ATE388136T1 - Verfahren zur herstellung von 4'-brommethyl-2- cyanobiphenyl - Google Patents
Verfahren zur herstellung von 4'-brommethyl-2- cyanobiphenylInfo
- Publication number
- ATE388136T1 ATE388136T1 AT02788757T AT02788757T ATE388136T1 AT E388136 T1 ATE388136 T1 AT E388136T1 AT 02788757 T AT02788757 T AT 02788757T AT 02788757 T AT02788757 T AT 02788757T AT E388136 T1 ATE388136 T1 AT E388136T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanobiphenyl
- bromomethyl
- bromine
- producing
- oxidant
- Prior art date
Links
- LFFIEVAMVPCZNA-UHFFFAOYSA-N 2-[4-(bromomethyl)phenyl]benzonitrile Chemical compound C1=CC(CBr)=CC=C1C1=CC=CC=C1C#N LFFIEVAMVPCZNA-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910000042 hydrogen bromide Inorganic materials 0.000 abstract 2
- 239000007800 oxidant agent Substances 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- ZGQVZLSNEBEHFN-UHFFFAOYSA-N 2-(4-methylphenyl)benzonitrile Chemical group C1=CC(C)=CC=C1C1=CC=CC=C1C#N ZGQVZLSNEBEHFN-UHFFFAOYSA-N 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000003999 initiator Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002172016 | 2002-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE388136T1 true ATE388136T1 (de) | 2008-03-15 |
Family
ID=29727838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02788757T ATE388136T1 (de) | 2002-06-12 | 2002-12-09 | Verfahren zur herstellung von 4'-brommethyl-2- cyanobiphenyl |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6861549B2 (de) |
| EP (1) | EP1535901B8 (de) |
| JP (1) | JPWO2003106406A1 (de) |
| KR (1) | KR100885148B1 (de) |
| CN (1) | CN1285570C (de) |
| AT (1) | ATE388136T1 (de) |
| AU (1) | AU2002354446A1 (de) |
| DE (1) | DE60225486T2 (de) |
| DK (1) | DK1535901T3 (de) |
| ES (1) | ES2299616T3 (de) |
| PT (1) | PT1535901E (de) |
| WO (1) | WO2003106406A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003234832A1 (en) * | 2003-05-20 | 2004-12-13 | Sumitomo Chemical Company, Limited | Process for producing bromomethyl-substituted aromatic carboxylic ester compound |
| CN1976926A (zh) * | 2004-09-02 | 2007-06-06 | 特瓦制药工业有限公司 | 奥美沙坦酯的制备 |
| US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
| KR20090102883A (ko) * | 2004-09-02 | 2009-09-30 | 테바 파마슈티컬 인더스트리즈 리미티드 | 올메살탄 메독소밀의 정제 |
| US20060258727A1 (en) * | 2005-01-03 | 2006-11-16 | Lilach Hedvati | Olmesartan medoxomil with reduced levels of impurities |
| JP2006206446A (ja) * | 2005-01-25 | 2006-08-10 | Sumitomo Chemical Co Ltd | アラルキルハライド化合物の脱ハロゲン化方法及びこれを用いるアラルキル化合物の回収方法 |
| CN101597243B (zh) * | 2009-06-26 | 2012-11-21 | 凯莱英生命科学技术(天津)有限公司 | 一种2-氰基-4’-溴甲基联苯的合成方法 |
| HUP0900788A2 (en) * | 2009-12-16 | 2011-11-28 | Sanofi Aventis | Process for producing 4-bromomethyl-biphenyl derivatives |
| CN108947870B (zh) * | 2018-07-23 | 2021-03-19 | 湖北宇阳药业有限公司 | 一种溴代沙坦联苯的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| GB8806584D0 (en) * | 1988-03-19 | 1988-04-20 | Interox Chemicals Ltd | Bromination |
| GB9017480D0 (en) | 1990-08-09 | 1990-09-26 | Ici Plc | Chemical process |
