DE69516960T2 - Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit - Google Patents
Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheitInfo
- Publication number
- DE69516960T2 DE69516960T2 DE69516960T DE69516960T DE69516960T2 DE 69516960 T2 DE69516960 T2 DE 69516960T2 DE 69516960 T DE69516960 T DE 69516960T DE 69516960 T DE69516960 T DE 69516960T DE 69516960 T2 DE69516960 T2 DE 69516960T2
- Authority
- DE
- Germany
- Prior art keywords
- hyaluronic acid
- less
- per unit
- groups per
- sulfate groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical group OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 title 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000002491 angiogenic effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- -1 biomedical objects Substances 0.000 abstract 1
- 238000013267 controlled drug release Methods 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT94PD000054A ITPD940054A1 (it) | 1994-03-23 | 1994-03-23 | Polisaccaridi solfatati |
PCT/EP1995/001111 WO1995025751A1 (en) | 1994-03-23 | 1995-03-23 | Novel heparin-like sulfated polysaccharides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69516960D1 DE69516960D1 (de) | 2000-06-21 |
DE69516960T2 true DE69516960T2 (de) | 2000-10-12 |
Family
ID=11390615
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69516960T Expired - Lifetime DE69516960T2 (de) | 1994-03-23 | 1995-03-23 | Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit |
DE69533370T Expired - Lifetime DE69533370T2 (de) | 1994-03-23 | 1995-03-23 | Heparinähnliche sulfatierte Polysaccharide |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69533370T Expired - Lifetime DE69533370T2 (de) | 1994-03-23 | 1995-03-23 | Heparinähnliche sulfatierte Polysaccharide |
Country Status (10)
Country | Link |
---|---|
US (3) | US6027741A (de) |
EP (2) | EP0940410B1 (de) |
JP (2) | JPH09510493A (de) |
AT (2) | ATE193023T1 (de) |
AU (1) | AU2072795A (de) |
CA (1) | CA2163337C (de) |
DE (2) | DE69516960T2 (de) |
ES (2) | ES2224541T3 (de) |
IT (1) | ITPD940054A1 (de) |
WO (1) | WO1995025751A1 (de) |
Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
DE69621528T2 (de) * | 1995-02-07 | 2003-01-16 | Shiseido Co Ltd | Anti-inflamatorische agenzien |
IT1282219B1 (it) * | 1995-12-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa |
GB2317182B (en) * | 1996-09-11 | 2000-11-01 | Johnson & Johnson Medical | Sulfated polysaccharides and uses thereof in medical treatment |
DK0971961T3 (da) * | 1997-04-04 | 2003-03-24 | Fidia Advanced Biopolymers Srl | N-sulfaterede hyaluronsyreforbindelser, derivater deraf og en fremgangsmåde til deres fremstilling |
IT1291452B1 (it) | 1997-04-14 | 1999-01-11 | Fidia Advanced Biopolymers Srl | Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni |
DE69832066T2 (de) * | 1997-05-27 | 2006-07-13 | Sanofi-Aventis | Verwendung eines oligosaccharids zur vorbeugung von blutgerinnung in extrakorporalen kreisläufen |
IT1293484B1 (it) * | 1997-06-11 | 1999-03-01 | Fidia Advanced Biopolymers Srl | Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile |
IT1294797B1 (it) * | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
US5945457A (en) * | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
ITPD980037A1 (it) * | 1998-02-25 | 1999-08-25 | Fidia Advanced Biopolymers Srl | Acido ialuronico solfatato e i suoi derivati legati covalentemente a polimeri sintetici pe la preparazione di biomateriali e per il rivesti |
DE19813234A1 (de) * | 1998-03-26 | 1999-09-30 | Knoell Hans Forschung Ev | Verfahren zur Herstellung hochsulfatierter Hyaluronsäuren |
