DE3833319A1 - Tumorantigene und adjuvantien enthaltende vakzine - Google Patents
Tumorantigene und adjuvantien enthaltende vakzineInfo
- Publication number
- DE3833319A1 DE3833319A1 DE3833319A DE3833319A DE3833319A1 DE 3833319 A1 DE3833319 A1 DE 3833319A1 DE 3833319 A DE3833319 A DE 3833319A DE 3833319 A DE3833319 A DE 3833319A DE 3833319 A1 DE3833319 A1 DE 3833319A1
- Authority
- DE
- Germany
- Prior art keywords
- tumor
- pyridine
- cell wall
- microorganism
- wall skeleton
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/102,909 US4877611A (en) | 1986-04-15 | 1987-09-30 | Vaccine containing tumor antigens and adjuvants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3833319A1 true DE3833319A1 (de) | 1989-04-13 |
| DE3833319C2 DE3833319C2 (enExample) | 1992-06-11 |
Family
ID=22292343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3833319A Granted DE3833319A1 (de) | 1987-09-30 | 1988-09-30 | Tumorantigene und adjuvantien enthaltende vakzine |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4877611A (enExample) |
| JP (1) | JPH01163130A (enExample) |
| BE (1) | BE1001634A4 (enExample) |
| CA (1) | CA1333152C (enExample) |
| CH (1) | CH678492A5 (enExample) |
| DE (1) | DE3833319A1 (enExample) |
| FR (1) | FR2620941B1 (enExample) |
| GB (1) | GB2210557B (enExample) |
| IT (1) | IT1226861B (enExample) |
| NL (1) | NL8802393A (enExample) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3922444A1 (de) * | 1988-03-01 | 1991-01-10 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| US5612476A (en) * | 1991-10-11 | 1997-03-18 | Eisai Co., Ltd. | Anti-endotoxin compounds |
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| US8957047B2 (en) | 2013-04-18 | 2015-02-17 | Immune Design Corp. | GLA monotherapy for use in cancer treatment |
| US9044420B2 (en) | 2011-04-08 | 2015-06-02 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| US9895435B2 (en) | 2012-05-16 | 2018-02-20 | Immune Design Corp. | Vaccines for HSV-2 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101125764B1 (ko) | 2010-01-27 | 2012-03-27 | 백태현 | 항산균 세포벽골격을 이용한 백신매개체 및 그에 의한 백신의 제조 방법 |
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| WO2012003205A2 (en) * | 2010-07-02 | 2012-01-05 | Intervet International B.V. | Vaccine against ehrlichia canis and associated methods |
| JP6119030B2 (ja) | 2010-07-06 | 2017-04-26 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | インフルエンザを治療するための組成物及び方法 |
| AR083454A1 (es) | 2010-10-15 | 2013-02-27 | Glaxosmithkline Biolog Sa | Antigeno de citomegalovirus |
| WO2012057904A1 (en) | 2010-10-27 | 2012-05-03 | Infectious Disease Research Institute | Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity |
| PT2635257T (pt) | 2010-11-05 | 2017-08-16 | Novavax Inc | Partículas semelhantes a vírus de glicoproteína de raiva (vlps) |
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| HUE028452T2 (en) | 2010-12-14 | 2016-12-28 | Glaxosmithkline Biologicals Sa | Mycobacterium antigenic preparations |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
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| GB201106357D0 (en) | 2011-04-14 | 2011-06-01 | Pessi Antonello | Composition and uses thereof |
| SI3275892T1 (sl) | 2011-05-13 | 2020-06-30 | Glaxosmithkline Biologicals S.A. | Prefuzijski RSV F antigeni |
| MX2013013627A (es) | 2011-06-21 | 2014-04-25 | Oncofactor Corp | Composiciones y metodos para la terapia y diagnostico de cancer. |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2894442C (en) | 2012-01-12 | 2020-01-21 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| US20150079077A1 (en) | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| CN104203270A (zh) | 2012-03-18 | 2014-12-10 | 葛兰素史密丝克莱恩生物有限公司 | 针对人乳头状瘤病毒的接种方法 |
| EP2666785A1 (en) | 2012-05-23 | 2013-11-27 | Affiris AG | Complement component C5a-based vaccine |
| WO2014042780A1 (en) | 2012-08-03 | 2014-03-20 | Infectious Disease Research Institute | Compositions and methods for treating an active mycobacterium tuberculosis infection |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| JP2015525794A (ja) | 2012-08-06 | 2015-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法 |
