DE60042904D1 - Orale Dosiszusammensetzung mit verlängerter Freigabe - Google Patents

Orale Dosiszusammensetzung mit verlängerter Freigabe

Info

Publication number
DE60042904D1
DE60042904D1 DE60042904T DE60042904T DE60042904D1 DE 60042904 D1 DE60042904 D1 DE 60042904D1 DE 60042904 T DE60042904 T DE 60042904T DE 60042904 T DE60042904 T DE 60042904T DE 60042904 D1 DE60042904 D1 DE 60042904D1
Authority
DE
Germany
Prior art keywords
oral dose
prolonged release
dose composition
composition
prolonged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042904T
Other languages
English (en)
Inventor
Wing-Kee Philip Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22629073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60042904(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE60042904D1 publication Critical patent/DE60042904D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
DE60042904T 1999-12-20 2000-12-20 Orale Dosiszusammensetzung mit verlängerter Freigabe Expired - Lifetime DE60042904D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17275299P 1999-12-20 1999-12-20

Publications (1)

Publication Number Publication Date
DE60042904D1 true DE60042904D1 (de) 2009-10-15

Family

ID=22629073

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60028710T Expired - Lifetime DE60028710T2 (de) 1999-12-20 2000-12-20 Orale Dosiszusammensetzung mit verlängerter Freigabe
DE122008000001C Pending DE122008000001I1 (de) 1999-12-20 2000-12-20 Orale Dosiszusammensetzungen mit verlängerter Freigabe
DE60042904T Expired - Lifetime DE60042904D1 (de) 1999-12-20 2000-12-20 Orale Dosiszusammensetzung mit verlängerter Freigabe

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE60028710T Expired - Lifetime DE60028710T2 (de) 1999-12-20 2000-12-20 Orale Dosiszusammensetzung mit verlängerter Freigabe
DE122008000001C Pending DE122008000001I1 (de) 1999-12-20 2000-12-20 Orale Dosiszusammensetzungen mit verlängerter Freigabe

Country Status (39)

