DK638187A - Hybridproteiner - Google Patents

Hybridproteiner

Info

Publication number
DK638187A
DK638187A DK638187A DK638187A DK638187A DK 638187 A DK638187 A DK 638187A DK 638187 A DK638187 A DK 638187A DK 638187 A DK638187 A DK 638187A DK 638187 A DK638187 A DK 638187A
Authority
DK
Denmark
Prior art keywords
human
amino acid
subsequences
plasminogen activators
glycosylation
Prior art date
Application number
DK638187A
Other languages
English (en)
Other versions
DK175483B1 (da
DK638187D0 (da
Inventor
Bhanu Rajput
Bhabatosh Chaudhuri
Fredericus Alphonsu Asselbergs
Bernd Meyhack
Jutta Heim
Jan Van Oostrum
Sefik Alkan
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629153A external-priority patent/GB8629153D0/en
Priority claimed from GB878709656A external-priority patent/GB8709656D0/en
Priority claimed from GB878715890A external-priority patent/GB8715890D0/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK638187D0 publication Critical patent/DK638187D0/da
Publication of DK638187A publication Critical patent/DK638187A/da
Application granted granted Critical
Publication of DK175483B1 publication Critical patent/DK175483B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
DK198706381A 1986-12-05 1987-12-04 Enkeltkædehybridplasminogenaktivator, DNA-sekvens, som koder derfor, hybridvektor indeholdende DNA-sekvensen, eukaryotisk værtscelle transformeret med hybridvektoren, fremgangsmåde til fremstilling af enkeltkædehybridplasminogenaktivatoren,...... DK175483B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB868629153A GB8629153D0 (en) 1986-12-05 1986-12-05 Hybrid proteins
GB8629153 1986-12-05
GB878701160A GB8701160D0 (en) 1986-12-05 1987-01-20 Hybrid proteins
GB8701160 1987-01-20
GB878709656A GB8709656D0 (en) 1986-12-05 1987-04-23 Hybrid proteins
GB8709656 1987-04-23
GB878715890A GB8715890D0 (en) 1986-12-05 1987-07-06 Hybrid proteins
GB8715890 1987-07-06

Publications (3)

Publication Number Publication Date
DK638187D0 DK638187D0 (da) 1987-12-04
DK638187A true DK638187A (da) 1988-06-06
DK175483B1 DK175483B1 (da) 2004-11-08

Family

ID=27449853

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198706381A DK175483B1 (da) 1986-12-05 1987-12-04 Enkeltkædehybridplasminogenaktivator, DNA-sekvens, som koder derfor, hybridvektor indeholdende DNA-sekvensen, eukaryotisk værtscelle transformeret med hybridvektoren, fremgangsmåde til fremstilling af enkeltkædehybridplasminogenaktivatoren,......

Country Status (17)

Country Link
EP (1) EP0277313B1 (da)
JP (2) JP2641875B2 (da)
AT (1) ATE148167T1 (da)
AU (1) AU621281B2 (da)
CA (1) CA1341479C (da)
CY (1) CY2156B1 (da)
DE (1) DE3752008T2 (da)
DK (1) DK175483B1 (da)
ES (1) ES2095825T3 (da)
FI (1) FI100106B (da)
GR (1) GR3023047T3 (da)
HK (1) HK1005037A1 (da)
IE (1) IE81116B1 (da)
IL (1) IL84700A (da)
NO (1) NO177603C (da)
NZ (1) NZ222793A (da)
PT (1) PT86276B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
FR2637600B1 (fr) * 1988-10-11 1992-03-06 Pasteur Institut Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques
ATE123057T1 (de) * 1988-10-27 1995-06-15 Tno Trombolytischer wirkstoff mit modifikation der domäne der kringle.
GB8826975D0 (en) * 1988-11-18 1988-12-21 Beecham Group Plc Novel compounds
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
GB8919803D0 (en) * 1989-09-01 1989-10-18 Ciba Geigy Pharmaceutical compositions
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
EP0462651A1 (en) * 1990-06-15 1991-12-27 Leuven Research & Development V.Z.W. Chimeric plasminogen activators
ES2107520T3 (es) * 1991-12-16 1997-12-01 Ciba Geigy Ag Endoproteasa dibasica recombinante situada en el reticulo endoplasmico y usos de la misma.
JPH07143877A (ja) * 1993-10-01 1995-06-06 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ類似体
TW517059B (en) 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
KR101393946B1 (ko) 2005-10-21 2014-05-12 카탈리스트 바이오사이언시즈, 인코포레이티드 보체 활성화를 억제하는 변형된 프로테아제
KR101778174B1 (ko) 2006-07-05 2017-09-13 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
DE3781420T2 (de) * 1986-01-31 1993-02-25 Sagami Chem Res Hybrides plasminogenaktivatoraehnliches polypeptid.
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質

Also Published As

Publication number Publication date
IE873299L (en) 1988-06-05
JP2645237B2 (ja) 1997-08-25
FI100106B (fi) 1997-09-30
JPS63160581A (ja) 1988-07-04
NZ222793A (en) 1990-09-26
FI875324A0 (fi) 1987-12-02
DE3752008T2 (de) 1997-08-14
DK175483B1 (da) 2004-11-08
ES2095825T3 (es) 1997-03-01
FI875324A (fi) 1988-06-06
NO875069L (no) 1988-06-06
ATE148167T1 (de) 1997-02-15
CA1341479C (en) 2005-04-12
IL84700A (en) 1992-11-15
PT86276A (en) 1988-06-01
JP2641875B2 (ja) 1997-08-20
NO875069D0 (no) 1987-12-04
DE3752008D1 (de) 1997-03-06
DK638187D0 (da) 1987-12-04
GR3023047T3 (en) 1997-07-30
EP0277313B1 (en) 1997-01-22
NO177603B (no) 1995-07-10
PT86276B (pt) 1990-11-07
IE81116B1 (en) 2000-03-22
JPH09117292A (ja) 1997-05-06
EP0277313A1 (en) 1988-08-10
HK1005037A1 (en) 1998-12-18
AU8209187A (en) 1988-06-16
NO177603C (no) 1995-10-18
IL84700A0 (en) 1988-05-31
AU621281B2 (en) 1992-03-12
CY2156B1 (en) 2002-08-23

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Legal Events

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