CA2229405C - Methods for enhancing the production of interferon in cell culture - Google Patents
Methods for enhancing the production of interferon in cell culture Download PDFInfo
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- CA2229405C CA2229405C CA002229405A CA2229405A CA2229405C CA 2229405 C CA2229405 C CA 2229405C CA 002229405 A CA002229405 A CA 002229405A CA 2229405 A CA2229405 A CA 2229405A CA 2229405 C CA2229405 C CA 2229405C
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- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
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- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32051—Methods of production or purification of viral material
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| Application Number | Priority Date | Filing Date | Title |
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| US262195P | 1995-08-22 | 1995-08-22 | |
| US60/002,621 | 1995-08-22 | ||
| PCT/US1996/013627 WO1997008324A1 (en) | 1995-08-22 | 1996-08-22 | Methods for enhancing the production of interferon in cell culture |
Publications (2)
| Publication Number | Publication Date |
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| CA2229405A1 CA2229405A1 (en) | 1997-03-06 |
| CA2229405C true CA2229405C (en) | 2004-03-02 |
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| CA002229405A Expired - Fee Related CA2229405C (en) | 1995-08-22 | 1996-08-22 | Methods for enhancing the production of interferon in cell culture |
| CA2229163A Expired - Lifetime CA2229163C (en) | 1995-08-22 | 1996-08-22 | Methods for enhancing the production of viral vaccines in cell culture by interferon suppression |
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| CA2229163A Expired - Lifetime CA2229163C (en) | 1995-08-22 | 1996-08-22 | Methods for enhancing the production of viral vaccines in cell culture by interferon suppression |
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| EP (2) | EP0846160B1 (enExample) |
| JP (2) | JP4267693B2 (enExample) |
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| AT (1) | ATE289348T1 (enExample) |
| AU (2) | AU6857696A (enExample) |
| BR (1) | BR9610550A (enExample) |
| CA (2) | CA2229405C (enExample) |
| DE (1) | DE69634360T2 (enExample) |
| WO (2) | WO1997008324A1 (enExample) |
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| US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
| US6855519B2 (en) * | 1995-08-22 | 2005-02-15 | The Regents Of The University Of California | Methods for enhancing the production of interferon in cell culture |
| US6740519B1 (en) | 1997-11-03 | 2004-05-25 | Mount Sinai School Of Medicine | Immortalized, homozygous stat1-deficient mammalian cell lines and their uses |
| JP4837827B2 (ja) | 1998-06-12 | 2011-12-14 | マウント シナイ スクール オブ メディシン | 新規なウイルス増殖方法およびそのためのインターフェロン欠損培養基 |
| US6762038B1 (en) * | 1998-09-09 | 2004-07-13 | The Cleveland Clinic Foundation | Mutant cell lines and methods for producing enhanced levels of recombinant proteins |
| HK1048650A1 (zh) * | 1999-06-15 | 2003-04-11 | Genetrol Biotherapeutics | 在细胞培养物中增强细胞激动素(cytokines)的方法 |
| EP1067179A1 (en) * | 1999-07-09 | 2001-01-10 | Pierre Fabre Medicament | Method to select attenuated paramyxoviridae useful for vaccines and therapeutics |
| HK1048135A1 (zh) * | 1999-09-08 | 2003-03-21 | Genetrol Biotherapeutics | 具增强细胞活力功能的高产量的细胞变动素(cytokine) |
| US20010031859A1 (en) * | 1999-09-08 | 2001-10-18 | Lau Allan S. | High level cytokine production with enhanced cell viability |
