GB729557A - Vitamin b - Google Patents

Vitamin b

Info

Publication number
GB729557A
GB729557A GB1065552A GB1065552A GB729557A GB 729557 A GB729557 A GB 729557A GB 1065552 A GB1065552 A GB 1065552A GB 1065552 A GB1065552 A GB 1065552A GB 729557 A GB729557 A GB 729557A
Authority
GB
United Kingdom
Prior art keywords
vitamin
solution
cyanide
butyl alcohol
normal butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1065552A
Inventor
John Godfrey Heathcote
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distillers Co Yeast Ltd
Distillers Co Ltd
Original Assignee
Distillers Co Yeast Ltd
Distillers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Distillers Co Yeast Ltd, Distillers Co Ltd filed Critical Distillers Co Yeast Ltd
Priority to GB1065552A priority Critical patent/GB729557A/en
Publication of GB729557A publication Critical patent/GB729557A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Crude Vitamin B12 in aqueous solution, e.g. a Streptomyces griseus culture broth elaboration product, is purified by reacting with a substance yielding cyanide ions, e.g. hydrocyanic acid gas, potassium, sodium, ammonium, calcium, or barium cyanide, the purity of the Vitamin B12 being not in excess of about 1 per cent, the concentration of vitamin B12 in the solution being not in excess of about 100 micrograms/ml., the concentration of cyanide ions in the solution being in the range of about 0.2 to 0.6 gram-mols. per litre, and the pH of the solution being not less than 6, extracting the Vitamin B12-cyanide complex so formed into normal butyl alcohol in the presence of a salting-out agent, e.g. sodium sulphate, ammonium sulphate or magnesium sulphate, thereafter decomposing the Vitamin B12-cyanide complex by adjusting the pH value of the solution to an acid value and recovering the Vitamin B12. The normal butyl alcohol and the salting-out agent may be introducing during or after the formation of the Vitamin B12-cyanide complex. The extraction into normal butyl alcohol may be effected in a continuous manner. Specification 727,146 is referred to.
GB1065552A 1952-04-28 1952-04-28 Vitamin b Expired GB729557A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1065552A GB729557A (en) 1952-04-28 1952-04-28 Vitamin b

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1065552A GB729557A (en) 1952-04-28 1952-04-28 Vitamin b

Publications (1)

Publication Number Publication Date
GB729557A true GB729557A (en) 1955-05-11

Family

ID=9971845

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1065552A Expired GB729557A (en) 1952-04-28 1952-04-28 Vitamin b

Country Status (1)

Country Link
GB (1) GB729557A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1100880B (en) * 1957-04-04 1961-03-02 Distillers Co Yeast Ltd Process for the preparation of a cobalamin-peptide complex which is orally effective against pernicious anemia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1100880B (en) * 1957-04-04 1961-03-02 Distillers Co Yeast Ltd Process for the preparation of a cobalamin-peptide complex which is orally effective against pernicious anemia

Similar Documents

Publication Publication Date Title
GB729557A (en) Vitamin b
GB727146A (en) Vitamin b
GB1392337A (en) Process for the production of hydroxylamino-and aminoanthra- quinones
GB1280729A (en) Process of recovering ammonium sulphate from an aqueous solution containing ammonium sulphate and methionine
GB1357614A (en) Purification of phosphoric acid
GB683423A (en) Improvements in and relating to antibiotic substances produced by group n streptococcus lactis
GB772345A (en) Improvements in or relating to preparation of polyvinylamine
ES257899A1 (en) Improvements in or relating to process for the manufacture of therapeutic useful preparations of iron
GB1374374A (en) Isoxazolopyrimidine derivatives
GB1472970A (en) Purfified phosphoric acid and its production
GB908024A (en) Method of producing citric acid by fermentation
GB1269873A (en) Process for producing ferrous sulphate
GB1036815A (en) Method of producing n-methyleneglycinonitrile
GB1315706A (en) Process for the production of sodium nitrilotriacetate monohydrate
GB1348798A (en) Process for the production of citric acid by submerged fermentation
GB1316277A (en) Process for the production of polyhalophenols
GB1479731A (en) Process for the production of crystals of monosodium glutamate pentahydrate
GB1318666A (en) Process for the production of non-caking urea
GB887012A (en) Process for the preparation of 18ª--glycyrrhetinic acid
Wang Relation of Chlorine Compounds Produced by Streptomyces Aureofaciens with Production of Chlortetracycline
GB1344682A (en) Process for producing dl/tryptophane
GB1310788A (en) Process for the production of dopa
GB681503A (en) Process for recovering vitamin b
GB787172A (en) Process for the production of sodium sulphide
GB772149A (en) Production of a new antibiotic bromotetracycline by fermentation