CA2309033A1 - Lacrimal gland specific emulsions for topical application to ocular tissue - Google Patents

Lacrimal gland specific emulsions for topical application to ocular tissue Download PDF

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Publication number
CA2309033A1
CA2309033A1 CA002309033A CA2309033A CA2309033A1 CA 2309033 A1 CA2309033 A1 CA 2309033A1 CA 002309033 A CA002309033 A CA 002309033A CA 2309033 A CA2309033 A CA 2309033A CA 2309033 A1 CA2309033 A1 CA 2309033A1
Authority
CA
Canada
Prior art keywords
cyclosporin
lacrimal gland
topical application
ocular tissue
gland specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002309033A
Other languages
French (fr)
Other versions
CA2309033C (en
Inventor
Shulin Ding
Walter L. Tien
Orest Olejnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Sales, Inc.
Shulin Ding
Walter L. Tien
Orest Olejnik
Allergan
Allergan Sales, Llc
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/243,279 external-priority patent/US5474979A/en
Application filed by Allergan Sales, Inc., Shulin Ding, Walter L. Tien, Orest Olejnik, Allergan, Allergan Sales, Llc, Allergan, Inc. filed Critical Allergan Sales, Inc.
Publication of CA2309033A1 publication Critical patent/CA2309033A1/en
Application granted granted Critical
Publication of CA2309033C publication Critical patent/CA2309033C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A pharmaceutical composition is disclosed in the form of a nonirritating emulsion which includes at least one cyclosporin in admixture with a higher fatty acid glyceride and polysorbate 80. More particularly, the cyclosporin may be cyclosporin A and the higher fatty acid glyceride may be castor oil. Composition has been found to be of a high comfort level and low irritation potential suitable for delivery of medications to sensitive areas such as ocular tissues with enhanced absorption in the lacrimal gland. In addition, the composition has stability for up to nine months without crystallization of cyclosporin.
CA002309033A 1994-05-17 1995-05-17 Lacrimal gland specific emulsions for topical application to ocular tissue Expired - Lifetime CA2309033C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/243,279 US5474979A (en) 1994-05-17 1994-05-17 Nonirritating emulsions for sensitive tissue
US08/243,279 1994-05-17
CA002190485A CA2190485C (en) 1994-05-17 1995-05-17 Lacrimal gland specific emulsions for topical application to ocular tissue

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002190485A Division CA2190485C (en) 1994-05-17 1995-05-17 Lacrimal gland specific emulsions for topical application to ocular tissue

Publications (2)

Publication Number Publication Date
CA2309033A1 true CA2309033A1 (en) 1995-11-23
CA2309033C CA2309033C (en) 2003-08-26

Family

ID=25678827

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309033A Expired - Lifetime CA2309033C (en) 1994-05-17 1995-05-17 Lacrimal gland specific emulsions for topical application to ocular tissue

Country Status (1)

Country Link
CA (1) CA2309033C (en)

Also Published As

Publication number Publication date
CA2309033C (en) 2003-08-26

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Effective date: 20150519