DE3118218A1 - Wasserloesliche einschluss-komplexe von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen und deren waessrige loesungen sowie deren herstellung und diese verbindungen enthaltende arzneimittelpraeparate - Google Patents

Wasserloesliche einschluss-komplexe von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen und deren waessrige loesungen sowie deren herstellung und diese verbindungen enthaltende arzneimittelpraeparate

Info

Publication number
DE3118218A1
DE3118218A1 DE19813118218 DE3118218A DE3118218A1 DE 3118218 A1 DE3118218 A1 DE 3118218A1 DE 19813118218 DE19813118218 DE 19813118218 DE 3118218 A DE3118218 A DE 3118218A DE 3118218 A1 DE3118218 A1 DE 3118218A1
Authority
DE
Germany
Prior art keywords
water
insoluble
soluble
dideoxy
cyclodextrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19813118218
Other languages
German (de)
English (en)
Inventor
geb. Pusztai Eva Dipl.-Ing.-Chem. Dr. 1023 Budapest Bolla
geb. Szabo Agnes Dipl.-Ing.-Chem. Dr. 1143 Budapest Stadler
Jozsef Dipl.-Ing.-Chem. Dr. 1026 Budapest Szejtli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of DE3118218A1 publication Critical patent/DE3118218A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19813118218 1980-05-09 1981-05-08 Wasserloesliche einschluss-komplexe von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen und deren waessrige loesungen sowie deren herstellung und diese verbindungen enthaltende arzneimittelpraeparate Withdrawn DE3118218A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU801141A HU181703B (en) 1980-05-09 1980-05-09 Process for producing aqueus solutuins of water insoluble or hardly soluble vitamines, steroides, localanesthetics, prostanoides and non-steroid and antiphlogistic agents

Publications (1)

Publication Number Publication Date
DE3118218A1 true DE3118218A1 (de) 1982-04-22

Family

ID=10953012

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813118218 Withdrawn DE3118218A1 (de) 1980-05-09 1981-05-08 Wasserloesliche einschluss-komplexe von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen und deren waessrige loesungen sowie deren herstellung und diese verbindungen enthaltende arzneimittelpraeparate

Country Status (7)

Country Link
JP (1) JPS574914A (fr)
AT (1) AT374684B (fr)
BE (1) BE888736A (fr)
CH (1) CH661517A5 (fr)
DE (1) DE3118218A1 (fr)
FR (1) FR2484252A1 (fr)
HU (1) HU181703B (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582900A (en) * 1983-12-17 1986-04-15 Hoechst Aktiengesellschaft Water-soluble mixed ethers of β-cyclodextrin and a process for their preparation
US4638058A (en) * 1983-12-17 1987-01-20 Hoechst Aktiengesellschaft Ethers of beta-cyclodextrin and a process for their preparation
DE3609116A1 (de) * 1986-03-14 1987-09-17 Herbe Wirkstoffe Gmbh Zubereitungen von gewuerzen oder drogen
DE3815902A1 (de) * 1988-05-10 1989-11-23 Schwarz Pharma Gmbh Einschlussverbindungen des 1-(4-(2-(5-chloro-2-methoxybenzamido)ethyl) -phenylsulfonyl)-3-cyclohexylharnstoffs mit (alpha)-,ss-,(gamma)-cyclodextrinen, jeweils diese enthaltendes pharmazeutisches praeparat und verfahren zu deren herstellung
EP0349091A1 (fr) 1988-07-01 1990-01-03 Walter Adrianus Josephus Johannes Hermens Composition pharmaceutique
WO1990015792A1 (fr) * 1989-06-20 1990-12-27 Aktiebolaget Hässle Nouveaux complexes d'inclusion de cyclodextrine
DE4207922A1 (de) * 1992-03-13 1993-09-23 Pharmatech Gmbh Wasserloesliche einschlussverbindungen und verfahren zu deren herstellung
DE4227569C1 (de) * 1992-08-20 1994-06-09 Inst Chemo Biosensorik Verfahren zum empfindlichen enzymatischen Nachweis von anorganischem Phosphat
DE4405545A1 (de) * 1994-02-22 1995-08-31 Dietl Hans Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
EP2272503A2 (fr) 2003-03-28 2011-01-12 Ares Trading S.A. Formulation orale de cladribine
US7888328B2 (en) 2003-03-28 2011-02-15 Ares Trading S.A. Oral formulations of cladribine
US8623408B2 (en) 2003-03-28 2014-01-07 Ares Trading S.A. Cladribine formulations for improved oral and transmucosal delivery
EP3865120A1 (fr) 2013-07-19 2021-08-18 Boehringer Ingelheim Vetmedica GmbH Dérivés de la cyclodextrine éthérifiée préservés contenant une composition pharmaceutique liquide aqueuse

