DE60225478D1 - Verfahren zur herstellung des coenzyms q10 - Google Patents

Verfahren zur herstellung des coenzyms q10

Info

Publication number
DE60225478D1
DE60225478D1 DE60225478T DE60225478T DE60225478D1 DE 60225478 D1 DE60225478 D1 DE 60225478D1 DE 60225478 T DE60225478 T DE 60225478T DE 60225478 T DE60225478 T DE 60225478T DE 60225478 D1 DE60225478 D1 DE 60225478D1
Authority
DE
Germany
Prior art keywords
coenzyme
reduced coenzyme
recovering
present
microbial cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60225478T
Other languages
English (en)
Other versions
DE60225478C5 (de
DE60225478T2 (de
Inventor
Kazuyoshi Yajima
Takahisa Kato
Akihisa Kanda
Shiro Kitamura
Yasuyoshi Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19189359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60225478(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of DE60225478D1 publication Critical patent/DE60225478D1/de
Application granted granted Critical
Publication of DE60225478T2 publication Critical patent/DE60225478T2/de
Publication of DE60225478C5 publication Critical patent/DE60225478C5/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60225478.7T 2001-12-27 2002-12-27 Verfahren zur herstellung des coenzyms q10 Expired - Lifetime DE60225478C5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001398545 2001-12-27
JP2001398545 2001-12-27
PCT/JP2002/013766 WO2003056024A1 (fr) 2001-12-27 2002-12-27 Procedes de production de la co-enzyme q10

Publications (3)

Publication Number Publication Date
DE60225478D1 true DE60225478D1 (de) 2008-04-17
DE60225478T2 DE60225478T2 (de) 2009-02-26
DE60225478C5 DE60225478C5 (de) 2015-09-17

Family

ID=19189359

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60225478.7T Expired - Lifetime DE60225478C5 (de) 2001-12-27 2002-12-27 Verfahren zur herstellung des coenzyms q10

Country Status (12)