Country Link
US (3) US6709676B2 (de)
EP (3) EP1674084B1 (de)
JP (2) JP5158919B2 (de)
KR (2) KR20010062543A (de)
CN (3) CN100415223C (de)
AR (1) AR027034A1 (de)
AT (2) ATE329584T1 (de)
AU (2) AU2276801A (de)
BR (1) BR0005938A (de)
CA (1) CA2329172C (de)
CO (1) CO5251421A1 (de)
CY (3) CY1105231T1 (de)
CZ (1) CZ302471B6 (de)
DE (3) DE60028710T2 (de)
DK (2) DK1674084T3 (de)
EC (1) ECSP003835A (de)
ES (2) ES2261158T3 (de)
FR (1) FR08C0004I2 (de)
HK (2) HK1034452A1 (de)
HU (1) HU227538B1 (de)
IL (1) IL140451A (de)
LU (1) LU91403I2 (de)
MX (1) MXPA00012957A (de)
MY (1) MY128658A (de)
NL (1) NL300328I2 (de)
NO (1) NO331653B1 (de)
NZ (1) NZ509034A (de)
PE (1) PE20010952A1 (de)
PL (1) PL209401B1 (de)
PT (2) PT1674084E (de)
RU (1) RU2284182C9 (de)
SA (2) SA01210740B1 (de)
SG (2) SG183573A1 (de)
SI (2) SI1110543T1 (de)
SK (1) SK287105B6 (de)
TR (1) TR200003788A2 (de)
TW (1) TWI222885B (de)
WO (1) WO2001045676A2 (de)
ZA (1) ZA200007714B (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2276801A (en) * 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
AU2277101A (en) * 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
JP2009132734A (ja) * 2001-08-27 2009-06-18 Daiichi Sankyo Healthcare Co Ltd 抗感冒剤
JP4318899B2 (ja) * 2001-08-27 2009-08-26 第一三共ヘルスケア株式会社 抗感冒剤
JP4320217B2 (ja) * 2002-07-10 2009-08-26 剤盛堂薬品株式会社 鼻炎用経口製剤
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
US20040253311A1 (en) * 2002-12-18 2004-12-16 Roger Berlin Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines
TWI313598B (en) * 2002-12-18 2009-08-21 Wyeth Corp Compositions of non-steroidal anti-inflammatory drugs, decongestants and anti-histamines
US20040229896A1 (en) * 2003-03-12 2004-11-18 Toth Zoltan G. Stable pharmaceutical compositions of desloratadine
WO2005046650A1 (en) * 2003-11-12 2005-05-26 Glenmark Pharmaceuticals Limited Pharmaceutical formulation containing muscle relaxant and cox-ii inhibitor
EP1696881A2 (de) * 2003-12-23 2006-09-06 Sun Pharmaceutical Industries Limited Stabile orale zusammensetzung
US20110081415A1 (en) * 2005-03-10 2011-04-07 Taisho Pharmaceutical Co., Ltd Coating apparatus
EP1859791B1 (de) * 2005-03-10 2011-12-07 Taisho Pharmaceutical Co., Ltd Dragee
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
US20070004671A1 (en) * 2005-05-20 2007-01-04 Agarwal Sudeep K Stable desloratadine compositions
EP1728513A3 (de) * 2005-05-20 2007-10-31 Dr. Reddy's Laboratories, Inc. Stabile Zusammensetzungen von Desloratadine
US20070014855A1 (en) * 2005-07-12 2007-01-18 Rahul Gawande S Stable desloratadine compositions
DK1931346T3 (da) 2005-09-09 2012-10-22 Angelini Labopharm Llc Trazodonsammensætning til indgivelse en gang om dagen
US20070124176A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US20080114577A1 (en) * 2005-11-30 2008-05-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems associated with nutraceutical related assays
US20080004905A1 (en) * 2006-06-28 2008-01-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for analysis of nutraceutical associated components
US20080052114A1 (en) * 2005-11-30 2008-02-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods related to nutraceuticals
US7827042B2 (en) * 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US20080033763A1 (en) * 2005-11-30 2008-02-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems related to receiving nutraceutical associated information