| US9605276B2 (en) | 2012-08-24 | 2017-03-28 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| EP2703483A1 (en) | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| AU2013354186A1 (en) | 2012-12-05 | 2014-06-12 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| SMT202400297T1 (it) | 2013-03-13 | 2024-09-16 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Proteine f del rsv pre-fusione e loro uso |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| EP3608332B1 (en) | 2013-03-15 | 2022-06-01 | GlaxoSmithKline Biologicals SA | Vaccine against human rhinovirus |
| EP2978447B1 (en) | 2013-03-28 | 2019-05-08 | Infectious Disease Research Institute | Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis |
| ES3020582T3 (en) | 2013-07-26 | 2025-05-23 | Inst Nat Sante Rech Med | Methods and pharmaceutical compositions for the treatment of bacterial infections |
| CA2919773A1 (en) | 2013-08-05 | 2015-02-12 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
| WO2015023710A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| EP3046579A1 (en) | 2013-09-19 | 2016-07-27 | Novavax, Inc. | Immunogenic middle east respiratory syndrome coronavirus (mers-cov) compositions and methods |
| US10774387B2 (en) | 2014-05-19 | 2020-09-15 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| CN106659777A (zh) | 2014-06-13 | 2017-05-10 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合产品 |
| SI3160500T1 (sl) | 2014-06-25 | 2019-11-29 | Glaxosmithkline Biologicals Sa | Imunogeni sestavek proti Clostridium difficile |
| CA2954475C (en) | 2014-07-31 | 2023-05-16 | Uab Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
| CA2959336A1 (en) | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| WO2016097865A1 (en) | 2014-12-19 | 2016-06-23 | Regenesance B.V. | Antibodies that bind human c6 and uses thereof |
| JP6647315B2 (ja) | 2015-01-09 | 2020-02-14 | イーチュービクス コーポレイション | 組み合わせ免疫療法のための方法および組成物 |
| EP3268037B1 (en) | 2015-03-09 | 2022-08-31 | Celldex Therapeutics, Inc. | Cd27 agonists |
| EP3286213B1 (en) | 2015-04-20 | 2021-08-04 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| WO2016180852A1 (en) | 2015-05-12 | 2016-11-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preparing antigen-specific t cells from an umbilical cord blood sample |
| MX375989B (es) | 2015-05-26 | 2025-03-07 | Ohio State Innovation Foundation | Estrategia de vacuna basada en nanoparticulas contra el virus de la influenza porcina. |
| US20170226171A1 (en) * | 2016-02-09 | 2017-08-10 | Vaccinogen, Inc. | Adenocarcinoma antigenic determinants and methods |
| AU2017225769B2 (en) | 2016-03-02 | 2023-01-05 | The Board Of Regents Of The University Of Texas System | Sting activating nanovaccine for immunotherapy |
| EP3445783A2 (en) | 2016-04-18 | 2019-02-27 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human cd40 and uses thereof |
| US20200148729A1 (en) | 2016-05-21 | 2020-05-14 | Infectious Disease Research Institute | Compositions and Methods for Treating Secondary Tuberculosis and Nontuberculosis Mycobacterium Infections |
| AU2017268822B2 (en) | 2016-05-27 | 2020-03-26 | Etubics Corporation | Neoepitope vaccine compositions and methods of use thereof |
| US11801290B2 (en) | 2016-09-16 | 2023-10-31 | Access To Advanced Health Institute | Vaccines comprising Mycobacterium leprae polypeptides for the prevention, treatment, and diagnosis of leprosy |
| GB201616904D0 (en) | 2016-10-05 | 2016-11-16 | Glaxosmithkline Biologicals Sa | Vaccine |
| CN110035770B (zh) | 2016-12-07 | 2023-06-16 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
| CA3043790A1 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
| IL269904B2 (en) | 2017-04-19 | 2025-10-01 | Inst Res Biomedicine | Plasmodium sporozoite NPDP peptides as a vaccine and target for novel malaria vaccines and antibody binding |
| CN110621339A (zh) | 2017-04-28 | 2019-12-27 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗接种 |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| FR3066920A1 (fr) | 2017-05-30 | 2018-12-07 | Glaxosmithkline Biologicals S.A. | Nouveaux procedes de fabrication d'un adjuvant |
