MD1444B2 - Metode de inducere a toleranţei celulelor T faţă de un transplant de organe sau ţesuturi - Google Patents

Metode de inducere a toleranţei celulelor T faţă de un transplant de organe sau ţesuturi

Info

Publication number
MD1444B2
MD1444B2 MD97-0009A MD970009A MD1444B2 MD 1444 B2 MD1444 B2 MD 1444B2 MD 970009 A MD970009 A MD 970009A MD 1444 B2 MD1444 B2 MD 1444B2
Authority
MD
Moldova
Prior art keywords
patient
receptor
organs
inducing
methods
Prior art date
Application number
MD97-0009A
Other languages
English (en)
Russian (ru)
Other versions
MD970009A (ro
Inventor
Randolph J. Noelle
Fiona H. Durie
David C. Parker
Michael C. Appel
Nancy E. Philips
John P. Mordes
Dale L. Grenier
Aldo A. Rossini
Original Assignee
Trustees Of Dartmouth College
University Of Massachusetts Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Dartmouth College, University Of Massachusetts Medical Center filed Critical Trustees Of Dartmouth College
Publication of MD970009A publication Critical patent/MD970009A/ro
Publication of MD1444B2 publication Critical patent/MD1444B2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)

Abstract

Invenţia se referă la domeniul medicinei, în special la transplantologie, şi poate fi utilizată pentru transplantul de organe sau ţesuturi la etapa preparativă.Esenţa invenţiei constă în aceea că pacientului i se administrează o celulă alogenă sau xenogenă care determină antigenii donatorului şi care are un ligand pe suprafaţa celulelor ce interacţionează cu un receptor pe suprafaţa unei celule T a pacientului, care mediază funcţia efectorului de ajutor dependent de contact şi a unui antagonist al receptorului care inhibă interacţiunea ligandului cu receptorul. De asemenea este propusă o metodă pentru tratarea diabetului care cuprinde administrarea unui pacient a celulelor alogene sau xenogene care determină antigenii donatorului antagonist gp39 şi a insulelor pancreatice.
MD97-0009A 1994-04-25 1995-04-25 Metode de inducere a toleranţei celulelor T faţă de un transplant de organe sau ţesuturi MD1444B2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/234,987 US5683693A (en) 1994-04-25 1994-04-25 Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
PCT/US1995/004832 WO1995028957A2 (en) 1994-04-25 1995-04-25 Methods for inducing t cell tolerance to a tissue or organ graft

Publications (2)

Publication Number Publication Date
MD970009A MD970009A (ro) 1999-01-31
MD1444B2 true MD1444B2 (ro) 2000-04-30

Family

ID=22883593

Family Applications (1)

Application Number Title Priority Date Filing Date
MD97-0009A MD1444B2 (ro) 1994-04-25 1995-04-25 Metode de inducere a toleranţei celulelor T faţă de un transplant de organe sau ţesuturi

Country Status (34)

