DE69516960D1 - Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit - Google Patents

Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit

Info

Publication number
DE69516960D1
DE69516960D1 DE69516960T DE69516960T DE69516960D1 DE 69516960 D1 DE69516960 D1 DE 69516960D1 DE 69516960 T DE69516960 T DE 69516960T DE 69516960 T DE69516960 T DE 69516960T DE 69516960 D1 DE69516960 D1 DE 69516960D1
Authority
DE
Germany
Prior art keywords
hyaluronic acid
less
per unit
groups per
sulfate groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69516960T
Other languages
English (en)
Other versions
DE69516960T2 (de
Inventor
Gloria Cialdi
Rolando Barbucci
Agnese Magnani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia Advanced Biopolymers SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers SRL filed Critical Fidia Advanced Biopolymers SRL
Application granted granted Critical
Publication of DE69516960D1 publication Critical patent/DE69516960D1/de
Publication of DE69516960T2 publication Critical patent/DE69516960T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69516960T 1994-03-23 1995-03-23 Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit Expired - Lifetime DE69516960T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT94PD000054A ITPD940054A1 (it) 1994-03-23 1994-03-23 Polisaccaridi solfatati
PCT/EP1995/001111 WO1995025751A1 (en) 1994-03-23 1995-03-23 Novel heparin-like sulfated polysaccharides

Publications (2)

Publication Number Publication Date
DE69516960D1 true DE69516960D1 (de) 2000-06-21
DE69516960T2 DE69516960T2 (de) 2000-10-12

Family

ID=11390615

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69516960T Expired - Lifetime DE69516960T2 (de) 1994-03-23 1995-03-23 Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit
DE69533370T Expired - Lifetime DE69533370T2 (de) 1994-03-23 1995-03-23 Heparinähnliche sulfatierte Polysaccharide

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69533370T Expired - Lifetime DE69533370T2 (de) 1994-03-23 1995-03-23 Heparinähnliche sulfatierte Polysaccharide

Country Status (10)

Country Link
US (3) US6027741A (de)
EP (2) EP0940410B1 (de)
JP (2) JPH09510493A (de)
AT (2) ATE193023T1 (de)
AU (1) AU2072795A (de)
CA (1) CA2163337C (de)
DE (2) DE69516960T2 (de)
ES (2) ES2224541T3 (de)
IT (1) ITPD940054A1 (de)
WO (1) WO1995025751A1 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD940054A1 (it) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
DE69621528T2 (de) * 1995-02-07 2003-01-16 Shiseido Co Ltd Anti-inflamatorische agenzien
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
GB2317182B (en) * 1996-09-11 2000-11-01 Johnson & Johnson Medical Sulfated polysaccharides and uses thereof in medical treatment
DK0971961T3 (da) * 1997-04-04 2003-03-24 Fidia Advanced Biopolymers Srl N-sulfaterede hyaluronsyreforbindelser, derivater deraf og en fremgangsmåde til deres fremstilling
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
DE69832066T2 (de) * 1997-05-27 2006-07-13 Sanofi-Aventis Verwendung eines oligosaccharids zur vorbeugung von blutgerinnung in extrakorporalen kreisläufen
IT1293484B1 (it) * 1997-06-11 1999-03-01 Fidia Advanced Biopolymers Srl Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile
IT1294797B1 (it) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
ITPD980037A1 (it) * 1998-02-25 1999-08-25 Fidia Advanced Biopolymers Srl Acido ialuronico solfatato e i suoi derivati legati covalentemente a polimeri sintetici pe la preparazione di biomateriali e per il rivesti
DE19813234A1 (de) * 1998-03-26 1999-09-30 Knoell Hans Forschung Ev Verfahren zur Herstellung hochsulfatierter Hyaluronsäuren
US6872819B1 (en) 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
US6388060B1 (en) 1998-11-06 2002-05-14 Vascular Therapeutics Inc. Process for the sulfation of uronic acid-containing polysaccharides
EP1140198B1 (de) 1999-01-13 2007-10-31 Alchemia Oncology Pty Limited Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
AU2599501A (en) * 1999-12-29 2001-07-09 Advanced Cardiovascular Systems Inc. Device and active component for inhibiting formation of thrombus-inflammatory cell matrix
JP2004513071A (ja) * 2000-05-23 2004-04-30 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 肺の弾性繊維損傷に関連した呼吸器疾患の治療方法
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
DE10053053A1 (de) * 2000-10-19 2002-05-16 Knoell Hans Forschung Ev Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden
WO2002076475A2 (en) * 2001-03-23 2002-10-03 Bioparken As Glycosaminoglycan anticoagulants derived from fish
ITPD20010108A1 (it) * 2001-05-08 2002-11-08 Fidia Advanced Biopolymers Srl Biomateriali polimerici elettricamente conduttori, loro processo di preparazione ed impiego nel settore biomedico sanitario.
ITTS20010013A1 (it) * 2001-06-04 2002-12-04 Ct Ricerche Poly Tec H A R L S Nuovi derivati di ialuronano.
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
US20050042303A1 (en) * 2001-08-27 2005-02-24 Brown Tracey Jean Therapeutic protocols
US7923431B2 (en) * 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US6806259B2 (en) * 2001-12-21 2004-10-19 Soft Gel Technologies, Inc. Hyaluronic Acid in soft gel form
ITPD20020003A1 (it) * 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
ITPD20020064A1 (it) * 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
AU2003228958C1 (en) * 2002-05-17 2009-01-08 Fidia Advanced Biopolymers, S.R.L. Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
NZ537735A (en) * 2002-07-03 2006-08-31 Pericor Science Inc Compositions of hyaluronic acid and methods of use
NZ538266A (en) 2002-08-16 2007-05-31 Denki Kagaku Kogyo Kk Separate type medical material
ITPD20020271A1 (it) 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
JP4636883B2 (ja) 2002-11-21 2011-02-23 中外製薬株式会社 薬物徐放担体
WO2004053051A2 (en) * 2002-12-11 2004-06-24 Ferrosan A/S Gelatine-based materials as swabs
US7238677B2 (en) * 2003-03-28 2007-07-03 Kimberly-Clark Worldwide, Inc. Prevention of urogenital infections
KR20060002933A (ko) * 2003-04-04 2006-01-09 베이코 테크 리미티드 혈관용 스텐트
JP4212970B2 (ja) * 2003-06-30 2009-01-21 株式会社キーエンス 安全リレーシステム
US20050095219A1 (en) * 2003-10-29 2005-05-05 Shu-Ping Yang Compositions for promoting vaginal cell proliferation and maturation
DE10352137A1 (de) * 2003-11-04 2005-06-16 Beschorner, Katharina, Dr. Verwendung sulfatierter Hyaluronsäure
DE10360425A1 (de) * 2003-12-19 2005-07-28 Ursapharm Arzneimittel Gmbh & Co. Kg Verwendung von Hyaluronsäure, Hyaluronat und/oder deren Derivate zur Herstellung einer pharmazeutischen Zusammensetzung
EP1713521B1 (de) * 2004-01-30 2010-07-28 Ferrosan A/S Hämostatische sprays und zusammensetzungen
US20050186269A1 (en) * 2004-02-25 2005-08-25 Udell Ronald G. Stabilized feverfew formulations
KR20070046093A (ko) * 2004-07-09 2007-05-02 훼로산 아크티에 셀스카브 히알루론산을 포함하는 지혈 조성물
US8512730B2 (en) * 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
WO2006033698A2 (en) * 2004-07-12 2006-03-30 Isto Technologies, Inc. Tissue matrix system
ITPD20040245A1 (it) * 2004-10-08 2005-01-08 Fidia Advanced Biopolymers Srl Biomateriali costituiti da acido ialuronico solfatato e gellano utilizzabili nella prevenzione delle adesioni spinali
DE102005004643B4 (de) * 2005-01-28 2010-04-08 Innovent E.V. Technologieentwicklung Antivirale Kombinationen sowie ihre Verwendung
ITPD20050206A1 (it) * 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
CA2616607C (en) 2005-07-27 2015-06-02 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
MY149606A (en) * 2005-09-07 2013-09-13 Alchemia Oncology Pty Ltd Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
JP2009518132A (ja) * 2005-12-07 2009-05-07 イスト・テクノロジーズ・インコーポレイテッド 軟骨修復方法
ITPD20060219A1 (it) 2006-05-31 2007-12-01 Fidia Farmaceutici Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi
WO2008090583A1 (en) * 2007-01-22 2008-07-31 Universita' Degli Studi Di Siena Phosphated derivatives of polysaccharides and uses thereof
US20080268039A1 (en) * 2007-03-06 2008-10-30 Soft Gel Technologies, Inc. Loquat compositions
