DE60223920T2 - Pyrrolidine als dipeptidyl-peptidase-inhibitoren - Google Patents

Pyrrolidine als dipeptidyl-peptidase-inhibitoren Download PDF

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Publication number
DE60223920T2
DE60223920T2 DE60223920T DE60223920T DE60223920T2 DE 60223920 T2 DE60223920 T2 DE 60223920T2 DE 60223920 T DE60223920 T DE 60223920T DE 60223920 T DE60223920 T DE 60223920T DE 60223920 T2 DE60223920 T2 DE 60223920T2
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disorders
compound
mmol
dpp
solution
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DE60223920T
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English (en)
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DE60223920D1 (en
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Curt Haffner
Amarjit Randhawa
David Deaton
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SmithKline Beecham Corp
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SmithKline Beecham Corp
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

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DE60223920T 2001-06-27 2002-06-26 Pyrrolidine als dipeptidyl-peptidase-inhibitoren Expired - Lifetime DE60223920T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30133301P 2001-06-27 2001-06-27
US301333P 2001-06-27
US38701102P 2002-06-06 2002-06-06
US387011P 2002-06-06
PCT/US2002/020466 WO2003002530A2 (en) 2001-06-27 2002-06-26 Pyrrolidines as dipeptidyl peptidase inhibitors

Publications (2)

Publication Number Publication Date
DE60223920D1 DE60223920D1 (en) 2008-01-17
DE60223920T2 true DE60223920T2 (de) 2008-11-13

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DE60223920T Expired - Lifetime DE60223920T2 (de) 2001-06-27 2002-06-26 Pyrrolidine als dipeptidyl-peptidase-inhibitoren

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US (1) US7196201B2 (enExample)
EP (1) EP1399420B1 (enExample)
JP (1) JP4300108B2 (enExample)
AT (1) ATE380175T1 (enExample)
AU (1) AU2002316437A1 (enExample)
DE (1) DE60223920T2 (enExample)
ES (1) ES2296962T3 (enExample)
WO (1) WO2003002530A2 (enExample)

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GB0010188D0 (en) * 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
EP1385508B1 (en) 2001-03-27 2008-05-21 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20040176914A1 (en) * 2001-04-13 2004-09-09 Biosite Incorporated Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
WO2003016910A1 (en) * 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
DE60233301D1 (de) * 2001-05-04 2009-09-24 Biosite Inc Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs
DE60222667T2 (de) * 2001-06-27 2008-07-17 Smithkline Beecham Corp. Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7608406B2 (en) * 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
AU2003297564A1 (en) * 2002-12-04 2004-06-23 Merck & Co., Inc. Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20040242566A1 (en) 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
NZ572274A (en) 2003-05-05 2009-06-26 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
MXPA05011861A (es) 2003-05-05 2006-02-17 Probiodrug Ag Uso de efectores de ciclasas de glutamato y glutaminil.
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
WO2004103276A2 (en) 2003-05-14 2004-12-02 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
EP1631679A2 (en) * 2003-05-21 2006-03-08 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase 7 (dpp7)
US7332520B2 (en) * 2003-06-06 2008-02-19 Merck & Co., Inc. Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
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JP2005518337A (ja) 2005-06-23
WO2003002530A3 (en) 2003-04-03
EP1399420A2 (en) 2004-03-24
ATE380175T1 (de) 2007-12-15
AU2002316437A1 (en) 2003-03-03
DE60223920D1 (en) 2008-01-17
EP1399420B1 (en) 2007-12-05
JP4300108B2 (ja) 2009-07-22
WO2003002530A2 (en) 2003-01-09
ES2296962T3 (es) 2008-05-01
US7196201B2 (en) 2007-03-27
US20040167341A1 (en) 2004-08-26

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Inventor name: HAFFNER, CURT, RESEARCH TRIANGLE PARK, N.C., US

Inventor name: RANDHAWA, AMARJIT, RESEARCH TRIANGLE PARK, N.C, US

Inventor name: DEATON, DAVID, RESEARCH TRIANGLE PARK, N.C., US

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