WO2008084828A1 - 補酵素ｑ10粒子の製造方法 - Google Patents

補酵素ｑ10粒子の製造方法 Download PDF

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Publication number
WO2008084828A1
WO2008084828A1 PCT/JP2008/050180 JP2008050180W WO2008084828A1 WO 2008084828 A1 WO2008084828 A1 WO 2008084828A1 JP 2008050180 W JP2008050180 W JP 2008050180W WO 2008084828 A1 WO2008084828 A1 WO 2008084828A1
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Prior art keywords
coenzyme
particle
less
temperature
stirred
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PCT/JP2008/050180
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English (en)
French (fr)
Inventor
Kento Kanaya
Shiro Kitamura
Takahiro Ueda
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Kaneka Corporation
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Publication date
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Priority to JP2008553111A priority Critical patent/JP5292105B2/ja
Priority to US12/522,792 priority patent/US8568779B2/en
Publication of WO2008084828A1 publication Critical patent/WO2008084828A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/30—Other Organic compounds
    • A23V2250/314—Ubiquinone, coenzyme Qn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/06—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen
    • C09K15/08—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen containing a phenol or quinone moiety

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明は、簡単な設備及び簡便な操作で、高含有量でかつ粉体流動特性に優れた補酵素Ｑ10粒子を効率的に工業生産できる製造方法を提供することを目的とする。本発明は、補酵素Ｑ10と貧溶媒とを、補酵素Ｑ10の融点以上の温度で撹拌混合し、補酵素Ｑ10を油滴状に分散させた後、該分散液を撹拌しながら補酵素Ｑ10の固化温度以下まで冷却して、固形粒子を得ることを特徴とする補酵素Ｑ10粒子の製造方法であって、貧溶媒が有機溶媒及び／又はＨＬＢが６以上の界面活性剤を含有する水溶液である、補酵素Ｑ10粒子の製造方法である。本発明の製造方法によれば、非常に粉体特性に優れた、例えば、粉体流動特性指数が８０以上である補酵素Ｑ10粒子を得ることができる。                                                                               
PCT/JP2008/050180 2007-01-11 2008-01-10 補酵素ｑ10粒子の製造方法 WO2008084828A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008553111A JP5292105B2 (ja) 2007-01-11 2008-01-10 補酵素ｑ１０粒子の製造方法
US12/522,792 US8568779B2 (en) 2007-01-11 2008-01-10 Method for producing coenzyme Q10 particle

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-003143 2007-01-11
JP2007-003144 2007-01-11
JP2007003144 2007-01-11
JP2007003143 2007-01-11

Publications (1)

Publication Number Publication Date
WO2008084828A1 true WO2008084828A1 (ja) 2008-07-17

Family

ID=39608715

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050180 WO2008084828A1 (ja) 2007-01-11 2008-01-10 補酵素ｑ10粒子の製造方法

Country Status (3)

Country Link
US (1) US8568779B2 (ja)
JP (1) JP5292105B2 (ja)
WO (1) WO2008084828A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009025277A1 (ja) * 2007-08-22 2009-02-26 Kaneka Corporation 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法
WO2009025372A1 (ja) * 2007-08-23 2009-02-26 Kaneka Corporation 還元型補酵素ｑ１０含有組成物及びその安定化方法
WO2010113900A1 (ja) * 2009-03-31 2010-10-07 三菱瓦斯化学株式会社 ユビキノン類の製剤用粉末の製造方法及びその製造物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9655849B2 (en) 2011-03-18 2017-05-23 Particle Dynamics International, Llc Solid particulate compositions comprising coenzyme Q10
JP6504404B2 (ja) * 2013-09-30 2019-04-24 ナガセ医薬品株式会社 内視鏡レンズクリーナー
CN110944970B (zh) 2018-08-06 2023-08-01 内蒙古金达威药业有限公司 用于生产辅酶q10的系统和方法
WO2020083412A1 (de) * 2018-10-22 2020-04-30 Ioi Oleo Gmbh Additiv für ein zur verpressung zu formkörpern vorgesehenes pulver
JP7376582B2 (ja) * 2018-10-22 2023-11-08 イーオーイー オレオ ゲーエムベーハー 成形体への圧縮を目的とした粉末材料用添加剤
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
EP4101442A1 (en) 2021-06-11 2022-12-14 Tradichem Industrial Services, S.L. Process for preparing compacted coenzyme q10 particles of high density and improved flowability
WO2023205196A1 (en) * 2022-04-21 2023-10-26 Merck Sharp & Dohme Llc Process for preparing agglomerated crystalline medium-chain fatty acid sodium salts
CN117919195B (zh) * 2024-02-05 2024-07-05 广东润和生物科技有限公司 一种强效抗氧化辅酶q10的制备方法