JP5088864B2 (ja) * 2007-03-16 2012-12-05 オリンパス株式会社 生体組織補填材とその製造方法
US8609634B2 (en) 2007-05-16 2013-12-17 Mcneil-Ppc, Inc. Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
US9579341B2 (en) 2007-05-16 2017-02-28 Johnson & Johnson Consumer Inc. Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
WO2009046451A1 (en) * 2007-10-05 2009-04-09 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting a protective immune response against c. perfringens
KR20100094982A (ko) 2007-11-13 2010-08-27 바이오-테크널러지 제너럴 (이스라엘) 리미티드 점탄성 바이오폴리머의 희석식 여과 멸균 방법
TWI465567B (zh) * 2007-12-07 2014-12-21 Univ Nat Cheng Kung A method of regulating cell growth
CN102014973A (zh) * 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
MX2010010904A (es) 2008-04-04 2010-11-04 Univ Utah Res Found Eteres de glicosaminoglicosano semisinteticos alquilados, y metodos para elaborarlos y usarlos.
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
US8426196B2 (en) * 2008-06-05 2013-04-23 Lynn L. H. Huang Method for regulating proliferation of cells
ES2829971T3 (es) 2008-09-02 2021-06-02 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos y usos de los mismos
CN103589529A (zh) * 2008-11-13 2014-02-19 诺维信公司 洗涤剂组合物
WO2010086696A1 (en) 2009-01-28 2010-08-05 Therapol Low-molecular-weight sulphated polysaccharides as candidates for anti-angiogenic therapy
IT1393945B1 (it) 2009-04-21 2012-05-17 Fidia Farmaceutici Composizioni comprendenti acido ialuronico, acido ialuronico solfatato, calcio e vitamina d3 nel trattamento delle malattie osteoarticolari e muscoloscheletriche
IT1397247B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi agenti regolatori dell'attivita' citochinica
IT1397246B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica
US8546353B2 (en) * 2010-05-06 2013-10-01 Glykos Finland Oy Compounds and combinations
US20130209531A1 (en) * 2010-06-08 2013-08-15 University Of Utah Research Foundation Applications of partially and fully sulfated hyaluronan
ES2385239B1 (es) 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
WO2012129461A1 (en) 2011-03-23 2012-09-27 University Of Utah Research Foundation Methods for treating or preventing urological inflammation
RU2657955C2 (ru) 2012-03-06 2018-06-18 Ферросан Медикал Дивайсиз А/С Контейнер под давлением, содержащий гемостатическую пасту
ITPD20120098A1 (it) 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
EP2825216B1 (de) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Trockene blutstillende zusammensetzung
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
EP2928500B1 (de) 2012-12-04 2019-03-06 Phosphorex Inc. Mikropartikel und nanopartikeln mit negativen oberflächenladungen
US10000582B2 (en) * 2013-04-02 2018-06-19 The Regents Of The University Of California Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof
JP6390873B2 (ja) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ
EA201691066A1 (ru) 2013-11-22 2016-09-30 СОМАЛЮШН, ЭлЭлСи Растворы для повышения стабильности и срок годности раствора для консервирования органов и тканей
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US10940111B2 (en) 2014-06-15 2021-03-09 Yeda Research And Development Co. Ltd. Surface treatment by water-soluble polymers and lipids/liposomes
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
WO2016102446A1 (en) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CN107406525B (zh) * 2015-03-31 2020-06-12 生化学工业株式会社 糖胺聚糖的硫酸化方法
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
ITUB20155623A1 (it) * 2015-11-16 2017-05-16 Fidia Farm Spa Processo migliorato per la produzione di HA solfatato di elevata purezza
MX2018012964A (es) 2016-04-27 2019-06-10 Anika Therapeutics Inc Métodos y composiciones de uso para el tratamiento de la degeneración de tendón.
US11337994B2 (en) 2016-09-15 2022-05-24 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
CN110809478A (zh) 2017-07-07 2020-02-18 斯米克Ip有限公司 合成的生物缀合物
WO2019010490A1 (en) * 2017-07-07 2019-01-10 Symic Ip, Llc BIOCONJUGATES WITH CHEMICALLY MODIFIED SKELETONS
US11129862B2 (en) 2017-08-30 2021-09-28 Johnson & Johnson Consumer Inc. Ophthalmic compositions
AU2019207781A1 (en) 2018-01-10 2020-07-30 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin System and methods for sealing a channel in tissue
WO2020144372A1 (en) 2019-01-10 2020-07-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
WO2019163948A1 (ja) * 2018-02-23 2019-08-29 学校法人創価大学 細胞培養用基材及び培養方法
IT201900006250A1 (it) 2019-04-23 2020-10-23 Fidia Farm Spa Medicazione per il trattamento della cute lesa
WO2019215572A1 (en) * 2018-05-08 2019-11-14 Fidia Farmaceutici S.P.A. Wound dressing for treatment of damaged skin
CA3097819A1 (en) 2018-05-09 2019-11-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
WO2020016820A1 (en) 2018-07-18 2020-01-23 Bio-Technology General (Israel) Ltd. Process of, and arrangement for, sterile filtering a non-newtonian liquid and formulation of a liquid obtainable thereby
IT201900003887A1 (it) 2019-03-18 2020-09-18 Fidia Farm Spa Sistemi di stabilizzazione e di rilascio controllato di farmaci instabili alla sterilizzazione
WO2020240034A1 (en) 2019-05-31 2020-12-03 University College Dublin Hyaluronic acid-based hybrid hydrogel
KR102277244B1 (ko) * 2019-09-03 2021-07-13 인제대학교 산학협력단 생체 영상화 및 광열치료용 탄소양자점-폴리피롤 나노 복합체 및 이의 제조방법
FR3118037B1 (fr) * 2020-12-17 2023-10-06 Commissariat Energie Atomique Acide hyaluronique modifié et sa mise en œuvre comme dopant de polymères de type PEDOT et/ou PProDOT
IT202000032243A1 (it) 2020-12-23 2022-06-23 Fidia Farm Spa Nuovi agenti antivirali
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
CN113754795B (zh) * 2021-10-19 2023-03-10 澳门大学 磺酸化透明质酸类化合物、其制备方法及其应用
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo
IT202200004613A1 (it) 2022-03-10 2023-09-10 Cmed Aesthetics S R L “procedimento di preparazione di prodotti sterili”

