JPH07503012A - 異種移植のための誘導された寛容 - Google Patents
異種移植のための誘導された寛容Info
- Publication number
- JPH07503012A JPH07503012A JP5512596A JP51259693A JPH07503012A JP H07503012 A JPH07503012 A JP H07503012A JP 5512596 A JP5512596 A JP 5512596A JP 51259693 A JP51259693 A JP 51259693A JP H07503012 A JPH07503012 A JP H07503012A
- Authority
- JP
- Japan
- Prior art keywords
- mammal
- cells
- species
- recipient
- hematopoietic stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Optics & Photonics (AREA)
- Virology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (26)
- 1.第1の不調和性種の被移植者哺乳動物における第2の種の哺乳動物から得た 移植片に対する寛容を誘導するために該被移植者哺乳動物に導入されるべき薬剤 の製造における該第2の種の哺乳動物からの造血幹細胞の利用であって、該造血 幹細胞を導入する前に該被移植者哺乳動物のナチュラルキラー細胞に結合し得る 抗体を該被移植者哺乳動物に導入する、上記の利用。
- 2.第1の種の被移植者哺乳動物における第2の不調和性ドナー種の哺乳動物か ら得た移植片に対する寛容を誘導するために該被移植者哺乳動物に導入されるべ き薬剤の製造における該第1の種の被移植者哺乳動物のナチュラルキラー細胞に 結合し得る抗体の利用であって、該抗体の導入に続いて該第2の種の哺乳動物の 造血幹細胞を被移植者哺乳動物に導入して該造血幹細胞が該被移植者哺乳動物中 の1つの部位に向かって進心ようにする、上記の利用。
- 3.前記の造血幹細胞の導入のための前記の哺乳動物の準備のための薬剤の製造 においてドナー種特異的な間質組織の利用を更に含む、請求の範囲第1項又は第 2項に記載の利用。
- 4.前記の造血幹細胞の導入のための前記の哺乳動物の準備において前記の被移 植者哺乳動物の成熟T細胞に結合し得る抗体の利用を更に含む、請求の範囲第1 項又は第2項に記載の利用。
- 5.前記の造血幹細胞が骨髄細胞を含む、請求の範囲第1項又は第2項に記載の 利用。
- 6.前記の骨髄細胞の導入のための前記の哺乳動物の準備のための薬剤の製造に おいて前記の被移植者哺乳動物の成熟T細胞に結合し得る抗体の利用を更に含む 、請求の範囲第5項に記載の利用。
- 7.前記の骨髄細胞の導入のための前記の哺乳動物の準備のための薬剤の製造に おけるドナ一種特異的な間質組織の利用を更に含む、請求の範囲第5項に記載の 利用。
- 8.第2の種の同じ哺乳動物が移植片及び造血幹細胞の両者のドナーである、請 求の範囲第1項又は第2項に記載の利用。
- 9.前記のドナー哺乳動物がブタである、請求の範囲第1項に記載の利用。
- 10.前記のブタが小型ブタである、請求の範囲第9項に記載の利用。
- 11.前記の抗体が抗一ヒト胸腺細胞ポリクローナル抗血清である、請求の範囲 第2項に記載の利用。
- 12.前記の抗血清がウマ又はブタから得られる、請求の範囲第11項に記載の 利用。
- 13.前記の被移植者哺乳動物の胸腺に低線量照射を供給する装置の製造におけ る放射線源の利用を更に含む、請求の範囲第1項又は第2項に記載の利用。
- 14.第2の種の哺乳動物から得た器官を血液灌流することによって前記の被移 植者哺乳動物の血液から天然抗体を吸収する装置の製造における灌流装置の利用 を更に含む、請求の範囲第1項又は第2項に記載の利用。
- 15.被移植者哺乳動物における同一種のドナー哺乳動物から得た移植片に対す る寛容を誘導するための薬剤及び装置の製造方法であって、 製薬上許容し得るキャリアー物質を哺乳動物から得た造血幹細胞と混合して該造 血幹細胞が前記の被移植者哺乳動物中の1つの部位に向かって進むようにし、製 薬上許容し得るキャリアー物質を前記の被移植者哺乳動物のナチュラルキラー細 胞に結合し得る抗体と混合し、 同一種の哺乳動物から得た器官を血液灌流するための灌流装置を用意し、そして 被移植者哺乳動物を低線量放射線で照射して該哺乳動物の骨髄を部分的に涸渇さ せるための放射線源を供給する ことを含む、上記の方法。
- 16.前記の造血幹細胞が骨髄細胞を含む、請求の範囲第15項に記載の方法。
- 17.製薬上許容し得るキャリアー物質を前記の被移植者哺乳動物の成熟T細胞 に結合し得る抗体と混合することを更に含む、請求の範囲第15項に記載の方法 。
- 18.被移植者哺乳動物の胸腺を照射するための放射線源を供給することを更に 含む、請求の範囲第15項に記載の方法。
- 19.第1の不調和性種の被移植者哺乳動物における第2の種の哺乳動物から得 た移植片に対する寛容を誘導するための薬剤の製造における前記の第2の種の哺 乳動物の霊長類ドナー種特異的な間質組織の利用であって、間質組織に加えて、 前記の第2の種の造血幹細胞及び被移植者哺乳動物のナチュラルキラー細胞に結 合し得る抗体を該被移植者哺乳動物に導入する、上記の利用。
- 20.前記の造血幹細胞が骨髄細胞を含む、請求の範囲第19項に記載の利用。
- 21.前記の被移植者哺乳動物に導入するための移植片の準備において、前記の 造血幹細胞ではなくて前記の哺乳動物の異なる器官から得た組織の利用を更に含 む、請求の範囲第20項に記載の利用。
- 22.前記の間質組織が胎児肝である、請求の範囲第20項に記載の利用。
- 23.前記の間質組織が胸腺である、請求の範囲第20項に記載の利用。
- 24.前記の移植片が肝臓である、請求の範囲第21項に記載の利用。
- 25.前記の移植片が腎臓である、請求の範囲第21項に記載の利用。
- 26.霊長類における第2の種の哺乳動物から得た移植片に対する寛容を誘導す るために該霊長類に導入されるべき薬剤の製造におけるドナー種特異的な造血間 質組織の利用であって、更に、霊長類に第2の種の霊長類骨髄細胞を導入して該 骨髄細胞が該霊長類中の1つの部位に向かって進むようにし、且つ該第2の種の 哺乳動物から得た移植片を該霊長類に導入する、上記の利用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81776192A | 1992-01-08 | 1992-01-08 | |
