DE69522104T2 - Tränendrüsen spezifische emulsion zur topischen anwendung an okulären geweben - Google Patents

Tränendrüsen spezifische emulsion zur topischen anwendung an okulären geweben

Info

Publication number
DE69522104T2
DE69522104T2 DE69522104T DE69522104T DE69522104T2 DE 69522104 T2 DE69522104 T2 DE 69522104T2 DE 69522104 T DE69522104 T DE 69522104T DE 69522104 T DE69522104 T DE 69522104T DE 69522104 T2 DE69522104 T2 DE 69522104T2
Authority
DE
Germany
Prior art keywords
tearrouses
topical application
ocular tissues
specific emulsion
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69522104T
Other languages
English (en)
Other versions
DE69522104D1 (de
Inventor
Shulin Ding
L Tien
Orest Olejnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Sales LLC
Original Assignee
Allergan Sales LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22918100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69522104(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Sales LLC filed Critical Allergan Sales LLC
Application granted granted Critical
Publication of DE69522104D1 publication Critical patent/DE69522104D1/de
Publication of DE69522104T2 publication Critical patent/DE69522104T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
DE69522104T 1994-05-17 1995-05-17 Tränendrüsen spezifische emulsion zur topischen anwendung an okulären geweben Expired - Lifetime DE69522104T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/243,279 US5474979A (en) 1994-05-17 1994-05-17 Nonirritating emulsions for sensitive tissue
PCT/US1995/006302 WO1995031211A1 (en) 1994-05-17 1995-05-17 Lacrimal gland specific emulsions for topical application to ocular tissue

Publications (2)

Publication Number Publication Date
DE69522104D1 DE69522104D1 (de) 2001-09-13
DE69522104T2 true DE69522104T2 (de) 2002-04-25

Family

ID=22918100

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69529932T Expired - Lifetime DE69529932T2 (de) 1994-05-17 1995-05-17 Tränendrüsenspezifische Emulsionen zur topischen Anwendung an okuläre Gewebe
DE69522104T Expired - Lifetime DE69522104T2 (de) 1994-05-17 1995-05-17 Tränendrüsen spezifische emulsion zur topischen anwendung an okulären geweben

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69529932T Expired - Lifetime DE69529932T2 (de) 1994-05-17 1995-05-17 Tränendrüsenspezifische Emulsionen zur topischen Anwendung an okuläre Gewebe

Country Status (17)