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2599172A (en) * 1948-11-29 1952-06-03 Searle & Co Sulfuric acid esters of hyaluronic acid and processes for the production thereof
US4141746A (en) * 1970-05-25 1979-02-27 Schweiger Richard Georg Cellulose sulfate esters
SE7811306L (sv) * 1978-11-01 1980-05-02 Rothman Gunnvor Antikoagulationsmedel samt sett for dess framstellning
US4240163A (en) * 1979-01-31 1980-12-23 Galin Miles A Medicament coated intraocular lens
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
SE8302789D0 (sv) * 1983-05-18 1983-05-18 Andersson A E Bror Oral tandvardskomposition
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
SE453394B (sv) * 1986-07-07 1988-02-01 Pharmacia Ab Forfarande for framstellning av sulfaterade polysackarider genom anvendning av ett reducerande medel for sulfateringsreaktionen
CA1327354C (en) * 1987-03-19 1994-03-01 David Cullis-Hill Anti-inflamatory compounds and compositions
EP0285357A3 (de) * 1987-03-31 1989-10-25 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Bekämpfung von Retroviren
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
DK505588D0 (da) * 1988-02-26 1988-09-09 Jesper Hamburger Middel og anvendelse af samme
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
DE4021066A1 (de) * 1990-07-03 1992-01-09 Hoechst Ag Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden
EP0473564B1 (de) * 1990-08-27 1996-03-20 Monsanto Company Anticoagulatorische Zusammensetzung aus LACI und sulfatierten Polysacchariden
JPH04117401A (ja) * 1990-09-07 1992-04-17 Dic Hercules Chem Inc スルフォン化キトサンの製造法
JP2604930B2 (ja) * 1990-12-14 1997-04-30 株式会社ディ・ディ・エス研究所 ヒアルロン酸およびコンドロイチン誘導体
GR920100122A (el) * 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
DK0601055T3 (da) * 1991-08-16 2000-10-02 Joseph C Salamone Medikamentovertrukket brydende okulært forkammerimplantat
US5550189A (en) * 1992-04-17 1996-08-27 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
IT1264530B (it) * 1992-07-31 1996-10-02 Crinos Industria Farmaco Impiego dei polisaccaridi nelle neuropatie atrofico degenerative
ITPD940054A1 (it) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
WO1996024392A1 (en) * 1995-02-07 1996-08-15 Fidia Advanced Biopolymers, S.R.L. Process for the coating of objects with hyaluronic acid, derivatives thereof, and semisynthetic polymers
IL124647A0 (en) * 1995-12-01 1998-12-06 Hyal Pharma Corp Targeting of dosages of medicine and therapeutic agents and other glycos aminoglycans (gags)
SE9601243D0 (sv) * 1996-03-29 1996-03-29 Hans Arne Hansson Promotion of regeneration of organized tissues
GB2317182B (en) * 1996-09-11 2000-11-01 Johnson & Johnson Medical Sulfated polysaccharides and uses thereof in medical treatment
DE19714059A1 (de) * 1997-04-05 1998-10-08 Wolff Walsrode Ag Thermoplastischer Werkstoff auf der Basis von Polysacchariden sowie ein Verfahren zu dessen Herstellung und Verwendung desselben
JPH11279042A (ja) * 1998-03-30 1999-10-12 Shiseido Co Ltd 皮膚外用剤
CA2365767A1 (en) * 1999-03-15 2000-09-21 Trustees Of Boston University Angiogenesis inhibition