Country Link
US (4) US5683693A (ro)
EP (2) EP1530973A3 (ro)
JP (1) JP2974415B2 (ro)
KR (1) KR100468330B1 (ro)
CN (1) CN1134266C (ro)
AP (1) AP764A (ro)
AT (1) ATE288281T1 (ro)
AU (1) AU710925B2 (ro)
BG (1) BG62121B1 (ro)
BR (1) BR9507509A (ro)
CA (1) CA2188672A1 (ro)
CZ (1) CZ291266B6 (ro)
DE (1) DE69533984T2 (ro)
DK (1) DK0757557T3 (ro)
EE (1) EE03516B1 (ro)
ES (1) ES2237757T3 (ro)
FI (1) FI118792B (ro)
GE (1) GEP20022648B (ro)
HU (1) HU221752B1 (ro)
IS (1) IS2118B (ro)
LT (1) LT4309B (ro)
LV (1) LV11785B (ro)
MD (1) MD1444B2 (ro)
NO (2) NO319787B1 (ro)
NZ (1) NZ284905A (ro)
OA (1) OA10591A (ro)
PL (1) PL180031B1 (ro)
PT (1) PT757557E (ro)
RO (1) RO114743B1 (ro)
RU (1) RU2169009C2 (ro)
SI (1) SI9520057A (ro)
SK (1) SK136996A3 (ro)
UA (1) UA44892C2 (ro)
WO (1) WO1995028957A2 (ro)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474771A (en) 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
US7070777B1 (en) * 1991-11-15 2006-07-04 The Trustees Of Columbia University In The City Of New York Method for inhibiting inflammation with an antibody that binds the 5C8 protein
US6472510B1 (en) 1992-02-14 2002-10-29 Bristol-Myers Squibb Company CD40 receptor ligands
ZA946765B (en) * 1993-09-02 1996-02-15 Dartmouth College Methods of prolonged suppression of humoral immunity
CN1127351C (zh) * 1993-09-02 2003-11-12 达特茅斯学院理事 诱导抗原特异性ｔ细胞耐受的方法
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
US5876950A (en) * 1995-01-26 1999-03-02 Bristol-Myers Squibb Company Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
US6440418B1 (en) * 1995-11-07 2002-08-27 Idec Pharmaceuticals Corporation Methods of treating autoimmune diseases with gp39-specific antibodies
US6001358A (en) * 1995-11-07 1999-12-14 Idec Pharmaceuticals Corporation Humanized antibodies to human gp39, compositions containing thereof
US6340459B1 (en) 1995-12-01 2002-01-22 The Trustees Of Columbia University In The City Of New York Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients
ATE219376T1 (de) * 1996-03-20 2002-07-15 Bristol Myers Squibb Co Verfahren zur inhibierung der immunreaktion durch blockierung der gp39/cd40 und ctla4/cd28/b7 routen und zusammensetzung zu deren verwendung
CA2277223A1 (en) * 1997-01-10 1998-07-16 Biogen, Inc. Methods of therapeutic administration of anti-cd40l compounds
EP2030614A1 (en) * 1997-02-27 2009-03-04 Novartis AG Pharmaceutical Composition comprising 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol and a lecithin
EA002550B1 (ru) * 1997-06-20 2002-06-27 Байоджен, Инк. Лечение посредством блокады cd154 при трансплантации ткани панкреатических островков
EP1754490A3 (en) * 1997-06-20 2010-01-20 Biogen Idec MA Inc. CD 154 blockage therapy for pancreatic islet tissue transplantation in primates
US6051228A (en) * 1998-02-19 2000-04-18 Bristol-Myers Squibb Co. Antibodies against human CD40
US20050031611A1 (en) * 1998-05-08 2005-02-10 Beth Israel Deaconess Medical Center Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis
ATE309808T1 (de) * 1998-07-30 2005-12-15 Univ Minnesota Ex vivo behandlung von allogenen und xenogenen t- zellen mit gp39-antagonisten
US20020199218A1 (en) * 1999-08-19 2002-12-26 Daphne Goring Proline-rich extensin-like receptor kinases
RU2162297C1 (ru) * 1999-11-25 2001-01-27 Камакин Владислав Владимирович Способ индивидуального подбора оптимального питания человека
WO2001079555A2 (en) 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Roles of jak/stat family members in tolerance induction
EP1284747A2 (en) 2000-05-12 2003-02-26 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for achieving immune suppression
WO2001093908A1 (en) * 2000-06-02 2001-12-13 Regents Of The University Of Minnesota Immunotherapeutic method to prevent islet cell rejection
AU7522401A (en) * 2000-06-06 2001-12-17 Idec Pharma Corp Non-agonistic antibodies to human gp39, compositions containing, and therapeuticuse thereof
CA2630062C (en) 2000-07-03 2014-10-14 Bristol-Myers Squibb Company Methods for treating graft versus host disease and immune disorders associated with rejection using a soluble ctla4 molecule
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
CA2364983A1 (en) * 2000-12-13 2002-06-13 John R. Coleman Nucleic acid molecules and polypeptides for catabolism of abscisic acid
WO2002078743A1 (en) * 2001-02-16 2002-10-10 University Of Rochester Compositions and methods for reducing tranfusion reactions
US7556807B2 (en) 2001-02-20 2009-07-07 Kane Biotech, Inc. Signal peptides, nucleic acid molecules and methods for treatment of caries
US7597895B2 (en) * 2001-02-20 2009-10-06 The Governing Council Of The University Of Toronto Signal peptides, nucleic acid molecules and methods for treatment of caries
ATE390931T1 (de) 2001-05-23 2008-04-15 Bristol Myers Squibb Co Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4- mutationsmolekülen
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
CN1678634A (zh) * 2002-06-28 2005-10-05 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体
DE10231655A1 (de) * 2002-07-12 2004-02-26 Blasticon Biotechnologische Forschung Gmbh Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
EP1460088A1 (en) * 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
US20070041971A1 (en) * 2003-07-07 2007-02-22 Wagner David H Methods for predicting development of auto-immune diseases and treatment of same
EP1707627B1 (en) * 2003-12-25 2012-11-14 Kyowa Hakko Kirin Co., Ltd. Antagonistic anti-CD40 antibody mutant
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
EP1795587A1 (en) * 2005-12-07 2007-06-13 Schuler, Gerold, Prof. Dr. Method for the direct culture of dendritic cells without a preceding centrifugation step
BRPI0708424A2 (pt) * 2006-03-02 2011-05-31 Alexion Pharma Inc prolongamento da sobreviência de uma aloenxerto por inibição da atividade do complemento
FR2934140B1 (fr) * 2008-07-25 2010-09-03 Seb Sa Couvercle d'appareil electromenager de cuisson comportant un sous-ensemble de filtration
JP5836940B2 (ja) 2009-06-26 2015-12-24 ソリシメド・バイオファーマ・インコーポレーテッド ソリシジン由来ペプチドならびにｔｒｐｖ−６がんの検出および薬剤送達のための方法
WO2013013708A1 (en) 2011-07-26 2013-01-31 Fundació Institut D'investigació Biomèdica De Bellvitge Treatment of acute rejection in renal transplant
WO2016094679A1 (en) 2014-12-10 2016-06-16 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
RU2580640C1 (ru) * 2014-12-25 2016-04-10 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ профилактики гуморального отторжения при аво-несовместимой трансплантации печени детям раннего возраста
RU2688172C1 (ru) * 2018-04-05 2019-05-20 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ профилактики отторжения трансплантата трупной почки