Country Link
US (4) US20050069996A1 (de)
EP (1) EP1466983B1 (de)
JP (4) JP4256782B2 (de)
KR (1) KR100913464B1 (de)
CN (1) CN100523205C (de)
AT (1) ATE388236T1 (de)
AU (1) AU2002357526B2 (de)
CA (1) CA2471763C (de)
DE (1) DE60225478C5 (de)
RU (1) RU2298035C2 (de)
TW (2) TWI349039B (de)
WO (1) WO2003056024A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI349039B (en) * 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
TW200302055A (en) * 2002-01-18 2003-08-01 Kaneka Corp Ubiquinol-enriched fat-containing foods
JP4426832B2 (ja) 2002-12-03 2010-03-03 株式会社分子生理化学研究所 コエンザイムｑ−１０及びその２電子還元体の分析方法
WO2006092449A2 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
JPWO2007126086A1 (ja) * 2006-04-28 2009-09-10 株式会社カネカ 還元型補酵素ｑ１０の精製方法
KR101406044B1 (ko) * 2007-06-08 2014-06-12 한국생산기술연구원 감귤박을 탄소원으로 첨가한 배지에서 로도토룰라균의배양을 통한 코엔자임큐텐의 제조방법
WO2009025277A1 (ja) * 2007-08-22 2009-02-26 Kaneka Corporation 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法
CN101307338B (zh) * 2008-07-17 2012-04-25 任雷 还原型辅酶q10的制备方法
CN101519681B (zh) * 2009-04-01 2012-11-07 宜都东阳光生化制药有限公司 一种辅酶q10的生产发酵工艺
WO2010132486A2 (en) 2009-05-11 2010-11-18 Cytotech Labs, Llc Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
US20110269196A1 (en) * 2010-04-13 2011-11-03 Syracuse University Coenzyme q10 production using sporidiobolus johnsonii
JP5016734B2 (ja) * 2010-07-22 2012-09-05 株式会社カネカ 脂溶性生理活性物質の製造方法
WO2012129072A1 (en) 2011-03-18 2012-09-27 Particle Dynamics International, Llc Solid particulate compositions comprising coenzyme q10
KR101933732B1 (ko) 2011-04-04 2018-12-28 버그 엘엘씨 중추 신경 시스템 종양들의 치료 방법
CN102557912B (zh) * 2011-12-31 2015-01-07 内蒙古金达威药业有限公司 一种辅酶q10提取液的皂化方法
EP3578990A1 (de) 2012-03-02 2019-12-11 Berg LLC Verfahren und kits zum nachweis des coenzyms q10
WO2014168993A1 (en) 2013-04-08 2014-10-16 Berg Llc Treatment of cancer using coenzyme q10 combination therapies
ES2825083T3 (es) 2013-09-04 2021-05-14 Berg Llc Métodos de tratamiento contra el cáncer mediante infusión continua de coenzima Q10
CN103819326B (zh) * 2013-12-11 2016-08-17 湖南科源生物制品有限公司 一种从微生物中分离纯化辅酶q10的方法
JP2016208909A (ja) * 2015-05-08 2016-12-15 株式会社カネカ 脂溶性生理活性物質の製造方法
JP6757724B2 (ja) * 2015-06-23 2020-09-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
CN105886562A (zh) * 2016-05-31 2016-08-24 兰州天和生物催化技术有限公司 微生物发酵法制备辅酶q10的方法
WO2018003974A1 (ja) * 2016-07-01 2018-01-04 株式会社カネカ 補酵素ｑ１０の製造方法
US10774350B2 (en) 2017-12-25 2020-09-15 Zhejiang Nhu Company Ltd. Method for fermentative production of oxidized coenzyme Q10
CN108048496B (zh) * 2017-12-25 2020-11-10 浙江新和成股份有限公司 氧化型辅酶q10的发酵生产方法、及由其制备而得的高含量氧化型辅酶q10
US20210032666A1 (en) * 2018-03-28 2021-02-04 Kaneka Corporation Method for producing coenzyme q10
CN112041454A (zh) * 2018-04-27 2020-12-04 株式会社钟化 辅酶q10的制造方法
CN108997153B (zh) * 2018-07-25 2021-02-02 中国人民大学 从光合细菌中逐级提取多种高价值物质的方法
CN109055417B (zh) 2018-08-28 2020-07-07 浙江新和成股份有限公司 一种重组微生物、其制备方法及其在生产辅酶q10中的应用
CN109762757B (zh) * 2018-12-25 2020-01-07 神舟生物科技有限责任公司 一种高产辅酶q10类球红细菌及其诱变选育和应用
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
CN112755589B (zh) * 2021-02-23 2022-04-15 山东泰和水处理科技股份有限公司 精制辅酶q10的萃取方法及装置
CN115584357B (zh) * 2022-11-02 2023-10-20 广东润和生物科技有限公司 一种辅酶q10的发酵提取方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB930752A (en) * 1958-12-29 1963-07-10 Merck & Co Inc Preparation of coenzyme q-10
US3066080A (en) 1961-03-22 1962-11-27 Merck & Co Inc Fermentation production of coenzyme q-10
JPS488836Y1 (de) 1969-11-28 1973-03-08
JPS4825517B1 (de) * 1970-08-24 1973-07-30
US3769170A (en) * 1970-03-31 1973-10-30 Ajinomoto Kk Method of producing coenzyme q10 by microorganisms
JPS488836B1 (de) * 1970-03-31 1973-03-17
JPS4825517A (de) 1971-08-04 1973-04-03
JPS5452790A (en) * 1977-10-04 1979-04-25 Kanegafuchi Chem Ind Co Ltd Preparation of coenzyme q
JPS54110388A (en) * 1978-01-10 1979-08-29 Kanegafuchi Chem Ind Co Ltd Microbial preparation of coenzyme q10
JPS5857155B2 (ja) * 1978-03-07 1983-12-19 協和醗酵工業株式会社 発酵法によるコエンチ−ムｑ↓１↓０の製造法
JPS54126792A (en) * 1978-03-20 1979-10-02 Hiroshi Aida Production of coenzyme q10
JPS5527A (en) * 1978-05-25 1980-01-05 Kanegafuchi Chem Ind Co Ltd Microbiological preparation of coenzyme q10
JPS5528A (en) * 1978-05-29 1980-01-05 Hiroshi Aida Preparation of coenzyme q9
JPS5521756A (en) * 1978-08-04 1980-02-16 Hiroshi Aida Preparation of coenzyme q
JPS593197B2 (ja) 1978-09-25 1984-01-23 十條製紙株式会社 補酵素ｑ↓１↓０の製造法
JPS5568295A (en) * 1978-11-17 1980-05-22 Godo Shiyusei Kk Production of ubiquinone
JPS55148084A (en) * 1979-05-08 1980-11-18 Mitsubishi Gas Chem Co Inc Incubation of microoranism
JPS5655196A (en) * 1979-10-08 1981-05-15 Mitsubishi Gas Chem Co Inc Method of culturing microorganism
JPS56154994A (en) * 1980-04-30 1981-11-30 Sekisui Chem Co Ltd Preparation of coenzyme q10
JPS56154996A (en) * 1980-05-02 1981-11-30 Sekisui Chem Co Ltd Preparation of coenzyme q10
JPS5733599A (en) * 1980-08-06 1982-02-23 Mitsubishi Gas Chem Co Inc Production of coenzyme q10
JPS5771396A (en) * 1980-10-07 1982-05-04 Univ Nagoya Preparation of coenzyme q10
JPS5770834A (en) * 1980-10-17 1982-05-01 Takara Shuzo Co Ltd Preparation of coenzyme q
AR228195A1 (es) * 1981-08-19 1983-01-31 Pfizer Procedimiento microbiologico para la preparacion de hidroquinona
JPS6075294A (ja) * 1984-03-16 1985-04-27 Nisshin Flour Milling Co Ltd 補酵素ｑの製造法
DD236552A1 (de) * 1985-04-26 1986-06-11 Akad Wissenschaften Ddr Verfahren zur herstellung von ubichinon-10
JPS61271994A (ja) * 1985-05-28 1986-12-02 Mitsubishi Gas Chem Co Inc 補酵素ｑ↓１↓０の製造法
JPS6336789A (ja) * 1986-07-29 1988-02-17 Mitsubishi Gas Chem Co Inc 補酵素ｑ↓１↓０の製造法
JPS63317092A (ja) * 1987-06-19 1988-12-26 Mitsubishi Gas Chem Co Inc 補酵素ｑ↓１↓０の製造法
JPS63102691A (ja) 1987-09-11 1988-05-07 Nisshin Flour Milling Co Ltd 補酵素ｑ↓１↓０の製造法
JPH088836B2 (ja) 1991-10-31 1996-01-31 社団法人長野県農村工業研究所 酵素により特性を改変した澱粉粒の利用方法
WO1996017626A2 (en) * 1994-12-06 1996-06-13 Ryan Pharmaceuticals, Inc. Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
JP3889481B2 (ja) 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
JPH1057072A (ja) * 1996-08-22 1998-03-03 Alpha- Shokuhin Kk ユビキノン−１０の生成方法
JP3926888B2 (ja) 1997-05-27 2007-06-06 株式会社カネカ コレステロール低下剤
JPH1156372A (ja) 1997-08-27 1999-03-02 Alpha- Shokuhin Kk ユビキノン−１０の生成方法
JP3941998B2 (ja) * 1999-08-24 2007-07-11 株式会社カネカ コエンザイムｑ１０の製造法
EP1227155B1 (de) 1999-10-14 2008-04-09 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur herstellung von ubiquinon-10
JP4191482B2 (ja) * 2000-11-20 2008-12-03 株式会社カネカ コエンザイムｑ１０の製造法
JP2002191367A (ja) 2000-12-27 2002-07-09 Kanegafuchi Chem Ind Co Ltd コエンザイムｑ１０の製造法
JP2002345469A (ja) 2001-04-25 2002-12-03 Kanegafuchi Chem Ind Co Ltd コエンザイムｑ１０の製造法
JP3742602B2 (ja) * 2001-05-09 2006-02-08 株式会社カネカ 還元型補酵素ｑの安定な溶液
TWI237019B (en) * 2001-07-13 2005-08-01 Kaneka Corp Method of producing reduced coenzyme Q10
TWI237018B (en) * 2001-07-13 2005-08-01 Kaneka Corp Method of producing reduced coenzyme Q10 crystals
CA2453164A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of crystallizing reduced coenzyme q10 from aqueous solution
TW200604159A (en) * 2001-07-13 2006-02-01 Kaneka Corp Method of producing reduced coenzyme Q10 as oily product
TWI310029B (de) * 2001-07-13 2009-05-21 Kaneka Corp
TWI235146B (en) * 2001-07-16 2005-07-01 Kaneka Corp Method of stabilizing reduced coenzyme q10 and method of acidic crystallization
TWI329510B (en) * 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
JP3822479B2 (ja) * 2001-10-10 2006-09-20 株式会社カネカ 還元型補酵素ｑ水溶液の安定化組成
TWI349039B (en) 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
JP3781118B2 (ja) 2003-03-03 2006-05-31 セイコーエプソン株式会社 配線基板の製造方法