| GB9017482D0 (en) | 1990-08-09 | 1990-09-26 | Ici Plc | Manufacturing process |
| JP2859791B2 (ja) | 1992-01-31 | 1999-02-24 | 吉富製薬株式会社 | ４−ブロモメチルビフェニル化合物の製造法 |
| FR2689887B1 (fr) | 1992-04-13 | 1995-06-23 | Sanofi Elf | Procede de preparation d'un derive de biphenyle. |
| JPH06298684A (ja) | 1993-04-15 | 1994-10-25 | Sankyo Co Ltd | 新規な４−（２−置換）フェニルベンジルブロミド類の製造法 |
| JP2928982B2 (ja) * | 1994-10-27 | 1999-08-03 | 住化ファインケム株式会社 | ４’−ブロモメチル−２−シアノビフェニルの製造法 |
| US5892094A (en) * | 1997-01-08 | 1999-04-06 | Sumika Fine Chemicals Co., Ltd. | Process for preparing 4'-methyl-2-cyanobiphenyl |
| DE19712339C1 (de) * | 1997-03-25 | 1998-04-09 | Clariant Gmbh | Verfahren zur Herstellung von in 2'-Stellung substituierten 4-Brommethyl-biphenyl-Verbindungen |
| IT1291551B1 (it) * | 1997-04-11 | 1999-01-11 | Luso Farmaco Inst | Processo per la preparazione di composti 4-bromometil bifenilici |
| FR2771090B1 (fr) * | 1997-11-17 | 2000-02-04 | Sanofi Sa | Procede de preparation de derives de bromomethyl-biphenyle |
| DE19757995A1 (de) * | 1997-12-29 | 1999-07-08 | Great Lakes Chem Konstanz Gmbh | Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen |
| JP2000256298A (ja) * | 1999-03-05 | 2000-09-19 | Sumika Fine Chemicals Co Ltd | 芳香族α−ブロモアルキル化合物の製造方法 |
| JP2002088044A (ja) * | 2000-09-14 | 2002-03-27 | Sumitomo Seika Chem Co Ltd | ４’−ブロモメチル−２−シアノビフェニルの製造方法 |
-
2002
- 2002-12-09 DK DK02788757T patent/DK1535901T3/da active
- 2002-12-09 PT PT02788757T patent/PT1535901E/pt unknown
- 2002-12-09 KR KR1020047020182A patent/KR100885148B1/ko not_active Expired - Fee Related
- 2002-12-09 AT AT02788757T patent/ATE388136T1/de active
- 2002-12-09 ES ES02788757T patent/ES2299616T3/es not_active Expired - Lifetime
- 2002-12-09 JP JP2004513240A patent/JPWO2003106406A1/ja active Pending
- 2002-12-09 EP EP02788757A patent/EP1535901B8/de not_active Expired - Lifetime
- 2002-12-09 AU AU2002354446A patent/AU2002354446A1/en not_active Abandoned
- 2002-12-09 DE DE60225486T patent/DE60225486T2/de not_active Expired - Lifetime
- 2002-12-09 CN CNB028291190A patent/CN1285570C/zh not_active Expired - Fee Related
- 2002-12-09 WO PCT/JP2002/012847 patent/WO2003106406A1/ja not_active Ceased
- 2002-12-17 US US10/322,017 patent/US6861549B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1535901B1 (de) | 2008-03-05 |
| PT1535901E (pt) | 2008-04-10 |
| EP1535901A4 (de) | 2006-04-12 |
| CN1628094A (zh) | 2005-06-15 |
| DK1535901T3 (da) | 2008-04-07 |
| DE60225486D1 (de) | 2008-04-17 |
| DE60225486T2 (de) | 2009-04-02 |
| EP1535901A1 (de) | 2005-06-01 |
| US6861549B2 (en) | 2005-03-01 |
| KR20050010046A (ko) | 2005-01-26 |
| JPWO2003106406A1 (ja) | 2005-10-13 |
| ES2299616T3 (es) | 2008-06-01 |
| KR100885148B1 (ko) | 2009-02-23 |
| US20030233009A1 (en) | 2003-12-18 |
| EP1535901B8 (de) | 2008-09-24 |
| AU2002354446A1 (en) | 2003-12-31 |
| CN1285570C (zh) | 2006-11-22 |
| WO2003106406A1 (ja) | 2003-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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