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936656A (ja) * 1982-08-23 1984-02-28 Teijin Ltd 新規包接化合物及びそれを活性成分とする薬剤
HU194858B (en) * 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
SE8305864D0 (sv) * 1983-10-25 1983-10-25 L E Medical Ogondroppar
DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
HU196128B (en) * 1985-01-10 1988-10-28 Chinoin Gyogyszer Es Vegyeszet Process for production of compound substituating bile and forwarding digestion of fat
JPH0651725B2 (ja) * 1985-02-28 1994-07-06 メルシャン株式会社 部分メチル化シクロデキストリン及びその製造方法
US6407079B1 (en) * 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
JPS62123196A (ja) * 1985-11-22 1987-06-04 Nisshin Flour Milling Co Ltd プレドニゾロン包接化合物
JPH0637388B2 (ja) * 1986-02-17 1994-05-18 千寿製薬株式会社 水性液剤
SE502288C2 (sv) * 1987-12-22 1995-09-25 Glaxo Group Ltd Vattenhaltig komposition innehållande ett piperidinylcyklopentylheptenonsyraderivat
ES2037385T3 (es) * 1988-01-14 1993-06-16 Akzo N.V. Un procedimiento de manufactura de una preparacion farmaceutica para administracion local.
DE68910113T2 (de) * 1988-01-19 1994-03-17 Childrens Hospital Corp Wachstuminhibierendes mittel und dessen verwendung.
JP2735122B2 (ja) * 1988-06-13 1998-04-02 旭化成工業株式会社 メキタジンの液状シロップ製剤
FR2640137A1 (fr) * 1988-12-08 1990-06-15 Texinfine Sa Systemes transporteurs de principes actifs lipophiles et leur procede d'obtention
US5093127A (en) * 1989-06-02 1992-03-03 Fujisawa Pharmaceutical Co., Ltd. Preparation of fr115224 substrate for parenteral administration
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
USRE34578E (en) * 1990-05-07 1994-04-05 Lubkin; Virginia Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
US5684169A (en) * 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
JPH0753396A (ja) * 1993-08-19 1995-02-28 Ensuiko Sugar Refining Co Ltd タキソールのサイクロデキストリン包接物，その製造法および用途
JPH06157330A (ja) * 1992-11-27 1994-06-03 Ensuiko Sugar Refining Co Ltd タキソールのサイクロデキストリン包接物，その製造法と用途
HU213200B (en) * 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
JP2715240B2 (ja) * 1993-05-18 1998-02-18 株式会社第一ラジオアイソトープ研究所 放射性ヨウ素標識脂肪酸−シクロデキストリン複合体およびこれを含有するイメージング剤
DE4338508A1 (de) * 1993-11-11 1995-05-18 Asta Medica Ag Arzneimittelzubereitungen enthaltend Thioctsäure oder Dihydroliponsäure in Form von Einschlußverbindungen mit Cyclodextrinen oder Cyclodextrinderivaten und in Form von Granulaten, Kau- oder Brausetabletten
CZ306394A3 (en) * 1993-12-14 1995-08-16 Lilly Co Eli Aqueous solution of inclusion complex of benzothiophene derivative with water-soluble cyclodextrins, process of its preparation and a pharmaceutical composition containing thereof
JP2006328090A (ja) * 1995-05-26 2006-12-07 Nobaruteisu Fuaama Kk サイクロデキストリン組成物
JP3934705B2 (ja) * 1995-05-26 2007-06-20 ノバルティス ファーマ株式会社 サイクロデキストリン組成物
CA2252374C (fr) 1996-04-19 2007-08-07 Alpha Therapeutic Corporation Procede d'inactivation de virus dans des proteines sanguines lyophilisees
EP0838225A3 (fr) * 1996-10-25 1999-03-24 Hiji, Yasutake Solution locale anesthétique aqueuse
US6962944B2 (en) 2001-07-31 2005-11-08 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US7074824B2 (en) 2001-07-31 2006-07-11 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
DE10200657B4 (de) * 2002-01-10 2010-12-09 Wacker Chemie Ag 2:1-Komplex aus β- oder γ-Cyclodextrin und α-Tocopherol
FR2835434B1 (fr) * 2002-02-01 2006-03-03 Lvmh Rech Utilisation cosmetique ou dermatologique de la vitamine a ou de ses esters, en association avec une beta-cyclodextrine partiellement methylee
US6960300B2 (en) * 2003-09-08 2005-11-01 Sami Labs Limited Process for preparing water soluble diterpenes and their applications
DE102005017775A1 (de) * 2005-04-13 2006-10-19 Schering Ag Komplexe aus Vitamin D-Verbindungen oder deren Analoga mit einem 5Z,7E,10(19)-Trien-System und methlierten Derivaten des ß-Cyclodextrins
BR112015014028A2 (pt) 2012-12-27 2017-07-11 Shell Int Research composição de aditivo para uso em um combustível diesel, formulação de combustível diesel, e, uso de uma ciclodextrina modificada
CN104903430A (zh) 2012-12-27 2015-09-09 国际壳牌研究有限公司 组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835968B2 (ja) * 1974-02-25 1983-08-05 帝人株式会社 サイクロデキストリン包接化合物の製造法

