ES435139A1 - Preparation of 2-aminomethyl-pyrrolidine - Google Patents

Preparation of 2-aminomethyl-pyrrolidine

Info

Publication number
ES435139A1
ES435139A1 ES435139A ES435139A ES435139A1 ES 435139 A1 ES435139 A1 ES 435139A1 ES 435139 A ES435139 A ES 435139A ES 435139 A ES435139 A ES 435139A ES 435139 A1 ES435139 A1 ES 435139A1
Authority
ES
Spain
Prior art keywords
pyrrolidine
aminomethyl
benzyl
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435139A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Publication of ES435139A1 publication Critical patent/ES435139A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A procedure for the preparation of 2-aminomethyl-pyrrolidine of the formula **(See formula)** and of its addition salts with mineral or organic acids, characterized in that 2-pyrrolidone is reacted with a reactive benzylated compound of the formula X-CH2-C6H5, in which X represents an atom or a reactive group such as a halogen atom or a tosyl group, because the formed N-benzyl-2-pyrrolidone is treated with a lower alcohol sulfate, an alkaline alcoholate, and nitromethane, and because the obtained N-benzyl-2-nitromethylene-pyrrolidine is reduces to 2-aminomethyl-pyrrolidine, either directly by catalytic reduction, or by passing through the intermediate compound of N-benzyl-2-aminomethyl-pyrrolidine by chemical or catalytic reduction, which may or may not be isolated and then reduced to form 2-aminomethyl-pyrrolidine. (Machine-translation by Google Translate, not legally binding)
ES435139A 1974-03-04 1975-02-27 Preparation of 2-aminomethyl-pyrrolidine Expired ES435139A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7407342A FR2263239B1 (en) 1974-03-04 1974-03-04

Publications (1)

Publication Number Publication Date
ES435139A1 true ES435139A1 (en) 1977-02-01

Family

ID=9135811

Family Applications (1)

Application Number Title Priority Date Filing Date
ES435139A Expired ES435139A1 (en) 1974-03-04 1975-02-27 Preparation of 2-aminomethyl-pyrrolidine

Country Status (33)

Country Link
JP (1) JPS5948825B2 (en)
AR (1) AR207350A1 (en)
AT (1) AT358569B (en)
BE (1) BE825728A (en)
BG (1) BG25077A3 (en)
CA (1) CA1047041A (en)
CH (1) CH602636A5 (en)
CS (1) CS179935B2 (en)
DD (1) DD117450A5 (en)
DE (1) DE2506515A1 (en)
DK (1) DK83875A (en)
EG (1) EG11753A (en)
ES (1) ES435139A1 (en)
FI (1) FI750558A (en)
FR (1) FR2263239B1 (en)
GB (1) GB1481251A (en)
HK (1) HK27878A (en)
HU (1) HU169274B (en)
IE (1) IE40685B1 (en)
IL (1) IL46657A (en)
LU (1) LU71947A1 (en)
MW (1) MW875A1 (en)
NL (1) NL7502425A (en)
NO (1) NO145439C (en)
OA (1) OA04856A (en)
PH (1) PH11269A (en)
PL (1) PL94801B1 (en)
RO (1) RO64007A (en)
SE (1) SE401367B (en)
SU (1) SU591139A3 (en)
YU (1) YU36500B (en)
ZA (1) ZA751072B (en)
ZM (1) ZM2775A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1785124A1 (en) * 1968-08-13 1971-11-11 Prym Werke William Zipper
JPS5146901B2 (en) * 1971-08-24 1976-12-11
CH556836A (en) * 1971-09-30 1974-12-13 Fratmann Ag PROCESS FOR THE PREPARATION OF 1-ALKENYL-2-AMINOMETHYLPYRROLIDINES.
NL7304089A (en) * 1972-03-30 1973-10-02
CH573404A5 (en) * 1972-07-28 1976-03-15 Inventa Ag

Also Published As

Publication number Publication date
JPS50121264A (en) 1975-09-23
NL7502425A (en) 1975-09-08
CS179935B2 (en) 1977-12-30
YU67675A (en) 1982-02-25
DD117450A5 (en) 1976-01-12
NO750699L (en) 1975-09-05
PL94801B1 (en) 1977-08-31
MW875A1 (en) 1975-10-08
SU591139A3 (en) 1978-01-30
AT358569B (en) 1980-09-25
GB1481251A (en) 1977-07-27
BG25077A3 (en) 1978-07-12
DE2506515A1 (en) 1975-09-11
RO64007A (en) 1978-08-15
AU7848675A (en) 1976-08-26
HU169274B (en) 1976-10-28
ZM2775A1 (en) 1975-12-22
EG11753A (en) 1978-06-30
SE401367B (en) 1978-05-02
FR2263239B1 (en) 1977-03-04
IL46657A (en) 1977-12-30
FR2263239A1 (en) 1975-10-03
LU71947A1 (en) 1976-02-04
NO145439C (en) 1982-03-24
SE7502340L (en) 1975-09-05
FI750558A (en) 1975-09-05
BE825728A (en) 1975-08-20
JPS5948825B2 (en) 1984-11-29
NO145439B (en) 1981-12-14
ZA751072B (en) 1976-01-28
DK83875A (en) 1975-09-05
AR207350A1 (en) 1976-09-30
ATA160575A (en) 1980-02-15
HK27878A (en) 1978-06-09
PH11269A (en) 1977-11-02
CA1047041A (en) 1979-01-23
IE40685B1 (en) 1979-08-01
IE40685L (en) 1975-09-04
OA04856A (en) 1980-10-31
CH602636A5 (en) 1978-07-31
YU36500B (en) 1984-02-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19920714