GB990757A - Process for the preparation of 3-acetamido-5-amino-2,4,6,-triiodobenzoic acid - Google Patents
Process for the preparation of 3-acetamido-5-amino-2,4,6,-triiodobenzoic acidInfo
- Publication number
- GB990757A GB990757A GB12563A GB12563A GB990757A GB 990757 A GB990757 A GB 990757A GB 12563 A GB12563 A GB 12563A GB 12563 A GB12563 A GB 12563A GB 990757 A GB990757 A GB 990757A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetamido
- amino
- acid
- iodo derivative
- iododichloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
3 - Acetamido - 5 - amino - 2,4,6 - tri - iodobenzoic acid is prepared by reacting 3-acetamido - 5 - amino - 2,6 - di - iodobenzoic acid in an aqueous medium having a pH less than 2, with iodine chloride or an alkali metal iododichloride at a temperature below 70 DEG C. The 3-acetamido - 5 - amino - 2,6 - di - iodobenzoic acid may be produced in situ by the addition of at least 3 equivalents, preferably 3.3 equivalents, of iodine chloride or alkali metal iododichloride to an aqueous solution of 3-acetamido-5-aminobenzoic acid. The di-iodo derivative is first precipitated, and then the di-iodo derivative reacts with the remaining iodine chloride or alkali metal iododichloride to produce the tri-iodo derivative. The 3-acetamido-5-amino-2,6-di-iodobenzoic acid is preferably used in the form of an aqueous suspension containing not more than 6% by weight of the di-iodo derivative and also containing at least a 0.5 molar excess of acid over that required to neutralize the di-iodo derivative. In the one step process, an aqueous solution containing 3-acetamido-5-aminobenzoic acid in a proportion of not more than 3% by weight and one mol. of acid is preferably used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB12563A GB990757A (en) | 1963-01-01 | 1963-01-01 | Process for the preparation of 3-acetamido-5-amino-2,4,6,-triiodobenzoic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB12563A GB990757A (en) | 1963-01-01 | 1963-01-01 | Process for the preparation of 3-acetamido-5-amino-2,4,6,-triiodobenzoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB990757A true GB990757A (en) | 1965-04-28 |
Family
ID=9698855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12563A Expired GB990757A (en) | 1963-01-01 | 1963-01-01 | Process for the preparation of 3-acetamido-5-amino-2,4,6,-triiodobenzoic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB990757A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991105A (en) | 1973-05-18 | 1976-11-09 | Nyegaard & Co. A/S | Process for the preparation of 3-acetamido-5-amino-2,4,6-triiodobenzoic acid |
-
1963
- 1963-01-01 GB GB12563A patent/GB990757A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991105A (en) | 1973-05-18 | 1976-11-09 | Nyegaard & Co. A/S | Process for the preparation of 3-acetamido-5-amino-2,4,6-triiodobenzoic acid |
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