DK1560812T3 - Aminocyclohexyletherforbindelser og anvendelser deraf - Google Patents

Aminocyclohexyletherforbindelser og anvendelser deraf

Info

Publication number
DK1560812T3
DK1560812T3 DK03781611T DK03781611T DK1560812T3 DK 1560812 T3 DK1560812 T3 DK 1560812T3 DK 03781611 T DK03781611 T DK 03781611T DK 03781611 T DK03781611 T DK 03781611T DK 1560812 T3 DK1560812 T3 DK 1560812T3
Authority
DK
Denmark
Prior art keywords
ether compounds
aminocyclohexyl ether
compounds
compositions
present
Prior art date
Application number
DK03781611T
Other languages
Danish (da)
English (en)
Inventor
Gregory N Beatch
Lewis Siu Leung Choi
Grace Jung
Yuzhong Liu
Bertrand Plouvier
Richard Wall
Jeff Zhu
Anthony G M Barrett
Alexander Zolotoy
Michael J A Walker
Tao Sheng
Sandro Yong
Doug Ta Hung Chou
Original Assignee
Cardiome Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiome Pharma Corp filed Critical Cardiome Pharma Corp
Application granted granted Critical
Publication of DK1560812T3 publication Critical patent/DK1560812T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
DK03781611T 2003-05-02 2003-10-31 Aminocyclohexyletherforbindelser og anvendelser deraf DK1560812T3 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US46715903P 2003-05-02 2003-05-02
US47608303P 2003-06-04 2003-06-04
US47644703P 2003-06-05 2003-06-05
US47591203P 2003-06-05 2003-06-05
US47588403P 2003-06-05 2003-06-05
US48965903P 2003-07-23 2003-07-23
US49339203P 2003-08-07 2003-08-07

Publications (1)

Publication Number Publication Date
DK1560812T3 true DK1560812T3 (da) 2006-09-04

Family

ID=33437310

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03781611T DK1560812T3 (da) 2003-05-02 2003-10-31 Aminocyclohexyletherforbindelser og anvendelser deraf

Country Status (21)

Country Link
US (3) US20070099983A1 (https=)
EP (3) EP1560812B1 (https=)
JP (2) JP4919661B2 (https=)
KR (1) KR101059379B1 (https=)
AT (2) ATE325789T1 (https=)
AU (2) AU2003287378B2 (https=)
BR (2) BR122018009866B8 (https=)
CA (1) CA2524323C (https=)
CY (1) CY1105137T1 (https=)
DE (1) DE60305200T2 (https=)
DK (1) DK1560812T3 (https=)
ES (2) ES2264776T3 (https=)
IL (2) IL171653A (https=)
NO (1) NO334094B1 (https=)
NZ (1) NZ543921A (https=)
PL (1) PL227937B1 (https=)
PT (1) PT1560812E (https=)
RU (1) RU2478617C2 (https=)
SG (2) SG167670A1 (https=)
SI (1) SI1560812T1 (https=)
WO (1) WO2004099137A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1087934T3 (da) 1998-04-01 2004-06-28 Cardiome Pharma Corp Aminocyclohexyletherforbindelser og anvendelser deraf
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) * 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US20080063707A1 (en) * 2003-05-02 2008-03-13 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
CA2524323C (en) 2003-05-02 2012-05-15 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
WO2005018635A2 (en) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
MXPA06011420A (es) * 2004-04-01 2007-04-20 Cardiome Pharma Corp Compuestos pegilados de modulacion de canal de iones.
WO2005097087A2 (en) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
CA2561819A1 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
US8263638B2 (en) * 2004-11-08 2012-09-11 Cardiome Pharma Corp. Dosing regimens for ion channel modulating compounds
US8692002B2 (en) 2004-11-18 2014-04-08 Cardiome Pharma Corp. Synthetic process for aminocyclohexyl ether compounds
CA2594680A1 (en) * 2005-01-12 2006-07-20 Astellas Pharma Inc. Production method of optically active cyclohexane ether compounds
MX2007016248A (es) 2005-06-15 2008-03-07 Cardiome Pharma Corp Procedimiento sintetico para la preparacion de compuestos de eter aminociclohexilico.
WO2007023824A1 (ja) 2005-08-23 2007-03-01 Kaneka Corporation ３－アラルキルオキシピロリジン誘導体の製造法
JP5004067B2 (ja) * 2005-10-31 2012-08-22 東レ・ファインケミカル株式会社 ベンジルオキシ含窒素環状化合物の製造法
WO2007052578A1 (ja) 2005-10-31 2007-05-10 Toray Fine Chemicals Co., Ltd. ベンジルオキシピロリジン誘導体の製造方法および光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体の製造法
JP5004073B2 (ja) * 2006-06-13 2012-08-22 東レ・ファインケミカル株式会社 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法
JP2007131597A (ja) * 2005-11-11 2007-05-31 Toray Fine Chemicals Co Ltd ベンジルオキシピロリジン誘導体の製造方法
EA200971025A1 (ru) * 2007-05-04 2010-04-30 Кардиом Фарма Корп. Пероральные композиции с регулируемым высвобождением соединений, модулирующих ионные каналы, и связанные с ними способы предупреждения аритмии
US9006460B2 (en) 2010-08-16 2015-04-14 Cardiome International Ag Process for preparing aminocyclohexyl ether compounds
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
JP6615865B2 (ja) * 2014-08-01 2019-12-04 コベストロ、ドイチュラント、アクチエンゲゼルシャフト 環状および直鎖状オリゴマーならびに改善した光学特性を有するコポリカーボネート組成物

