GB609803A - A process for the preparation of 2-methyl-2.3-di-halogen-tetrahydrofuranes and their conversion to vitamin b and the like - Google Patents
A process for the preparation of 2-methyl-2.3-di-halogen-tetrahydrofuranes and their conversion to vitamin b and the likeInfo
- Publication number
- GB609803A GB609803A GB4543/41A GB454341A GB609803A GB 609803 A GB609803 A GB 609803A GB 4543/41 A GB4543/41 A GB 4543/41A GB 454341 A GB454341 A GB 454341A GB 609803 A GB609803 A GB 609803A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aceto
- halogen
- vitamin
- methyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
Vitamin B1 is obtained by reacting, preferably in the presence of acid binding agents, 2-alkyl-4-amino - 5 - (thioformamido - alkyl) pyrimidines with 2-methyl-2 : 3-dihalogen-tetrahydrofuranes prepared by subjecting g - aceto - g - halogen - propyl alcohol, or its cyclic form, or an ether of the cyclic form such as an alkyl ether or its ether formed with g -aceto-g -halogen-propyl alcohol, or mixtures of them, or reaction mixtures containing any one of these compounds, to reagents which are generally used for substituting a hydroxyl by a halogen group. Preferably, the reaction is carried out in 90 per cent formic acid as the reaction medium. Suitable acid binding agents are pyridine and potassium formate. Detailed examples are given of the preparation of 2-methyl-2 : 3-dichloro-tetrahydrofurane by treating aceto-chloro-propyl alcohol with an aceto-chlorobutyrolactone with thionyl chloride, hydrogen chloride gas and hydrochloric acid. An additional example describes the preparation of Vitamin B1 using pyridine as the acid binding agent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU609803X | 1940-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB609803A true GB609803A (en) | 1948-10-07 |
Family
ID=10979734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4543/41A Expired GB609803A (en) | 1940-05-25 | 1941-04-04 | A process for the preparation of 2-methyl-2.3-di-halogen-tetrahydrofuranes and their conversion to vitamin b and the like |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB609803A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2678319A (en) * | 1952-02-20 | 1954-05-11 | Du Pont | Preparation of 2,3-dihalotetrahydro-2-methylfurans |
-
1941
- 1941-04-04 GB GB4543/41A patent/GB609803A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2678319A (en) * | 1952-02-20 | 1954-05-11 | Du Pont | Preparation of 2,3-dihalotetrahydro-2-methylfurans |
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