Also Published As

Publication number Publication date
CN100523205C (zh) 2009-08-05
US9926580B2 (en) 2018-03-27
CN1608136A (zh) 2005-04-20
JP2014166191A (ja) 2014-09-11
CA2471763C (en) 2012-02-14
JPWO2003056024A1 (ja) 2005-05-12
US20110136191A1 (en) 2011-06-09
WO2003056024A1 (fr) 2003-07-10
JP2012157360A (ja) 2012-08-23
US7910340B2 (en) 2011-03-22
JP5074287B2 (ja) 2012-11-14
TW200301306A (en) 2003-07-01
KR20040076266A (ko) 2004-08-31
AU2002357526B2 (en) 2007-10-18
EP1466983A1 (de) 2004-10-13
DE60225478C5 (de) 2015-09-17
EP1466983B1 (de) 2008-03-05
RU2298035C2 (ru) 2007-04-27
JP4256782B2 (ja) 2009-04-22
ATE388236T1 (de) 2008-03-15
CA2471763A1 (en) 2003-07-10
TWI305547B (en) 2009-01-21
TWI349039B (en) 2011-09-21
DE60225478T2 (de) 2009-02-26
KR100913464B1 (ko) 2009-08-25
US20050069996A1 (en) 2005-03-31
TW200900507A (en) 2009-01-01
US20080171373A1 (en) 2008-07-17
US9315839B2 (en) 2016-04-19
JP2008253271A (ja) 2008-10-23
JP5788831B2 (ja) 2015-10-07
US20160304915A1 (en) 2016-10-20
AU2002357526A1 (en) 2003-07-15
RU2004122912A (ru) 2005-06-27
EP1466983A4 (de) 2005-11-09

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