US7927787B2 (en) * 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US20080103746A1 (en) * 2005-11-30 2008-05-01 Searete Llc, A Limited Liability Corporation Systems and methods for pathogen detection and response
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US20070124219A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized nutraceutical selection and packaging
US20070289258A1 (en) * 2006-06-14 2007-12-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Individualized pharmaceutical selection and packaging
US20070136092A1 (en) * 2005-11-30 2007-06-14 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US10296720B2 (en) * 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US8340944B2 (en) * 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US20070174128A1 (en) * 2005-11-30 2007-07-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US20110145009A1 (en) * 2005-11-30 2011-06-16 Jung Edward K Y Methods and systems related to transmission of nutraceutical associatd information
WO2007096733A2 (en) * 2006-02-22 2007-08-30 Orchid Chemicals & Pharmaceuticals Limited Desloratadine-containing formulation stabilized with cyclodextrin
CA2541045A1 (en) * 2006-03-24 2007-09-24 Pharmascience Inc. A descarbonylethoxyloratadine containing pharmaceutical composition
CA2653953C (en) 2006-06-01 2015-12-08 Schering-Plough Healthcare Products, Inc. Phenylephrine pharmaceutical formulations and compositions for colonic absorption
KR20090015103A (ko) * 2006-06-01 2009-02-11 쉐링 코포레이션 페닐에프린 펄스 방출 제형 및 약제학적 조성물
AR061166A1 (es) * 2006-06-01 2008-08-06 Schering Corp Composiciones farmaceuticas para la liberacion sostenida de fenilferina
NZ573174A (en) * 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
US7718649B1 (en) * 2006-11-10 2010-05-18 Pisgah Labs, Inc. Physical states of a pharmaceutical drug substance
CA2697959A1 (en) * 2007-06-01 2008-12-11 Schering-Plough Healthcare Products, Inc. Pharmaceutical composition comprising a substrate and a coating containing an active ingredient and polyvinylalcohol
TWI400042B (zh) * 2007-06-08 2013-07-01 Tci Co Ltd 食品錠劑
CN101827590A (zh) 2007-10-16 2010-09-08 莱博法姆公司 用于持续释放对乙酰氨基酚和曲马多的双层组合物
PE20091084A1 (es) * 2007-12-07 2009-07-23 Schering Plough Healthcare Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal
CA2707980C (en) 2007-12-17 2015-05-12 Labopharm Inc. Misuse preventative, controlled release formulation
JP5667575B2 (ja) 2008-12-16 2015-02-12 パラディン ラブス インコーポレーテッド 誤用を防止する放出制御製剤
US20140357651A1 (en) 2011-05-04 2014-12-04 Yi Liu Combination pharmaceutical compositions and uses thereof
BR102012030828A2 (pt) 2012-12-03 2014-09-16 Ems Sa Composição farmacêutica compreendendo desloratadina e prednisolona e seu uso
CA3038263C (en) 2016-09-26 2022-04-05 The Procter & Gamble Company Extended relief dosage form
US10463656B2 (en) 2017-01-05 2019-11-05 Iowa State University Research Foundation, Inc. Methods and compositions for prevention of feedlot bovine respiratory disease
CN109966254B (zh) * 2017-12-28 2021-06-01 广州医药研究总院有限公司 复方地氯伪麻缓释小丸及其制备方法
CN108578406A (zh) * 2018-04-18 2018-09-28 曹建华 一种用于过敏性鼻炎治疗的组合物
US11806320B2 (en) * 2020-02-19 2023-11-07 Endo Ventures Limited Isoproterenol compositions and methods
CN113230235B (zh) * 2021-04-15 2022-11-11 海南普利制药股份有限公司 含地氯雷他定的复方缓释胶囊及其制备方法

