DE69634360T2 - Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon - Google Patents

Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon Download PDF

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Publication number
DE69634360T2
DE69634360T2 DE69634360T DE69634360T DE69634360T2 DE 69634360 T2 DE69634360 T2 DE 69634360T2 DE 69634360 T DE69634360 T DE 69634360T DE 69634360 T DE69634360 T DE 69634360T DE 69634360 T2 DE69634360 T2 DE 69634360T2
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virus
cell
pkr
gene
cells
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DE69634360D1 (de
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S. Allan LAU
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University of California
University of California Berkeley
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University of California
University of California Berkeley
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
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    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/111Antisense spanning the whole gene, or a large part of it
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    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32051Methods of production or purification of viral material

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  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69634360T 1995-08-22 1996-08-22 Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon Expired - Lifetime DE69634360T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US262195P 1995-08-22 1995-08-22
US2621P 1995-08-22
PCT/US1996/013745 WO1997008292A1 (en) 1995-08-22 1996-08-22 Methods for enhancing the production of viral vaccines in cell culture by interferon suppression

Publications (2)

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DE69634360D1 DE69634360D1 (de) 2005-03-24
DE69634360T2 true DE69634360T2 (de) 2005-12-29

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US (6) US5840565A (enExample)
EP (2) EP0846160B1 (enExample)
JP (2) JP4267693B2 (enExample)
CN (1) CN1161469C (enExample)
AT (1) ATE289348T1 (enExample)
AU (2) AU6857696A (enExample)
BR (1) BR9610550A (enExample)
CA (2) CA2229405C (enExample)
DE (1) DE69634360T2 (enExample)
WO (2) WO1997008324A1 (enExample)

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Publication number Publication date
CA2229405A1 (en) 1997-03-06
AU6857696A (en) 1997-03-19
US20010001709A1 (en) 2001-05-24
US20040157310A1 (en) 2004-08-12
CN1161469C (zh) 2004-08-11
WO1997008292A1 (en) 1997-03-06
JP4267693B2 (ja) 2009-05-27
AU707130B2 (en) 1999-07-01
WO1997008324A1 (en) 1997-03-06
EP0846160A1 (en) 1998-06-10
ATE289348T1 (de) 2005-03-15
US20010001290A1 (en) 2001-05-17
EP0846174A1 (en) 1998-06-10
CA2229405C (en) 2004-03-02
MX9801423A (es) 1998-05-31
US6673591B2 (en) 2004-01-06
BR9610550A (pt) 1999-07-06
EP0846160B1 (en) 2005-02-16
US6686190B2 (en) 2004-02-03
EP0846160A4 (en) 2002-01-02
JP3432519B2 (ja) 2003-08-04
AU6860896A (en) 1997-03-19
US6159712A (en) 2000-12-12
JPH11514344A (ja) 1999-12-07
EP0846174A4 (en) 2003-02-05
US5840565A (en) 1998-11-24
CA2229163C (en) 2011-04-05
US7132271B2 (en) 2006-11-07
CN1200148A (zh) 1998-11-25
CA2229163A1 (en) 1997-03-06
US6489144B1 (en) 2002-12-03
DE69634360D1 (de) 2005-03-24
JPH11511324A (ja) 1999-10-05

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