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* Cited by examiner, † Cited by third party
Title
Adv. in Catalysis, 1973, 23, 209-218 *
Amer. J. Pathol. 1976, 83, 367-674 *
Berichte, 1936, 69, 2041-2045 *
Bioorg. Chem., 1976, 5, 121-126 *
Carbohydr. Res., 1979, 76, 59-66 *
Chem. Ber. 1957, 90, 2561-2573 *
Die Starke, 1977, 29, 26-33 *
Starke, 1974, 26, 111-118 *
Starke, 1976, 28, 226-227 *
Tetrahedron, 1968, 24, 803-821 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582900A (en) * 1983-12-17 1986-04-15 Hoechst Aktiengesellschaft Water-soluble mixed ethers of β-cyclodextrin and a process for their preparation
US4638058A (en) * 1983-12-17 1987-01-20 Hoechst Aktiengesellschaft Ethers of beta-cyclodextrin and a process for their preparation
DE3609116A1 (de) * 1986-03-14 1987-09-17 Herbe Wirkstoffe Gmbh Zubereitungen von gewuerzen oder drogen
DE3815902A1 (de) * 1988-05-10 1989-11-23 Schwarz Pharma Gmbh Einschlussverbindungen des 1-(4-(2-(5-chloro-2-methoxybenzamido)ethyl) -phenylsulfonyl)-3-cyclohexylharnstoffs mit (alpha)-,ss-,(gamma)-cyclodextrinen, jeweils diese enthaltendes pharmazeutisches praeparat und verfahren zu deren herstellung
EP0349091A1 (fr) 1988-07-01 1990-01-03 Walter Adrianus Josephus Johannes Hermens Composition pharmaceutique
WO1990015792A1 (fr) * 1989-06-20 1990-12-27 Aktiebolaget Hässle Nouveaux complexes d'inclusion de cyclodextrine
DE4207922A1 (de) * 1992-03-13 1993-09-23 Pharmatech Gmbh Wasserloesliche einschlussverbindungen und verfahren zu deren herstellung
DE4227569C1 (de) * 1992-08-20 1994-06-09 Inst Chemo Biosensorik Verfahren zum empfindlichen enzymatischen Nachweis von anorganischem Phosphat
DE4405545A1 (de) * 1994-02-22 1995-08-31 Dietl Hans Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US6380227B1 (en) 1998-02-19 2002-04-30 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US6656711B2 (en) 1998-02-19 2003-12-02 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US7101702B2 (en) 1998-02-19 2006-09-05 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
EP2272503A2 (fr) 2003-03-28 2011-01-12 Ares Trading S.A. Formulation orale de cladribine
US7888328B2 (en) 2003-03-28 2011-02-15 Ares Trading S.A. Oral formulations of cladribine
US8623408B2 (en) 2003-03-28 2014-01-07 Ares Trading S.A. Cladribine formulations for improved oral and transmucosal delivery
US8785415B2 (en) 2003-03-28 2014-07-22 Ares Trading S.A. Oral formulations of cladribine
EP3865120A1 (fr) 2013-07-19 2021-08-18 Boehringer Ingelheim Vetmedica GmbH Dérivés de la cyclodextrine éthérifiée préservés contenant une composition pharmaceutique liquide aqueuse

Also Published As

Publication number Publication date
FR2484252B1 (fr) 1984-06-29
HU181703B (en) 1983-11-28
FR2484252A1 (fr) 1981-12-18
AT374684B (de) 1984-05-25
CH661517A5 (de) 1987-07-31
ATA204781A (de) 1983-10-15
BE888736A (fr) 1981-08-28
JPS574914A (en) 1982-01-11

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