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3940485A (en) 1973-12-12 1976-02-24 Levinson Harold N Treatment and pre-treatment of dysmetric dyslexia by improving sequential scanning and ocular fixation abilities and therapeutic compounds
US4008796A (en) 1974-03-26 1977-02-22 General Concrete Of Canada Limited Control method for feeding items on a conveyor
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
US4282233B1 (en) 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
AU570306B2 (en) 1984-02-15 1988-03-10 Schering Corporation 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts.
US4552899A (en) 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4783465A (en) 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
SE8404467D0 (sv) 1984-09-06 1984-09-06 Ferrosan Ab Controlled-release medical preparations
US4731447A (en) 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
US4804666A (en) 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
JPS6396126A (ja) 1986-10-13 1988-04-27 Taisho Pharmaceut Co Ltd 安定化組成物
US5089496A (en) 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4777170A (en) 1987-02-03 1988-10-11 Heinrich William A Method to prevent and treat the signs and symptoms of motion sickness
GB8707421D0 (en) 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US4863931A (en) 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US5019591A (en) 1989-02-17 1991-05-28 Pennsylvania Research Corporation Method for treating retinopathy and other small vessel disorders associated with diabetes
US4990535A (en) * 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
NZ238629A (en) 1990-06-22 1993-09-27 Schering Corp Bis-benzo- or benzopyrido-cyclohepta (where z is c, o, s or n) piperidine, piperidylidene or piperazine compounds, medicaments and methods of preparation
EP0563134B1 (de) 1990-12-18 1996-06-19 The Wellcome Foundation Limited Mittel zur verstaerkung der wirkung von antitumoralen mittel und zur widerstandsbekaempfung von vielfachdrogen
PT100502A (pt) 1991-05-20 1993-08-31 Alza Corp Composicoes farmaceuticas para aumentar a capacidade de permeacao na pele utilizando monolinoleato de glicerol
YU48263B (sh) * 1991-06-17 1997-09-30 Byk Gulden Lomberg Chemische Fabrik Gmbh. Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
US5314697A (en) 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
IT1264517B1 (it) * 1993-05-31 1996-09-24 Ekita Investments Nv Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati
JP2646972B2 (ja) 1993-11-01 1997-08-27 日本電気株式会社 多ビットメモリ
DE4442999A1 (de) 1994-12-02 1996-06-05 Hexal Pharma Gmbh Pharmazeutische Zusammensetzung mit einem aktiven Loratidin-Metaboliten
US7214683B1 (en) * 1994-12-30 2007-05-08 Sepracor Inc. Compositions of descarboethoxyloratadine
US5595997A (en) 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
US7211582B1 (en) * 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
WO1998018470A1 (en) * 1996-10-31 1998-05-07 Schering Corporation Composition, for the treatment of asthma, containing loratadine and a decongestant
PE71699A1 (es) * 1997-02-07 1999-08-03 Sepracor Inc Composicion farmaceutica de descarboetoxiloratadina sin lactosa, no higroscopica y anhidra
US5900421A (en) 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5939426A (en) 1997-02-28 1999-08-17 Sepracor Inc. Methods for treating urinary incontinence using descarboethoxyloratadine
US6506767B1 (en) 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
CN1159012C (zh) * 1997-08-26 2004-07-28 阿旺蒂斯制药公司 用于组合哌啶子基烷醇-减充血剂的药物组合物
WO1999021556A1 (en) 1997-10-29 1999-05-06 J-Med Pharmaceuticals, Inc. Antihistamine/decongestant regimens for treating rhinitis
US6132758A (en) * 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
DE69916042T2 (de) * 1998-07-10 2004-11-11 Schering Corp. Orale zusammensetzungen mit 8-chloro-6,11-dihydro-11-(4-piperidyliden)-5h-benzo[5,6]cyclohepta[1,2-b]pyridin
US6423721B1 (en) * 1998-09-10 2002-07-23 Schering Corporation Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines
US6521254B2 (en) 1998-12-07 2003-02-18 J-Med Pharmaceuticals, Inc. Single-dose antihistamine/decongestant formulations for treating rhinitis
US6051585A (en) 1998-12-07 2000-04-18 Weinstein; Robert E. Single-dose antihistamine/decongestant formulations for treating rhinitis
US6100274A (en) 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
US6114346A (en) * 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
AU2277101A (en) 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
AU2276801A (en) 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
CN1213752C (zh) * 2000-02-03 2005-08-10 先灵公司 变应性和炎性疾病的治疗
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
AU5722701A (en) * 2000-05-19 2001-12-03 Alcon Universal Ltd Aniline disulfide derivatives for treating allergic diseases
US6599913B1 (en) 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions
US6679463B1 (en) * 2003-06-11 2004-01-20 Kye Systems Corp. Support with multi-stage clamping mechanism
EP1696881A2 (de) * 2003-12-23 2006-09-06 Sun Pharmaceutical Industries Limited Stabile orale zusammensetzung
EP1778195A2 (de) * 2004-07-16 2007-05-02 Cipla Limited Anti-histaminische zusammensetzung