Country Link
US (1) US5474979A (de)
EP (2) EP1044678B1 (de)
JP (2) JP3441462B2 (de)
KR (2) KR100368181B1 (de)
CN (2) CN1229136C (de)
AT (2) ATE203911T1 (de)
AU (1) AU693213B2 (de)
BR (1) BR9507664A (de)
CA (1) CA2190485C (de)
DE (2) DE69529932T2 (de)
DK (2) DK0759773T3 (de)
ES (2) ES2194670T3 (de)
GR (1) GR3036945T3 (de)
HK (1) HK1034190A1 (de)
NZ (1) NZ287635A (de)
PT (2) PT759773E (de)
WO (1) WO1995031211A1 (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585104A (en) * 1995-04-12 1996-12-17 The Procter & Gamble Company Cleansing emulsions
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
JPH10218760A (ja) * 1997-02-04 1998-08-18 Nobel Igaku Kenkyusho:Kk ドライアイ治療用の微量油添加目薬
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
AUPQ228199A0 (en) * 1999-08-18 1999-09-09 Sly, Anthony William Ophthalmic fluid
CN1268623C (zh) * 1999-10-15 2006-08-09 苏坎波公司 组合物和使该组合物稳定的方法
US7270767B1 (en) 1999-10-18 2007-09-18 Foster-Miller, Inc. Environmentally friendly de-icer and anti-icer compositions
DE60100866T2 (de) * 2000-04-07 2004-07-29 Laboratoire Medidom S.A. Cyklosporin, Hyaluronsäure und Polysorbate enthaltenes Augenarzneimittel
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
AU7326801A (en) 2000-07-14 2002-01-30 Allergan Sales Inc Compositions containing therapeutically active components having enhanced solubility
DE60218153T2 (de) 2001-05-21 2007-06-28 Alcon Inc. Verwendung von proteasom-inhibitoren zur behandlung des trockenen auges
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
BR0209965A (pt) 2001-05-21 2004-04-06 Alcon Inc Uso de inibidores de nf-kappab para tratar distúrbios do olho seco
US7112588B2 (en) 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US6872705B2 (en) * 2001-07-13 2005-03-29 Allergan, Inc. Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions
PL206018B1 (pl) * 2001-10-19 2010-06-30 Isotechnika Inc Preparat farmaceutyczny, sposób jego wytwarzania, mikroemulsja i zastosowanie tego preparatu farmaceutycznego
US6656460B2 (en) 2001-11-01 2003-12-02 Yissum Research Development Method and composition for dry eye treatment
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US6982079B2 (en) * 2002-04-26 2006-01-03 Allergan, Inc. Compositions for treating hyperemia
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
US6984628B2 (en) 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
MX2007000208A (es) 2004-07-01 2007-08-07 Schepens Eye Res Inst Composiciones y metodos para tratar trastornos y condiciones del ojo.
CA2573058C (en) * 2004-07-01 2010-11-23 E-L Management Corp. Cosmetic compositions and methods for sensory cooling
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US9241918B2 (en) 2005-03-16 2016-01-26 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
CN100478025C (zh) * 2005-03-25 2009-04-15 中国科学院上海药物研究所 一种环孢菌素a眼用微乳制剂及其制备方法
CN100562340C (zh) * 2005-06-17 2009-11-25 中国科学院上海药物研究所 一种微乳型人工泪液
CN1319515C (zh) * 2005-07-12 2007-06-06 沈阳何氏生物工程有限公司 活肤眼霜
US7297679B2 (en) * 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US8288348B2 (en) * 2005-07-13 2012-10-16 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) * 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
NZ568694A (en) * 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
WO2008137617A1 (en) * 2007-05-04 2008-11-13 Allergan, Inc. Use of cyclosporines in the treatment of patients with intraocular lenses
FR2916636B1 (fr) * 2007-05-29 2009-09-04 Octalia Technologies Vehicule sous forme d'une emulsion huile-dans-eau notamment destine a une utilisation ophtalmique ou dermocosmetique
EP2008651A1 (de) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited Biologisch erodierbares Patch
JP5668476B2 (ja) 2007-10-08 2015-02-12 オーリニア・ファーマシューティカルズ・インコーポレイテッドAurinia Pharmaceuticals Inc. カルシニューリン阻害剤またはmTOR阻害剤を含む眼科用組成物
KR100985279B1 (ko) * 2008-03-05 2010-11-05 디렉스 팜 (주) 안구건조증 치료를 위한 안약조성물 및 그 제조방법
KR20110031973A (ko) * 2008-07-10 2011-03-29 알러간, 인코포레이티드 눈 및 피부의 질환 및 상태를 치료하기 위한 사이클로스포린 유도체
US20100016219A1 (en) * 2008-07-19 2010-01-21 Jerry Zhang Ophthalmic compositions containing solubilized cyclosporin
FR2938757B1 (fr) * 2008-11-27 2010-12-31 Octalia Technologies Vehicule sous forme d'une emulsion huile-dans-eau notamment destine a une utilisation cosmetique ou dermatologique
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
BRPI1006826A2 (pt) 2009-01-08 2017-08-15 Allergan Inc Composições para melhorar o crescimento de unhas
US20110009339A1 (en) 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
US20100279951A1 (en) * 2009-05-01 2010-11-04 Aileen Morgan Method of treating allergic conjunctivitis with cyclosporin compositions
MY172185A (en) 2009-06-05 2019-11-15 Allergan Inc Artificial tears and therapeutic uses
ES2537385T3 (es) 2009-06-09 2015-06-08 Aurinia Pharmaceuticals Inc. Sistemas de suministro tópico para uso oftálmico
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
CN102724951A (zh) 2009-11-09 2012-10-10 阿勒根公司 用于刺激毛发生长的组合物和方法
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
CN101897949B (zh) * 2010-02-24 2016-07-06 温士顿医药股份有限公司 低刺激性透明乳化液剂型以供眼睛或眼睛周围有关组织表面免疫调节及消炎的眼用药物组合物
EP3078385A1 (de) * 2010-05-25 2016-10-12 Allergan, Inc. Cyclosporinemulsionen
WO2012015211A2 (ko) * 2010-07-30 2012-02-02 주식회사종근당 사이클로스포린 에이 함유 점안제 조성물
US8501796B2 (en) 2010-09-16 2013-08-06 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for lowering intraocular pressure
CN103261212A (zh) 2010-10-12 2013-08-21 阿勒根公司 环孢菌素类似物
EP2627664B1 (de) 2010-10-12 2018-04-04 Allergan, Inc. Cyclosporinanaloga
WO2013172838A1 (en) 2012-05-17 2013-11-21 Steven Yoelin Compositions and methods for hair growth
CA2818610C (en) 2010-11-18 2020-02-18 Steven Yoelin Compositions and methods for hair growth
US9018202B2 (en) 2010-12-03 2015-04-28 Allergan, Inc. Methods for treating diseases of the retina
CN103282044B (zh) 2010-12-28 2016-07-06 韩林制药株式会社 纳米乳剂形态的眼科用组合物
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
ES2672238T3 (es) 2011-01-26 2018-06-13 Allergan, Inc. Composición androgénica para el tratamiento de una afección oftálmica
PT2686017T (pt) * 2011-03-14 2019-10-24 Drug Delivery Solutions Ltd Uma composição oftálmica.
CN103649108B (zh) * 2011-05-27 2017-03-29 阿勒根公司 环孢素a的晶型、制备方法及其使用方法
CA2840734A1 (en) * 2011-06-29 2013-01-03 Allergan, Inc. Macrogol 15 hydroxystearate formulations
US20130029919A1 (en) * 2011-07-26 2013-01-31 Allergan, Inc. Two part formulation system for opthalmic delivery
DE102011108948A1 (de) 2011-07-29 2013-01-31 Achim Göpferich Wässrige, kolloidale Lösungen von lipophilen Substanzen,insbesondere Arzneistofflösungen
AU2012318823A1 (en) 2011-10-05 2014-04-24 Allergan, Inc. Compositions for enhancing nail health
RU2014117580A (ru) 2011-10-05 2015-11-10 Аллерган, Инк. Составы для улучшения здоровья ногтей
US8957048B2 (en) * 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
AU2012339701B8 (en) * 2011-11-15 2017-11-16 Allergan, Inc. Autoclavable suspensions of cyclosporin A Form 2
EP2779994B1 (de) 2011-11-15 2020-02-19 Allergan, Inc. Cyclosporin a form 2 suspensionen
AU2012340806B2 (en) 2011-11-21 2017-10-19 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20130197002A1 (en) 2012-01-30 2013-08-01 Allergan, Inc. Brimonidine for treating visual disorders mediated by central visual projections from the eye
US9278132B2 (en) * 2012-02-13 2016-03-08 Bausch & Lomb Incorporated Ophthalmic pharmaceutical compositions and methods of making and using same
WO2013181339A2 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
US20140256694A1 (en) 2013-03-08 2014-09-11 Allergan, Inc. Steroid antibiotic conjugates
KR101492447B1 (ko) 2013-05-20 2015-02-23 주식회사태준제약 사이클로스포린을 함유하는 나노에멀젼 점안 조성물 및 그의 제조 방법
MX2017000855A (es) * 2014-07-18 2017-05-01 Allergan Inc Composiciones en suspension de ciclosporina a para inyecciones subconjuntivales y perioculares.
MX2017006474A (es) 2014-11-25 2017-09-12 Allergan Inc Composiciones oftalmicas estabilizadas de omega 3.
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US20200237859A1 (en) 2019-01-25 2020-07-30 Newport Research, Inc. Aqueous suspensions of cyclosporin
US11324800B2 (en) 2015-01-15 2022-05-10 Wellspring Ophthalmics, Inc. Aqueous suspensions of cyclosporin
EP3253372B8 (de) 2015-02-06 2022-06-22 Woodstock Sterile Solutions, Inc. Herstellung einer öl-in-wasser-emulsion für polymerstabilisierte pharmazeutische formulierungen
EP3277704A1 (de) 2015-03-31 2018-02-07 Allergan, Inc. An der mebmt-seitenkette durch heterocyclische ringe modifizierte cyclosporine
KR101587385B1 (ko) 2015-07-29 2016-01-21 국제약품공업주식회사 사이클로스포린 함유 무자극성의 안약조성물 및 편리한 제조방법
US9820954B2 (en) 2015-08-19 2017-11-21 Jenivision Inc. Quantitative peri-orbital application of ophthalmology drugs
FR3041883B1 (fr) * 2015-10-02 2019-03-15 Chu Clermont-Ferrand Procede de preparation d'un collyre de ciclosporine a
WO2017066429A1 (en) 2015-10-14 2017-04-20 Paul Gavaris Ophthalmic treatment composition and vehicle for delivery of pharmaceutical substances or therapeutic agents
CN106692052B (zh) * 2015-11-13 2021-03-26 天津金耀集团有限公司 一种环孢素眼用乳剂组合物
JP7044714B2 (ja) * 2016-11-17 2022-03-30 千寿製薬株式会社 乳剤点眼液
KR102115158B1 (ko) 2016-11-29 2020-05-26 주식회사 지트리파마슈티컬 티모신 베타 4 를 함유하는 제형
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
USD841152S1 (en) 2017-06-27 2019-02-19 Monica S. Naylor Eye drop container
EP3542788A1 (de) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topische zusammensetzung enthaltend calcipotriol und betamethason dipropionat
CN109010268B (zh) * 2018-09-28 2020-07-10 湖北远大天天明制药有限公司 一种提高氯霉素稳定性的眼用组合物及其制备方法
CN114245737A (zh) 2019-06-11 2022-03-25 司斐股份有限公司 微乳剂组合物
US20220378698A1 (en) * 2019-07-12 2022-12-01 Pharmathen S.A. Preservative free pharmaceutical composition for ophthalmic administration containing cyclosporine
LT3886799T (lt) 2019-08-07 2023-12-27 Aneira Pharma, Inc. Kompozicija, skirta plaukų slinkimo gydymui
GR1010012B (el) * 2020-05-12 2021-05-27 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση περιεχον κυκλοσπορινη
CN113749092A (zh) * 2020-06-03 2021-12-07 迈克斯(如东)化工有限公司 不饱和脂肪酸酯化物应用、农化组合物和低眼刺农药制剂及其应用
IL294896A (en) * 2022-07-20 2024-02-01 LYOTROPIC DELIVERY SYSTEMS Ltd Topical administration of cyclosporine to the eye