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415553A (en) * 1973-08-06 1983-11-15 Dso "Pharmachim" Compositions, processes for their preparation and method for treatment of neoplasms
PT89107A (pt) * 1987-11-30 1989-11-30 Idec Pharma Corp Metodo e meios para a seleccao de anticorpos anti-idiotipos e seu uso para o diagnostico, monitorizacao, tratamento e/ou prevencao de doencas cancerosas, da autoimunidade ou infecciosas
EP0408859B1 (en) * 1989-05-23 1995-08-09 Otsuka Pharmaceutical Co., Ltd. Monoclonal antibodies to activated endothelial cells
US5690933A (en) * 1989-05-31 1997-11-25 Glaxo Wellcome Inc. Monoclonal antibodies for inducing tolerance
US5283058A (en) * 1990-08-30 1994-02-01 The General Hospital Corporation Methods for inhibiting rejection of transplanted tissue
BR9206649A (pt) * 1991-10-18 1995-10-24 Cantab Pharma Res Processo para o tratamento in vitro de um rim antes do transplante em um receptor humano
DK0897983T3 (da) * 1991-10-25 2003-08-11 Immunex Corp Antistoffer mod CD40-L
US5474771A (en) * 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
CA2089229C (en) * 1992-02-14 2010-04-13 Alejandro A. Aruffo Cd40cr receptor and ligands therefor
WO1994004570A1 (en) * 1992-08-21 1994-03-03 Schering Corporation Cd40 ligand, anti cd40 antibodies, and soluble cd40
US5597563A (en) * 1992-09-04 1997-01-28 Beschorner; William E. Method induction of antigen-specific immune tolerance
US5540926A (en) * 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
CA2109398A1 (en) * 1992-10-30 1994-05-01 Alejandro A. Aruffo Extracellular matrix receptor ligands that modulate leukocyte function
ZA946765B (en) * 1993-09-02 1996-02-15 Dartmouth College Methods of prolonged suppression of humoral immunity
US5869049A (en) * 1993-09-02 1999-02-09 Trustees Of Dartmouth College Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists
CN1127351C (zh) * 1993-09-02 2003-11-12 达特茅斯学院理事 诱导抗原特异性ｔ细胞耐受的方法
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Carpenter C. B. Immunosuppression in Organ Transplantation. The New England Journal of Medicine. Massachusetts Medical Society, 1990 vol. 322, № 17, p. 1224 *
Faseb Journal, Abstracts, Part I, vol. 8, № 4, March 15, 1994, p. a 477, abstract № 2763 *
Kahan B. D. Immunosuppressive Therapy. Current Opinion In Immunology, 1992, vol. 4, № 5, p. 553 *
Roark J.H. et. al. Prolongation of Rat Pancreatic Islet Allograf Survival by Anti-CD2 Monoclonal Antibody Treatment. Transplantation. Williams & Wilkins, 1992, vol. 54, № 6, p. 1098 *
Robertson R. P. "Pancreatic and Islet Transplantation for Diabets-Cures or Curiosities". The New England Journal of Medicine. Massachusetts Medical Society, 1992, vol. 327, №. 26, p. 1861 *

