DE4027052C2 - - Google Patents

Info

Publication number
DE4027052C2
DE4027052C2 DE4027052A DE4027052A DE4027052C2 DE 4027052 C2 DE4027052 C2 DE 4027052C2 DE 4027052 A DE4027052 A DE 4027052A DE 4027052 A DE4027052 A DE 4027052A DE 4027052 C2 DE4027052 C2 DE 4027052C2
Authority
DE
Germany
Prior art keywords
general formula
aminopropoxyimino
cycloalkane
derivatives
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE4027052A
Other languages
German (de)
English (en)
Other versions
DE4027052A1 (de
Inventor
Zoltan Dr. Budapest Hu Budai
Tibor Dr. Budapest Hu Mezei
Lujza Dr. Budapest Hu Petoecz
Geb. Hegedues Maria Budapest Hu Szecsey
Marton Dr. Budapest Hu Fekete
Geb. Fekete Valeria Budapest Hu Hoffmann
Geb. Esses Klara Dr. Budapest Hu Reiter
Geb. Kiszelly Enikoe Budapest Hu Szirt
Gizella Budapest Hu Zsila
Gabor Budapest Hu Gigler
Lazlo Budapest Hu Kapolnat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GYOGYSZERGYAR EGIS BUDAPEST HU
Original Assignee
GYOGYSZERGYAR EGIS BUDAPEST HU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GYOGYSZERGYAR EGIS BUDAPEST HU filed Critical GYOGYSZERGYAR EGIS BUDAPEST HU
Publication of DE4027052A1 publication Critical patent/DE4027052A1/de
Application granted granted Critical
Publication of DE4027052C2 publication Critical patent/DE4027052C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/20—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DE4027052A 1989-08-25 1990-08-27 (aminopropoxyimino)-cycloalkanderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel Granted DE4027052A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU894401A HU212415B (en) 1989-08-25 1989-08-25 Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components

Publications (2)

Publication Number Publication Date
DE4027052A1 DE4027052A1 (de) 1991-03-07
DE4027052C2 true DE4027052C2 (en, 2012) 1993-09-09

Family

ID=10967860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4027052A Granted DE4027052A1 (de) 1989-08-25 1990-08-27 (aminopropoxyimino)-cycloalkanderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Country Status (24)