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH204625A (de) * 1937-07-13 1939-05-15 Telefunken Gmbh Eisenkernspule mit als Drehkondensator ausgebildetem Abgleichkondensator.
US2224205A (en) * 1938-07-18 1940-12-10 Hoover Co Suction cleaner
EP0028110B1 (de) * 1979-10-26 1984-03-07 Smith and Nephew Associated Companies p.l.c. Autoklavierbare Emulsionen
JPS59196816A (ja) * 1983-04-22 1984-11-08 Senjiyu Seiyaku Kk 水溶性アズレン誘導体の安定な水溶液の製造法
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
KR920003601B1 (ko) * 1987-09-03 1992-05-04 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 점안 싸이클로스포린(cyclosporin)의 조성물
ES2033086T3 (es) * 1988-01-29 1993-03-01 Sankyo Company Limited Un procedimiento para la preparacion de una composicion farmaceutica.
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
CA2052950A1 (en) * 1990-10-10 1992-04-11 David P. Evitts Aqueous ophthalmic microemulsions of tepoxalin
JPH0558906A (ja) * 1991-09-06 1993-03-09 Sankyo Co Ltd シクロスポリン点眼製剤
JPH06219949A (ja) * 1993-01-25 1994-08-09 Mitsubishi Kasei Corp 抗トロンビン剤及びその製造方法