US817,761 | 1992-01-08 | ||
US83859592A | 1992-02-19 | 1992-02-19 | |
US838,595 | 1992-02-19 | ||
PCT/US1993/000184 WO1993013785A1 (en) | 1992-01-08 | 1993-01-07 | Induced tolerance to xenografts |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH07503012A true JPH07503012A (ja) | 1995-03-30 |
Family
ID=27124202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5512596A Pending JPH07503012A (ja) | 1992-01-08 | 1993-01-07 | 異種移植のための誘導された寛容 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6296846B1 (ja) |
EP (1) | EP0621786B1 (ja) |
JP (1) | JPH07503012A (ja) |
AT (1) | ATE215375T1 (ja) |
AU (3) | AU679437B2 (ja) |
CA (1) | CA2126094A1 (ja) |
DE (1) | DE69331778T2 (ja) |
DK (1) | DK0621786T3 (ja) |
ES (1) | ES2172514T3 (ja) |
PT (1) | PT621786E (ja) |
WO (1) | WO1993013785A1 (ja) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010033840A1 (en) * | 1994-04-25 | 2001-10-25 | Trustees Of Dartmouth College | Methods for inducing T cell tolerance to a tissue or organ graft |
WO1997041863A1 (en) * | 1996-05-09 | 1997-11-13 | The General Hospital Corporation | Mixed chimerism and tolerance |
AU7798198A (en) * | 1997-05-23 | 1998-12-11 | Baxter International Inc. | Non-myeloablative tolerogenic treatment |
US6428782B1 (en) | 1997-05-23 | 2002-08-06 | Hadasit Medical Research Services And Development Ltd. | Non-myeloablative tolerogenic treatment |
US6447767B1 (en) | 1997-05-23 | 2002-09-10 | Hadasit Medical Research Services And Development Ltd. | Non-myeloablative tolerogenic treatment |
AU1585799A (en) * | 1997-11-14 | 1999-06-07 | General Hospital Corporation, The | Treatment of hematologic disorders |
ATE265220T1 (de) | 1998-02-04 | 2004-05-15 | Gen Hospital Corp | Kostimulatorische blockade und gemischter chimerismus in allotransplantationen |
US20040265285A1 (en) * | 1999-04-15 | 2004-12-30 | Monash University | Normalization of defective T cell responsiveness through manipulation of thymic regeneration |
AUPR074500A0 (en) * | 2000-10-13 | 2000-11-09 | Monash University | Treatment of t cell disorders |
US20040259803A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Disease prevention by reactivation of the thymus |
US20070274946A1 (en) * | 1999-04-15 | 2007-11-29 | Norwood Immunoloty, Ltd. | Tolerance to Graft Prior to Thymic Reactivation |
US20040241842A1 (en) * | 1999-04-15 | 2004-12-02 | Monash University | Stimulation of thymus for vaccination development |
US20040258672A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Graft acceptance through manipulation of thymic regeneration |
US20050020524A1 (en) * | 1999-04-15 | 2005-01-27 | Monash University | Hematopoietic stem cell gene therapy |
US20060088512A1 (en) * | 2001-10-15 | 2006-04-27 | Monash University | Treatment of T cell disorders |
US20040197335A1 (en) * | 2001-06-14 | 2004-10-07 | Shimon Slavin | Non-myeloablative tolerogenic treatment with tyrphostins |
