ES2128440T3 - Derivado de 4-alcoxi-2,6-di-t-butilfenol. - Google Patents

Derivado de 4-alcoxi-2,6-di-t-butilfenol.

Info

Publication number
ES2128440T3
ES2128440T3 ES93922643T ES93922643T ES2128440T3 ES 2128440 T3 ES2128440 T3 ES 2128440T3 ES 93922643 T ES93922643 T ES 93922643T ES 93922643 T ES93922643 T ES 93922643T ES 2128440 T3 ES2128440 T3 ES 2128440T3
Authority
ES
Spain
Prior art keywords
represents hydrogen
alkyl
cycloalkyl group
lower alkyl
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93922643T
Other languages
English (en)
Inventor
Kunio Tamura
Yoshiaki Kato
Mitsutaka Yoshida
Osamu Cynshi
Yasuhiro Ohba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2128440T3 publication Critical patent/ES2128440T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (I) Y UN INTERMEDIO PARA LA SINTESIS DEL MISMO (EN DONDE R1 REPRESENTA HIDROGENO O ACILO; R2 REPRESENTA ALQUILO INFERIOR; R3 REPRESENTA HIDROGENO O ALQUILO INFERIOR; Y R4, R5 Y R6 PUEDEN SER IGUALES O DIFERENTES Y CADA UNO REPRESENTA HIDROGENO, ALQUILO OPCIONALMENTE SUSTITUIDO, ALQUENILO, ALQUINILO O ARILO, O ALTERNATIVAMENTE R2 Y R4 SE PUEDEN COMBINAR PARA FORMAR UN ANILLO DE 5 MIEMBROS Y R5 Y R6 SE PUEDEN COMBINAR PARA FORMAR UN GRUPO CICLOALQUILO O UN GRUPO HETEROCICLICO FORMADOS MEDIANTE LA SUSTITUCION DE UNO O MAS GRUPOS METILO DEL GRUPO CICLOALQUILO POR UN ATOMO O ATOMOS DE NITROGENO SUSTITUIDOS POR OXIGENO, AZUFRE O ALQUILO, CON LA CONDICION DE QUE CUANDO EL ANILLO FORMADO MEDIANTE LA COMBINACION DE R2 Y R4 SEA UN ANILLO DE BENZOFURANO, R6 ESTE AUSENTE). ESTE COMPUESTO TIENE UN EFECTO ANTIOXIDANTE MUY EFECTIVO Y ES UTIL COMO REMEDIO CONTRA LA ARTERIOSCLEROSIS, EL INFARTO DE MIOCARDIO, ETCETERA.
ES93922643T 1992-10-16 1993-10-18 Derivado de 4-alcoxi-2,6-di-t-butilfenol. Expired - Lifetime ES2128440T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32110192 1992-10-16

Publications (1)

Publication Number Publication Date
ES2128440T3 true ES2128440T3 (es) 1999-05-16

Family

ID=18128834

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93922643T Expired - Lifetime ES2128440T3 (es) 1992-10-16 1993-10-18 Derivado de 4-alcoxi-2,6-di-t-butilfenol.

Country Status (14)

