DE69323090T2 - 4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE - Google Patents

4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE

Info

Publication number
DE69323090T2
DE69323090T2 DE69323090T DE69323090T DE69323090T2 DE 69323090 T2 DE69323090 T2 DE 69323090T2 DE 69323090 T DE69323090 T DE 69323090T DE 69323090 T DE69323090 T DE 69323090T DE 69323090 T2 DE69323090 T2 DE 69323090T2
Authority
DE
Germany
Prior art keywords
tert
butyl
acetoxy
mixture
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69323090T
Other languages
German (de)
English (en)
Other versions
DE69323090D1 (de
Inventor
Osamu Cynshi
Yoshiaki Kato
Yasuhiro Ohba
Kunio Tamura
Mitsutaka Chugai Seiyaku Kabushiki Kaisha Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE69323090D1 publication Critical patent/DE69323090D1/de
Application granted granted Critical
Publication of DE69323090T2 publication Critical patent/DE69323090T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69323090T 1992-10-16 1993-10-18 4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE Expired - Fee Related DE69323090T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP32110192 1992-10-16
PCT/JP1993/001489 WO1994008930A1 (fr) 1992-10-16 1993-10-18 DERIVE DE 4-ALCOXY-2,6-DI-t-BUTHYLPHENOL

Publications (2)

Publication Number Publication Date
DE69323090D1 DE69323090D1 (de) 1999-02-25
DE69323090T2 true DE69323090T2 (de) 2000-01-27

Family

ID=18128834

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323090T Expired - Fee Related DE69323090T2 (de) 1992-10-16 1993-10-18 4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE

Country Status (14)

Country Link
US (3) US5574178A (enExample)
EP (1) EP0665208B1 (enExample)
KR (1) KR100247213B1 (enExample)
CN (1) CN1054128C (enExample)
AT (1) ATE175658T1 (enExample)
AU (1) AU6241894A (enExample)
CA (1) CA2147263C (enExample)
DE (1) DE69323090T2 (enExample)
DK (1) DK0665208T3 (enExample)
ES (1) ES2128440T3 (enExample)
GR (1) GR3029810T3 (enExample)
SG (1) SG49937A1 (enExample)
TW (1) TW393475B (enExample)
WO (1) WO1994008930A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029906A1 (en) * 1994-04-28 1995-11-09 Meiji Milk Products Co., Ltd. Benzofuran derivative and use thereof
US5674876A (en) * 1995-01-20 1997-10-07 Research Development Foundation ρ-heteroatom-substituted phenols and uses thereof
EP0749972A1 (en) * 1995-06-21 1996-12-27 Merrell Pharmaceuticals Inc. A process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives
TW565558B (en) * 1995-11-09 2003-12-11 Chugai Pharmaceutical Co Ltd Intimal thickening inhibitory agent
KR100383835B1 (ko) * 1996-06-26 2003-08-27 쥬가이 세이야쿠 가부시키가이샤 신장질환치료제및장기보존제
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
DE69721040T2 (de) * 1996-11-20 2003-10-16 Aventis Pharmaceuticals Inc., Bridgewater Als antioxydanten verwendbare substituierte phenole und thiophenole
US5679820A (en) * 1996-12-16 1997-10-21 General Electric Company Silylated ultraviolet light absorbers having resistance to humidity
KR20010012189A (ko) * 1997-05-08 2001-02-15 나가야마 오사무 동맥경화증의 예방ㆍ치료제
TW472051B (en) 1997-05-23 2002-01-11 Chugai Pharmaceutical Co Ltd 2,3-dihydrobenzofuran derivatives
AU2571400A (en) * 1999-02-23 2000-09-14 Chugai Seiyaku Kabushiki Kaisha Seam soft capsule preparations containing dihydrobenzofuran derivative
DE19941595A1 (de) * 1999-09-01 2001-03-08 Basf Ag Verwendung von anellierten Benzolderivaten als Antioxidans oder Radikalfänger in kosmetischen Zubereitungen
AU2001272770A1 (en) * 2000-07-19 2002-01-30 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of a benzofuran derivative
EP1428529A4 (en) * 2001-08-31 2005-10-05 Chugai Pharmaceutical Co Ltd Apolipoprotein E SEKRETIONSFÖRDERER
EP1490048A4 (en) * 2002-03-29 2005-06-01 Chugai Pharmaceutical Co Ltd PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF RESPIRATORY DISEASES
US6882245B2 (en) * 2002-06-05 2005-04-19 Rf Stream Corporation Frequency discrete LC filter bank
EP1666035A4 (en) * 2003-09-26 2010-04-28 Chugai Pharmaceutical Co Ltd MEDICAL COMPOSITION FOR THE TREATMENT OF FAT OR LIVER DISEASE
CN110940747B (zh) * 2019-12-03 2022-06-28 酒泉市食品检验检测中心 一种马铃薯及其制品中α-茄碱和α-卡茄碱的测定方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
JPH085871B2 (ja) * 1986-12-27 1996-01-24 武田薬品工業株式会社 クマラン誘導体およびその製造法
JP2855340B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 ２―置換クマラン誘導体
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
IT1229482B (it) * 1988-08-01 1991-09-03 Foscama Biomed Chim Farma Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
JPH02121975A (ja) * 1988-10-28 1990-05-09 Eisai Co Ltd ２，３−ジヒドロベンゾフラン誘導体
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
DE4109627A1 (de) * 1991-03-23 1992-09-24 Boehringer Mannheim Gmbh Neue phenolether, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPH04300878A (ja) * 1991-03-28 1992-10-23 Fujirebio Inc ベンゼンジオール誘導体
SG48108A1 (en) * 1991-11-22 1998-04-17 Lipogenenics Inc Tocotrienols and tocotrienol-like compounds and methods for their use
JP3150740B2 (ja) * 1991-12-26 2001-03-26 エーザイ株式会社 ジヒドロベンゾフラン誘導体
FI944655L (fi) * 1992-04-06 1994-10-05 Merrell Dow Pharma Uudet 2,3-dihydro-2,2,4,6,7-penta-alkyyli-5-bentsofuranolit