US7258839B2 (en) * | 2001-12-21 | 2007-08-21 | Cytonome, Inc. | Temperature controlled microfabricated two-pin liquid sample dispensing system |
US20030217374A1 (en) * | 2002-01-15 | 2003-11-20 | Advanced Cell Technology | Cloning B and T lymphocytes |
US20080279812A1 (en) * | 2003-12-05 | 2008-11-13 | Norwood Immunology, Ltd. | Disease Prevention and Vaccination Prior to Thymic Reactivation |
DK1799236T3 (da) * | 2004-09-10 | 2012-09-03 | Cognate Therapeutics Inc | Leverstromaceller til forebyggelse og behandling af immunresponser ved transplantation |
EP2428563A1 (en) | 2005-02-10 | 2012-03-14 | Regents Of The University Of Minnesota | Vascular/lymphatic endothelial cells |
US20070113297A1 (en) * | 2005-09-13 | 2007-05-17 | Yongguang Yang | Methods and compositions for inhibition of immune responses |
CA2969847A1 (en) | 2014-12-10 | 2016-06-16 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
US11819520B2 (en) | 2018-02-23 | 2023-11-21 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
CA3089593A1 (en) | 2018-02-23 | 2019-08-29 | Mary Louise MARKERT | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4772552A (en) | 1984-04-23 | 1988-09-20 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibody which recognizes a 200-220 KD antigen on natural killer cells |
US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
US5087570A (en) * | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
-
1993
- 1993-01-07 PT PT93903046T patent/PT621786E/pt unknown
- 1993-01-07 EP EP93903046A patent/EP0621786B1/en not_active Expired - Lifetime
- 1993-01-07 DK DK93903046T patent/DK0621786T3/da active
- 1993-01-07 JP JP5512596A patent/JPH07503012A/ja active Pending
- 1993-01-07 DE DE69331778T patent/DE69331778T2/de not_active Expired - Fee Related
- 1993-01-07 ES ES93903046T patent/ES2172514T3/es not_active Expired - Lifetime
- 1993-01-07 CA CA002126094A patent/CA2126094A1/en not_active Abandoned
- 1993-01-07 WO PCT/US1993/000184 patent/WO1993013785A1/en active IP Right Grant
- 1993-01-07 AT AT93903046T patent/ATE215375T1/de not_active IP Right Cessation
- 1993-01-07 AU AU34400/93A patent/AU679437B2/en not_active Ceased
-
1995
- 1995-05-26 US US08/451,210 patent/US6296846B1/en not_active Expired - Lifetime
-
1997
- 1997-10-02 AU AU39895/97A patent/AU3989597A/en not_active Abandoned
-
2000
- 2000-04-27 AU AU30170/00A patent/AU759994B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US6296846B1 (en) | 2001-10-02 |
DE69331778D1 (de) | 2002-05-08 |
DK0621786T3 (da) | 2002-04-29 |
ES2172514T3 (es) | 2002-10-01 |
EP0621786B1 (en) | 2002-04-03 |
PT621786E (pt) | 2002-07-31 |
EP0621786A4 (en) | 1994-12-14 |
AU3989597A (en) | 1998-01-08 |
AU3017000A (en) | 2000-06-29 |
EP0621786A1 (en) | 1994-11-02 |
DE69331778T2 (de) | 2002-11-14 |
WO1993013785A1 (en) | 1993-07-22 |
AU759994B2 (en) | 2003-05-01 |
AU3440093A (en) | 1993-08-03 |
AU679437B2 (en) | 1997-07-03 |
CA2126094A1 (en) | 1993-07-22 |
ATE215375T1 (de) | 2002-04-15 |
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