Country Link
US (3) US5574178A (es)
EP (1) EP0665208B1 (es)
KR (1) KR100247213B1 (es)
CN (1) CN1054128C (es)
AT (1) ATE175658T1 (es)
AU (1) AU6241894A (es)
CA (1) CA2147263C (es)
DE (1) DE69323090T2 (es)
DK (1) DK0665208T3 (es)
ES (1) ES2128440T3 (es)
GR (1) GR3029810T3 (es)
SG (1) SG49937A1 (es)
TW (1) TW393475B (es)
WO (1) WO1994008930A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029906A1 (fr) * 1994-04-28 1995-11-09 Meiji Milk Products Co., Ltd. Derive de benzofurane et son utilisation
US5674876A (en) * 1995-01-20 1997-10-07 Research Development Foundation ρ-heteroatom-substituted phenols and uses thereof
EP0749972A1 (en) * 1995-06-21 1996-12-27 Merrell Pharmaceuticals Inc. A process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives
TW565558B (en) 1995-11-09 2003-12-11 Chugai Pharmaceutical Co Ltd Intimal thickening inhibitory agent
WO1997049388A1 (fr) * 1996-06-26 1997-12-31 Chugai Seiyaku Kabushiki Kaisha Medicaments contre des maladies renales et agents de preservation d'organes
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
CA2271054C (en) * 1996-11-20 2005-12-13 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US5679820A (en) * 1996-12-16 1997-10-21 General Electric Company Silylated ultraviolet light absorbers having resistance to humidity
CN1255058A (zh) * 1997-05-08 2000-05-31 中外制药株式会社 动脉硬化症的预防、治疗剂
TW472051B (en) * 1997-05-23 2002-01-11 Chugai Pharmaceutical Co Ltd 2,3-dihydrobenzofuran derivatives
WO2000050029A1 (fr) * 1999-02-23 2000-08-31 Chugai Seiyaku Kabushiki Kaisha Preparations de capsules molles jonctionnees contenant des derives dihydrobenzofuranes
DE19941595A1 (de) * 1999-09-01 2001-03-08 Basf Ag Verwendung von anellierten Benzolderivaten als Antioxidans oder Radikalfänger in kosmetischen Zubereitungen
US6852867B2 (en) * 2000-07-19 2005-02-08 Chugai Seiyaku Kabushiki Kaisha Process for preparation of a benzofuran derivative
JPWO2003018001A1 (ja) * 2001-08-31 2004-12-09 中外製薬株式会社 アポリポタンパク質ｅの分泌促進剤
CN1646118A (zh) * 2002-03-29 2005-07-27 中外制药株式会社 预防或治疗呼吸系统疾病的药物组合物
US6882245B2 (en) * 2002-06-05 2005-04-19 Rf Stream Corporation Frequency discrete LC filter bank
EP1666035A4 (en) * 2003-09-26 2010-04-28 Chugai Pharmaceutical Co Ltd MEDICINAL COMPOSITION FOR THE TREATMENT OF HEPATIC STEATOSIS OR LIVER DISEASES
CN110940747B (zh) * 2019-12-03 2022-06-28 酒泉市食品检验检测中心 一种马铃薯及其制品中α-茄碱和α-卡茄碱的测定方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH085871B2 (ja) * 1986-12-27 1996-01-24 武田薬品工業株式会社 クマラン誘導体およびその製造法
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
JP2855340B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 ２―置換クマラン誘導体
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
IT1229482B (it) * 1988-08-01 1991-09-03 Foscama Biomed Chim Farma Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
JPH02121975A (ja) * 1988-10-28 1990-05-09 Eisai Co Ltd ２，３−ジヒドロベンゾフラン誘導体
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
DE4109627A1 (de) * 1991-03-23 1992-09-24 Boehringer Mannheim Gmbh Neue phenolether, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPH04300878A (ja) * 1991-03-28 1992-10-23 Fujirebio Inc ベンゼンジオール誘導体
EP0543417A1 (en) * 1991-11-22 1993-05-26 Lipogenics, Incorporated Tocotrienols and tocotrienol-like compounds and methods for their use
JP3150740B2 (ja) * 1991-12-26 2001-03-26 エーザイ株式会社 ジヒドロベンゾフラン誘導体
DE69314022T2 (de) * 1992-04-06 1998-02-12 Merrell Pharma Inc Derivate von 2,3-dihydro-2,2,4,6,7-pentaalkyl-5-benzofuranen

Also Published As

Publication number Publication date
EP0665208B1 (en) 1999-01-13
SG49937A1 (en) 1998-06-15
DE69323090D1 (de) 1999-02-25
AU6241894A (en) 1994-05-09
ATE175658T1 (de) 1999-01-15
CN1112115A (zh) 1995-11-22
CA2147263A1 (en) 1994-04-28
TW393475B (en) 2000-06-11
US5663373A (en) 1997-09-02
EP0665208A4 (es) 1995-08-23
US5574178A (en) 1996-11-12
EP0665208A1 (en) 1995-08-02
KR100247213B1 (ko) 2000-03-15
GR3029810T3 (en) 1999-06-30
KR950703503A (ko) 1995-09-20
DK0665208T3 (da) 1999-08-30
DE69323090T2 (de) 2000-01-27
CN1054128C (zh) 2000-07-05
US5606089A (en) 1997-02-25
WO1994008930A1 (en) 1994-04-28
CA2147263C (en) 2004-12-21

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