SE329236B - - Google Patents

Info

Publication number
SE329236B
SE329236B SE442360A SE442360A SE329236B SE 329236 B SE329236 B SE 329236B SE 442360 A SE442360 A SE 442360A SE 442360 A SE442360 A SE 442360A SE 329236 B SE329236 B SE 329236B
Authority
SE
Sweden
Prior art keywords
ferric
dextrin
complex
ferrous
aqueous solution
Prior art date
Application number
SE442360A
Inventor
A Mueller
H Schwarz
T Bersin
Original Assignee
Hausmann Ag Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hausmann Ag Labor filed Critical Hausmann Ag Labor
Publication of SE329236B publication Critical patent/SE329236B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A therapeutically useful ferric hydroxide-partially depolymerized dextrin complex is obtained by mixing an aqueous solution of a water soluble dextrin fraction having an average intrinsic viscosity at 25 DEG C. of from 0,025 to 0,075 with an aqueous solution containing ferrous or ferric ions or a suspension of ferrous or ferric hydroxide and an excess of alkali, heating the reaction mixture to form the ferrous or ferric complex and in the former case oxidizing to give the ferric complex. The initial dextrin is preferably obtained by roasting starch in the presence of an acid. In a typical example (No. 2) dextrin is heated in water at 75 DEG C. and firstly ferric hydroxide solution and then caustic soda solution added slowly. After cooling the pH is adjusted to 6,2 and ethyl alcohol added and the solution rendered isotonic by the addition of sodium chloride and then filled into ampoules. Phenol may be added as a preservative. Specification 748,024 is referred to.ALSO:A therapeutically useful ferric-hydroxide-partially depolymerized dextrin complex is obtained by mixing an aqueous solution of a water soluble dextrin fraction having an average intrinsic viscosity at 25 DEG C. of from 0.025 to 0.075 with an aqueous solution containing ferrous or ferric ions or a suspension of ferrous or ferric hydroxide and an excess of alkali, heating the reaction mixture to form the ferrous or ferric complex and in the former case oxidizing to give the ferric complex. The complex may be prepared from dextrin obtained by roasting starch with acid as described in Group IV (a). It may be rendered isotonic with sodium chloride and filled into ampoules with 0.5% of phenol as a preservative. Specification 748,024 is referred to.
SE442360A 1959-05-08 1960-05-04 SE329236B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH7302359A CH397628A (en) 1959-05-08 1959-05-08 Process for the preparation of therapeutically useful iron (III) hydroxide-polymaltose complexes

Publications (1)

Publication Number Publication Date
SE329236B true SE329236B (en) 1970-10-05

Family

ID=4532293

Family Applications (1)

Application Number Title Priority Date Filing Date
SE442360A SE329236B (en) 1959-05-08 1960-05-04

Country Status (5)

Country Link
CH (1) CH397628A (en)
DK (1) DK126683B (en)
ES (1) ES257899A1 (en)
GB (1) GB918929A (en)
SE (1) SE329236B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1183940A (en) * 1966-10-22 1970-03-11 Fisons Pharmaceuticals Ltd Ferric Hydroxide Complexes
JPS6039681B2 (en) * 1976-01-01 1985-09-07 日本臓器製薬株式会社 Dextrin-citric acid-ferric polynuclear complex and parenteral iron preparation containing the complex
IT1301728B1 (en) * 1998-06-16 2000-07-07 Therapicon Srl PREPARATION OF AN ANTI-ANEMIC COMPLEX.
TWI592159B (en) 2007-11-16 2017-07-21 威佛（國際）股份有限公司 Pharmaceutical compositions

Also Published As

Publication number Publication date
DK126683B (en) 1973-08-13
CH397628A (en) 1965-08-31
GB918929A (en) 1963-02-20
ES257899A1 (en) 1960-07-16

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