DE60305200T2 - Aminocyclohexylether-verbindungen und deren verwendung - Google Patents
Aminocyclohexylether-verbindungen und deren verwendung Download PDFInfo
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- DE60305200T2 DE60305200T2 DE60305200T DE60305200T DE60305200T2 DE 60305200 T2 DE60305200 T2 DE 60305200T2 DE 60305200 T DE60305200 T DE 60305200T DE 60305200 T DE60305200 T DE 60305200T DE 60305200 T2 DE60305200 T2 DE 60305200T2
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- Prior art keywords
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- stereoisomerically pure
- reaction
- substantially stereoisomerically
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (15)
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|---|---|---|---|
| US46715903P | 2003-05-02 | 2003-05-02 | |
| US467159P | 2003-05-02 | ||
| US47608303P | 2003-06-04 | 2003-06-04 | |
| US476083P | 2003-06-04 | ||
| US47644703P | 2003-06-05 | 2003-06-05 | |
| US47591203P | 2003-06-05 | 2003-06-05 | |
| US47588403P | 2003-06-05 | 2003-06-05 | |
| US475912P | 2003-06-05 | ||
| US475884P | 2003-06-05 | ||
| US476447P | 2003-06-05 | ||
| US48965903P | 2003-07-23 | 2003-07-23 | |
| US489659P | 2003-07-23 | ||
| US49339203P | 2003-08-07 | 2003-08-07 | |
| US493392P | 2003-08-07 | ||
| PCT/US2003/034655 WO2004099137A1 (en) | 2003-05-02 | 2003-10-31 | Aminocyclohexyl ether compounds and uses thereof |
Publications (2)
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| DE60305200D1 DE60305200D1 (de) | 2006-06-14 |
| DE60305200T2 true DE60305200T2 (de) | 2007-05-10 |
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| DE60305200T Expired - Lifetime DE60305200T2 (de) | 2003-05-02 | 2003-10-31 | Aminocyclohexylether-verbindungen und deren verwendung |
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| US (3) | US20070099983A1 (https=) |
| EP (3) | EP1560812B1 (https=) |
| JP (2) | JP4919661B2 (https=) |
| KR (1) | KR101059379B1 (https=) |
| AT (2) | ATE325789T1 (https=) |
| AU (2) | AU2003287378B2 (https=) |
| BR (2) | BR122018009866B8 (https=) |
| CA (1) | CA2524323C (https=) |
| CY (1) | CY1105137T1 (https=) |
| DE (1) | DE60305200T2 (https=) |
| DK (1) | DK1560812T3 (https=) |
| ES (2) | ES2264776T3 (https=) |
| IL (2) | IL171653A (https=) |
| NO (1) | NO334094B1 (https=) |
| NZ (1) | NZ543921A (https=) |
| PL (1) | PL227937B1 (https=) |
| PT (1) | PT1560812E (https=) |
| RU (1) | RU2478617C2 (https=) |
| SG (2) | SG167670A1 (https=) |
| SI (1) | SI1560812T1 (https=) |
| WO (1) | WO2004099137A1 (https=) |
Families Citing this family (26)
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| DK1087934T3 (da) | 1998-04-01 | 2004-06-28 | Cardiome Pharma Corp | Aminocyclohexyletherforbindelser og anvendelser deraf |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US20080063707A1 (en) * | 2003-05-02 | 2008-03-13 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| CA2524323C (en) | 2003-05-02 | 2012-05-15 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| MXPA06011420A (es) * | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Compuestos pegilados de modulacion de canal de iones. |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US8263638B2 (en) * | 2004-11-08 | 2012-09-11 | Cardiome Pharma Corp. | Dosing regimens for ion channel modulating compounds |
| US8692002B2 (en) | 2004-11-18 | 2014-04-08 | Cardiome Pharma Corp. | Synthetic process for aminocyclohexyl ether compounds |
| CA2594680A1 (en) * | 2005-01-12 | 2006-07-20 | Astellas Pharma Inc. | Production method of optically active cyclohexane ether compounds |
| MX2007016248A (es) | 2005-06-15 | 2008-03-07 | Cardiome Pharma Corp | Procedimiento sintetico para la preparacion de compuestos de eter aminociclohexilico. |
| WO2007023824A1 (ja) | 2005-08-23 | 2007-03-01 | Kaneka Corporation | ３－アラルキルオキシピロリジン誘導体の製造法 |
| JP5004067B2 (ja) * | 2005-10-31 | 2012-08-22 | 東レ・ファインケミカル株式会社 | ベンジルオキシ含窒素環状化合物の製造法 |
| WO2007052578A1 (ja) | 2005-10-31 | 2007-05-10 | Toray Fine Chemicals Co., Ltd. | ベンジルオキシピロリジン誘導体の製造方法および光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体の製造法 |
| JP5004073B2 (ja) * | 2006-06-13 | 2012-08-22 | 東レ・ファインケミカル株式会社 | 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法 |
| JP2007131597A (ja) * | 2005-11-11 | 2007-05-31 | Toray Fine Chemicals Co Ltd | ベンジルオキシピロリジン誘導体の製造方法 |
| EA200971025A1 (ru) * | 2007-05-04 | 2010-04-30 | Кардиом Фарма Корп. | Пероральные композиции с регулируемым высвобождением соединений, модулирующих ионные каналы, и связанные с ними способы предупреждения аритмии |
| US9006460B2 (en) | 2010-08-16 | 2015-04-14 | Cardiome International Ag | Process for preparing aminocyclohexyl ether compounds |
| EP2606139B1 (en) | 2010-08-16 | 2015-07-15 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
| JP6615865B2 (ja) * | 2014-08-01 | 2019-12-04 | コベストロ、ドイチュラント、アクチエンゲゼルシャフト | 環状および直鎖状オリゴマーならびに改善した光学特性を有するコポリカーボネート組成物 |
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| US2954380A (en) * | 1958-11-26 | 1960-09-27 | Us Vitamin Pharm Corp | Piperazinocyclohexyl esters |
| US3218328A (en) * | 1963-02-18 | 1965-11-16 | U S Vitamin & Pharmacentical C | Heterocyclic amino phenoxyacetic acids, acid addition salts and quaternary ammonium salts thereof |
| DE2259260A1 (de) | 1972-12-04 | 1974-06-06 | Merck Patent Gmbh | Neue amine |
| US4179501A (en) * | 1976-11-12 | 1979-12-18 | The Upjohn Company | Analgesic N-(2-aminocycloaliphatic)azidobenzamides |
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| DE2658401A1 (de) | 1976-12-23 | 1978-07-06 | Merck Patent Gmbh | Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
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