| KR102673794B1 (ko) | 2017-06-15 | 2024-06-11 | 액세스 투 어드밴스드 헬스 인스티튜트 | 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도 |
| EP3638301A1 (en) | 2017-06-16 | 2020-04-22 | GlaxoSmithKline Biologicals S.A. | Method of treatment |
| WO2019035963A1 (en) | 2017-08-16 | 2019-02-21 | Ohio State Innovation Foundation | NANOPARTICLE COMPOSITIONS FOR VACCINES AGAINST SALMONELLA |
| WO2019106192A1 (en) | 2017-12-01 | 2019-06-06 | Glaxosmithkline Biologicals Sa | Saponin purification |
| CN111836639A (zh) | 2018-01-26 | 2020-10-27 | 河谷细胞有限公司 | 用于联合癌症疫苗和免疫辅助疗法的组合物和方法 |
| TW201946650A (zh) | 2018-03-12 | 2019-12-16 | 美商詹森藥物公司 | 針對腹內感染之疫苗 |
| MX2020010913A (es) | 2018-04-17 | 2021-01-08 | Celldex Therapeutics Inc | Anticuerpos anti-cd27 y anti-pd-l1 y constructos biespecíficos. |
| EP3581201A1 (en) | 2018-06-15 | 2019-12-18 | GlaxoSmithKline Biologicals S.A. | Escherichia coli o157:h7 proteins and uses thereof |
| US20210292395A1 (en) | 2018-07-31 | 2021-09-23 | Glaxosmithkline Biologicals Sa | Antigen purification method |
| CN111315407B (zh) | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| JP2022520067A (ja) * | 2019-02-08 | 2022-03-28 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | モノホスホリルリピドａリポソーム系癌ワクチン |
| CA3142300C (en) | 2019-06-05 | 2025-02-04 | Glaxosmithkline Biologicals Sa | SAPONIN PURIFICATION |
| EP4004018A1 (en) | 2019-07-24 | 2022-06-01 | GlaxoSmithKline Biologicals SA | Modified human cytomegalovirus proteins |
| EP3777884A1 (en) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| CN114466659A (zh) | 2019-09-09 | 2022-05-10 | 葛兰素史克生物有限公司 | 免疫治疗组合物 |
| AU2020358862A1 (en) | 2019-10-02 | 2022-04-14 | Janssen Vaccines & Prevention B.V. | Staphylococcus peptides and methods of use |
| WO2021122551A1 (en) | 2019-12-19 | 2021-06-24 | Glaxosmithkline Biologicals Sa | S. aureus antigens and compositions thereof |
| WO2021144369A1 (en) | 2020-01-16 | 2021-07-22 | Janssen Pharmaceuticals, Inc. | Fimh mutant, compositions therewith and use thereof |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
| WO2021178637A1 (en) | 2020-03-05 | 2021-09-10 | Iowa State University Research Foundation, Inc. | IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2 |
| WO2021214766A1 (en) | 2020-04-21 | 2021-10-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing viral infections and vaccines thereto |
| MX2022013855A (es) | 2020-05-05 | 2022-11-30 | Glaxosmithkline Biologicals Sa | Dispositivos de mezcla de microfluidos y metodos de uso. |
| EP4158352A1 (en) | 2020-06-01 | 2023-04-05 | Loop Diagnostics, S.L. | Method and kit for the early detection of sepsis |
| US20230293659A1 (en) | 2020-08-03 | 2023-09-21 | Glaxosmithkline Biologicals Sa | Truncated fusobacterium nucleatum fusobacterium adhesin a (fada) protein and immunogenic compositions thereof |
| US20230310323A1 (en) | 2020-09-04 | 2023-10-05 | Access To Advanced Health Institute | Co-lyophilized rna and nanostructured lipid carrier |
| JP2023553854A (ja) | 2020-12-02 | 2023-12-26 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ドナー鎖補完性ｆｉｍｈ |
| CA3203278A1 (en) | 2020-12-09 | 2022-06-16 | Glaxosmithkline Biologicals Sa | Saponins |
| AU2021405724A1 (en) | 2020-12-24 | 2023-08-03 | Plant Bioscience Limited | Methods and enzymes for producing quillaic acid derivatives |
| TW202241929A (zh) | 2021-01-12 | 2022-11-01 | 美商詹森藥物公司 | ＦｉｍＨ突變體、其組成物及其用途 |
| CN117222428A (zh) | 2021-02-11 | 2023-12-12 | 葛兰素史克生物有限公司 | Hpv疫苗生产 |
| CA3215752A1 (en) | 2021-04-01 | 2022-10-06 | Janssen Pharmaceuticals, Inc. | Production of e. coli o18 bioconjugates |
| US20240417459A1 (en) | 2021-04-09 | 2024-12-19 | Celldex Therapeutics, Inc. | Antibodies against ilt4, bispecific anti-ilt4/pd-l1 antibody and uses thereof |
| WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023077521A1 (en) | 2021-11-08 | 2023-05-11 | Celldex Therapeutics, Inc | Anti-ilt4 and anti-pd-1 bispecific constructs |
| WO2023144665A1 (en) | 2022-01-28 | 2023-08-03 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
| US20250207166A1 (en) | 2022-03-25 | 2025-06-26 | Plant Bioscience Limited | Biosynthesis |
| JP2025525334A (ja) | 2022-06-15 | 2025-08-05 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | サポニンの酵素的修飾 |
