GB930752A - Preparation of coenzyme q-10 - Google Patents
Preparation of coenzyme q-10Info
- Publication number
- GB930752A GB930752A GB3271159A GB3271159A GB930752A GB 930752 A GB930752 A GB 930752A GB 3271159 A GB3271159 A GB 3271159A GB 3271159 A GB3271159 A GB 3271159A GB 930752 A GB930752 A GB 930752A
- Authority
- GB
- United Kingdom
- Prior art keywords
- coenzyme
- specified
- sources
- proteus
- pseudomonas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
Abstract
The hydroquinone corresponding to coenzyme Q-10 (see Group IV(b)) is used as antioxidant to prevent the devolopment of rancidity in fats and oils.ALSO:A process for producing coenzyme Q-10 comprises cultivation of a bacterial strain selected from the genera Pseudomonas and Proteus in an aqueous medium containing assimilable sources of carbohydrates, nitrogen and essential inorganic salts until a demonstrable amount of the quinone, coenzyme Q-10 has been formed and isolating coenzyme Q-10 by a method which comprises treating the resulting broth by extraction with an organic solvent phase either after or without previous hydrolytic treatment. Carbohydrate sources specified include sucrose or brown sugar, dextrose, maltose, lactose, beet molasses, rye, ribose, dried whey and cottonseed meal, sources of assimilable nitrogen specified include pure or degraded proteins, amino acids, corn-step liquor yeast autolysate, soybean meal, urea and inorganic ammonium compounds. The addition of sources of potassium, phosphorus and traces of zinc, inon, manganese and magnesium which may be in the forms of salts such as nitrates, chlorides or sulphates is desirable. Hydrolysis may be carried out with acid or alkaline agents e.g. aqueous ethanolic potassium hydroxide or sodium hydroxide and in the presence of antioxidants e.g. pyrogallol or reducing agents. Solvents specified include light petroleum fractions, hexane, chloroform, acetone and alcohol. Crude preparations of the coenzyme may be purified by chromotography or countercurrent extraction. Methods for the determination of the coenzyme are indicated. Bacterial strains specified for use in the process include Proteus vulgaris and Pseudomonas denitrifians, specified for use in the process include Proteus azotocolligans, diminuta, woodsii, tomato, and vitiswoodrowii. Mutant strains commonly used in the art produced from species of the genus Proteus and the genus Pseudomonas ultra violet or X-ray irradiation and other physical and chemical treatments may be employed in the process.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78314758A | 1958-12-29 | 1958-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB930752A true GB930752A (en) | 1963-07-10 |
Family
ID=25128315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3271159A Expired GB930752A (en) | 1958-12-29 | 1959-09-25 | Preparation of coenzyme q-10 |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE583839A (en) |
| CH (1) | CH379446A (en) |
| GB (1) | GB930752A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1466983A1 (en) * | 2001-12-27 | 2004-10-13 | Kaneka Corporation | Processes for producing coenzyme q sb 10 /sb |
| CN109415744A (en) * | 2016-07-01 | 2019-03-01 | 株式会社钟化 | The manufacturing method of Co-Q10 |
| CN112755589A (en) * | 2021-02-23 | 2021-05-07 | 山东泰和水处理科技股份有限公司 | Extraction method and device of refined coenzyme Q10 |
-
1959
- 1959-09-25 GB GB3271159A patent/GB930752A/en not_active Expired
- 1959-10-07 CH CH7911659A patent/CH379446A/en unknown
- 1959-10-21 BE BE583839A patent/BE583839A/en unknown
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1466983A1 (en) * | 2001-12-27 | 2004-10-13 | Kaneka Corporation | Processes for producing coenzyme q sb 10 /sb |
| EP1466983A4 (en) * | 2001-12-27 | 2005-11-09 | Kaneka Corp | Processes for producing coenzyme q10 |
| US7910340B2 (en) | 2001-12-27 | 2011-03-22 | Kaneka Corporation | Processes for producing coenzyme Q10 |
| US9315839B2 (en) | 2001-12-27 | 2016-04-19 | Kaneka Corporation | Processes for producing coenzyme Q10 |
| US9926580B2 (en) | 2001-12-27 | 2018-03-27 | Kaneka Corporation | Process for producing coenzyme Q10 |
| CN109415744A (en) * | 2016-07-01 | 2019-03-01 | 株式会社钟化 | The manufacturing method of Co-Q10 |
| JPWO2018003974A1 (en) * | 2016-07-01 | 2019-04-25 | 株式会社カネカ | Method of producing coenzyme Q10 |
| EP3480317A4 (en) * | 2016-07-01 | 2020-01-22 | Kaneka Corporation | Method for producing coenzyme q10 |
| US10837043B2 (en) | 2016-07-01 | 2020-11-17 | Kaneka Corporation | Method for producing coenzyme Q10 |
| CN112755589A (en) * | 2021-02-23 | 2021-05-07 | 山东泰和水处理科技股份有限公司 | Extraction method and device of refined coenzyme Q10 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH379446A (en) | 1964-07-15 |
| BE583839A (en) | 1960-04-21 |
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