KR960021036A - Anti-hepatotoxic composition containing colchicine as an active ingredient and method for preparing the same - Google Patents

Anti-hepatotoxic composition containing colchicine as an active ingredient and method for preparing the same Download PDF

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Publication number
KR960021036A
KR960021036A KR1019940032645A KR19940032645A KR960021036A KR 960021036 A KR960021036 A KR 960021036A KR 1019940032645 A KR1019940032645 A KR 1019940032645A KR 19940032645 A KR19940032645 A KR 19940032645A KR 960021036 A KR960021036 A KR 960021036A
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South Korea
Prior art keywords
preparing
colchicine
weight
parts
hepatotoxic
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KR1019940032645A
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Korean (ko)
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KR0135351B1 (en
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안양찬
이성구
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윤종여
부광약품공업 주식회사
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Priority to KR1019940032645A priority Critical patent/KR0135351B1/en
Publication of KR960021036A publication Critical patent/KR960021036A/en
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Publication of KR0135351B1 publication Critical patent/KR0135351B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 콜치신을 유효성분으로 함유하는 항간독성 약학적 조성물 및 그 제조방법에 관한 것으로, 콜치신을 DDB, 클루타치온 및 프포헤파룸에서 선택된 1종 이상의 성분과 통상의 약학적으로 허용되는 통상의 부형제와 함께 통상의 약학적 제제의 제조방법으로 통상의 약학적 제제로 제형화시킨 항간독성 약학적 조성물을 제공한다.The present invention relates to an anti-hepatotoxic pharmaceutical composition containing colchicine as an active ingredient and a method for preparing the same, wherein the colchicine is conventionally pharmaceutically acceptable with at least one component selected from DDB, glutathione, and phofoparum. Provided is an anti- hepatotoxic pharmaceutical composition formulated into a conventional pharmaceutical formulation by a conventional method for preparing a conventional pharmaceutical formulation together with conventional excipients.

본 발명의 조성물은 각각의 약물을 단독으로 투여하였을 때 비하여 그 항간독성 효과가 상승적으로 나타나며 또한 콜치신의 안전역이 대단히 커져서 안전하게 의약으로 사용할 수 있다.The composition of the present invention exhibits a synergistic anti-toxic effect compared to when each drug is administered alone, and can also be used safely as a safe area of colchicine.

Description

콜치신을 유효성분으로 함유하는 항간독성 조성물 및 그 제조방법Anti-hepatotoxic composition containing colchicine as an active ingredient and method for preparing the same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

콜치신을 DDB, 클루타치온 및 프로헤파룸에서 선택된 1종 이상의 성분과 통상의 약학적으로 허용되는 통상의 부형제와 함께 통상의 약학적 제제의 제조방법으로 통상의 약학적 제제로 제형화시킨 항간독성 약학적 조성물.Anti liver formulated with colchicine in conventional pharmaceutical formulations by the method of preparing conventional pharmaceutical formulations with one or more ingredients selected from DDB, glutathione and proheparum and conventional pharmaceutically acceptable excipients Toxic Pharmaceutical Compositions. 제1항에서 콜치신 0.1~50중량부에 대하여; DDB 10~1000중량부, 글루타치온 10~1000중량부 및 프로헤파룸 10~1000중량부에서 선택된 1종 이상의 성분을 통상의 약학적으로 허용되는 통상의 부형제와 함께 통상의 약학적 제제의 제조방법으로 통상의 약학적 제제의 형태로 제형화시킨 항간독성 약학적 조성물.To 0.1 to 50 parts by weight of colchicine according to claim 1; At least one component selected from 10 to 1000 parts by weight of DDB, 10 to 1000 parts by weight of glutathione and 10 to 1000 parts by weight of proheparum is prepared by a method for preparing a conventional pharmaceutical preparation together with conventional pharmaceutically acceptable excipients. An anti hepatotoxic pharmaceutical composition formulated in the form of a conventional pharmaceutical formulation. 콜치신을 DDB, 글루타치온 및 프로헤파룸에서 선택된 1종 이상의 성분과 통상의 약학적으로 허용되는 통상의 부형제과 함께 통상의 약학적 제제의 제조방법으로 통상의 약학적 제제로 제형화시켜서 항간독성 약학적 조성물을 제조하는 방법.Colchicine is formulated as a conventional pharmaceutical preparation with one or more ingredients selected from DDB, glutathione and proheparum and conventional pharmaceutically acceptable excipients to form a conventional pharmaceutical preparation for the anti-heptotoxic pharmaceutical Method of preparing the composition. 제3항에 있어서, 콜치신 0.1~5O중량부에 대하여; DDB 10~1000중량부, 글루타치온 10~ 1000중량부 및 프로헤파룸 10~1000중량부에서 선택된 종 이상의 성분을 통상의 약학적으로 허용되는 통상의 부형제와 함께 통상의 약학적 제제의 제조방법으로 통상의 약학적 제제로 제형화시켜서 항간독성 약학적 조성물을 제조하는 방법.The method according to claim 3, with respect to 0.1 to 50 parts by weight of colchicine; At least 10 to 1000 parts by weight of DDB, 10 to 1000 parts by weight of glutathione and 10 to 1000 parts by weight of proheparum, together with conventional pharmaceutically acceptable excipients, are conventionally used for the preparation of conventional pharmaceutical preparations. A method for preparing an anti-hepatotoxic pharmaceutical composition by formulating it in a pharmaceutical formulation of ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940032645A 1994-12-03 1994-12-03 Antilivertoxic composition having colchicum KR0135351B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940032645A KR0135351B1 (en) 1994-12-03 1994-12-03 Antilivertoxic composition having colchicum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940032645A KR0135351B1 (en) 1994-12-03 1994-12-03 Antilivertoxic composition having colchicum

Publications (2)

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KR960021036A true KR960021036A (en) 1996-07-18
KR0135351B1 KR0135351B1 (en) 1998-04-23

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