IE40685L - 2-aminomethyl-pyrrolidine - Google Patents
2-aminomethyl-pyrrolidineInfo
- Publication number
- IE40685L IE40685L IE750377A IE37775A IE40685L IE 40685 L IE40685 L IE 40685L IE 750377 A IE750377 A IE 750377A IE 37775 A IE37775 A IE 37775A IE 40685 L IE40685 L IE 40685L
- Authority
- IE
- Ireland
- Prior art keywords
- pyrrolidine
- aminomethyl
- benzyl
- acid
- aminomethylpyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1481251 2 - Aminomethylpyrrolidine SOC D'ETUDES SCIENTIFIQUES ET INDUSTTRIELLES DE L'ILE-DE-FRANCE 24 Feb 1975 [4 March 1974] 7645/75 Heading C2C 2 - Aminomethylpyrrolidine and its acid addition salts are prepared by reacting 2-pyrrolidone in a basic medium in a solvent with a reactive benzyl compound of formula wherein X is a reactive atom or group (e.g. a halogen atom or a tosyl group), to produce N- benzyl-2-pyrrolidone, treating the latter with a di(C 1-3 alkyl)sulphate and an alkali metal alcoholate, followed by nitromethane, to produce N-benzyl-2-nitromethylene-pyrrolidine and then (a) reducing the latter to 2-aminomethylpyrrolidine by hydrogen in the presence of a catalyst either directly or via the intermediate N-benzyl-2-aminomethyl-pyrrolidine or (b) reducing to N-benzyl-2-aminomethyl-pyrrolidine by a metal/acid system and then to 2-aminomethyl-pyrrolidine by hydrogen in the presence of a catalyst, the 2-aminomethyl-pyrrolidine being optionally converted to an acid-addition salt by treatment with an acid.
[GB1481251A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7407342A FR2263239B1 (en) | 1974-03-04 | 1974-03-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE40685L true IE40685L (en) | 1975-09-04 |
IE40685B1 IE40685B1 (en) | 1979-08-01 |
Family
ID=9135811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE377/75A IE40685B1 (en) | 1974-03-04 | 1975-02-24 | Preparation of 2-aminomethyl-pyrrolidine |
Country Status (33)
Country | Link |
---|---|
JP (1) | JPS5948825B2 (en) |
AR (1) | AR207350A1 (en) |
AT (1) | AT358569B (en) |
BE (1) | BE825728A (en) |
BG (1) | BG25077A3 (en) |
CA (1) | CA1047041A (en) |
CH (1) | CH602636A5 (en) |
CS (1) | CS179935B2 (en) |
DD (1) | DD117450A5 (en) |
DE (1) | DE2506515A1 (en) |
DK (1) | DK83875A (en) |
EG (1) | EG11753A (en) |
ES (1) | ES435139A1 (en) |
FI (1) | FI750558A (en) |
FR (1) | FR2263239B1 (en) |
GB (1) | GB1481251A (en) |
HK (1) | HK27878A (en) |
HU (1) | HU169274B (en) |
IE (1) | IE40685B1 (en) |
IL (1) | IL46657A (en) |
LU (1) | LU71947A1 (en) |
MW (1) | MW875A1 (en) |
NL (1) | NL7502425A (en) |
NO (1) | NO145439C (en) |
OA (1) | OA04856A (en) |
PH (1) | PH11269A (en) |
PL (1) | PL94801B1 (en) |
RO (1) | RO64007A (en) |
SE (1) | SE401367B (en) |
SU (1) | SU591139A3 (en) |
YU (1) | YU36500B (en) |
ZA (1) | ZA751072B (en) |
ZM (1) | ZM2775A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1785124A1 (en) * | 1968-08-13 | 1971-11-11 | Prym Werke William | Zipper |
JPS5146901B2 (en) * | 1971-08-24 | 1976-12-11 | ||
CH556836A (en) * | 1971-09-30 | 1974-12-13 | Fratmann Ag | PROCESS FOR THE PREPARATION OF 1-ALKENYL-2-AMINOMETHYLPYRROLIDINES. |
NL7304089A (en) * | 1972-03-30 | 1973-10-02 | ||
CH573404A5 (en) * | 1972-07-28 | 1976-03-15 | Inventa Ag |
-
1974
- 1974-03-04 CH CH272675A patent/CH602636A5/xx not_active IP Right Cessation
- 1974-03-04 FR FR7407342A patent/FR2263239B1/fr not_active Expired
- 1974-03-04 RO RO7400081539A patent/RO64007A/en unknown
-
1975
- 1975-01-01 AR AR257827A patent/AR207350A1/en active
- 1975-02-15 DE DE19752506515 patent/DE2506515A1/en active Pending
- 1975-02-18 IL IL46657A patent/IL46657A/en unknown
- 1975-02-20 ZA ZA00751072A patent/ZA751072B/en unknown
- 1975-02-20 BE BE1006472A patent/BE825728A/en not_active IP Right Cessation
- 1975-02-24 IE IE377/75A patent/IE40685B1/en unknown
- 1975-02-24 GB GB7645/75A patent/GB1481251A/en not_active Expired
- 1975-02-25 EG EG93/75A patent/EG11753A/en active
- 1975-02-26 FI FI750558A patent/FI750558A/fi not_active Application Discontinuation
- 1975-02-26 CA CA220,855A patent/CA1047041A/en not_active Expired
- 1975-02-27 ES ES435139A patent/ES435139A1/en not_active Expired
- 1975-02-28 NL NL7502425A patent/NL7502425A/en not_active Application Discontinuation
- 1975-02-28 MW MW8/75A patent/MW875A1/en unknown
- 1975-03-03 SE SE7502340A patent/SE401367B/en not_active IP Right Cessation
- 1975-03-03 NO NO750699A patent/NO145439C/en unknown
- 1975-03-03 HU HUSO1136A patent/HU169274B/hu not_active IP Right Cessation
- 1975-03-03 PH PH16855A patent/PH11269A/en unknown
- 1975-03-03 AT AT160575A patent/AT358569B/en not_active IP Right Cessation
- 1975-03-03 LU LU71947A patent/LU71947A1/xx unknown
- 1975-03-03 SU SU752111076A patent/SU591139A3/en active
- 1975-03-03 DD DD184512A patent/DD117450A5/xx unknown
- 1975-03-03 BG BG7500029132A patent/BG25077A3/en unknown
- 1975-03-03 DK DK83875*#A patent/DK83875A/da not_active Application Discontinuation
- 1975-03-03 PL PL1975178472A patent/PL94801B1/en unknown
- 1975-03-04 OA OA55432A patent/OA04856A/en unknown
- 1975-03-04 ZM ZM27/75A patent/ZM2775A1/en unknown
- 1975-03-04 CS CS7500001451A patent/CS179935B2/en unknown
- 1975-03-04 JP JP50026947A patent/JPS5948825B2/en not_active Expired
- 1975-03-19 YU YU00676/75A patent/YU36500B/en unknown
-
1978
- 1978-06-01 HK HK278/78A patent/HK27878A/en unknown
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