ATE145657T1 - Herstellung und verwendung von hochmolekularen polyanhydriden - Google Patents

Herstellung und verwendung von hochmolekularen polyanhydriden

Info

Publication number
ATE145657T1
ATE145657T1 AT87110971T AT87110971T ATE145657T1 AT E145657 T1 ATE145657 T1 AT E145657T1 AT 87110971 T AT87110971 T AT 87110971T AT 87110971 T AT87110971 T AT 87110971T AT E145657 T1 ATE145657 T1 AT E145657T1
Authority
AT
Austria
Prior art keywords
polyanhydrides
molecular weight
high molecular
prepolymers
production
Prior art date
Application number
AT87110971T
Other languages
English (en)
Inventor
Robert S Langer
Abraham J Domb
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE145657T1 publication Critical patent/ATE145657T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
    • C08G67/04—Polyanhydrides
AT87110971T 1986-08-01 1987-07-29 Herstellung und verwendung von hochmolekularen polyanhydriden ATE145657T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/892,809 US4757128A (en) 1986-08-01 1986-08-01 High molecular weight polyanhydride and preparation thereof

Publications (1)

Publication Number Publication Date
ATE145657T1 true ATE145657T1 (de) 1996-12-15

Family

ID=25400529

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87110971T ATE145657T1 (de) 1986-08-01 1987-07-29 Herstellung und verwendung von hochmolekularen polyanhydriden

Country Status (11)

