DE3752008T2 - Hybride Plasminogenaktivatoren - Google Patents

Hybride Plasminogenaktivatoren

Info

Publication number
DE3752008T2
DE3752008T2 DE3752008T DE3752008T DE3752008T2 DE 3752008 T2 DE3752008 T2 DE 3752008T2 DE 3752008 T DE3752008 T DE 3752008T DE 3752008 T DE3752008 T DE 3752008T DE 3752008 T2 DE3752008 T2 DE 3752008T2
Authority
DE
Germany
Prior art keywords
plasminogen activators
hybrid plasminogen
human
amino acid
subsequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3752008T
Other languages
English (en)
Other versions
DE3752008D1 (de
Inventor
Bhanu Dr Rajput
Bhabatosh Dr Chaudhuri
Fredericus Alphonsu Asselbergs
Bernd Dr Meyhack
Jutta Dr Heim
Oostrum Jan Dr Van
Sefik Prof Dr Alkan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629153A external-priority patent/GB8629153D0/en
Priority claimed from GB878709656A external-priority patent/GB8709656D0/en
Priority claimed from GB878715890A external-priority patent/GB8715890D0/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of DE3752008D1 publication Critical patent/DE3752008D1/de
Publication of DE3752008T2 publication Critical patent/DE3752008T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Amplifiers (AREA)
  • Adhesives Or Adhesive Processes (AREA)
DE3752008T 1986-12-05 1987-12-03 Hybride Plasminogenaktivatoren Expired - Lifetime DE3752008T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868629153A GB8629153D0 (en) 1986-12-05 1986-12-05 Hybrid proteins
GB878701160A GB8701160D0 (en) 1986-12-05 1987-01-20 Hybrid proteins
GB878709656A GB8709656D0 (en) 1986-12-05 1987-04-23 Hybrid proteins
GB878715890A GB8715890D0 (en) 1986-12-05 1987-07-06 Hybrid proteins

Publications (2)

Publication Number Publication Date
DE3752008D1 DE3752008D1 (de) 1997-03-06
DE3752008T2 true DE3752008T2 (de) 1997-08-14

Family

ID=27449853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3752008T Expired - Lifetime DE3752008T2 (de) 1986-12-05 1987-12-03 Hybride Plasminogenaktivatoren

Country Status (17)

Country Link
EP (1) EP0277313B1 (de)
JP (2) JP2641875B2 (de)
AT (1) ATE148167T1 (de)
AU (1) AU621281B2 (de)
CA (1) CA1341479C (de)
CY (1) CY2156B1 (de)
DE (1) DE3752008T2 (de)
DK (1) DK175483B1 (de)
ES (1) ES2095825T3 (de)
FI (1) FI100106B (de)
GR (1) GR3023047T3 (de)
HK (1) HK1005037A1 (de)
IE (1) IE81116B1 (de)
IL (1) IL84700A (de)
NO (1) NO177603C (de)
NZ (1) NZ222793A (de)
PT (1) PT86276B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
FR2637600B1 (fr) * 1988-10-11 1992-03-06 Pasteur Institut Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques
ATE123057T1 (de) * 1988-10-27 1995-06-15 Tno Trombolytischer wirkstoff mit modifikation der domäne der kringle.
GB8826975D0 (en) * 1988-11-18 1988-12-21 Beecham Group Plc Novel compounds
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
GB8919803D0 (en) * 1989-09-01 1989-10-18 Ciba Geigy Pharmaceutical compositions
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
EP0462651A1 (de) * 1990-06-15 1991-12-27 Leuven Research & Development V.Z.W. Chimäre Plasminogenaktivatoren
EP0548012B1 (de) * 1991-12-16 1997-09-03 Novartis AG Endoplasmatisches Retikulum-ständige rekombinante dibasische Endoprotease und deren Verwendungen
JPH07143877A (ja) * 1993-10-01 1995-06-06 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ類似体
TW517059B (en) 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
WO2007047995A2 (en) * 2005-10-21 2007-04-26 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
SG175602A1 (en) 2006-07-05 2011-11-28 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
ES2043610T3 (es) * 1986-01-31 1994-01-01 Sagami Chem Res Procedimiento para la produccion de un polipeptido hibrido del tipo activador de plasminogeno.
AU612974B2 (en) * 1986-01-31 1991-07-25 Genetics Institute, Llc Novel thrombolytic proteins

Also Published As

Publication number Publication date
DK175483B1 (da) 2004-11-08
CY2156B1 (en) 2002-08-23
IL84700A (en) 1992-11-15
IE873299L (en) 1988-06-05
DK638187A (da) 1988-06-06
EP0277313A1 (de) 1988-08-10
FI100106B (fi) 1997-09-30
DK638187D0 (da) 1987-12-04
ATE148167T1 (de) 1997-02-15
FI875324A (fi) 1988-06-06
JP2641875B2 (ja) 1997-08-20
DE3752008D1 (de) 1997-03-06
IE81116B1 (en) 2000-03-22
ES2095825T3 (es) 1997-03-01
AU8209187A (en) 1988-06-16
PT86276B (pt) 1990-11-07
FI875324A0 (fi) 1987-12-02
NO875069D0 (no) 1987-12-04
JPS63160581A (ja) 1988-07-04
NO177603C (no) 1995-10-18
NZ222793A (en) 1990-09-26
JP2645237B2 (ja) 1997-08-25
JPH09117292A (ja) 1997-05-06
HK1005037A1 (en) 1998-12-18
PT86276A (en) 1988-06-01
EP0277313B1 (de) 1997-01-22
AU621281B2 (en) 1992-03-12
IL84700A0 (en) 1988-05-31
NO177603B (no) 1995-07-10
NO875069L (no) 1988-06-06
GR3023047T3 (en) 1997-07-30
CA1341479C (en) 2005-04-12

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN