GB1072374A - Preparation of 6-aminopencillanic acid - Google Patents

Preparation of 6-aminopencillanic acid

Info

Publication number
GB1072374A
GB1072374A GB4663363A GB4663363A GB1072374A GB 1072374 A GB1072374 A GB 1072374A GB 4663363 A GB4663363 A GB 4663363A GB 4663363 A GB4663363 A GB 4663363A GB 1072374 A GB1072374 A GB 1072374A
Authority
GB
United Kingdom
Prior art keywords
penicillin
preparation
cells
borate buffer
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4663363A
Inventor
Thomas Boyne Platt
Rudy Joseph Wodzinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olin Corp
Original Assignee
Olin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olin Corp filed Critical Olin Corp
Priority to GB4663363A priority Critical patent/GB1072374A/en
Publication of GB1072374A publication Critical patent/GB1072374A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/42—Compounds with a free primary amino radical attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

6-Amino-penicillanic acid is produced by subjecting a penicillin to the action of enzymes present in or obtained from Streptomyces griseus, S. azureus, S. fradiae, S. olivaceus or Bacterium cyclo-oxydans. The penicillin may be penicillin G, penicillin V or a -phenoxyethyl penicillin. According to the example, a five day culture of the cells in a conventional medium is separated from the broth, resuspended in N/5 borate buffer at pH 8.5 and centrifuged. The cells are incubated with the penicillin in N/5 borate buffer at pH 8.5 and 45 DEG C. The 6-aminopenicillanic acid formed is recovered in the coventional manner.
GB4663363A 1963-11-26 1963-11-26 Preparation of 6-aminopencillanic acid Expired GB1072374A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4663363A GB1072374A (en) 1963-11-26 1963-11-26 Preparation of 6-aminopencillanic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4663363A GB1072374A (en) 1963-11-26 1963-11-26 Preparation of 6-aminopencillanic acid

Publications (1)

Publication Number Publication Date
GB1072374A true GB1072374A (en) 1967-06-14

Family

ID=10442000

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4663363A Expired GB1072374A (en) 1963-11-26 1963-11-26 Preparation of 6-aminopencillanic acid

Country Status (1)

Country Link
GB (1) GB1072374A (en)

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