0892643T3 (da) | 2002-10-14 |
| DK0892643T4 (da) | 2009-12-14 |
| DE69713499D1 (de) | 2002-07-25 |
| JP4751493B2 (ja) | 2011-08-17 |
| AU2331097A (en) | 1997-10-10 |
| EP0892643B1 (en) | 2002-06-19 |
| WO1997034633A1 (en) | 1997-09-25 |
| US20090186037A1 (en) | 2009-07-23 |
| NO326922B1 (no) | 2009-03-16 |
| US20050202011A1 (en) | 2005-09-15 |
| US5916560A (en) | 1999-06-29 |
| ATE219376T1 (de) | 2002-07-15 |
| CA2246352C (en) | 2011-11-08 |
| ES2177967T3 (es) | 2002-12-16 |
| JP2001518066A (ja) | 2001-10-09 |
| ES2177967T5 (es) | 2009-12-17 |
| EP0892643A1 (en) | 1999-01-27 |
| IL125928A0 (en) | 1999-04-11 |
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