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2954380A (en) * 1958-11-26 1960-09-27 Us Vitamin Pharm Corp Piperazinocyclohexyl esters
US3218328A (en) * 1963-02-18 1965-11-16 U S Vitamin & Pharmacentical C Heterocyclic amino phenoxyacetic acids, acid addition salts and quaternary ammonium salts thereof
DE2259260A1 (de) 1972-12-04 1974-06-06 Merck Patent Gmbh Neue amine
US4179501A (en) * 1976-11-12 1979-12-18 The Upjohn Company Analgesic N-(2-aminocycloaliphatic)azidobenzamides
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
DE2658401A1 (de) 1976-12-23 1978-07-06 Merck Patent Gmbh Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4598087A (en) * 1983-12-06 1986-07-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4656182A (en) * 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
CH667646A5 (de) * 1984-05-18 1988-10-31 Glaxo Group Ltd Aminocyclopentylether, ihre herstellung und pharmazeutische formulierung.
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
EP0222533A1 (en) 1985-10-25 1987-05-20 The Upjohn Company Cis-N-[(2-aminocycloaliphatic)benzene acetamide and -benzamide anticonvulsants
US5059620A (en) * 1985-12-27 1991-10-22 The Du Pont Merck Pharmaceutical Company Aryl substituted aminomethyl benzene derivatives
US4855316A (en) * 1988-02-18 1989-08-08 Warner-Lambert Company 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
AU626949B2 (en) 1988-12-06 1992-08-13 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
JPH02270864A (ja) 1989-04-12 1990-11-05 Asahi Glass Co Ltd フルオロカルバサイクリックヌクレオシドおよびその製造法
US5428031A (en) 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
CA2058502A1 (en) 1991-12-27 1993-06-28 David C. Horwell 2-amino-mono-methoxycyclohexyl amides useful as analgesics
EP0552386A1 (en) 1992-01-13 1993-07-28 Warner-Lambert Company 2-Amino-3 or 6-methoxycyclohexyl amide derivatives
EP0632806B1 (en) 1992-03-26 1997-07-02 The University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
US5506257A (en) * 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
GB9220286D0 (en) 1992-09-25 1992-11-11 Merck Sharp & Dohme Therapeutic agents
US5451596A (en) 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5747278A (en) * 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
US5492825A (en) * 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
DE69429524T2 (de) * 1993-09-24 2002-08-08 The University Of British Columbia, Vancouver Aminocyclohexylester und ihre anwendung
GB9406043D0 (en) * 1994-03-26 1994-05-18 Smithkline Beecham Plc Compounds
US5441946A (en) 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
CA2195107A1 (en) * 1994-08-02 1996-02-15 Richard Alexander Jelley Azetidine, pyrrolidine and piperidine derivatives
JP3823194B2 (ja) * 1994-09-19 2006-09-20 アステラス製薬株式会社 ５ｈｔ▲３▼拮抗剤の新規医薬用途
US5556990A (en) 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
CN1087348C (zh) 1995-02-03 2002-07-10 巴斯福股份公司 通过酶催化酰化拆分杂原子取代的伯胺和仲胺的外消旋体
