DE3751964T2 - Herstellung und Verwendung von hochmolekularen Polyanhydriden - Google Patents

Herstellung und Verwendung von hochmolekularen Polyanhydriden

Info

Publication number
DE3751964T2
DE3751964T2 DE3751964T DE3751964T DE3751964T2 DE 3751964 T2 DE3751964 T2 DE 3751964T2 DE 3751964 T DE3751964 T DE 3751964T DE 3751964 T DE3751964 T DE 3751964T DE 3751964 T2 DE3751964 T2 DE 3751964T2
Authority
DE
Germany
Prior art keywords
molecular weight
polyanhydrides
high molecular
prepolymers
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751964T
Other languages
English (en)
Other versions
DE3751964D1 (de
Inventor
Robert S Langer
Abraham J Domb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE3751964D1 publication Critical patent/DE3751964D1/de
Publication of DE3751964T2 publication Critical patent/DE3751964T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
    • C08G67/04—Polyanhydrides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
DE3751964T 1986-08-01 1987-07-29 Herstellung und Verwendung von hochmolekularen Polyanhydriden Expired - Lifetime DE3751964T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/892,809 US4757128A (en) 1986-08-01 1986-08-01 High molecular weight polyanhydride and preparation thereof

Publications (2)

Publication Number Publication Date
DE3751964D1 DE3751964D1 (de) 1997-01-09
DE3751964T2 true DE3751964T2 (de) 1997-06-05

Family

ID=25400529

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198787110971T Pending DE260415T1 (de) 1986-08-01 1987-07-29 Herstellung und verwendung von hochmolekularen polyanhydriden.
DE3751964T Expired - Lifetime DE3751964T2 (de) 1986-08-01 1987-07-29 Herstellung und Verwendung von hochmolekularen Polyanhydriden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198787110971T Pending DE260415T1 (de) 1986-08-01 1987-07-29 Herstellung und verwendung von hochmolekularen polyanhydriden.

Country Status (11)