Country Link
US (1) US4757128A (de)
EP (1) EP0260415B1 (de)
JP (1) JP2700646B2 (de)
KR (1) KR880002904A (de)
AT (1) ATE145657T1 (de)
CA (1) CA1274339A (de)
DE (2) DE3751964T2 (de)
ES (1) ES2006417T3 (de)
GR (2) GR880300163T1 (de)
LU (1) LU90462I2 (de)
NL (1) NL990036I2 (de)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512676A (en) 1987-09-03 1996-04-30 The Boeing Company Extended amideimide hub for multidimensional oligomers
US5516876A (en) 1983-09-27 1996-05-14 The Boeing Company Polyimide oligomers and blends
US5705598A (en) 1985-04-23 1998-01-06 The Boeing Company Polyester sulfone oligomers and blends
US5693741A (en) 1988-03-15 1997-12-02 The Boeing Company Liquid molding compounds
US5969079A (en) 1985-09-05 1999-10-19 The Boeing Company Oligomers with multiple chemically functional end caps
US5210213A (en) 1983-06-17 1993-05-11 The Boeing Company Dimensional, crosslinkable oligomers
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5618907A (en) 1985-04-23 1997-04-08 The Boeing Company Thallium catalyzed multidimensional ester oligomers
US5610317A (en) 1985-09-05 1997-03-11 The Boeing Company Multiple chemically functional end cap monomers
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US4933431A (en) * 1987-07-31 1990-06-12 Massachusetts Institute Of Technology One step preparation of poly(amide-anhydride)
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5817744A (en) 1988-03-14 1998-10-06 The Boeing Company Phenylethynyl capped imides
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
US5001215A (en) * 1989-11-02 1991-03-19 Hoechst Celanese Corp. Aromatic polyester from 1,3-bis(p-carboxyphenoxy)propane
EP0510080A4 (en) * 1989-12-26 1992-12-02 Nova Pharmaceutical Corporation Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use
US5175235A (en) * 1990-06-04 1992-12-29 Nova Pharmaceutical Corporation Branched polyanhydrides
US5240963A (en) * 1990-01-19 1993-08-31 Nova Pharmaceutical Corporation Branched polyanhydrides
US5270419A (en) * 1990-01-19 1993-12-14 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5179189A (en) * 1990-01-19 1993-01-12 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydrides
US5171812A (en) * 1990-01-19 1992-12-15 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5317079A (en) * 1990-01-19 1994-05-31 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydride
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
WO1992013567A1 (en) * 1991-02-01 1992-08-20 Nova Pharmaceutical Corporation Biodegradable polymer blends for drug delivery
US5330768A (en) * 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
ES2038072B1 (es) * 1991-07-12 1994-02-16 Univ Valladolid Procedimiento para la obtencion de polianhidridos a base de acidos dicarboxilicos y anhidrido acetico.
WO1993007913A1 (en) * 1991-10-24 1993-04-29 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
AU660511B2 (en) * 1991-11-26 1995-06-29 Kansai Paint Company, Limited Cross-linking agent and curable composition
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5264540A (en) * 1992-07-20 1993-11-23 Ethicon, Inc. Aromatic polyanhydrides
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5618563A (en) * 1992-09-10 1997-04-08 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5321113A (en) * 1993-05-14 1994-06-14 Ethicon, Inc. Copolymers of an aromatic anhydride and aliphatic ester
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5473103A (en) * 1993-12-16 1995-12-05 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Biopolymers derived from hydrolyzable diacid fats
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5942241A (en) 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
CA2228118A1 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
US5968543A (en) * 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
US5756652A (en) * 1996-02-29 1998-05-26 Depuy Orthopaedics, Inc. Poly (ester-anhydrides) and intermediates therefor
HU226714B1 (en) * 1996-03-05 2009-07-28 Acusphere Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US6299905B1 (en) 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US5668288A (en) * 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
US5905134A (en) * 1996-04-17 1999-05-18 Abbott Laboratories Process for the preparation of polyanhydrides
JPH11511763A (ja) 1996-06-24 1999-10-12 ユーロ―セルティーク，エス．エイ． 安全な局所麻酔の提供方法
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
WO1998044021A1 (en) 1997-04-03 1998-10-08 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same
BR9815499A (pt) * 1997-07-02 2001-01-02 Euro Celtique Sa Anestesia prolongada nas juntas e nos espacos corporais.
US6123956A (en) * 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US7122615B1 (en) 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
JP4130305B2 (ja) * 1997-09-10 2008-08-06 ラトガーズ，ザ ステート ユニバーシティー オブ ニュージャージー 治療的に有用な分解産物を有するポリアンヒドリド
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US6486214B1 (en) 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6350464B1 (en) 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
US6294643B1 (en) 1999-04-20 2001-09-25 Sumitomo Chemical Co., Ltd. Aromatic polyester and molded article using the same
US6503528B1 (en) 1999-11-19 2003-01-07 Abbott Laboratories Polymeric compositions and a method of making the same
US20040038948A1 (en) * 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
JP2003528044A (ja) 1999-12-07 2003-09-24 ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー 治療組成物および治療方法
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
AU2001264595A1 (en) 2000-05-19 2001-12-03 Guilford Pharmaceuticals Inc. Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses
AU2001275085A1 (en) 2000-06-01 2001-12-11 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
US6602915B2 (en) 2000-07-27 2003-08-05 Rutgers, The State University Of New Jersey Therapeutic azo-compounds for drug delivery
CA2771263A1 (en) 2000-07-27 2002-02-07 Rutgers, The State University Therapeutic polyesters and polyamides
WO2002058670A1 (en) * 2001-01-25 2002-08-01 Euroceltique S.A. Local anesthetic, and method of use
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials
ES2220247T3 (es) * 2001-05-07 2007-11-16 Cornell Research Foundation, Inc. Copolimeros biodegradables enlazados a un segmento con una pluralidad de grupos funcionales.
EP1406593B1 (de) * 2001-06-22 2010-08-25 Johns Hopkins University School of Medicine Biologisch abbaubare polymerzusammensetzungen, zusammensetzungen und damit in beziehung stehende verwendungen