Citations (8)

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JPS56103109A (en) * 1979-08-31 1981-08-18 Eisai Co Ltd Ubidecarenone-containing composition having improved dispersion properties
JPH09124405A (ja) * 1995-08-18 1997-05-13 Rohm & Haas Co ビーズ状の生成物の製造方法
WO2003006411A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of crystallizing reduced coenzyme q10 from aqueous solution
JP2003089669A (ja) * 2001-07-13 2003-03-28 Kanegafuchi Chem Ind Co Ltd 還元型補酵素ｑ１０の結晶化法
JP2004123594A (ja) * 2002-10-01 2004-04-22 Asahi Kasei Chemicals Corp ユビデカレノン混合粉体および錠剤の製造方法
WO2005033054A1 (ja) * 2003-09-10 2005-04-14 Kaneka Corporation 安定性に優れた還元型補酵素ｑ１０結晶及び還元型補酵素ｑ１０結晶を含有する組成物
JP2005526020A (ja) * 2002-02-01 2005-09-02 ファイザー・プロダクツ・インク アジスロマイシンの乾式造粒配合物
JP2006213601A (ja) * 2005-02-01 2006-08-17 Nof Corp ユビデカレノン含有粉体及びその製造方法

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EP1462081B1 (en) * 2001-12-10 2012-08-08 Kao Corporation Production of ceramide emulsions
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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56103109A (en) * 1979-08-31 1981-08-18 Eisai Co Ltd Ubidecarenone-containing composition having improved dispersion properties
JPH09124405A (ja) * 1995-08-18 1997-05-13 Rohm & Haas Co ビーズ状の生成物の製造方法
WO2003006411A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of crystallizing reduced coenzyme q10 from aqueous solution
JP2003089669A (ja) * 2001-07-13 2003-03-28 Kanegafuchi Chem Ind Co Ltd 還元型補酵素ｑ１０の結晶化法
JP2005526020A (ja) * 2002-02-01 2005-09-02 ファイザー・プロダクツ・インク アジスロマイシンの乾式造粒配合物
JP2004123594A (ja) * 2002-10-01 2004-04-22 Asahi Kasei Chemicals Corp ユビデカレノン混合粉体および錠剤の製造方法
WO2005033054A1 (ja) * 2003-09-10 2005-04-14 Kaneka Corporation 安定性に優れた還元型補酵素ｑ１０結晶及び還元型補酵素ｑ１０結晶を含有する組成物
JP2006213601A (ja) * 2005-02-01 2006-08-17 Nof Corp ユビデカレノン含有粉体及びその製造方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009025277A1 (ja) * 2007-08-22 2009-02-26 Kaneka Corporation 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法
WO2009025372A1 (ja) * 2007-08-23 2009-02-26 Kaneka Corporation 還元型補酵素ｑ１０含有組成物及びその安定化方法
WO2010113900A1 (ja) * 2009-03-31 2010-10-07 三菱瓦斯化学株式会社 ユビキノン類の製剤用粉末の製造方法及びその製造物
US8466326B2 (en) 2009-03-31 2013-06-18 Mitsubishi Gas Chemical Company, Inc. Production method for ubiquinone powder for use in preparations and product thereof
JP5673527B2 (ja) * 2009-03-31 2015-02-18 三菱瓦斯化学株式会社 ユビキノン類の製剤用粉末の製造方法及びその製造物

Also Published As

Publication number Publication date
US8568779B2 (en) 2013-10-29
JP5292105B2 (ja) 2013-09-18
JPWO2008084828A1 (ja) 2010-05-06
US20100004473A1 (en) 2010-01-07

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