Country Link
US (1) US4757128A (de)
EP (1) EP0260415B1 (de)
JP (1) JP2700646B2 (de)
KR (1) KR880002904A (de)
AT (1) ATE145657T1 (de)
CA (1) CA1274339A (de)
DE (2) DE260415T1 (de)
ES (1) ES2006417T3 (de)
GR (2) GR880300163T1 (de)
LU (1) LU90462I2 (de)
NL (1) NL990036I2 (de)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705598A (en) 1985-04-23 1998-01-06 The Boeing Company Polyester sulfone oligomers and blends
US5969079A (en) 1985-09-05 1999-10-19 The Boeing Company Oligomers with multiple chemically functional end caps
US5512676A (en) 1987-09-03 1996-04-30 The Boeing Company Extended amideimide hub for multidimensional oligomers
US5516876A (en) 1983-09-27 1996-05-14 The Boeing Company Polyimide oligomers and blends
US5693741A (en) 1988-03-15 1997-12-02 The Boeing Company Liquid molding compounds
US5714566A (en) 1981-11-13 1998-02-03 The Boeing Company Method for making multiple chemically functional oligomers
US5210213A (en) 1983-06-17 1993-05-11 The Boeing Company Dimensional, crosslinkable oligomers
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5618907A (en) 1985-04-23 1997-04-08 The Boeing Company Thallium catalyzed multidimensional ester oligomers
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US5759830A (en) * 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US4933431A (en) * 1987-07-31 1990-06-12 Massachusetts Institute Of Technology One step preparation of poly(amide-anhydride)
US5817744A (en) 1988-03-14 1998-10-06 The Boeing Company Phenylethynyl capped imides
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
US5001215A (en) * 1989-11-02 1991-03-19 Hoechst Celanese Corp. Aromatic polyester from 1,3-bis(p-carboxyphenoxy)propane
WO1991009831A1 (en) * 1989-12-26 1991-07-11 Nova Pharmaceutical Corporation Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use
US5171812A (en) * 1990-01-19 1992-12-15 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5179189A (en) * 1990-01-19 1993-01-12 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydrides
US5270419A (en) * 1990-01-19 1993-12-14 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5175235A (en) * 1990-06-04 1992-12-29 Nova Pharmaceutical Corporation Branched polyanhydrides
US5317079A (en) * 1990-01-19 1994-05-31 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydride
US5240963A (en) * 1990-01-19 1993-08-31 Nova Pharmaceutical Corporation Branched polyanhydrides
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
DE69232555T2 (de) * 1991-02-01 2002-10-31 Massachusetts Inst Technology Biologisch abbaubare Polymermischungen zur Arzneistoffabgabe
US5330768A (en) * 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
ES2038072B1 (es) * 1991-07-12 1994-02-16 Univ Valladolid Procedimiento para la obtencion de polianhidridos a base de acidos dicarboxilicos y anhidrido acetico.
AU2900792A (en) * 1991-10-24 1993-05-21 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
KR970004670B1 (ko) * 1991-11-26 1997-04-02 간사이뻬인또 가부시끼가이샤 가교제 및 경화성 조성물
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5264540A (en) * 1992-07-20 1993-11-23 Ethicon, Inc. Aromatic polyanhydrides
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
EP1132080A3 (de) * 1992-09-10 2001-10-17 Children's Medical Center Corporation Biodegradierbare Polymeren Matrizen mit verzögerter Freisetzung von Lokalanaesthetika
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5321113A (en) * 1993-05-14 1994-06-14 Ethicon, Inc. Copolymers of an aromatic anhydride and aliphatic ester
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5473103A (en) * 1993-12-16 1995-12-05 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Biopolymers derived from hydrolyzable diacid fats
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) * 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
EP0778768B1 (de) 1995-06-09 2004-05-26 Euroceltique S.A. Formulierungen und verfahren für eine verlängerte lokalanästhesie
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
ATE342295T1 (de) * 1995-07-28 2006-11-15 Genzyme Corp Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5968543A (en) * 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
US5756652A (en) * 1996-02-29 1998-05-26 Depuy Orthopaedics, Inc. Poly (ester-anhydrides) and intermediates therefor
EP0904113B1 (de) * 1996-03-05 2004-05-12 Acusphere, Inc. Mikroverkapselte fluorierte gase zur anwendung als bilderzeugende mittel
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US6299905B1 (en) 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US5668288A (en) * 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