JP2004537401A (ja) 2001-08-08 2004-12-16 ブラウン ユニバーシティ リサーチ ファウンデーション 疎水性薬物の微粉砕方法
CN1684582A (zh) 2001-11-23 2005-10-19 拉特格斯州立大学 聚酐类的改进合成法
US6993846B2 (en) * 2002-05-08 2006-02-07 Eveready Battery Company, Inc. Lubricating strip
US20040096476A1 (en) * 2002-07-17 2004-05-20 Uhrich Kathryn E. Therapeutic devices for patterned cell growth
CN100366249C (zh) * 2002-09-29 2008-02-06 天津帝士力投资控股集团有限公司 一种替莫唑胺控释给药系统
JP2006514698A (ja) * 2002-10-30 2006-05-11 スフェリックス， インコーポレイテッド ナノ粒子生物活性物質
CA2510320C (en) * 2002-12-20 2012-10-09 St. James Associates Llc/Faber Research Series Coated particles for sustained-release pharmaceutical administration
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US7662864B2 (en) * 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
JP2007517776A (ja) * 2003-12-09 2007-07-05 スフェリックス， インコーポレイテッド カテコール官能基を有する生体接着性ポリマー
WO2005072710A2 (en) * 2004-01-28 2005-08-11 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
ES2319332T3 (es) 2005-05-05 2009-05-06 Antisense Pharma Gmbh Uso terapeutico de oligonucleotidos antisentido tgf-beta 2'.
US20090317376A1 (en) 2005-06-06 2009-12-24 Georgetown University Medical School Compositions And Methods For Lipo Modeling
US20070225472A1 (en) * 2006-03-23 2007-09-27 Varshney Sunil K Polyanhydride polymers and their uses in biomedical devices
WO2007143698A2 (en) 2006-06-06 2007-12-13 Rutgers, The State University Of New Jersey Iodinated polymers
JP2009544406A (ja) * 2006-07-27 2009-12-17 ユニヴァースティ オブ ヴァージニア パテント ファウンデイション 治療又は診断用薬の頭蓋内注入用システム及び方法
US9744137B2 (en) * 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
DE602007012559D1 (de) * 2006-09-08 2011-03-31 Univ Johns Hopkins H die schleimhaut
EP2102144A4 (de) 2006-09-13 2011-03-23 Univ Rutgers Wirkstoffe und ihre oligomere und polymere
EP2077861A2 (de) * 2006-10-23 2009-07-15 Bioabsorbable Therapeutics, Inc. Arzneimittel freisetzende zusammensetzung mit einem therapeutischen träger
US8298576B2 (en) 2006-11-17 2012-10-30 Supernus Pharmaceuticals, Inc. Sustained-release formulations of topiramate
US8252302B2 (en) * 2007-06-11 2012-08-28 Edge Therapeutics, Inc. Methods and compositions to treat hemorrhagic conditions of the brain
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
KR20150140868A (ko) 2008-01-09 2015-12-16 히타치가세이가부시끼가이샤 열경화성 수지 조성물, 에폭시 수지 성형 재료 및 다가 카르복시산 축합체
US8637593B2 (en) 2008-01-09 2014-01-28 Hitachi Chemical Company, Ltd. Thermosetting resin composition, epoxy resin molding material, and polyvalent carboxylic acid condensate
WO2011006073A1 (en) 2009-07-10 2011-01-13 President And Fellows Of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
EP2470287A4 (de) 2009-08-28 2015-01-21 Univ Columbia Systeme, verfahren und vorrichtungen zur herstellung gasgefüllter mikroblasen
WO2011075557A1 (en) 2009-12-16 2011-06-23 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for on-demand ultrasound-triggered drug delivery
US8673359B2 (en) 2010-07-08 2014-03-18 Brown University Nanoparticle compositions and methods for improved oral delivery of active agents
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
AU2012214137B2 (en) 2011-02-11 2016-10-06 Edge Therapeutics, Inc. Compositions and methods for improving prognosis of a human with subarachnoid hemorrhage
CN103517726B (zh) 2011-04-05 2016-08-17 优势医疗 用于改善脑损伤后影响脑血流的结果的脑室内药物递送系统
EA032552B1 (ru) 2012-03-16 2019-06-28 Дзе Джонс Хопкинс Юниверсити Препараты с контролируемым высвобождением для доставки ингибиторов hif-1
EA030318B1 (ru) 2012-03-16 2018-07-31 Дзе Джонс Хопкинс Юниверсити Конъюгаты нелинейного мультиблочного сополимера с лекарственным средством для доставки активных агентов
JP6360040B2 (ja) 2012-05-03 2018-07-18 カラ ファーマシューティカルズ インコーポレイテッド 粘液浸透性被覆粒子、組成物、医薬組成物、医薬製剤、及びそれらの形成方法
EP4008355A1 (de) 2012-05-03 2022-06-08 Kala Pharmaceuticals, Inc. Pharmazeutische nanopartikel mit verbessertem mukosalem transport
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
AU2014235854B2 (en) 2013-03-21 2019-04-11 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
WO2015058868A1 (en) 2013-10-25 2015-04-30 Pangaea Biotech, S.L. Compositions and methods for the treatment of cancer
WO2015191742A1 (en) 2014-06-13 2015-12-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
MX2017001863A (es) 2014-08-13 2017-07-17 Univ Johns Hopkins Nanoparticulas cargadas con glucocorticoides para prevencion de rechazo de aloinjerto corneal y neovascularizacion.
WO2016118506A1 (en) 2015-01-20 2016-07-28 The Johns Hopkins University Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers
AU2016301282B2 (en) 2015-08-03 2022-03-17 Children's Medical Center Corporation Charged ion channel blockers and methods for use
AU2016319782A1 (en) 2015-09-09 2018-04-05 Micell Technologies, Inc. Biopharma application of micell technology
PL3206672T3 (pl) 2015-10-27 2018-09-28 Eupraxia Pharmaceuticals Inc. Preparaty o przedłużonym uwalnianiu środków znieczulających miejscowo
EP3246050A1 (de) 2016-05-17 2017-11-22 BSN medical GmbH Wund- oder hautauflage
US10449269B2 (en) 2016-08-29 2019-10-22 Yale University Particle conjugated prosthetic patches and methods of making and using thereof
WO2020028907A1 (en) 2018-08-03 2020-02-06 Brown University Compositions and methods for improving the bioavailability of glp1 and analogues thereof
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2022527690A (ja) 2019-03-11 2022-06-03 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
MA55320A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques substitués par un ester et méthodes d'utilisation
EP3937945A4 (de) 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
CN114828845A (zh) 2019-11-06 2022-07-29 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2023517604A (ja) 2020-03-11 2023-04-26 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
WO2024011218A1 (en) 2022-07-08 2024-01-11 Brown University Polymeric nanoparticles for long acting delivery of a peptide and methods of making and using thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2071251A (en) * 1931-07-03 1937-02-16 Du Pont Fiber and method of producing it
US2071250A (en) * 1931-07-03 1937-02-16 Du Pont Linear condensation polymers
GB968715A (en) * 1961-10-12 1964-09-02 Ici Ltd Polymeric anhydrides
US3526612A (en) * 1969-04-16 1970-09-01 Marathon Oil Co Polyanhydrides,and processes for their production
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
US3986510A (en) * 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
JPS60141725A (ja) * 1983-12-29 1985-07-26 Okamura Seiyu Kk ポリ酸ポリ無水物粉体
CH671402A5 (de) * 1985-10-02 1989-08-31 Sandoz Ag

