KR101059379B1 - 아미노사이클로헥실 에테르 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 - Google Patents

아미노사이클로헥실 에테르 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 Download PDF

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KR101059379B1
KR101059379B1 KR1020057020862A KR20057020862A KR101059379B1 KR 101059379 B1 KR101059379 B1 KR 101059379B1 KR 1020057020862 A KR1020057020862 A KR 1020057020862A KR 20057020862 A KR20057020862 A KR 20057020862A KR 101059379 B1 KR101059379 B1 KR 101059379B1
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formula
compound
group
formulas
suitable conditions
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Korean (ko)
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KR20060057531A (ko
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그레고리 엔. 비취
루이스 슈 륭 최
그레이스 정
위종 류
버트랜드 플러비어
리처드 월
제프 주
알렉산더 졸로토이
안쏘니 지. 엠. 바렛
마이클 제이.에이. 워커
산드로 엘. 용
타오 성
더웅 타 훙 처우
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카디오메 파마 코포레이션
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Publication of KR20060057531A publication Critical patent/KR20060057531A/ko
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Assigned to 코레비오 캐나다 코포레이션 reassignment 코레비오 캐나다 코포레이션 권리의 전부이전등록 Assignors: 코레비오 파마 코포레이션
Assigned to 코레비오 인터내셔널 에스에이알엘 reassignment 코레비오 인터내셔널 에스에이알엘 권리의 전부이전등록 Assignors: 코레비오 캐나다 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
KR1020057020862A 2003-05-02 2003-10-31 아미노사이클로헥실 에테르 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 Expired - Lifetime KR101059379B1 (ko)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US46715903P 2003-05-02 2003-05-02
US60/467,159 2003-05-02
US47608303P 2003-06-04 2003-06-04
US60/476,083 2003-06-04
US47588403P 2003-06-05 2003-06-05
US47591203P 2003-06-05 2003-06-05
US47644703P 2003-06-05 2003-06-05
US60/475,884 2003-06-05
US60/475,912 2003-06-05
US60/476,447 2003-06-05
US48965903P 2003-07-23 2003-07-23
US60/489,659 2003-07-23
US49339203P 2003-08-07 2003-08-07
US60/493,392 2003-08-07
PCT/US2003/034655 WO2004099137A1 (en) 2003-05-02 2003-10-31 Aminocyclohexyl ether compounds and uses thereof

Publications (2)

Publication Number Publication Date
KR20060057531A KR20060057531A (ko) 2006-05-26
KR101059379B1 true KR101059379B1 (ko) 2011-08-26

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KR1020057020862A Expired - Lifetime KR101059379B1 (ko) 2003-05-02 2003-10-31 아미노사이클로헥실 에테르 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물

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Country Link
US (3) US20070099983A1 (https=)
EP (3) EP2298735A1 (https=)
JP (2) JP4919661B2 (https=)
KR (1) KR101059379B1 (https=)
AT (2) ATE325789T1 (https=)
AU (2) AU2003287378B2 (https=)
BR (2) BRPI0318278B8 (https=)
CA (1) CA2524323C (https=)
CY (1) CY1105137T1 (https=)
DE (1) DE60305200T2 (https=)
DK (1) DK1560812T3 (https=)
ES (2) ES2264776T3 (https=)
IL (2) IL171653A (https=)
NO (1) NO334094B1 (https=)
NZ (1) NZ543921A (https=)
PL (1) PL227937B1 (https=)
PT (1) PT1560812E (https=)
RU (1) RU2478617C2 (https=)
SG (2) SG167670A1 (https=)
SI (1) SI1560812T1 (https=)
WO (1) WO2004099137A1 (https=)

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JP2006525227A (ja) 2006-11-09
KR20060057531A (ko) 2006-05-26
BR0318278A (pt) 2006-05-23
ES2375820T3 (es) 2012-03-06
HK1091814A1 (zh) 2007-01-26
JP2007077162A (ja) 2007-03-29
DE60305200D1 (de) 2006-06-14
IL216579A0 (en) 2012-01-31
US7767830B2 (en) 2010-08-03
SG167670A1 (en) 2011-01-28
NO20055130L (no) 2005-12-01
CA2524323C (en) 2012-05-15
PL378918A1 (pl) 2006-06-12
WO2004099137A1 (en) 2004-11-18
ES2264776T3 (es) 2007-01-16
US20070254945A1 (en) 2007-11-01
EP1560812A1 (en) 2005-08-10
EP1666459B1 (en) 2011-10-19
SI1560812T1 (sl) 2006-10-31
US20110004006A1 (en) 2011-01-06
AU2003287378B2 (en) 2010-12-16
BR122018009866B1 (pt) 2018-12-18
IL216579A (en) 2015-02-26
RU2478617C2 (ru) 2013-04-10
PL227937B1 (pl) 2018-01-31
EP1666459A3 (en) 2006-09-20
US20070099983A1 (en) 2007-05-03
BRPI0318278B8 (pt) 2024-01-09
AU2011201015A1 (en) 2011-03-31
NO334094B1 (no) 2013-12-09
BRPI0318278B1 (pt) 2018-11-06
CA2524323A1 (en) 2004-11-18
DE60305200T2 (de) 2007-05-10
SG2010079697A (en) 2016-09-29
BR122018009866B8 (pt) 2021-07-27
IL171653A (en) 2013-06-27
RU2008104198A (ru) 2009-08-10
CY1105137T1 (el) 2010-03-03
AU2003287378A1 (en) 2004-11-26
NZ543921A (en) 2008-11-28
JP4919661B2 (ja) 2012-04-18
AU2011201015B2 (en) 2012-02-02
ATE529401T1 (de) 2011-11-15
US8163938B2 (en) 2012-04-24
EP1666459A2 (en) 2006-06-07
EP2298735A1 (en) 2011-03-23
PT1560812E (pt) 2006-09-29

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