Also Published As

Publication number Publication date
ATE193023T1 (de) 2000-06-15
US6027741A (en) 2000-02-22
DE69533370T2 (de) 2005-08-11
CA2163337A1 (en) 1995-09-28
DE69516960T2 (de) 2000-10-12
ES2224541T3 (es) 2005-03-01
ITPD940054A1 (it) 1995-09-23
AU2072795A (en) 1995-10-09
EP0940410A1 (de) 1999-09-08
WO1995025751A1 (en) 1995-09-28
US6339074B1 (en) 2002-01-15
JPH09510493A (ja) 1997-10-21
CA2163337C (en) 2010-07-27
JP2007262426A (ja) 2007-10-11
EP0940410B1 (de) 2004-08-11
US6051701A (en) 2000-04-18
ITPD940054A0 (it) 1994-03-23
EP0702699B1 (de) 2000-05-17
ATE273324T1 (de) 2004-08-15
JP5165298B2 (ja) 2013-03-21
DE69533370D1 (de) 2004-09-16
EP0702699A1 (de) 1996-03-27
ES2148504T3 (es) 2000-10-16

Similar Documents

Publication Publication Date Title
DE69516960T2 (de) Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit
US4767628B1 (de)
EP0265116A3 (de) Vernetzte Ester von Hyaluronsäure
DE69434963D1 (de) Selektiv auf die leber wirkende pharmazeutisch aktive substanz
ITPD20020064A1 (it) Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
PT99108A (pt) Processo de preparacao de uma composicao farmaceutica a base de portadores naoaquosos de perfluorocarbonetos ou silicone fluorado
AU7991882A (en) Aromatic heterocyclic esters of steroids
GR3018157T3 (en) Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use.
FR2694290B1 (fr) Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
MY104535A (en) Oral composition for the treatment of inflammatory bowel diseases.
DE69116184T2 (de) Topisch anwendbare Zusammensetzungen auf der Basis von hoch molekularer Hyaluronsäure zur Behandlung von Entzündungen der Mundhöhle, zu deren Hygiene und kosmetischer Behandlung
ES2169272T3 (es) Diaminopirimidinas, composiciones farmaceuticas que las contienen y su utilizacion como agente antibacteriano.
AU5283890A (en) Fibroblast growth factor (fgf)-based stabilized compositions
DE59107336D1 (de) Oligosaccharidderivate und deren Verwendung in Heilmitteln
IT1254898B (it) Idrogeli di tipo polietereammidoamminico come materiali eparinizzabili
EP0475383A3 (en) Polysaccharide composition or polysaccharide having heparinoid activity, process for producing the same, and anticoagulant containing the same as active ingredient
IT1248321B (it) Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
YU184090A (sh) Stabilizovani interferoni leukocita
ATA86690A (de) 2-substituierte n,n'-ditrimethoxybenzoylpiperazine, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
IL56442A (en) Solvent vehicle for the parenteral administration of therapeutics containing an adipic acid ester,pharmaceutical compositions comprising said vehicle and their use in the prophylaxis and/or treatment of certain diseases
ATE132877T1 (de) Emulgatorfreie emulsionspolymere in pharmazeutischen zubereitungen mit verzögerter wirkstofffreigabe und ihre herstellung
DE69009765D1 (de) Kynurensäurederivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
SE8306792D0 (sv) Neues terapeutisches preparat enthaltend hydrierte ergotalkaloide und heparin
DE69213628D1 (de) Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
IT1227158B (it) Esteri dell'acido tiamorfolinone carbossilico e di suoi derivati, loro procedimento di preparazione e loro impiego nel settore cosmetico e nel settore dermo farmaceutico.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: FIDIA FARMACEUTICI S.P.A., ABANO TERME, PADUA/PADO