Also Published As

Publication number Publication date
IS4378A (is) 1996-10-22
DE69533984D1 (de) 2005-03-10
BG100991A (en) 1998-01-30
KR100468330B1 (ko) 2005-12-30
DE69533984T2 (de) 2006-04-27
CN1134266C (zh) 2004-01-14
NO964440L (no) 1996-12-23
BR9507509A (pt) 1997-02-02
LT4309B (lt) 1998-03-25
LV11785B (en) 1998-02-20
BG62121B1 (bg) 1999-03-31
CZ312596A3 (en) 1997-03-12
SI9520057A (sl) 1998-06-30
EE03516B1 (et) 2001-10-15
US6375950B1 (en) 2002-04-23
FI964272A0 (fi) 1996-10-23
AU710925B2 (en) 1999-09-30
PT757557E (pt) 2005-05-31
EP1530973A2 (en) 2005-05-18
PL180031B1 (pl) 2000-12-29
GEP20022648B (en) 2002-03-25
JP2974415B2 (ja) 1999-11-10
SK136996A3 (en) 1999-01-11
RO114743B1 (ro) 1999-07-30
MD970009A (ro) 1999-01-31
NO20051182L (no) 1996-12-23
US5902585A (en) 1999-05-11
AP764A (en) 1999-09-16
US5683693A (en) 1997-11-04
OA10591A (en) 2002-07-15
WO1995028957A2 (en) 1995-11-02
LT96165A (en) 1997-11-25
NO964440D0 (no) 1996-10-18
EP0757557A1 (en) 1997-02-12
IS2118B (is) 2006-06-15
US7501124B2 (en) 2009-03-10
CZ291266B6 (cs) 2003-01-15
AU2358595A (en) 1995-11-16
ES2237757T3 (es) 2005-08-01
HU9602924D0 (en) 1996-12-30
UA44892C2 (uk) 2002-03-15
EP1530973A3 (en) 2006-12-27
CA2188672A1 (en) 1995-11-02
DK0757557T3 (da) 2005-05-23
FI118792B (fi) 2008-03-31
WO1995028957A3 (en) 1995-11-23
EE9600162A (et) 1997-06-16
ATE288281T1 (de) 2005-02-15
CN1150760A (zh) 1997-05-28
EP0757557B1 (en) 2005-02-02
LV11785A (lv) 1997-06-20
RU2169009C2 (ru) 2001-06-20
FI964272A7 (fi) 1996-12-19
HU221752B1 (hu) 2002-12-28
NO319787B1 (no) 2005-09-12
JPH09512271A (ja) 1997-12-09
US20050152897A1 (en) 2005-07-14
NZ284905A (en) 2004-10-29
PL317022A1 (en) 1997-03-03
AP9600906A0 (en) 1997-01-31
HUT76091A (en) 1997-06-30

