KR950703503A - 4-알콕시-2,6-디-t-부틸페놀 유도체(4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATVE) - Google Patents

4-알콕시-2,6-디-t-부틸페놀 유도체(4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATVE) Download PDF

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KR950703503A
KR950703503A KR1019950701454A KR19950701454A KR950703503A KR 950703503 A KR950703503 A KR 950703503A KR 1019950701454 A KR1019950701454 A KR 1019950701454A KR 19950701454 A KR19950701454 A KR 19950701454A KR 950703503 A KR950703503 A KR 950703503A
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South Korea
Prior art keywords
group
ring
lower alkyl
alkoxy
butylphenol
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KR1019950701454A
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KR100247213B1 (ko
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구니오 다무라
요시아끼 가또
미쓰따까 요시다
오사무 신시
야스히로 오바
Original Assignee
나가야마 오사무
쥬우가이세이야꾸 가부시끼가이샤
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Publication of KR950703503A publication Critical patent/KR950703503A/ko
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Publication of KR100247213B1 publication Critical patent/KR100247213B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

하기 일반식(Ⅰ)로 나타내는 화합물.
(식중 R1은 수소원자 또는 아실기를, R2는 저급 알킬기를, R3은 수소 원자 또는 저급 알킬기를 R4, R5, R6은 동일해도 상이하여도 좋으며, 수소 원자, 치환기를 가지고 있어도 좋은 아킬기, 아케닐기, 아릴기를 나타내고, 또한 R2와 R4는 함께 5원 고리를 형성해도 좋고, R5와 R6는 함께 시클로알킬기, 또는 시클로알킬기의 고리상의 1개 이상의 임의의 메틸렌이 산소 원자나 황원자 혹은 알킬기로 치환된 질소 원자로 치환된 헤테로 고리기를 형성해도 좋다. 단 R2와 R4가 함께 형성하는 고리가 벤조푸란 고리일 경우에는 R6은 존재하지 않는다) 및 그의 합성 중간체. 상기 일반식으로 나타내는 화합물은 선택성이 높은 항산화작용을 가지며, 동맥경화증, 심근경색증 등의 치료제로서 유용하다.

Description

4-알콕시-2,6-디-t-부틸페놀 유도체(4-ALKOXY-2,6-Dl-t-BUTYLPHENOL DERIVATIVE)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(Ⅰ)로 나타내는 화합물.
    (식중 R1은 수소원자 또는 아실기를, R2는 저급 알킬기를, R3은 수소 원자 또는 저급 알킬기를 R4, R5, R6은 동일해도 상이하여도 좋으며, 수소 원자, 치환기를 가지고 있어도 좋은 아킬기, 아케닐기, 아릴기를 나타내고, 또한 R2와 R4는 함께 5원 고리를 형성해도 좋고, R5와 R6는 함께 시클로알킬기, 또는 시클로알킬기의 고리상의 1개 이상의 임의의 메틸렌이 산소 원자나 황원자 혹은 알킬기로 치환된 질소 원자로 치환된 헤테로 고리기를 형성해도 좋다. 단 R2와 R4가 함께 형성하는 고리가 벤조푸란 고리일 경우에는 R6은 존재하지 않는다)
  2. 하기 일반식(Ⅱ)로 나타내는 화합물.
    식 중, R3는 상기와 동일한 의미를 나타내며 A는 보호기를 나타내고, Ra는 수소 원자 또는 저급 알킬기를 나타내고, m은 0 또는 1의 정수를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950701454A 1992-10-16 1993-10-18 4-알콕시-2,6-디-t-부틸페놀 유도체 KR100247213B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP92-321101 1992-10-16
JP32110192 1992-10-16
PCT/JP1993/001489 WO1994008930A1 (en) 1992-10-16 1993-10-18 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE

Publications (2)

Publication Number Publication Date
KR950703503A true KR950703503A (ko) 1995-09-20
KR100247213B1 KR100247213B1 (ko) 2000-03-15

Family

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KR1019950701454A KR100247213B1 (ko) 1992-10-16 1993-10-18 4-알콕시-2,6-디-t-부틸페놀 유도체

Country Status (14)

Country Link
US (3) US5574178A (ko)
EP (1) EP0665208B1 (ko)
KR (1) KR100247213B1 (ko)
CN (1) CN1054128C (ko)
AT (1) ATE175658T1 (ko)
AU (1) AU6241894A (ko)
CA (1) CA2147263C (ko)
DE (1) DE69323090T2 (ko)
DK (1) DK0665208T3 (ko)
ES (1) ES2128440T3 (ko)
GR (1) GR3029810T3 (ko)
SG (1) SG49937A1 (ko)
TW (1) TW393475B (ko)
WO (1) WO1994008930A1 (ko)

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TW565558B (en) 1995-11-09 2003-12-11 Chugai Pharmaceutical Co Ltd Intimal thickening inhibitory agent
EP0950405A4 (en) * 1996-06-26 2004-03-17 Chugai Pharmaceutical Co Ltd TREATMENT OF KIDNEY DISEASES AND PROTECTION OF THE ORGANS
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WO2003018001A1 (fr) * 2001-08-31 2003-03-06 Chugai Seiyaku Kabushiki Kaisha Promoteurs de secretion de l'apolipoproteine e
WO2003082264A1 (en) * 2002-03-29 2003-10-09 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for preventing or treating respiratory disease
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Also Published As

Publication number Publication date
US5606089A (en) 1997-02-25
DE69323090T2 (de) 2000-01-27
ATE175658T1 (de) 1999-01-15
ES2128440T3 (es) 1999-05-16
CA2147263A1 (en) 1994-04-28
EP0665208A1 (en) 1995-08-02
US5663373A (en) 1997-09-02
WO1994008930A1 (en) 1994-04-28
TW393475B (en) 2000-06-11
SG49937A1 (en) 1998-06-15
GR3029810T3 (en) 1999-06-30
EP0665208B1 (en) 1999-01-13
DE69323090D1 (de) 1999-02-25
DK0665208T3 (da) 1999-08-30
US5574178A (en) 1996-11-12
AU6241894A (en) 1994-05-09
CA2147263C (en) 2004-12-21
KR100247213B1 (ko) 2000-03-15
CN1112115A (zh) 1995-11-22
EP0665208A4 (ko) 1995-08-23
CN1054128C (zh) 2000-07-05

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