US5905134A (en) * 1996-04-17 1999-05-18 Abbott Laboratories Process for the preparation of polyanhydrides
WO1997049391A1 (en) 1996-06-24 1997-12-31 Euro-Celtique, S.A. Methods for providing safe local anesthesia
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
KR20010006026A (ko) 1997-04-03 2001-01-15 존스 홉킨스 유니버시티 스쿨 오브 메디슨 생물분해성 테레프탈레이트 폴리에스테르-폴리(포스페이트) 중합체, 조성물, 약품 및 그의 제조방법과 이용방법
IL129951A0 (en) * 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US6123956A (en) * 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
KR20010023852A (ko) * 1997-09-10 2001-03-26 루트거스, 주립대학교 치료적으로 유용한 분해 산물을 갖는 폴리안하이드라이드
US6468519B1 (en) 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US7122615B1 (en) * 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
US6486214B1 (en) 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6350464B1 (en) * 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
US6294643B1 (en) 1999-04-20 2001-09-25 Sumitomo Chemical Co., Ltd. Aromatic polyester and molded article using the same
US6503528B1 (en) 1999-11-19 2003-01-07 Abbott Laboratories Polymeric compositions and a method of making the same
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
DE60043075D1 (de) 1999-12-07 2009-11-12 Univ Rutgers Therapeutische zusammensetzungen und verfahren zur behandlung von periodontitis mit entzündunshemmenden mitteln
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
WO2001091796A2 (en) 2000-06-01 2001-12-06 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
CA2771263A1 (en) * 2000-07-27 2002-02-07 Rutgers, The State University Therapeutic polyesters and polyamides
US6602915B2 (en) 2000-07-27 2003-08-05 Rutgers, The State University Of New Jersey Therapeutic azo-compounds for drug delivery
WO2002058670A1 (en) * 2001-01-25 2002-08-01 Euroceltique S.A. Local anesthetic, and method of use
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials
DE02717541T1 (de) * 2001-05-07 2004-08-26 Cornell Research Foundation, Inc. Biologisch abbaubare copolymere, die an ein segment mit mehreren funktionellen gruppen gebunden sind
JP4758607B2 (ja) * 2001-06-22 2011-08-31 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン 生分解性ポリマー組成物、及びその使用方法
CA2456806C (en) 2001-08-08 2011-10-18 Brown University Research Foundation Methods for micronization of hydrophobic drugs
JP2005510571A (ja) * 2001-11-23 2005-04-21 ラトガーズ， ザ ステート ユニバーシティー ポリ無水物の改善された合成
US6993846B2 (en) * 2002-05-08 2006-02-07 Eveready Battery Company, Inc. Lubricating strip
WO2004006863A2 (en) * 2002-07-17 2004-01-22 Rutgers, The State University Therapeutic devices for patterned cell growth
CN100366249C (zh) * 2002-09-29 2008-02-06 天津帝士力投资控股集团有限公司 一种替莫唑胺控释给药系统
AU2003304108B2 (en) * 2002-10-30 2007-03-22 Spherics, Inc. Nanoparticulate bioactive agents
EP1585500B8 (de) * 2002-12-20 2017-07-26 Auritec Pharmaceuticals Beschichtete partikel für arzneimittelverabreichung mit verzögerter freisetzung
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US7662864B2 (en) * 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
JP2007517776A (ja) * 2003-12-09 2007-07-05 スフェリックス， インコーポレイテッド カテコール官能基を有する生体接着性ポリマー
US8957034B2 (en) * 2004-01-28 2015-02-17 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
WO2006026504A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Mucoadhesive oral formulations of high permeability, high solubility drugs
PL1877070T3 (pl) 2005-05-05 2009-06-30 Antisense Pharma Gmbh Zastosowanie terapeutyczne TGF-beta2 antysensownych oligonukleotydów
CA2610022A1 (en) 2005-06-06 2006-12-14 Georgetown University Compositions and methods for lipo modeling
US20070225472A1 (en) * 2006-03-23 2007-09-27 Varshney Sunil K Polyanhydride polymers and their uses in biomedical devices
JP2009539501A (ja) * 2006-06-06 2009-11-19 ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー ヨウ化ポリマー
US9669198B2 (en) * 2006-07-27 2017-06-06 University Of Virginia Patent Foundation System and method for intracranial implantation of therapeutic or diagnostic agents
US9744137B2 (en) * 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
JP2010502713A (ja) * 2006-09-08 2010-01-28 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘液を通る輸送を増強するための組成物および方法
EP2102144A4 (de) 2006-09-13 2011-03-23 Univ Rutgers Wirkstoffe und ihre oligomere und polymere
CA2667325A1 (en) * 2006-10-23 2008-05-02 Bioabsorbable Therapeutics, Inc. A drug-release composition having a therapeutic carrier
EP1973528B1 (de) 2006-11-17 2012-11-07 Supernus Pharmaceuticals, Inc. Verzögert freigesetzte formulierungen aus topiramat
US9364432B2 (en) 2007-06-11 2016-06-14 Edge Therapeutics, Inc. Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