Similar Documents

Publication Publication Date Title
MD970009A (ro) Metode pentru inducerea tolerantei celulelor T la transplantul de organe sau tesuturi
FI104732B (fi) Menetelmä transplantaatiossa käyttökelpoisen solun tai kudoksen valmistamiseksi
Grand et al. Axonal regeneration after cold preservation of nerve allografts and immunosuppression with tacrolimus in mice
WO1996012794A3 (en) Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity
CA2387542A1 (en) Supernatant from mesenchymal stem cells for prevention and treatment of immune responses in transplantation
JP2011037865A (ja) 移植における免疫応答抑制のための線維芽細胞または線維芽細胞からの上澄みを使用する方法とその組成物
ATE212230T1 (de) Methoden zur krankheitsbehandlung unter verwendung von sertoli-zellen und allotransplantat oder xenotransplantat
DK0621786T3 (da) Induceret tolerance over for xenotransplantater
CA2284079A1 (en) Immunotoxins and methods of inducing immune tolerance
NO992569D0 (no) FremgangsmÕter for Õ hindre podingsforkastelse i transplantasjon og for fremstilling av en universell genterapi vertcelle ved Õ anvende lymfocytt aktivering (LAG-3)
Siemionow et al. Advances in the development of experimental composite tissue transplantation models
DE69638145D1 (de) Verfahren zur herbeiführung einer immuntoleranz mit hilfe von immuntoxinen
Gambacorti-Passerini et al. Lysis by activated lymphocytes of melanoma and small cell lung cancer cells surviving in vitro treatment with Mafosfamide
Gilhar et al. Description of and treatment to inhibit the rejection of human split-thickness skin grafts by congenitally athymic (nude) rats
Black et al. Cyclosporine and Skin Allografts for the Treatment of Thermal Injury: II. Development of an Experimental Massive Third-Degree Burn Model Demonstrating Extensive Graft Survival
NO983917L (no) Anvendelse av IL-7 for behandling av autoimmune sykdommer og sµrlig insulinavhengig diabetes mellitus
AOKI et al. Involvement of vasoactive intestinal peptide (VIP) as a humoral mediator of penile erectile function in the dog
CA2473749A1 (en) Pure populations of astrocyte restricted precursor cells and methods for isolation and use thereof
Szabo et al. Endothelin-A receptor antagonist BQ123 protects against myocardial and endothelial reperfusion injury
ATE306278T1 (de) Behandlung von knochenleiden mit adrenomedullin
Markmann et al. Prevention of recurrent diabetes in BB rats after islet transplantation by monoclonal antibody therapy
MX9605051A (es) Metodos para inducir la tolerancia de celulas t a un injerto u organo.
Zhu et al. Immunomodulatory effect of mesenchymal stromal cell overexpressing HLA-G1 in cell-based therapy for myocardial infarction
Fink et al. Graft-versus-host disease in rats after donor treatment with cyclophosphamide and spleen cells of host origin
JPH06298654A (ja) 抗原特異的免疫抑制剤

Legal Events

Date Code Title Description
PD99 Pending application