SK101398A3 (en) 1996-01-25 1998-12-02 Schering Ag Improved concentrated injection and infusion solutions for intravenous administration
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
CZ425598A3 (cs) 1996-06-27 1999-08-11 Smithkline Beecham Corporation Antagonista IL-8 receptoru
US5935945A (en) * 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6180632B1 (en) * 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
TW536401B (en) 1997-09-03 2003-06-11 Cardiome Pharma Corp A pharmaceutical composition of N,N-bis(phenylcarbamoylmethyl)dimethylammomum chloride and derivatives for the treatment of pain
MXPA00002969A (es) 1997-09-26 2002-06-21 Nortran Pharmaceuticals Inc Mezclas de enantiomeros de aminociclohexilamidas para producir analgesia simultanea con anestesia local o antiarritmia.
JP3773644B2 (ja) * 1998-01-06 2006-05-10 芝府エンジニアリング株式会社 接点材料
US6013830A (en) 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
DK1087934T3 (da) * 1998-04-01 2004-06-28 Cardiome Pharma Corp Aminocyclohexyletherforbindelser og anvendelser deraf
US6624761B2 (en) * 1998-12-11 2003-09-23 Realtime Data, Llc Content independent data compression method and system
WO2000047547A2 (en) 1999-02-12 2000-08-17 Nortran Pharmaceuticals Inc. Cycloalkyl amine compounds and uses thereof
US6979685B1 (en) * 1999-02-12 2005-12-27 Cardiome Pharma Corp. Cycloalkyl amine compounds and uses thereof
US7053087B1 (en) * 1999-03-04 2006-05-30 Cardiome Pharma Corp. Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics
US7507545B2 (en) * 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
CA2268590A1 (en) * 1999-04-12 2000-10-12 Nortran Pharmaceuticals Inc. Ion channel modulating compounds and uses thereof
US6150357A (en) 1999-05-10 2000-11-21 Merck & Co., Inc. Potassium channel agonists
ATE274494T1 (de) * 2000-04-20 2004-09-15 Hoffmann La Roche Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen
CA2311483A1 (en) 2000-06-12 2001-12-12 Gregory N Beatch IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF
US6521619B2 (en) * 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6498170B2 (en) * 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
WO2003105756A2 (en) * 2002-06-14 2003-12-24 Johnson Matthey Pharmaceutical Materials, Inc. Stereoselective synthesis of 1,2-disubstituted cycloalkyls
AU2003251937A1 (en) 2002-07-12 2004-02-02 Cardiome Inc. Mutations of voltage-gated potassium channels
CA2524323C (en) 2003-05-02 2012-05-15 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7345086B2 (en) * 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
CA2524034A1 (en) 2003-05-02 2004-11-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
WO2005016242A2 (en) * 2003-06-04 2005-02-24 Cardiome Pharma Corp. Synthetic process for trans-aminocyclohexyl ether compounds
WO2005018635A2 (en) * 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US20070197632A1 (en) 2003-10-31 2007-08-23 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof

Also Published As

Publication number Publication date
KR101059379B1 (ko) 2011-08-26
SI1560812T1 (sl) 2006-10-31
BRPI0318278B8 (pt) 2024-01-09
RU2008104198A (ru) 2009-08-10
JP4919661B2 (ja) 2012-04-18
RU2478617C2 (ru) 2013-04-10
BRPI0318278B1 (pt) 2018-11-06
IL216579A0 (en) 2012-01-31
CA2524323A1 (en) 2004-11-18
IL171653A (en) 2013-06-27
SG2010079697A (en) 2016-09-29
WO2004099137A1 (en) 2004-11-18
EP1666459B1 (en) 2011-10-19
AU2011201015B2 (en) 2012-02-02
US7767830B2 (en) 2010-08-03
CY1105137T1 (el) 2010-03-03
NO20055130L (no) 2005-12-01
BR0318278A (pt) 2006-05-23
NZ543921A (en) 2008-11-28
NO334094B1 (no) 2013-12-09
SG167670A1 (en) 2011-01-28
JP2007077162A (ja) 2007-03-29
AU2003287378B2 (en) 2010-12-16
BR122018009866B1 (pt) 2018-12-18
AU2003287378A1 (en) 2004-11-26
DE60305200T2 (de) 2007-05-10
PL227937B1 (pl) 2018-01-31
KR20060057531A (ko) 2006-05-26
DE60305200D1 (de) 2006-06-14
BR122018009866B8 (pt) 2021-07-27
ES2375820T3 (es) 2012-03-06
ATE529401T1 (de) 2011-11-15
EP2298735A1 (en) 2011-03-23
AU2011201015A1 (en) 2011-03-31
PT1560812E (pt) 2006-09-29
ATE325789T1 (de) 2006-06-15
HK1091814A1 (zh) 2007-01-26
CA2524323C (en) 2012-05-15
US8163938B2 (en) 2012-04-24
EP1666459A2 (en) 2006-06-07
PL378918A1 (pl) 2006-06-12
US20070254945A1 (en) 2007-11-01
ES2264776T3 (es) 2007-01-16
IL216579A (en) 2015-02-26
EP1560812B1 (en) 2006-05-10
EP1666459A3 (en) 2006-09-20
NO20055130D0 (no) 2005-11-02
EP1560812A1 (en) 2005-08-10
JP2006525227A (ja) 2006-11-09
US20070099983A1 (en) 2007-05-03
US20110004006A1 (en) 2011-01-06

Similar Documents

Publication Publication Date Title
DK1560812T3 (da) Aminocyclohexyletherforbindelser og anvendelser deraf
BRPI0418251A (pt) fosfonatos, monofosfonamidatos, bisfosfonamidatos para o tratamento de doenças virais
ATE407967T1 (de) Nukleierungsmittel
EP1432714A4 (en) CHEMICAL COMPOUNDS
WO2004034990A3 (en) Methods and compositions for use in treating cancer
NL1026892A1 (nl) ó1,8!Naftyridin-2-onen en verwante verbindingen voor de behandeling van schizofrenie.
BR0007720A (pt) Porfirinas substituìdas
MY142988A (en) Novel aminobenzophenone compounds
DK1594833T3 (da) 1-phenylalkancarboxylsyrederivater til behandling af neurodegenerative sygdomme
DE602006017980D1 (de) 3,4-substituierte pyrrolidin-derivate zur behandlung von hypertonie
WO2005044200A3 (en) Methods and compositions for treating mcp-1 related pathologies
BRPI0509660A (pt) compostos de beta-carbolina de utilidade no tratamento de doenças inflamatórias
SE0301650D0 (sv) Novel compounds
WO2005000208A3 (en) Combination therapy for the treatment of neoplasms
TW200716088A (en) Formulations and methods for treating amyloidosis
EP1551388A4 (en) COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, COMPOSITIONS AND METHODS COMPRISING THE SAME
WO2004105696A3 (en) Combination therapy for the treatment of neoplasms
ATE410166T1 (de) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin- derivate zur behandlung von unfruchtbarkeit
NO20053903D0 (no) Nukleotidlipidesterderivater.
ATE391489T1 (de) Haarbehandlungszusammensetzungen
IL185653A (en) Antibodies that call for the 1-kim salt region
MXPA05009428A (es) Composiciones y metodos para prevenir y tratar enfermedades relacionadas con endotoxinas.
ATE460168T1 (de) Nicht-radioaktives strontiummittel zur behandlung von krebs
EP1436279A4 (en) CHEMICAL COMPOUNDS
MY176850A (en) Aminocyclohexyl ether compounds and uses thereof