| GB202209588D0 (en) | 2022-06-29 | 2022-08-10 | Plant Bioscience Ltd | Methods and compositions |
| CA3266697A1 (en) | 2022-09-09 | 2024-03-14 | Access To Advanced Health Inst | COMPOSITION OF AN IMMUNOGENEOUS VACCINE CONTAINING A SAPONIN |
| WO2024160901A1 (en) | 2023-02-02 | 2024-08-08 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| KR20250167153A (ko) | 2023-03-03 | 2025-11-28 | 셀덱스 쎄라퓨틱스, 인크. | 항-줄기 세포 인자(scf) 및 항-흉선 기질 림포포이에틴(tslp) 항체, 및 이중특이적 구축물 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3318569A1 (de) * | 1982-05-26 | 1984-01-12 | Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. | Verfahren zur herstellung von gereinigtem, entgiftetem endotoxin |
| DE3318567A1 (de) * | 1982-05-26 | 1984-01-12 | Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. | Therapeutische zusammensetzung enthaltend gereinigtes, entgiftetes endotoxin, zellwandgeruest und trehalosedimycolat |
| US4505903A (en) * | 1982-06-30 | 1985-03-19 | Ribi Immunochem Research, Inc. | Pyridine soluble extract of a microorganism |
| DE3434766A1 (de) * | 1983-09-23 | 1986-04-30 | Ribi Immunochem Research, Inc., Hamilton, Mont. | Einen pyridinloeslichen extrakt und gereinigtes entgiftetes endotoxin enthaltendes pharmazeutisches praeparat |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2160326B1 (enExample) * | 1971-11-19 | 1975-02-07 | Anvar | |
| US4338334A (en) * | 1977-12-29 | 1982-07-06 | Merck & Co., Inc. | 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases |
| US4307229A (en) * | 1979-11-07 | 1981-12-22 | Avraham Liav | 6,6'-Diesters of trehalose and process for the synthesis thereof |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
-
1987
- 1987-09-30 US US07/102,909 patent/US4877611A/en not_active Expired - Lifetime
-
1988
- 1988-09-28 GB GB8822749A patent/GB2210557B/en not_active Expired - Lifetime
- 1988-09-28 CA CA000578719A patent/CA1333152C/en not_active Expired - Fee Related
- 1988-09-29 NL NL8802393A patent/NL8802393A/nl active Search and Examination
- 1988-09-30 JP JP63244691A patent/JPH01163130A/ja active Granted
- 1988-09-30 FR FR888812793A patent/FR2620941B1/fr not_active Expired - Fee Related
- 1988-09-30 BE BE8801122A patent/BE1001634A4/fr not_active IP Right Cessation
- 1988-09-30 CH CH3632/88A patent/CH678492A5/de not_active IP Right Cessation
- 1988-09-30 DE DE3833319A patent/DE3833319A1/de active Granted
- 1988-09-30 IT IT8822145A patent/IT1226861B/it active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3318569A1 (de) * | 1982-05-26 | 1984-01-12 | Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. | Verfahren zur herstellung von gereinigtem, entgiftetem endotoxin |
| DE3318567A1 (de) * | 1982-05-26 | 1984-01-12 | Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. | Therapeutische zusammensetzung enthaltend gereinigtes, entgiftetes endotoxin, zellwandgeruest und trehalosedimycolat |
| US4505903A (en) * | 1982-06-30 | 1985-03-19 | Ribi Immunochem Research, Inc. | Pyridine soluble extract of a microorganism |
| DE3434766A1 (de) * | 1983-09-23 | 1986-04-30 | Ribi Immunochem Research, Inc., Hamilton, Mont. | Einen pyridinloeslichen extrakt und gereinigtes entgiftetes endotoxin enthaltendes pharmazeutisches praeparat |
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3922444A1 (de) * | 1988-03-01 | 1991-01-10 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| US5612476A (en) * | 1991-10-11 | 1997-03-18 | Eisai Co., Ltd. | Anti-endotoxin compounds |
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Also Published As
| Publication number | Publication date |
|---|---|
| GB2210557B (en) | 1991-11-13 |
| GB8822749D0 (en) | 1988-11-02 |
| CH678492A5 (enExample) | 1991-09-30 |
| CA1333152C (en) | 1994-11-22 |
| US4877611A (en) | 1989-10-31 |
| NL8802393A (nl) | 1989-04-17 |
| BE1001634A4 (fr) | 1990-01-02 |
| JPH01163130A (ja) | 1989-06-27 |
| FR2620941B1 (fr) | 1990-08-10 |
| JPH0575731B2 (enExample) | 1993-10-21 |
| IT8822145A0 (it) | 1988-09-30 |
| FR2620941A1 (fr) | 1989-03-31 |
| DE3833319C2 (enExample) | 1992-06-11 |
| GB2210557A (en) | 1989-06-14 |
| IT1226861B (it) | 1991-02-19 |
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