Also Published As

Publication number Publication date
DE3751964D1 (de) 1997-01-09
US4757128A (en) 1988-07-12
CA1274339A (en) 1990-09-18
GR880300163T1 (en) 1989-01-31
EP0260415B1 (de) 1996-11-27
GR3022577T3 (en) 1997-05-31
KR880002904A (ko) 1988-05-12
ES2006417A4 (es) 1989-05-01
JPS63258924A (ja) 1988-10-26
DE3751964T2 (de) 1997-06-05
NL990036I1 (nl) 1999-12-01
EP0260415A3 (de) 1988-05-18
ES2006417T3 (es) 1997-07-01
EP0260415A2 (de) 1988-03-23
DE260415T1 (de) 1989-02-16
JP2700646B2 (ja) 1998-01-21
LU90462I2 (fr) 2000-01-03
NL990036I2 (nl) 2001-01-02

Similar Documents

Publication Publication Date Title
ATE145657T1 (de) Herstellung und verwendung von hochmolekularen polyanhydriden
FI932442A0 (fi) Kristallina propenpolymerer med foerbaettrad bearbetbarhet i smaelt tillstaond samt foerfarande foer deras framstaellning
DE3675642D1 (de) Einsatz von antistatika zur vermeidung von belagbildung bei der herstellung von ethylenpolymerisaten in gasphasenreakatoren.
DE3751694T2 (de) Metallocen-katalysatorsysteme für die Polymersation von Olefinen, mit einer Silizium-Hydrocarbyl-Brücke.
DE3485955D1 (de) Herstellung von polyarylenetherketonen.
EP0227838A4 (de) Polyäthylenzusammensetzung.
DE3853810D1 (de) Propylenpolymere und Herstellung derselben.
ATE133988T1 (de) Thermoplastische polymere zusammensetzungen, welche modifikatoren der schmelz-rheologie enthalten
BR8800716A (pt) Processo de preparacao de polimeros com grupamentos imidas e polimeros
KR960022679A (ko) 발포된 폴리 (에틸렌 나프탈레이트)의 고체 상태 중합 방법
ES2033425T3 (es) Composicion reticulable de polimeros sililicos.
ATE137778T1 (de) Verfahren zur herstellung von poly(arylensulfid- sulfon)-polymeren
DE3778091D1 (de) Mit harzen verstaerkte emulsionspolymere und verfahren zu deren herstellung.
AU630240B2 (en) Isocyanate-reactive composition
FI875540A0 (fi) Polymerer innehaollande imidgrupper, framstaellda av steriskt foerhindrade diaminer, och foerfaranden foer framstaellning av dem.
ATE97919T1 (de) Stereoregulaere acrylonitril-polymere und diese enthaltende zusammensetzungen.
ATE356135T1 (de) Silikonhaltige polymere
FI874684A0 (fi) Polymerer innehaollande imidgrupper och deras framstaellningsfoerfaranden.
Smith Jr Process for the Production of Silicon Carbide by the Pyrolysis of a Polycarbosilane Polymer
DE3667064D1 (en) Process for the preparation of nylon 4,6
DE69934021D1 (de) Herstellung von polymeren mit hilfe von sternverknüpfungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time