GB918929A - Improvements in or relating to process for the manufacture of therapeutic useful preparations of iron - Google Patents

Improvements in or relating to process for the manufacture of therapeutic useful preparations of iron

Info

Publication number
GB918929A
GB918929A GB1617860A GB1617860A GB918929A GB 918929 A GB918929 A GB 918929A GB 1617860 A GB1617860 A GB 1617860A GB 1617860 A GB1617860 A GB 1617860A GB 918929 A GB918929 A GB 918929A
Authority
GB
United Kingdom
Prior art keywords
ferric
dextrin
complex
ferrous
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1617860A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vifor International AG
Original Assignee
Laboratorien Hausmann AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorien Hausmann AG filed Critical Laboratorien Hausmann AG
Publication of GB918929A publication Critical patent/GB918929A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch

Abstract

A therapeutically useful ferric hydroxide-partially depolymerized dextrin complex is obtained by mixing an aqueous solution of a water soluble dextrin fraction having an average intrinsic viscosity at 25 DEG C. of from 0,025 to 0,075 with an aqueous solution containing ferrous or ferric ions or a suspension of ferrous or ferric hydroxide and an excess of alkali, heating the reaction mixture to form the ferrous or ferric complex and in the former case oxidizing to give the ferric complex. The initial dextrin is preferably obtained by roasting starch in the presence of an acid. In a typical example (No. 2) dextrin is heated in water at 75 DEG C. and firstly ferric hydroxide solution and then caustic soda solution added slowly. After cooling the pH is adjusted to 6,2 and ethyl alcohol added and the solution rendered isotonic by the addition of sodium chloride and then filled into ampoules. Phenol may be added as a preservative. Specification 748,024 is referred to.ALSO:A therapeutically useful ferric-hydroxide-partially depolymerized dextrin complex is obtained by mixing an aqueous solution of a water soluble dextrin fraction having an average intrinsic viscosity at 25 DEG C. of from 0.025 to 0.075 with an aqueous solution containing ferrous or ferric ions or a suspension of ferrous or ferric hydroxide and an excess of alkali, heating the reaction mixture to form the ferrous or ferric complex and in the former case oxidizing to give the ferric complex. The complex may be prepared from dextrin obtained by roasting starch with acid as described in Group IV (a). It may be rendered isotonic with sodium chloride and filled into ampoules with 0.5% of phenol as a preservative. Specification 748,024 is referred to.
GB1617860A 1959-05-08 1960-05-06 Improvements in or relating to process for the manufacture of therapeutic useful preparations of iron Expired GB918929A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH7302359A CH397628A (en) 1959-05-08 1959-05-08 Process for the preparation of therapeutically useful iron (III) hydroxide-polymaltose complexes

Publications (1)

Publication Number Publication Date
GB918929A true GB918929A (en) 1963-02-20

Family

ID=4532293

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1617860A Expired GB918929A (en) 1959-05-08 1960-05-06 Improvements in or relating to process for the manufacture of therapeutic useful preparations of iron

Country Status (5)

Country Link
CH (1) CH397628A (en)
DK (1) DK126683B (en)
ES (1) ES257899A1 (en)
GB (1) GB918929A (en)
SE (1) SE329236B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10682376B2 (en) 2007-11-16 2020-06-16 Vifor Fresenius Medical Care Renal Pharma Ltd Pharmaceutical compositions

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1183940A (en) * 1966-10-22 1970-03-11 Fisons Pharmaceuticals Ltd Ferric Hydroxide Complexes
JPS6039681B2 (en) * 1976-01-01 1985-09-07 日本臓器製薬株式会社 Dextrin-citric acid-ferric polynuclear complex and parenteral iron preparation containing the complex
IT1301728B1 (en) * 1998-06-16 2000-07-07 Therapicon Srl PREPARATION OF AN ANTI-ANEMIC COMPLEX.

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10682376B2 (en) 2007-11-16 2020-06-16 Vifor Fresenius Medical Care Renal Pharma Ltd Pharmaceutical compositions
US10695367B2 (en) 2007-11-16 2020-06-30 Vifor Fresenius Medical Care Renal Pharma Ltd Pharmaceutical compositions
US10780113B2 (en) 2007-11-16 2020-09-22 Vifor Fresenius Medical Care Renal Pharma Ltd. Pharmaceutical compositions
US10925897B2 (en) 2007-11-16 2021-02-23 Vifor Fresenius Medical Care Renal Pharma Ltd Pharmaceutical compositions
US10925896B2 (en) 2007-11-16 2021-02-23 Vifor Fresenius Medical Care Renal Pharma Ltd Pharmaceutical compositions
US10933090B2 (en) 2007-11-16 2021-03-02 Vifor Fresenius Medical Care Renal Pharma Ltd Pharmaceutical compositions
US11013761B1 (en) 2007-11-16 2021-05-25 Vifor Fresenius Medical Care Renal Pharma Ltd. Pharmaceutical compositions
US11013762B1 (en) 2007-11-16 2021-05-25 Vifor Fresenius Medical Care Renal Pharma Ltd. Pharmaceutical compositions

Also Published As

Publication number Publication date
CH397628A (en) 1965-08-31
DK126683B (en) 1973-08-13
SE329236B (en) 1970-10-05
ES257899A1 (en) 1960-07-16

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