WO2009025277A1 - 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法 - Google Patents

還元型補酵素ｑ10の製造方法、ならびに、その安定化方法 Download PDF

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Publication number
WO2009025277A1
WO2009025277A1 PCT/JP2008/064778 JP2008064778W WO2009025277A1 WO 2009025277 A1 WO2009025277 A1 WO 2009025277A1 JP 2008064778 W JP2008064778 W JP 2008064778W WO 2009025277 A1 WO2009025277 A1 WO 2009025277A1
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Prior art keywords
reduced coenzyme
coenzyme
food
stabilizing
same
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PCT/JP2008/064778
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English (en)
French (fr)
Inventor
Takahiro Ueda
Yozo Nagira
Shiro Kitamura
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Kaneka Corporation
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Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Priority to JP2009529037A priority Critical patent/JP5364580B2/ja
Priority to EP08827632.4A priority patent/EP2186789B1/en
Priority to US12/674,604 priority patent/US20110123505A1/en
Publication of WO2009025277A1 publication Critical patent/WO2009025277A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

　本発明は、食品、栄養機能食品、特定保健用食品、栄養補助剤、栄養剤、動物薬、飲料、飼料、化粧品、医薬品、治療薬、予防薬等として有用な還元型補酵素Ｑ10の安定化方法並びに安定化された組成物を提供すること。さらには、酸化型補酵素Ｑ10を原料とする簡便な還元型補酵素Ｑ10の製造方法を提供することを課題とする。本発明によって、甘草疎水性抽出物と還元型補酵素Ｑ10を共存させることにより、還元型補酵素Ｑ10の酸化を抑制させ、還元型補酵素Ｑ10を安定に保持することができる。また、酸化型補酵素Ｑ10と甘草疎水性抽出物を共存させることにより、還元型補酵素Ｑ10を製造することができる。                                                                               
PCT/JP2008/064778 2007-08-22 2008-08-20 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法 WO2009025277A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009529037A JP5364580B2 (ja) 2007-08-22 2008-08-20 還元型補酵素ｑ１０の製造方法、ならびに、その安定化方法
EP08827632.4A EP2186789B1 (en) 2007-08-22 2008-08-20 Method of producing reduced coenzyme q10 and method of stabilizing the same
US12/674,604 US20110123505A1 (en) 2007-08-22 2008-08-20 Method of producing reduced coenzyme q10 and method of stabilizing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007216001 2007-08-22
JP2007-216001 2007-08-22

Publications (1)

Publication Number Publication Date
WO2009025277A1 true WO2009025277A1 (ja) 2009-02-26

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ID=40378178

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PCT/JP2008/064778 WO2009025277A1 (ja) 2007-08-22 2008-08-20 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法

Country Status (4)

Country Link
US (1) US20110123505A1 (ja)
EP (1) EP2186789B1 (ja)
JP (2) JP5364580B2 (ja)
WO (1) WO2009025277A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
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JP2011001348A (ja) * 2009-05-18 2011-01-06 Kaneka Corp 酒酔い又は二日酔い防止・軽減用組成物
JPWO2009044852A1 (ja) * 2007-10-05 2011-02-10 株式会社カネカ 還元型補酵素ｑ１０の製造方法
JP2011057674A (ja) * 2009-09-11 2011-03-24 Omnica Gmbh コエンザイムｑ−１０と抗酸化剤とを含む組成物
WO2011045934A1 (ja) * 2009-10-16 2011-04-21 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
WO2011132718A1 (ja) * 2010-04-20 2011-10-27 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法

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RU2535928C1 (ru) * 2013-05-31 2014-12-20 Закрытое акционерное общество "Научно-производственное объединение "ДОМ ФАРМАЦИИ" Экспрессный способ получения восстановленной формы коэнзима q10 на основе катализаторов для использования в фармацевтических и пищевых композициях
US20200260767A1 (en) 2017-10-06 2020-08-20 Cargill, Incorporated Readily dissolvable steviol glycoside compositions
WO2020210161A1 (en) 2019-04-06 2020-10-15 Cargill, Incorporated Methods for making botanical extract composition
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009044852A1 (ja) * 2007-10-05 2011-02-10 株式会社カネカ 還元型補酵素ｑ１０の製造方法
JP5558823B2 (ja) * 2007-10-05 2014-07-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
JP2011001348A (ja) * 2009-05-18 2011-01-06 Kaneka Corp 酒酔い又は二日酔い防止・軽減用組成物
JP2011057674A (ja) * 2009-09-11 2011-03-24 Omnica Gmbh コエンザイムｑ−１０と抗酸化剤とを含む組成物
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WO2011132718A1 (ja) * 2010-04-20 2011-10-27 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法
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JPWO2011132718A1 (ja) * 2010-04-20 2013-07-18 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法
JP5810079B2 (ja) * 2010-04-20 2015-11-11 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法

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