Also Published As

Publication number Publication date
CN100415223C (zh) 2008-09-03
CN101322708A (zh) 2008-12-17
EP2100600A1 (de) 2009-09-16
FR08C0004I2 (fr) 2009-01-15
PL344714A1 (en) 2001-07-02
NO20006503L (no) 2001-06-21
CY1109636T1 (el) 2014-08-13
PL209401B1 (pl) 2011-08-31
HU0004989D0 (de) 2001-02-28
HUP0004989A3 (en) 2008-04-28
LU91403I2 (fr) 2008-02-21
DE60028710D1 (de) 2006-07-27
MXPA00012957A (es) 2003-06-19
CY1105231T1 (el) 2010-03-03
TR200003788A3 (tr) 2001-07-23
JP2008081509A (ja) 2008-04-10
CA2329172C (en) 2005-10-25
NL300328I2 (nl) 2008-07-01
FR08C0004I1 (de) 2008-03-21
CN101134038A (zh) 2008-03-05
WO2001045676A2 (en) 2001-06-28
AU2276801A (en) 2001-07-03
CY2007031I1 (el) 2009-11-04
KR20080044214A (ko) 2008-05-20
NO20006503D0 (no) 2000-12-20
US20030031713A1 (en) 2003-02-13
CZ302471B6 (cs) 2011-06-08
CN1302605A (zh) 2001-07-11
SA01210740A (ar) 2005-12-03
HUP0004989A2 (hu) 2004-05-28
ECSP003835A (es) 2002-02-25
NO331653B1 (no) 2012-02-13
SG149667A1 (en) 2009-02-27
IL140451A0 (en) 2002-02-10
WO2001045676A3 (en) 2002-01-03
SA01210740B1 (ar) 2006-10-31
PT1674084E (pt) 2009-10-19
ES2261158T3 (es) 2006-11-16
AU7244200A (en) 2001-06-21
US20100021542A1 (en) 2010-01-28
DK1110543T3 (da) 2006-09-18
CO5251421A1 (es) 2003-02-28
DK1674084T3 (da) 2009-12-14
ATE441404T1 (de) 2009-09-15
PE20010952A1 (es) 2001-09-25
EP1674084A2 (de) 2006-06-28
AU777419B2 (en) 2004-10-14
EP1674084B1 (de) 2009-09-02
EP1110543A3 (de) 2001-08-29
NZ509034A (en) 2002-09-27
EP1674084A3 (de) 2006-07-05
RU2284182C2 (ru) 2006-09-27
EP1110543A2 (de) 2001-06-27
US7618649B2 (en) 2009-11-17
ATE329584T1 (de) 2006-07-15
EP1110543B1 (de) 2006-06-14
KR20010062543A (ko) 2001-07-07
CY2007031I2 (el) 2009-11-04
US6709676B2 (en) 2004-03-23
JP2001206846A (ja) 2001-07-31
NL300328I1 (nl) 2008-03-03
MY128658A (en) 2007-02-28
SK19662000A3 (sk) 2001-09-11
CA2329172A1 (en) 2001-06-20
DE60028710T2 (de) 2007-06-14
SA06270068B1 (ar) 2009-12-23
SK287105B6 (sk) 2009-12-07
CZ20004813A3 (cs) 2001-08-15
BR0005938A (pt) 2001-11-27
HU227538B1 (en) 2011-08-29
US20040097536A1 (en) 2004-05-20
HK1090840A1 (en) 2007-01-05
CN101134038B (zh) 2013-11-06
TWI222885B (en) 2004-11-01
US8187630B2 (en) 2012-05-29
SI1110543T1 (sl) 2006-10-31
AR027034A1 (es) 2003-03-12
DE122008000001I1 (de) 2008-04-17
IL140451A (en) 2011-11-30
TR200003788A2 (tr) 2001-07-23
SI1674084T1 (sl) 2010-01-29
ZA200007714B (en) 2001-08-16
HK1034452A1 (en) 2001-10-26
RU2284182C9 (ru) 2007-11-20
PT1110543E (pt) 2006-08-31
SG183573A1 (en) 2012-09-27
ES2330873T3 (es) 2009-12-16
JP5158919B2 (ja) 2013-03-06

Similar Documents

Publication Publication Date Title
DE60042904D1 (de) Orale Dosiszusammensetzung mit verlängerter Freigabe
ZA200007715B (en) Stable extended release oral dosage composition.
ATE308319T1 (de) Dosierungsform mit verlängerter wirkstoffabgabe
DE60043447D1 (de) Zusammensetzungen mit kontrollierter freigabe enthaltend nimesulid
ATE306253T1 (de) Orale bioadhäsive tablette mit verlängerter wirkstoffabgabe
NO20003218D0 (no) Oralfarmasøytisk doseringsform med forlenget frigivningsvirkning
DE60014511D1 (de) Zahnärztliche Haftmittelzusammensetzung
FI4823U1 (fi) Muunnetulla tavalla vapauttava lääkeformulaatio
DE60109207T8 (de) Orale zusammensetzung
ITMI991826A0 (it) Nuova formulazione orale
NO20021452L (no) Orale kontrollerte frigivelsesformuleringer
NO20003677D0 (no) Langvarig frigivelses tigabim formuleringer med reduserte bivirkninger
ATA4212003A (de) Strahlungsempfindliche zusammensetzung
SE9901967D0 (sv) New solid dosage formulation

Legal Events

Date Code Title Description
8364 No opposition during term of opposition