ES257899A1 - Improvements in or relating to process for the manufacture of therapeutic useful preparations of iron - Google Patents
Improvements in or relating to process for the manufacture of therapeutic useful preparations of ironInfo
- Publication number
- ES257899A1 ES257899A1 ES0257899A ES257899A ES257899A1 ES 257899 A1 ES257899 A1 ES 257899A1 ES 0257899 A ES0257899 A ES 0257899A ES 257899 A ES257899 A ES 257899A ES 257899 A1 ES257899 A1 ES 257899A1
- Authority
- ES
- Spain
- Prior art keywords
- ferric
- dextrin
- complex
- ferrous
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
A therapeutically useful ferric hydroxide-partially depolymerized dextrin complex is obtained by mixing an aqueous solution of a water soluble dextrin fraction having an average intrinsic viscosity at 25 DEG C. of from 0,025 to 0,075 with an aqueous solution containing ferrous or ferric ions or a suspension of ferrous or ferric hydroxide and an excess of alkali, heating the reaction mixture to form the ferrous or ferric complex and in the former case oxidizing to give the ferric complex. The initial dextrin is preferably obtained by roasting starch in the presence of an acid. In a typical example (No. 2) dextrin is heated in water at 75 DEG C. and firstly ferric hydroxide solution and then caustic soda solution added slowly. After cooling the pH is adjusted to 6,2 and ethyl alcohol added and the solution rendered isotonic by the addition of sodium chloride and then filled into ampoules. Phenol may be added as a preservative. Specification 748,024 is referred to.ALSO:A therapeutically useful ferric-hydroxide-partially depolymerized dextrin complex is obtained by mixing an aqueous solution of a water soluble dextrin fraction having an average intrinsic viscosity at 25 DEG C. of from 0.025 to 0.075 with an aqueous solution containing ferrous or ferric ions or a suspension of ferrous or ferric hydroxide and an excess of alkali, heating the reaction mixture to form the ferrous or ferric complex and in the former case oxidizing to give the ferric complex. The complex may be prepared from dextrin obtained by roasting starch with acid as described in Group IV (a). It may be rendered isotonic with sodium chloride and filled into ampoules with 0.5% of phenol as a preservative. Specification 748,024 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH7302359A CH397628A (en) | 1959-05-08 | 1959-05-08 | Process for the preparation of therapeutically useful iron (III) hydroxide-polymaltose complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES257899A1 true ES257899A1 (en) | 1960-07-16 |
Family
ID=4532293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0257899A Expired ES257899A1 (en) | 1959-05-08 | 1960-04-29 | Improvements in or relating to process for the manufacture of therapeutic useful preparations of iron |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH397628A (en) |
| DK (1) | DK126683B (en) |
| ES (1) | ES257899A1 (en) |
| GB (1) | GB918929A (en) |
| SE (1) | SE329236B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1183940A (en) * | 1966-10-22 | 1970-03-11 | Fisons Pharmaceuticals Ltd | Ferric Hydroxide Complexes |
| JPS6039681B2 (en) * | 1976-01-01 | 1985-09-07 | 日本臓器製薬株式会社 | Dextrin-citric acid-ferric polynuclear complex and parenteral iron preparation containing the complex |
| IT1301728B1 (en) * | 1998-06-16 | 2000-07-07 | Therapicon Srl | PREPARATION OF AN ANTI-ANEMIC COMPLEX. |
| TWI468167B (en) | 2007-11-16 | 2015-01-11 | 威佛（國際）股份有限公司 | Pharmaceutical compositions |
-
1959
- 1959-05-08 CH CH7302359A patent/CH397628A/en unknown
-
1960
- 1960-04-26 DK DK160460A patent/DK126683B/en unknown
- 1960-04-29 ES ES0257899A patent/ES257899A1/en not_active Expired
- 1960-05-04 SE SE442360A patent/SE329236B/xx unknown
- 1960-05-06 GB GB1617860A patent/GB918929A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB918929A (en) | 1963-02-20 |
| CH397628A (en) | 1965-08-31 |
| SE329236B (en) | 1970-10-05 |
| DK126683B (en) | 1973-08-13 |
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