Also Published As

Publication number Publication date
DK0665208T3 (da) 1999-08-30
US5606089A (en) 1997-02-25
TW393475B (en) 2000-06-11
CN1054128C (zh) 2000-07-05
KR950703503A (ko) 1995-09-20
DE69323090D1 (de) 1999-02-25
AU6241894A (en) 1994-05-09
CN1112115A (zh) 1995-11-22
CA2147263A1 (en) 1994-04-28
US5663373A (en) 1997-09-02
US5574178A (en) 1996-11-12
EP0665208A1 (en) 1995-08-02
EP0665208A4 (enExample) 1995-08-23
ES2128440T3 (es) 1999-05-16
CA2147263C (en) 2004-12-21
EP0665208B1 (en) 1999-01-13
SG49937A1 (en) 1998-06-15
KR100247213B1 (ko) 2000-03-15
WO1994008930A1 (fr) 1994-04-28
ATE175658T1 (de) 1999-01-15
GR3029810T3 (en) 1999-06-30

Similar Documents

Publication Publication Date Title
DE69323090T2 (de) 4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE
DE3929913A1 (de) 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
DE2726619A1 (de) Allylcarbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung
DE2440606A1 (de) Polyenverbindungen
CH494223A (de) Verfahren zur Herstellung von cyclischen äthylenisch ungesättigten Imiden durch Cyclisierung eines mono-N-substituierten a,B-äthylenisch ungesättigten cis-a,B-Säureamids
DE69525763T2 (de) 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE, DIE LDL OXIDATION HEMMEN
FR2553773A1 (fr) Derives d'acides prostaglandine-phenylalcanoiques 7-oxabicyclo-substitues utiles notamment comme agents cardiovasculaires et medicaments les contenant
CH618968A5 (enExample)
JP3050733B2 (ja) ４−アルコキシ−２，６−ジ−ｔ−ブチルフェノール誘導体
DE2310141A1 (de) Verfahren zur herstellung von 1phenyl-2-aminoaethanolderivaten
DE3401986A1 (de) 7-oxabicycloheptansubstituierte carbamatprostaglandin-analoge
DE3009508A1 (de) Verfahren zur herstellung von alpha -niederalkylfurocumarinen und neuartigen zwischenprodukten
DE3214828A1 (de) Phosphorverbindungen
DE2610503C2 (de) Optisch aktive 13,14-Dehydro-11- desoxy-prostaglandine, Verfahren zu ihrer Herstellung und sie enthaltendes pharmazeutisches Mittel
DE2330333A1 (de) 9-desoxy-prosta-5,9(10),13-triensaeurederivate
DE2347172A1 (de) Prostaglandin e tief 1-synthese
DD201792A5 (de) Verfahren zur herstellung der 2,3,4,5-tetrahydro-1-benzoxepin-3,5-dion-derivate
DE2642670A1 (de) Syntheseverfahren fuer in 6-stellung substituierte 2,3-dimethoxy-5-methyl-1,4- benzochinone
KR930001324B1 (ko) 페놀 유도체의 제조방법
DE2731456A1 (de) 2-phenylindolderivate, deren herstellung und verwendung
DE60319439T2 (de) Verfahren zur herstellung von langkettigen cyclohexenonalkolen
CH683340A5 (de) Verfahren zur Herstellung von 2,2-Dimethyl-5-(2,5-Dimethylphenoxy)-Pentansäure.
DE2463432C2 (enExample)
DE1950012C2 (de) Neue tricyclische Verbindungen und deren Herstellung
EP0270481B1 (de) Neues Verfahren zur Herstellung von optisch aktiven Carbacyclin-Zwischenprodukten

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee