DE3442639A1 - Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten - Google Patents

Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Info

Publication number
DE3442639A1
DE3442639A1 DE19843442639 DE3442639A DE3442639A1 DE 3442639 A1 DE3442639 A1 DE 3442639A1 DE 19843442639 DE19843442639 DE 19843442639 DE 3442639 A DE3442639 A DE 3442639A DE 3442639 A1 DE3442639 A1 DE 3442639A1
Authority
DE
Germany
Prior art keywords
alk
silibinin
ethyl acetate
independently
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19843442639
Other languages
German (de)
English (en)
Other versions
DE3442639C2 (enExample
Inventor
Reinhard Dr. 5300 Bonn Graatz
Klaus Dr. 5060 Bergisch Gladbach Görler
Günter Dr. Halbach
Karlheinz Prof. Dr. 7408 Wankheim Schmidt
Hartwig Dr. 5000 Köln Soicke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Priority to DE19843442639 priority Critical patent/DE3442639A1/de
Priority to IE280885A priority patent/IE58791B1/en
Priority to LU86163A priority patent/LU86163A1/de
Priority to SI8511786A priority patent/SI8511786A8/sl
Priority to YU1786/85A priority patent/YU43689B/xx
Priority to AR302267A priority patent/AR240931A1/es
Priority to GB08528226A priority patent/GB2167414B/en
Priority to NL8503171A priority patent/NL192387C/nl
Priority to FI854535A priority patent/FI84064C/fi
Priority to CH4935/85A priority patent/CH659473A5/de
Priority to AT3371/85A priority patent/AT393268B/de
Priority to SE8505487A priority patent/SE465676B/sv
Priority to CS837885A priority patent/CS273610B2/cs
Priority to CA000495804A priority patent/CA1337124C/en
Priority to DD85283042A priority patent/DD259191A1/de
Priority to PT81532A priority patent/PT81532B/pt
Priority to ES549116A priority patent/ES8609311A1/es
Priority to DK537785A priority patent/DK164865C/da
Priority to IT22932/85A priority patent/IT1190426B/it
Priority to HU854448A priority patent/HU195503B/hu
Priority to PL1985256374A priority patent/PL146890B1/pl
Priority to ZA858951A priority patent/ZA858951B/xx
Priority to SU853985401A priority patent/SU1436875A3/ru
Priority to EG74085A priority patent/EG19424A/xx
Priority to NO854655A priority patent/NO160205C/no
Priority to KR1019850008733A priority patent/KR870001020B1/ko
Priority to JP60261629A priority patent/JPS61143377A/ja
Priority to BE2/60850A priority patent/BE903693A/fr
Priority to MX009022A priority patent/MX168415B/es
Priority to FR858517321A priority patent/FR2573427B1/fr
Publication of DE3442639A1 publication Critical patent/DE3442639A1/de
Application granted granted Critical
Publication of DE3442639C2 publication Critical patent/DE3442639C2/de
Priority to HRP-1786/85A priority patent/HRP950126B1/xx
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
DE19843442639 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten Granted DE3442639A1 (de)

