DE69431107T2 - Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesen - Google Patents
Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesenInfo
- Publication number
- DE69431107T2 DE69431107T2 DE69431107T DE69431107T DE69431107T2 DE 69431107 T2 DE69431107 T2 DE 69431107T2 DE 69431107 T DE69431107 T DE 69431107T DE 69431107 T DE69431107 T DE 69431107T DE 69431107 T2 DE69431107 T2 DE 69431107T2
- Authority
- DE
- Germany
- Prior art keywords
- cells
- surrogate
- pct
- organ graft
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000004027 cell Anatomy 0.000 abstract 6
- 210000000056 organ Anatomy 0.000 abstract 6
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000000998 lymphohematopoietic effect Effects 0.000 abstract 2
- 230000003302 anti-idiotype Effects 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 230000001605 fetal effect Effects 0.000 abstract 1
- 230000006058 immune tolerance Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Environmental Sciences (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
- Transplanting Machines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6537093A | 1993-05-24 | 1993-05-24 | |
PCT/US1994/005844 WO1994027622A1 (en) | 1993-05-24 | 1994-05-24 | Surrogate tolerogenesis for the development of tolerance to xenografts |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69431107D1 DE69431107D1 (de) | 2002-09-05 |
DE69431107T2 true DE69431107T2 (de) | 2003-03-27 |
Family
ID=22062242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69431107T Expired - Fee Related DE69431107T2 (de) | 1993-05-24 | 1994-05-24 | Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesen |
Country Status (8)
Country | Link |
---|---|
US (1) | US6060049A (de) |
EP (1) | EP0700297B1 (de) |
JP (1) | JP4236279B2 (de) |
AT (1) | ATE221382T1 (de) |
AU (1) | AU693452B2 (de) |
CA (1) | CA2163517C (de) |
DE (1) | DE69431107T2 (de) |
WO (1) | WO1994027622A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2220007A1 (en) * | 1995-05-26 | 1996-11-28 | Diacrin, Inc. | Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function |
ATE408417T1 (de) * | 2000-01-25 | 2008-10-15 | Univ Nebraska | Für die transplantation präparierte organe und abstossungsresistenz |
WO2001065934A2 (en) * | 2000-03-09 | 2001-09-13 | Lee Walters | Applications of immune system tolerance to treatment of various diseases |
IL142802A (en) * | 2000-04-27 | 2015-01-29 | Enzo Therapeutics Inc | Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma |
CA2416877C (en) * | 2000-07-27 | 2013-03-12 | Apogene Gmbh & Co. Kg | Somatic cloning gene transfer for producing recombinant proteins, cells and organs |
US20030096016A1 (en) * | 2001-09-07 | 2003-05-22 | Yeda Research And Development Co. Ltd. | Methods of kidney transplantation utilizing developing nephric tissue |
US7780993B2 (en) * | 2001-09-07 | 2010-08-24 | Yeda Research And Development Co. Ltd. | Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts |
US20040136972A1 (en) * | 2001-09-07 | 2004-07-15 | Yeda Research And Development Co. Ltd. | Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues |
JP2005523328A (ja) * | 2002-04-19 | 2005-08-04 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 胎盤由来の幹細胞及びその使用 |
US20040161419A1 (en) * | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
IL165425A0 (en) * | 2004-11-28 | 2006-01-15 | Yeda Res & Dev | Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues |
AU2005290849B2 (en) * | 2004-10-04 | 2009-09-03 | Yeda Research And Development Co. Ltd. | Disease treatment via developing non-syngeneic graft transplantation |
US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
WO2006113220A2 (en) * | 2005-04-13 | 2006-10-26 | Ximerex, Inc. | Transgenic mammals expressing human preproinsulin |
US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
WO2010047676A1 (en) * | 2008-10-20 | 2010-04-29 | Yangxin Fu | An immunocompetent xenograft model |
US8263823B2 (en) * | 2008-10-20 | 2012-09-11 | Adimmu Institute Inc. | Immunocompetent xenograft model |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
WO2012092663A1 (en) * | 2011-01-04 | 2012-07-12 | Network Immunology Inc. | Monoclonal anti-anti-anti-mhc antibodies and uses thereof |
WO2015061550A1 (en) * | 2013-10-24 | 2015-04-30 | Kansas State University Research Foundation | Immune competent models of human disease |
SG11202002118XA (en) * | 2017-09-19 | 2020-04-29 | Univ Meiji | Method for developing organ that lacks specific functional cell |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2026340B (en) * | 1978-07-03 | 1982-12-22 | Ash P | Stabilising microvesicles |
US4406885A (en) * | 1978-12-28 | 1983-09-27 | Research Corporation | Preparation of native oncornavirus envelope subunits and vaccines therefrom |
EP0031812B1 (de) * | 1979-03-27 | 1983-06-15 | National Research Development Corporation | Verbesserungen an immunologischen zusammensetzungen |
US4624917A (en) * | 1982-02-17 | 1986-11-25 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for the production of human T-cell growth factor |
JPS6339820A (ja) * | 1986-08-05 | 1988-02-20 | Kingo Yoshida | 拒絶反応抑制,幼若細胞移植による不老長寿法 |
JPS63170322A (ja) * | 1986-12-30 | 1988-07-14 | Kingo Yoshida | 幼若臓器・器管・組織移植による延命長寿法 |
US5004681B1 (en) * | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
JPH01132528A (ja) * | 1987-11-19 | 1989-05-25 | Kingo Yoshida | 母体胎児免疫抑制を応用した若細胞移植による不老長寿法並びに病気治療法 |
US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
EP0484512A4 (en) * | 1990-05-25 | 1993-05-05 | Systemix, Inc. | Human peripheral blood cells in an immunocompromised host |
CA2124858A1 (en) * | 1991-11-05 | 1993-05-13 | Samuel Strober | Suppressor and progenitor cells |
-
1994
- 1994-05-24 CA CA2163517A patent/CA2163517C/en not_active Expired - Fee Related
- 1994-05-24 EP EP94919227A patent/EP0700297B1/de not_active Expired - Lifetime
- 1994-05-24 US US08/295,899 patent/US6060049A/en not_active Expired - Lifetime
- 1994-05-24 AU AU70445/94A patent/AU693452B2/en not_active Ceased
- 1994-05-24 DE DE69431107T patent/DE69431107T2/de not_active Expired - Fee Related
- 1994-05-24 JP JP50090795A patent/JP4236279B2/ja not_active Expired - Lifetime
- 1994-05-24 WO PCT/US1994/005844 patent/WO1994027622A1/en active IP Right Grant
- 1994-05-24 AT AT94919227T patent/ATE221382T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69431107D1 (de) | 2002-09-05 |
WO1994027622A1 (en) | 1994-12-08 |
AU7044594A (en) | 1994-12-20 |
EP0700297A4 (de) | 1997-04-09 |
CA2163517A1 (en) | 1994-12-08 |
JP4236279B2 (ja) | 2009-03-11 |
EP0700297B1 (de) | 2002-07-31 |
CA2163517C (en) | 2011-03-15 |
JPH09500618A (ja) | 1997-01-21 |
EP0700297A1 (de) | 1996-03-13 |
ATE221382T1 (de) | 2002-08-15 |
AU693452B2 (en) | 1998-07-02 |
US6060049A (en) | 2000-05-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: PUSCHMANN & BORCHERT, 82041 OBERHACHING |
|
8339 | Ceased/non-payment of the annual fee |