DK0621786T3 - Induceret tolerance over for xenotransplantater - Google Patents
Induceret tolerance over for xenotransplantaterInfo
- Publication number
- DK0621786T3 DK0621786T3 DK93903046T DK93903046T DK0621786T3 DK 0621786 T3 DK0621786 T3 DK 0621786T3 DK 93903046 T DK93903046 T DK 93903046T DK 93903046 T DK93903046 T DK 93903046T DK 0621786 T3 DK0621786 T3 DK 0621786T3
- Authority
- DK
- Denmark
- Prior art keywords
- recipient
- organ
- cells
- injected
- xenograft
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 abstract 3
- 241000894007 species Species 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 230000001951 hemoperfusion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Optics & Photonics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81776192A | 1992-01-08 | 1992-01-08 | |
US83859592A | 1992-02-19 | 1992-02-19 | |
PCT/US1993/000184 WO1993013785A1 (en) | 1992-01-08 | 1993-01-07 | Induced tolerance to xenografts |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0621786T3 true DK0621786T3 (da) | 2002-04-29 |
Family
ID=27124202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93903046T DK0621786T3 (da) | 1992-01-08 | 1993-01-07 | Induceret tolerance over for xenotransplantater |
Country Status (11)
Country | Link |
---|---|
US (1) | US6296846B1 (da) |
EP (1) | EP0621786B1 (da) |
JP (1) | JPH07503012A (da) |
AT (1) | ATE215375T1 (da) |
AU (3) | AU679437B2 (da) |
CA (1) | CA2126094A1 (da) |
DE (1) | DE69331778T2 (da) |
DK (1) | DK0621786T3 (da) |
ES (1) | ES2172514T3 (da) |
PT (1) | PT621786E (da) |
WO (1) | WO1993013785A1 (da) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010033840A1 (en) * | 1994-04-25 | 2001-10-25 | Trustees Of Dartmouth College | Methods for inducing T cell tolerance to a tissue or organ graft |
US6006752A (en) | 1996-05-09 | 1999-12-28 | The General Hospital Corporation | Mixed chimerism and tolerance |
WO1998052582A2 (en) * | 1997-05-23 | 1998-11-26 | Hadasit Medical Research Services And Development Ltd. | Non-myeloablative tolerogenic treatment |
US6447767B1 (en) | 1997-05-23 | 2002-09-10 | Hadasit Medical Research Services And Development Ltd. | Non-myeloablative tolerogenic treatment |
US6428782B1 (en) | 1997-05-23 | 2002-08-06 | Hadasit Medical Research Services And Development Ltd. | Non-myeloablative tolerogenic treatment |
ATE439137T1 (de) * | 1997-11-14 | 2009-08-15 | Gen Hospital Corp | Behandlung von hämatologischen störungen |
WO1999039726A1 (en) | 1998-02-04 | 1999-08-12 | The General Hospital Corporation | Costimulatory blockade and mixed chimerism in transplantation |
AUPR074500A0 (en) * | 2000-10-13 | 2000-11-09 | Monash University | Treatment of t cell disorders |
US20040259803A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Disease prevention by reactivation of the thymus |
US20050020524A1 (en) * | 1999-04-15 | 2005-01-27 | Monash University | Hematopoietic stem cell gene therapy |
US20040241842A1 (en) * | 1999-04-15 | 2004-12-02 | Monash University | Stimulation of thymus for vaccination development |
US20040258672A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Graft acceptance through manipulation of thymic regeneration |
US20070274946A1 (en) * | 1999-04-15 | 2007-11-29 | Norwood Immunoloty, Ltd. | Tolerance to Graft Prior to Thymic Reactivation |
US20040265285A1 (en) * | 1999-04-15 | 2004-12-30 | Monash University | Normalization of defective T cell responsiveness through manipulation of thymic regeneration |
US20060088512A1 (en) * | 2001-10-15 | 2006-04-27 | Monash University | Treatment of T cell disorders |
IL159270A0 (en) * | 2001-06-14 | 2004-06-01 | Yissum Res Dev Co | Non-myeloablative tolerogenic treatment with tyrphostins |
US7258839B2 (en) * | 2001-12-21 | 2007-08-21 | Cytonome, Inc. | Temperature controlled microfabricated two-pin liquid sample dispensing system |
AU2003235652A1 (en) * | 2002-01-15 | 2003-07-30 | Advanced Cell Technology, Inc. | Cloning b and t lymphocytes |
US20080279812A1 (en) * | 2003-12-05 | 2008-11-13 | Norwood Immunology, Ltd. | Disease Prevention and Vaccination Prior to Thymic Reactivation |
DK1799236T3 (da) * | 2004-09-10 | 2012-09-03 | Cognate Therapeutics Inc | Leverstromaceller til forebyggelse og behandling af immunresponser ved transplantation |
CA2597757C (en) | 2005-02-10 | 2016-06-28 | Regents Of The University Of Minnesota | Vascular/lymphatic endothelial cells |
US20070113297A1 (en) * | 2005-09-13 | 2007-05-17 | Yongguang Yang | Methods and compositions for inhibition of immune responses |
CA2969847A1 (en) | 2014-12-10 | 2016-06-16 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
US11819520B2 (en) | 2018-02-23 | 2023-11-21 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4772552A (en) | 1984-04-23 | 1988-09-20 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibody which recognizes a 200-220 KD antigen on natural killer cells |
US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
US5087570A (en) * | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
-
1993
- 1993-01-07 PT PT93903046T patent/PT621786E/pt unknown
- 1993-01-07 WO PCT/US1993/000184 patent/WO1993013785A1/en active IP Right Grant
- 1993-01-07 JP JP5512596A patent/JPH07503012A/ja active Pending
- 1993-01-07 DE DE69331778T patent/DE69331778T2/de not_active Expired - Fee Related
- 1993-01-07 AU AU34400/93A patent/AU679437B2/en not_active Ceased
- 1993-01-07 CA CA002126094A patent/CA2126094A1/en not_active Abandoned
- 1993-01-07 EP EP93903046A patent/EP0621786B1/en not_active Expired - Lifetime
- 1993-01-07 ES ES93903046T patent/ES2172514T3/es not_active Expired - Lifetime
- 1993-01-07 AT AT93903046T patent/ATE215375T1/de not_active IP Right Cessation
- 1993-01-07 DK DK93903046T patent/DK0621786T3/da active
-
1995
- 1995-05-26 US US08/451,210 patent/US6296846B1/en not_active Expired - Lifetime
-
1997
- 1997-10-02 AU AU39895/97A patent/AU3989597A/en not_active Abandoned
-
2000
- 2000-04-27 AU AU30170/00A patent/AU759994B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO1993013785A1 (en) | 1993-07-22 |
AU3017000A (en) | 2000-06-29 |
AU3989597A (en) | 1998-01-08 |
DE69331778D1 (de) | 2002-05-08 |
US6296846B1 (en) | 2001-10-02 |
EP0621786A1 (en) | 1994-11-02 |
EP0621786B1 (en) | 2002-04-03 |
CA2126094A1 (en) | 1993-07-22 |
ATE215375T1 (de) | 2002-04-15 |
AU679437B2 (en) | 1997-07-03 |
ES2172514T3 (es) | 2002-10-01 |
AU3440093A (en) | 1993-08-03 |
PT621786E (pt) | 2002-07-31 |
DE69331778T2 (de) | 2002-11-14 |
EP0621786A4 (en) | 1994-12-14 |
AU759994B2 (en) | 2003-05-01 |
JPH07503012A (ja) | 1995-03-30 |
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