| WO2001077394A1 (en) | 2000-04-10 | 2001-10-18 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
| IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
| US6660471B2 (en) * | 2000-08-04 | 2003-12-09 | Chiron Corporation | Enhanced replication of HCV RNA |
| US20020150541A1 (en) * | 2000-09-12 | 2002-10-17 | Gene Trol Biotherapeutics, Inc. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
| AU2001290855A1 (en) | 2000-09-14 | 2002-03-26 | Genetrol Biotherapeutics, Inc. | Method and cell composition for screening compounds for anti-inflammatory activity |
| AU2002251714A1 (en) * | 2000-12-19 | 2002-08-19 | Genetrol Biotherapeutics, Inc. | Cells with enhanced pkr expression for increasing cytokine production |
| DE10104094C1 (de) * | 2001-01-31 | 2002-07-25 | Angelika Vallbracht-Flehmig | Verfahren zur Erhöhung der Virusvermehrung und Virusausbeute in Zellkulturen, durch Blockade der RNaseL-Aktivierung |
| EP2332651A3 (en) * | 2001-10-25 | 2011-08-31 | Bar Ilan University | Interactive transparent individual cells biochip processor |
| IL154677A0 (en) * | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
| US7888110B2 (en) | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
| WO2004113492A1 (en) * | 2003-06-26 | 2004-12-29 | Molecular Cytomics Ltd. | Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| US8597597B2 (en) | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
| WO2005008626A1 (en) * | 2003-07-11 | 2005-01-27 | University Of North Carolina At Chapel Hill | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
| KR101280094B1 (ko) * | 2003-08-11 | 2013-06-28 | 사이단호진한다이비세이부쯔뵤우겐큐우카이 | 점막 면역을 유도할 수 있는 보강제를 함유한 신규한 백신 |
| US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
| NZ591879A (en) * | 2003-10-23 | 2012-11-30 | Kineta Two Llc | Detection of mutations in a gene associated with resistance to viral infection, OAS1 |
| KR20060116825A (ko) | 2003-10-23 | 2006-11-15 | 일루미겐 바이오사이언시스, 인코포레이티드 | 바이러스 감염에 대한 저항성과 관련된 유전자인ｏａｓ1에서의 돌연변이의 검출 |
| CN103755800B (zh) | 2004-02-02 | 2016-02-24 | Ambrx公司 | 经修饰的人类生长激素多肽与其用途 |
| BRPI0506610A (pt) * | 2004-02-03 | 2007-05-02 | Chemagis Ltd | montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico |
| ES2329607T3 (es) * | 2004-02-23 | 2009-11-27 | Crucell Holland B.V. | Metodos de purificacion de virus. |
| BR122015032743B1 (pt) | 2004-06-01 | 2018-04-03 | Mount Sinai School Of Medicine Of New York University | Vírus atenuado de influenza de suínos geneticamente engenheirado, formulação imunogênica, formulação farmacêutica, seus usos e métodos para produzir uma vacina |
| US20080063251A1 (en) * | 2004-07-07 | 2008-03-13 | Mordechai Deutsch | Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing |
| US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
| WO2006021959A2 (en) * | 2004-08-25 | 2006-03-02 | Seng Enterprises Ltd. | Method and device for isolating cells |
| US20060051369A1 (en) * | 2004-08-27 | 2006-03-09 | Taylor Deborah R | ADAR1 antiviral pathway |
| US20080107683A1 (en) * | 2004-11-30 | 2008-05-08 | David Hone | Bacterial Packaging Strains Useful for Generation and Production of Recombinant Double-Stranded RNA Nucleocapsids and Uses Thereof |
| DE602005023534D1 (de) | 2005-01-25 | 2010-10-21 | Seng Entpr Ltd | Mikrofluidische vorrichtung zur untersuchung zellen |
| EP1855713B1 (en) | 2005-02-15 | 2016-04-27 | Mount Sinai School of Medicine | Genetically engineered equine influenza virus and uses thereof |