US6872819B1 (en) | 1998-05-27 | 2005-03-29 | Fidia Advanced Biopolymers S.R.L. | Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells |
ITPD980149A1 (it) | 1998-06-17 | 1999-12-17 | Fidia Advanced Biopolymers Srl | Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la |
US6388060B1 (en) | 1998-11-06 | 2002-05-14 | Vascular Therapeutics Inc. | Process for the sulfation of uronic acid-containing polysaccharides |
EP1140198B1 (de) | 1999-01-13 | 2007-10-31 | Alchemia Oncology Pty Limited | Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln |
IT1306644B1 (it) | 1999-04-08 | 2001-10-02 | Fidia Advanced Biopolymers Srl | Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico. |
AU2599501A (en) * | 1999-12-29 | 2001-07-09 | Advanced Cardiovascular Systems Inc. | Device and active component for inhibiting formation of thrombus-inflammatory cell matrix |
JP2004513071A (ja) * | 2000-05-23 | 2004-04-30 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 肺の弾性繊維損傷に関連した呼吸器疾患の治療方法 |
AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
DE10053053A1 (de) * | 2000-10-19 | 2002-05-16 | Knoell Hans Forschung Ev | Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden |
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US7923431B2 (en) * | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
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-
1994
- 1994-03-23 IT IT94PD000054A patent/ITPD940054A1/it unknown
-
1995
- 1995-03-23 EP EP99200468A patent/EP0940410B1/de not_active Expired - Lifetime
- 1995-03-23 ES ES99200468T patent/ES2224541T3/es not_active Expired - Lifetime
- 1995-03-23 AT AT95913158T patent/ATE193023T1/de not_active IP Right Cessation
- 1995-03-23 CA CA2163337A patent/CA2163337C/en not_active Expired - Lifetime
- 1995-03-23 DE DE69516960T patent/DE69516960T2/de not_active Expired - Lifetime
- 1995-03-23 AU AU20727/95A patent/AU2072795A/en not_active Abandoned
- 1995-03-23 JP JP7524398A patent/JPH09510493A/ja not_active Withdrawn
- 1995-03-23 EP EP95913158A patent/EP0702699B1/de not_active Expired - Lifetime
- 1995-03-23 US US08/553,290 patent/US6027741A/en not_active Expired - Lifetime
- 1995-03-23 WO PCT/EP1995/001111 patent/WO1995025751A1/en active IP Right Grant
- 1995-03-23 DE DE69533370T patent/DE69533370T2/de not_active Expired - Lifetime
- 1995-03-23 AT AT99200468T patent/ATE273324T1/de active
- 1995-03-23 ES ES95913158T patent/ES2148504T3/es not_active Expired - Lifetime
-
1998
- 1998-07-30 US US09/126,135 patent/US6051701A/en not_active Expired - Lifetime
-
1999
- 1999-11-23 US US09/447,429 patent/US6339074B1/en not_active Expired - Lifetime
-
2007
- 2007-07-18 JP JP2007187244A patent/JP5165298B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE193023T1 (de) | 2000-06-15 |
US6027741A (en) | 2000-02-22 |
DE69533370T2 (de) | 2005-08-11 |
CA2163337A1 (en) | 1995-09-28 |
ES2224541T3 (es) | 2005-03-01 |
ITPD940054A1 (it) | 1995-09-23 |
AU2072795A (en) | 1995-10-09 |
EP0940410A1 (de) | 1999-09-08 |
WO1995025751A1 (en) | 1995-09-28 |
US6339074B1 (en) | 2002-01-15 |
JPH09510493A (ja) | 1997-10-21 |
CA2163337C (en) | 2010-07-27 |
JP2007262426A (ja) | 2007-10-11 |
EP0940410B1 (de) | 2004-08-11 |
US6051701A (en) | 2000-04-18 |
ITPD940054A0 (it) | 1994-03-23 |
EP0702699B1 (de) | 2000-05-17 |
DE69516960D1 (de) | 2000-06-21 |
ATE273324T1 (de) | 2004-08-15 |
JP5165298B2 (ja) | 2013-03-21 |
DE69533370D1 (de) | 2004-09-16 |
EP0702699A1 (de) | 1996-03-27 |
ES2148504T3 (es) | 2000-10-16 |
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