US8637593B2 (en) 2008-01-09 2014-01-28 Hitachi Chemical Company, Ltd. Thermosetting resin composition, epoxy resin molding material, and polyvalent carboxylic acid condensate
KR101895831B1 (ko) 2008-01-09 2018-09-07 히타치가세이가부시끼가이샤 열경화성 수지 조성물, 에폭시 수지 성형 재료 및 다가 카르복시산 축합체
EP3485881B1 (de) 2009-07-10 2024-03-13 President and Fellows of Harvard College Permanent geladene natrium- und calciumkanalblocker als entzündungshemmende mittel
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
EP2512588A4 (de) 2009-12-16 2014-06-04 Univ Columbia Verfahren, vorrichtungen und systeme für ultraschallausgelöste on-demand-wirkstofffreisetzung
CN102834104A (zh) * 2010-02-22 2012-12-19 优势医疗公司 治疗脑的出血性病状的方法和组合物
US8673359B2 (en) 2010-07-08 2014-03-18 Brown University Nanoparticle compositions and methods for improved oral delivery of active agents
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
CN105997890A (zh) 2011-02-11 2016-10-12 优势医疗公司 用于改善患有蛛网膜下腔出血的人的预后的组合物和方法
CN104363924B (zh) 2012-03-16 2018-04-17 约翰霍普金斯大学 用于递送hif‑1抑制剂的控制释放调配物
CA2867203C (en) 2012-03-16 2016-09-20 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
CA2871745C (en) 2012-05-03 2023-01-24 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
KR102140989B1 (ko) 2012-05-03 2020-08-04 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
TWI686213B (zh) 2013-03-21 2020-03-01 美商優普順藥物公司美國分部 可注射持續釋放組合物及使用其治療關節之發炎及與發炎有關之疼痛之方法
WO2014194055A1 (en) 2013-05-29 2014-12-04 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
WO2015058868A1 (en) 2013-10-25 2015-04-30 Pangaea Biotech, S.L. Compositions and methods for the treatment of cancer
WO2015191742A1 (en) 2014-06-13 2015-12-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
US10195212B2 (en) 2014-08-13 2019-02-05 The Johns Hopkins University Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization
CN107206099A (zh) 2015-01-20 2017-09-26 约翰霍普金斯大学 用于持续释放抗青光眼剂以控制眼内压的组合物
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers
CA2994545A1 (en) 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
WO2017044789A1 (en) 2015-09-09 2017-03-16 Micell Technologies, Inc. Biopharma application of micell technology
SG11201803156TA (en) 2015-10-27 2018-05-30 Eupraxia Pharmaceuticals Inc Sustained release formulations of local anesthetics
EP3246050A1 (de) 2016-05-17 2017-11-22 BSN medical GmbH Wund- oder hautauflage
US10449269B2 (en) 2016-08-29 2019-10-22 Yale University Particle conjugated prosthetic patches and methods of making and using thereof
WO2020028907A1 (en) 2018-08-03 2020-02-06 Brown University Compositions and methods for improving the bioavailability of glp1 and analogues thereof
KR20210145164A (ko) 2019-03-11 2021-12-01 녹시온 테라퓨틱스 인코포레이티드 에스테르 치환된 이온 채널 차단제 및 사용 방법
CA3129117A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2022525856A (ja) 2019-03-11 2022-05-20 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP4054586A4 (de) 2019-11-06 2023-11-22 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
IL292505A (en) 2019-11-06 2022-06-01 Nocion Therapeutics Inc Charged ion channel blockers and methods of use
AU2021236130A1 (en) 2020-03-11 2022-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2024011218A1 (en) 2022-07-08 2024-01-11 Brown University Polymeric nanoparticles for long acting delivery of a peptide and methods of making and using thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2071251A (en) * 1931-07-03 1937-02-16 Du Pont Fiber and method of producing it
US2071250A (en) * 1931-07-03 1937-02-16 Du Pont Linear condensation polymers
GB968715A (en) * 1961-10-12 1964-09-02 Ici Ltd Polymeric anhydrides
US3526612A (en) * 1969-04-16 1970-09-01 Marathon Oil Co Polyanhydrides,and processes for their production
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3986510A (en) * 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
JPS60141725A (ja) * 1983-12-29 1985-07-26 Okamura Seiyu Kk ポリ酸ポリ無水物粉体
CH671402A5 (de) * 1985-10-02 1989-08-31 Sandoz Ag

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EP0260415B1 (de) 1996-11-27
DE260415T1 (de) 1989-02-16
ATE145657T1 (de) 1996-12-15
LU90462I2 (fr) 2000-01-03
EP0260415A2 (de) 1988-03-23
CA1274339A (en) 1990-09-18
DE3751964D1 (de) 1997-01-09
US4757128A (en) 1988-07-12
KR880002904A (ko) 1988-05-12
NL990036I1 (nl) 1999-12-01
EP0260415A3 (de) 1988-05-18
ES2006417T3 (es) 1997-07-01
GR3022577T3 (en) 1997-05-31
JPS63258924A (ja) 1988-10-26
GR880300163T1 (en) 1989-01-31
ES2006417A4 (es) 1989-05-01
JP2700646B2 (ja) 1998-01-21
NL990036I2 (nl) 2001-01-02

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