| US8574595B2 (en) * | 2005-04-11 | 2013-11-05 | Crucell Holland B.V. | Virus purification using ultrafiltration |
| UA95446C2 (ru) * | 2005-05-04 | 2011-08-10 | Іллюміджен Байосайєнсіз, Інк. | Мутаци в генах oas1 |
| DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
| US20070111309A1 (en) * | 2005-10-04 | 2007-05-17 | Daelli Marcelo G | Vero cell line adapted to grow in suspension |
| US20070141555A1 (en) * | 2005-10-11 | 2007-06-21 | Mordechai Deutsch | Current damper for the study of cells |
| WO2007052245A1 (en) | 2005-11-03 | 2007-05-10 | Seng Enterprises Ltd. | Method and device for studying floating, living cells |
| US20070196333A1 (en) * | 2006-02-23 | 2007-08-23 | Fu-Yung Lin | Composition comprising mixtures of IFN-alpha subtypes |
| US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
| KR20100019467A (ko) | 2007-05-02 | 2010-02-18 | 암브룩스, 인코포레이티드 | 변형된 인터페론 베타 폴리펩티드 및 그의 용도 |
| US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
| US9975118B2 (en) | 2007-11-15 | 2018-05-22 | Seng Enterprises Ltd. | Device for the study of living cells |
| NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| EP2133358A1 (en) * | 2008-06-10 | 2009-12-16 | Universitätsklinikum Freiburg | Rift valley fever virus-like particles and their use for immunization and as test system |
| KR101707569B1 (ko) * | 2008-08-01 | 2017-02-16 | 감마 백신즈 피티와이 리미티드 | 인플루엔자 백신 |
| CN102257135B (zh) | 2008-12-16 | 2017-06-09 | 纳米医疗公司 | 流感疫苗的生产 |
| JP2013523175A (ja) | 2010-04-14 | 2013-06-17 | イーエムディー・ミリポア・コーポレーション | 高力価、高純度のウイルスストックの作製方法及びその使用方法 |
| US20140079732A1 (en) | 2011-01-27 | 2014-03-20 | Gamma Vaccines Pty Limited | Combination vaccines |
| EP2855701A1 (en) * | 2012-06-04 | 2015-04-08 | Novartis AG | Improved safety testing |
| WO2014123967A2 (en) * | 2013-02-05 | 2014-08-14 | University Of Georgia Research Foundation, Inc. | Cell lines for virus production and methods of use |
| EP3261664A1 (en) | 2015-02-26 | 2018-01-03 | Boehringer Ingelheim Vetmedica GmbH | Bivalent swine influenza virus vaccine |
| WO2017070167A1 (en) | 2015-10-20 | 2017-04-27 | The University Of North Carolina At Chapel Hill | Methods and compositions for modified factor ix fusion proteins |
| KR102651055B1 (ko) | 2016-03-24 | 2024-03-26 | 삼성디스플레이 주식회사 | 광학 필름 및 디스플레이 장치 |
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| USRE33164E (en) * | 1979-05-15 | 1990-02-13 | Mobay Corporation | Influenza vaccine production in liquid cell culture |
| JPS5754586A (en) * | 1980-09-18 | 1982-04-01 | Ajinomoto Co Inc | Cell strain producing human interferon prolongably, its preparation, and preparation of human interferon using it |
| US4579821A (en) * | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
| JPS58209993A (ja) * | 1982-05-31 | 1983-12-07 | Mochida Pharmaceut Co Ltd | インタ−フエロンの産生方法 |
| ATE55620T1 (de) * | 1982-06-21 | 1990-09-15 | Wellcome Found | Verfahren zur herstellung von interferon. |
| US4485038A (en) * | 1982-10-19 | 1984-11-27 | Health Research (Roswell Park Division) | Method for the production and purification of human leukocyte interferon |
| US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| US4745053A (en) * | 1983-07-08 | 1988-05-17 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyojo | Process for producing human interferon and method for assaying the interferon productivity of blood |
| JPS6062997A (ja) * | 1983-09-17 | 1985-04-11 | Mochida Pharmaceut Co Ltd | インタ−フエロンの生産方法 |