Priority Applications (31)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
IE280885A IE58791B1 (en) 1984-11-22 1985-11-11 Flavolignan derivatives and pharmaceutical compositions containing them
LU86163A LU86163A1 (de) 1984-11-22 1985-11-13 Flavolignanderivate,verfahren zu deren herstellung und arzneimittel,die diese verbindungen enthalten
YU1786/85A YU43689B (en) 1984-11-22 1985-11-14 Process for preparing derivatives of silibinine
AR302267A AR240931A1 (es) 1984-11-22 1985-11-14 Un procedimiento para la preparacion de derivados de silibinina"
SI8511786A SI8511786A8 (sl) 1984-11-22 1985-11-14 Postopek za pripravo derivatov silibinina
GB08528226A GB2167414B (en) 1984-11-22 1985-11-15 Flavolignan derivatives and pharmaceutical compositions containing them
NL8503171A NL192387C (nl) 1984-11-22 1985-11-18 Zuivere silibininederivaten, werkwijze voor de bereiding daarvan en farmaceutisch preparaat dat een dergelijk derivaat bevat.
FI854535A FI84064C (fi) 1984-11-22 1985-11-18 Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat.
CH4935/85A CH659473A5 (de) 1984-11-22 1985-11-19 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten.
AT3371/85A AT393268B (de) 1984-11-22 1985-11-19 Verfahren zur herstellung neuer flavolignanderivate
CS837885A CS273610B2 (en) 1984-11-22 1985-11-20 Method of silibinene's new derivatives production
CA000495804A CA1337124C (en) 1984-11-22 1985-11-20 Flavolignan derivatives, processes for the preparation thereof and pharmaceutical compositions containing these compounds
DD85283042A DD259191A1 (de) 1984-11-22 1985-11-20 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
SE8505487A SE465676B (sv) 1984-11-22 1985-11-20 Flavolignanderivat, saett att framstaella detta och ett farmaceutiskt medel
NO854655A NO160205C (no) 1984-11-22 1985-11-21 Fremgangsmaate ved fremstilling av silibininderivater.
PT81532A PT81532B (pt) 1984-11-22 1985-11-21 Processo para a preparacao de derivados da flavolignana e de composicoes farmaceuticas que os contem
IT22932/85A IT1190426B (it) 1984-11-22 1985-11-21 Derivati del flavolignano,procedimento per la loro preparazione e medicinali che contengono questi composti
HU854448A HU195503B (en) 1984-11-22 1985-11-21 Process for preparing flavolignane derivatives and pharmaceutical compositions containing them
PL1985256374A PL146890B1 (en) 1984-11-22 1985-11-21 Process for preparing novel derivatives of silibinin
ZA858951A ZA858951B (en) 1984-11-22 1985-11-21 Flavolignane derivatives,process for preparation thereof and pharmaceuticals,which contain these combinations
SU853985401A SU1436875A3 (ru) 1984-11-22 1985-11-21 Способ получени производных силибинина
EG74085A EG19424A (en) 1984-11-22 1985-11-21 Flavolignan derivatives, process for their preparation.
ES549116A ES8609311A1 (es) 1984-11-22 1985-11-21 Procedimiento para obtencion de derivados de flavolignano
DK537785A DK164865C (da) 1984-11-22 1985-11-21 Silibininderivater, fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende silibininderivaterne
KR1019850008733A KR870001020B1 (ko) 1984-11-22 1985-11-22 실리비닌 유도체의 제조방법
JP60261629A JPS61143377A (ja) 1984-11-22 1985-11-22 シリビニン誘導体、その製法及びこれを含有する火傷、肝臓障害及びキノコ毒の治療剤
BE2/60850A BE903693A (fr) 1984-11-22 1985-11-22 Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes.
MX009022A MX168415B (es) 1984-11-22 1985-11-22 Procedimiento para la preparacion de derivados de silibinina
FR858517321A FR2573427B1 (fr) 1984-11-22 1985-11-22 Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes
HRP-1786/85A HRP950126B1 (en) 1984-11-22 1995-03-16 Process for the preparation of silibinine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
DE3442639A1 true DE3442639A1 (de) 1986-05-22
DE3442639C2 DE3442639C2 (enExample) 1989-08-10

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843442639 Granted DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Country Status (29)

Country Link
JP (1) JPS61143377A (enExample)
KR (1) KR870001020B1 (enExample)
AR (1) AR240931A1 (enExample)
AT (1) AT393268B (enExample)
BE (1) BE903693A (enExample)
CA (1) CA1337124C (enExample)
CH (1) CH659473A5 (enExample)
CS (1) CS273610B2 (enExample)
DD (1) DD259191A1 (enExample)
DE (1) DE3442639A1 (enExample)
DK (1) DK164865C (enExample)
EG (1) EG19424A (enExample)
ES (1) ES8609311A1 (enExample)
FI (1) FI84064C (enExample)
FR (1) FR2573427B1 (enExample)
GB (1) GB2167414B (enExample)
HU (1) HU195503B (enExample)
IE (1) IE58791B1 (enExample)
IT (1) IT1190426B (enExample)
LU (1) LU86163A1 (enExample)
MX (1) MX168415B (enExample)
NL (1) NL192387C (enExample)
NO (1) NO160205C (enExample)
PL (1) PL146890B1 (enExample)
PT (1) PT81532B (enExample)
SE (1) SE465676B (enExample)
SU (1) SU1436875A3 (enExample)
YU (1) YU43689B (enExample)
ZA (1) ZA858951B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
AU2006222556B2 (en) * 2005-03-11 2011-09-29 Armaron Bio Pty Ltd Flavonoid compounds and uses thereof
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
AU2008323156B2 (en) 2007-11-15 2012-05-31 Madaus Gmbh Silibinin component for the treatment of hepatitis
US8614341B2 (en) 2009-05-14 2013-12-24 Euromed S.A. Amorphous silibinin for the treatment of viral hepatitis
RU2666953C2 (ru) 2012-07-05 2018-09-13 Нутрамакс Лабораториз, Инк. Композиции, содержащие сульфорафан или предшественник сульфорафана и экстракт или порошок молочного чертополоха
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318B (de) * Dr Willmar Schwabe GmbH, 7500 Karls ruhe Durlach Süybinhalbestersauren des Süybins mit 1 und bzw oder 2 Mol und deren Salze mit pharmakologisch vertraglichen anorga nischen oder organischen Basen, und Arznei mittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318B (de) * Dr Willmar Schwabe GmbH, 7500 Karls ruhe Durlach Süybinhalbestersauren des Süybins mit 1 und bzw oder 2 Mol und deren Salze mit pharmakologisch vertraglichen anorga nischen oder organischen Basen, und Arznei mittel

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Arch. Pharm. 316, 1983, S.385-394 *
Arzneimittel-Forsch./Drug Res. 30, (1), 1980, S.452-454 *
Arzneimittelforschung 24 (4), 1974, S. 466-471 *
J. Chem. Soc., Chem. Comm. 16, 1979, S. 696-697 *

Also Published As

Publication number Publication date
FI84064B (fi) 1991-06-28
FI854535A0 (fi) 1985-11-18
PT81532B (pt) 1987-11-11
PL256374A1 (en) 1986-12-02
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
BE903693A (fr) 1986-05-22
JPH0432073B2 (enExample) 1992-05-28
SU1436875A3 (ru) 1988-11-07
KR860004056A (ko) 1986-06-16
SE8505487L (sv) 1986-05-23
YU43689B (en) 1989-10-31
YU178685A (en) 1988-02-29
CS273610B2 (en) 1991-03-12
JPS61143377A (ja) 1986-07-01
IE58791B1 (en) 1993-11-17
GB2167414B (en) 1989-01-11
IT8522932A0 (it) 1985-11-21
NO854655L (no) 1986-05-23
IT1190426B (it) 1988-02-16
SE8505487D0 (sv) 1985-11-20
DK537785A (da) 1986-05-23
FR2573427A1 (fr) 1986-05-23
HU195503B (en) 1988-05-30
FI84064C (fi) 1991-10-10
PT81532A (de) 1985-12-01
NO160205C (no) 1989-03-22
AT393268B (de) 1991-09-25
NO160205B (no) 1988-12-12
CH659473A5 (de) 1987-01-30
CS837885A2 (en) 1990-08-14
GB8528226D0 (en) 1985-12-18
CA1337124C (en) 1995-09-26
KR870001020B1 (ko) 1987-05-23
ES549116A0 (es) 1986-09-01
ZA858951B (en) 1986-08-27
LU86163A1 (de) 1986-03-24
EG19424A (en) 1995-02-28
FR2573427B1 (fr) 1989-03-10
AR240931A2 (es) 1991-03-27
DK164865C (da) 1993-01-18
IE852808L (en) 1986-05-22
DE3442639C2 (enExample) 1989-08-10
NL192387B (nl) 1997-03-03
MX168415B (es) 1993-05-24
AR240931A1 (es) 1991-03-27
ATA337185A (de) 1991-02-15
HUT40114A (en) 1986-11-28
ES8609311A1 (es) 1986-09-01
NL192387C (nl) 1997-07-04
DD259191A1 (de) 1988-08-17
NL8503171A (nl) 1986-06-16
DK164865B (da) 1992-08-31
DK537785D0 (da) 1985-11-21
GB2167414A (en) 1986-05-29
FI854535A7 (fi) 1986-05-23

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8327 Change in the person/name/address of the patent owner

Owner name: MADAUS AG, 5000 KOELN, DE

8364 No opposition during term of opposition