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PT1044678E (pt) 2003-08-29
ATE234076T1 (de) 2003-03-15
KR100450703B1 (ko) 2004-10-01
HK1034190A1 (en) 2001-10-19
JPH10500414A (ja) 1998-01-13
EP1044678B1 (de) 2003-03-12
DE69529932T2 (de) 2003-12-18
CN1229136C (zh) 2005-11-30
DK1044678T3 (da) 2003-07-14
NZ287635A (en) 1998-09-24
EP0759773A1 (de) 1997-03-05
DE69529932D1 (de) 2003-04-17
WO1995031211A1 (en) 1995-11-23
CN1288722A (zh) 2001-03-28
AU2640995A (en) 1995-12-05
AU693213B2 (en) 1998-06-25
BR9507664A (pt) 1997-10-07
CA2190485C (en) 2003-04-15
ES2161895T3 (es) 2001-12-16
CA2190485A1 (en) 1995-11-23
DK0759773T3 (da) 2001-11-26
PT759773E (pt) 2002-02-28
CN1198587C (zh) 2005-04-27
ES2194670T3 (es) 2003-12-01
US5474979A (en) 1995-12-12
GR3036945T3 (en) 2002-01-31
KR100368181B1 (ko) 2003-04-10
JP4119284B2 (ja) 2008-07-16
ATE203911T1 (de) 2001-08-15
EP0759773B1 (de) 2001-08-08
DE69522104D1 (de) 2001-09-13
MX9605599A (es) 1998-08-30
CN1152876A (zh) 1997-06-25
EP1044678A1 (de) 2000-10-18
JP3441462B2 (ja) 2003-09-02
JP2003231646A (ja) 2003-08-19

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