| US5196323A (en) * | 1985-04-27 | 1993-03-23 | Boehringer Ingelheim International Gmbh | Process for preparing and purifying alpha-interferon |
| US4732683A (en) * | 1986-12-02 | 1988-03-22 | Biospectrum, Inc. | Purification method for alpha interferon |
| ES2110411T3 (es) * | 1989-08-25 | 1998-02-16 | Chiron Corp | Metodos para cultivar el virus de la hepatitis c (hcv) en lineas celulares de linfocitos b o t. |
| US5149531A (en) * | 1990-06-27 | 1992-09-22 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of using cold-adapted live influenza virus vaccine as an antiviral agent against influenza |
| JPH05260981A (ja) * | 1992-03-02 | 1993-10-12 | Massachusetts Inst Of Technol <Mit> | ヘムに調節される真核細胞開始因子２αキナーゼをコードするＤＮＡ |
| FR2689520B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
| US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
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- 1996-08-22 AU AU68576/96A patent/AU6857696A/en not_active Abandoned
- 1996-08-22 EP EP96929066A patent/EP0846160B1/en not_active Expired - Lifetime
- 1996-08-22 EP EP96929017A patent/EP0846174A4/en not_active Withdrawn
- 1996-08-22 CA CA002229405A patent/CA2229405C/en not_active Expired - Fee Related
- 1996-08-22 CN CNB961977515A patent/CN1161469C/zh not_active Expired - Fee Related
- 1996-08-22 WO PCT/US1996/013627 patent/WO1997008324A1/en not_active Ceased
- 1996-08-22 CA CA2229163A patent/CA2229163C/en not_active Expired - Lifetime
- 1996-08-22 DE DE69634360T patent/DE69634360T2/de not_active Expired - Lifetime
- 1996-08-22 AT AT96929066T patent/ATE289348T1/de active
- 1996-08-22 BR BR9610550A patent/BR9610550A/pt not_active Application Discontinuation
- 1996-08-22 JP JP51050897A patent/JP4267693B2/ja not_active Expired - Lifetime
- 1996-08-22 AU AU68608/96A patent/AU707130B2/en not_active Expired
- 1996-08-22 WO PCT/US1996/013745 patent/WO1997008292A1/en not_active Ceased
- 1996-08-22 JP JP51045097A patent/JP3432519B2/ja not_active Expired - Fee Related
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1999
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2000
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2003
- 2003-11-24 US US10/722,349 patent/US7132271B2/en not_active Expired - Fee Related
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| EP0846160A1 (en) | 1998-06-10 |
| AU6860896A (en) | 1997-03-19 |
| CA2229405A1 (en) | 1997-03-06 |
| ATE289348T1 (de) | 2005-03-15 |
| US6159712A (en) | 2000-12-12 |
| CA2229163C (en) | 2011-04-05 |
| EP0846174A4 (en) | 2003-02-05 |
| US6686190B2 (en) | 2004-02-03 |
| EP0846160B1 (en) | 2005-02-16 |
| US7132271B2 (en) | 2006-11-07 |
| MX9801423A (es) | 1998-05-31 |
| DE69634360T2 (de) | 2005-12-29 |
| BR9610550A (pt) | 1999-07-06 |
| JP3432519B2 (ja) | 2003-08-04 |
| US6489144B1 (en) | 2002-12-03 |
| US6673591B2 (en) | 2004-01-06 |
| AU707130B2 (en) | 1999-07-01 |
| AU6857696A (en) | 1997-03-19 |
| CA2229163A1 (en) | 1997-03-06 |
| US20010001709A1 (en) | 2001-05-24 |
| US20010001290A1 (en) | 2001-05-17 |
| DE69634360D1 (de) | 2005-03-24 |
| CN1161469C (zh) | 2004-08-11 |
| JPH11514344A (ja) | 1999-12-07 |
| JPH11511324A (ja) | 1999-10-05 |
| US5840565A (en) | 1998-11-24 |
| EP0846160A4 (en) | 2002-01-02 |
| US20040157310A1 (en) | 2004-08-12 |
| JP4267693B2 (ja) | 2009-05-27 |
| EP0846174A1 (en) | 1998-06-10 |
| CN1200148A (zh) | 1998-11-25 |
| WO1997008324A1 (en) | 1997-03-06 |
| WO1997008292A1 (en) | 1997-03-06 |
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