Country Link
US (1) US5130487A (en, 2012)
JP (1) JPH03169841A (en, 2012)
KR (1) KR910004547A (en, 2012)
AT (1) AT399504B (en, 2012)
BE (1) BE1004530A3 (en, 2012)
BG (1) BG92749A (en, 2012)
CA (1) CA2023957A1 (en, 2012)
CH (1) CH681369A5 (en, 2012)
DD (1) DD297402A5 (en, 2012)
DE (1) DE4027052A1 (en, 2012)
DK (1) DK203290A (en, 2012)
ES (1) ES2021261A6 (en, 2012)
FI (1) FI904191A7 (en, 2012)
FR (1) FR2651227B1 (en, 2012)
GB (1) GB2235198B (en, 2012)
GR (1) GR1000740B (en, 2012)
HU (1) HU212415B (en, 2012)
IT (1) IT1243203B (en, 2012)
NL (1) NL9001865A (en, 2012)
PL (1) PL163028B1 (en, 2012)
RU (1) RU2066310C1 (en, 2012)
SE (1) SE9002727L (en, 2012)
YU (1) YU48372B (en, 2012)
ZA (1) ZA906744B (en, 2012)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212262B (en) * 1992-10-30 1996-04-29 Egyt Gyogyszervegyeszeti Gyar Process to prepare benz /e/ indene derivs. and the pharmaceutical compns. contg. them
HUT67314A (en) * 1993-04-09 1995-03-28 Egyt Gyogyszervegyeszeti Gyar Process for prepg. new trisubstituted cykloalkane deriv.s and pharmaceutical compn.s contg. them
HU213421B (en) * 1993-04-09 1997-06-30 Egyt Gyogyszervegyeszeti Gyar New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them
HU213472B (en) * 1993-07-20 1997-06-30 Egyt Gyogyszervegyeszeti Gyar Process to preparare pharmaceutical compns. with gastroprotective and anti helicobacter pylori activity
US5597822A (en) * 1993-07-20 1997-01-28 Egis Pharmaceutical Pharmaceutical compositions for the prevention and/or treatment a gastrointestinal diseases
DE19722848A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Derivate, insbesondere Oximo-LTB¶4¶-Antagonisten
KR20080035702A (ko) 2002-01-11 2008-04-23 상꾜 가부시키가이샤 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물
CN1921847B (zh) 2004-02-24 2010-06-16 三共株式会社 氨基醇化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1474316A (en) * 1975-02-12 1977-05-25 Seperic O-aminoalkyl oximes
GB1493222A (en) * 1976-01-27 1977-11-30 Egyt Gyogyszervegyeszeti Gyar Cycloalkanone oxime ethers and process for the preparation thereof
AT339276B (de) * 1976-01-27 1977-10-10 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von basischen cycloalkanonoximathern und deren saureadditionssalzen
DE2658938A1 (de) * 1976-12-24 1978-07-06 Hoechst Ag Neue basisch substituierte 0-propyloxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
US4652586A (en) * 1980-11-07 1987-03-24 The General Hospital Corporation Selective beta-2 adrenergic antagonists for the treatment of glaucoma
FR2521856A1 (fr) * 1982-02-19 1983-08-26 Pos Lab Medicament ophtalmique pour le traitement des glaucomes, a base d'ethers-oxydes ou d'ether-oximes de derives alcoylamines
HU189226B (en) * 1983-02-08 1986-06-30 Egyt Gyogyszervegyeszeti Gyar,Hu Process for producing basic oxime-ethers
HU189227B (en) * 1983-02-08 1986-06-30 Egyt Gyogyszervegyeszeti Gyar,Hu Process for preparing basic oxime-ethers
HU197205B (en) * 1984-07-10 1989-03-28 Egyt Gyogyszervegyeszeti Gyar Process for production of medical compositions against angine
US4803286A (en) * 1987-08-19 1989-02-07 Merck & Co., Inc. Amino-2-hydroxypropyloximinoheterocycle α-blockers

Also Published As

Publication number Publication date
KR910004547A (ko) 1991-03-28
IT9021305A0 (it) 1990-08-24
GR1000740B (el) 1992-12-30
PL163028B1 (pl) 1994-02-28
AT399504B (de) 1995-05-26
GB2235198A (en) 1991-02-27
GB9018583D0 (en) 1990-10-10
DK203290A (da) 1991-02-26
ZA906744B (en) 1991-06-26
JPH03169841A (ja) 1991-07-23
PL286613A1 (en) 1991-05-06
HU212415B (en) 1996-06-28
DK203290D0 (da) 1990-08-24
HUT58282A (en) 1992-02-28
GB2235198B (en) 1993-06-02
FI904191A0 (fi) 1990-08-24
IT1243203B (it) 1994-05-24
SE9002727L (sv) 1991-02-26
IT9021305A1 (it) 1992-02-24
FI904191A7 (fi) 1991-02-26
CH681369A5 (en, 2012) 1993-03-15
GR900100627A (en) 1991-12-30
YU160990A (sh) 1992-12-21
YU48372B (sh) 1998-07-10
FR2651227A1 (fr) 1991-03-01
NL9001865A (nl) 1991-03-18
DE4027052A1 (de) 1991-03-07
DD297402A5 (de) 1992-01-09
CA2023957A1 (en) 1991-02-26
RU2066310C1 (ru) 1996-09-10
FR2651227B1 (fr) 1992-07-31
BG92749A (bg) 1993-12-24
ES2021261A6 (es) 1991-10-16
SE9002727D0 (sv) 1990-08-24
ATA174290A (de) 1994-10-15
US5130487A (en) 1992-07-14
BE1004530A3 (fr) 1992-12-08

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8330 Complete renunciation