CN1161469C - 在细胞培养中增强干扰素生产的方法 - Google Patents

在细胞培养中增强干扰素生产的方法 Download PDF

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CN1161469C
CN1161469C CNB961977515A CN96197751A CN1161469C CN 1161469 C CN1161469 C CN 1161469C CN B961977515 A CNB961977515 A CN B961977515A CN 96197751 A CN96197751 A CN 96197751A CN 1161469 C CN1161469 C CN 1161469C
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interferon
cells
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CN1200148A (zh
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阿兰·S·劳
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University of California, San Diego
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/67—General methods for enhancing the expression
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32051—Methods of production or purification of viral material

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  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB961977515A 1995-08-22 1996-08-22 在细胞培养中增强干扰素生产的方法 Expired - Fee Related CN1161469C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US262195P 1995-08-22 1995-08-22
US60/002,621 1995-08-22

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CN1200148A CN1200148A (zh) 1998-11-25
CN1161469C true CN1161469C (zh) 2004-08-11

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US (6) US5840565A (enExample)
EP (2) EP0846160B1 (enExample)
JP (2) JP4267693B2 (enExample)
CN (1) CN1161469C (enExample)
AT (1) ATE289348T1 (enExample)
AU (2) AU707130B2 (enExample)
BR (1) BR9610550A (enExample)
CA (2) CA2229405C (enExample)
DE (1) DE69634360T2 (enExample)
WO (2) WO1997008324A1 (enExample)

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AU6857696A (en) 1997-03-19
CA2229405C (en) 2004-03-02
US20010001290A1 (en) 2001-05-17
CA2229163C (en) 2011-04-05
US20040157310A1 (en) 2004-08-12
EP0846174A1 (en) 1998-06-10
US20010001709A1 (en) 2001-05-24
US6159712A (en) 2000-12-12
DE69634360T2 (de) 2005-12-29
EP0846160A1 (en) 1998-06-10
BR9610550A (pt) 1999-07-06
EP0846174A4 (en) 2003-02-05
JP4267693B2 (ja) 2009-05-27
MX9801423A (es) 1998-05-31
CA2229163A1 (en) 1997-03-06
EP0846160B1 (en) 2005-02-16
JP3432519B2 (ja) 2003-08-04
US6686190B2 (en) 2004-02-03
JPH11511324A (ja) 1999-10-05
EP0846160A4 (en) 2002-01-02
WO1997008324A1 (en) 1997-03-06
US6489144B1 (en) 2002-12-03
JPH11514344A (ja) 1999-12-07
US6673591B2 (en) 2004-01-06
AU6860896A (en) 1997-03-19
US7132271B2 (en) 2006-11-07
AU707130B2 (en) 1999-07-01
CA2229405A1 (en) 1997-03-06
ATE289348T1 (de) 2005-03-15
WO1997008292A1 (en) 1997-03-06
DE69634360D1 (de) 2005-03-24
US5840565A (en) 1998-11-24
CN1200148A (zh) 1998-11-25

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