DE3105624A1 - Material zum abdichten und heilen von wunden - Google Patents
Material zum abdichten und heilen von wundenInfo
- Publication number
- DE3105624A1 DE3105624A1 DE19813105624 DE3105624A DE3105624A1 DE 3105624 A1 DE3105624 A1 DE 3105624A1 DE 19813105624 DE19813105624 DE 19813105624 DE 3105624 A DE3105624 A DE 3105624A DE 3105624 A1 DE3105624 A1 DE 3105624A1
- Authority
- DE
- Germany
- Prior art keywords
- thrombin
- fibrinogen
- component
- collagen
- substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010052428 Wound Diseases 0.000 title claims abstract description 20
- 208000027418 Wounds and injury Diseases 0.000 title claims abstract description 20
- 238000007789 sealing Methods 0.000 title claims abstract description 6
- 239000000463 material Substances 0.000 title claims description 20
- 102000008186 Collagen Human genes 0.000 claims abstract description 58
- 108010035532 Collagen Proteins 0.000 claims abstract description 58
- 229920001436 collagen Polymers 0.000 claims abstract description 56
- 108010049003 Fibrinogen Proteins 0.000 claims abstract description 41
- 102000008946 Fibrinogen Human genes 0.000 claims abstract description 41
- 229940012952 fibrinogen Drugs 0.000 claims abstract description 41
- 108090000190 Thrombin Proteins 0.000 claims abstract description 40
- 229960004072 thrombin Drugs 0.000 claims abstract description 40
- 239000000126 substance Substances 0.000 claims abstract description 22
- 108010071289 Factor XIII Proteins 0.000 claims abstract description 15
- 229940012444 factor xiii Drugs 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 230000035876 healing Effects 0.000 claims abstract description 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 102000016359 Fibronectins Human genes 0.000 claims abstract description 4
- 108010067306 Fibronectins Proteins 0.000 claims abstract description 4
- 210000001124 body fluid Anatomy 0.000 claims abstract description 4
- 239000010839 body fluid Substances 0.000 claims abstract description 4
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 4
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims abstract description 4
- 210000002950 fibroblast Anatomy 0.000 claims abstract description 4
- 229920000669 heparin Polymers 0.000 claims abstract description 4
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims abstract description 4
- 239000000654 additive Substances 0.000 claims abstract description 3
- 239000002245 particle Substances 0.000 claims description 18
- 239000006260 foam Substances 0.000 claims description 15
- 239000000725 suspension Substances 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 239000003960 organic solvent Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 230000023555 blood coagulation Effects 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000002924 anti-infective effect Effects 0.000 claims description 3
- 238000012986 modification Methods 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002607 heparin antagonist Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 239000003899 bactericide agent Substances 0.000 abstract description 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000003114 blood coagulation factor Substances 0.000 description 10
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 8
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- 102000007327 Protamines Human genes 0.000 description 8
- 108010007568 Protamines Proteins 0.000 description 8
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 8
- 108010073385 Fibrin Proteins 0.000 description 7
- 102000009123 Fibrin Human genes 0.000 description 7
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 7
- 229950003499 fibrin Drugs 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 229940048914 protamine Drugs 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 108010039627 Aprotinin Proteins 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 229960004405 aprotinin Drugs 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 229940105784 coagulation factor xiii Drugs 0.000 description 4
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- -1 acetonitrile Chemical compound 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 229940106780 human fibrinogen Drugs 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 1
- 229940025294 hemin Drugs 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N methyl monoether Natural products COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 210000004911 serous fluid Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229960003766 thrombin (human) Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S602/00—Surgery: splint, brace, or bandage
- Y10S602/90—Method of making bandage structure
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813105624 DE3105624A1 (de) | 1981-02-16 | 1981-02-16 | Material zum abdichten und heilen von wunden |
| EP81110421A EP0059265B1 (de) | 1981-02-16 | 1981-12-14 | Material zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung |
| DE2001199040 DE10199040I2 (de) | 1981-02-16 | 1981-12-14 | Material zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung |
| AT81110421T ATE15143T1 (de) | 1981-02-16 | 1981-12-14 | Material zum abdichten und heilen von wunden und verfahren zu dessen herstellung. |
| DE8181110421T DE3172087D1 (en) | 1981-02-16 | 1981-12-14 | Material for filling and healing wounds, and method for its preparation |
| GR66787A GR75042B (enExample) | 1981-02-16 | 1981-12-15 | |
| ZA82123A ZA82123B (en) | 1981-02-16 | 1982-01-08 | Material for sealing and healing of wounds |
| CA000394076A CA1181689A (en) | 1981-02-16 | 1982-01-13 | Material for sealing and healing of wounds |
| DD82237263A DD206936A1 (de) | 1981-02-16 | 1982-02-08 | Verfahren zur herstellung eines verbandmaterials |
| US06/347,817 US4453939A (en) | 1981-02-16 | 1982-02-11 | Composition for sealing and healing wounds |
| CS82938A CS241502B2 (en) | 1981-02-16 | 1982-02-11 | Method of bandage cloth production |
| EG72/82A EG15603A (en) | 1981-02-16 | 1982-02-12 | Preparation of composition for sealing and healing wounds |
| HU82451A HU183823B (en) | 1981-02-16 | 1982-02-15 | Method for producing bandage material |
| JP57022153A JPS57153645A (en) | 1981-02-16 | 1982-02-16 | Material for closing and treating injured part and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813105624 DE3105624A1 (de) | 1981-02-16 | 1981-02-16 | Material zum abdichten und heilen von wunden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3105624A1 true DE3105624A1 (de) | 1982-09-02 |
Family
ID=6124998
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19813105624 Withdrawn DE3105624A1 (de) | 1981-02-16 | 1981-02-16 | Material zum abdichten und heilen von wunden |
| DE2001199040 Active DE10199040I2 (de) | 1981-02-16 | 1981-12-14 | Material zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung |
| DE8181110421T Expired DE3172087D1 (en) | 1981-02-16 | 1981-12-14 | Material for filling and healing wounds, and method for its preparation |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2001199040 Active DE10199040I2 (de) | 1981-02-16 | 1981-12-14 | Material zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung |
| DE8181110421T Expired DE3172087D1 (en) | 1981-02-16 | 1981-12-14 | Material for filling and healing wounds, and method for its preparation |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4453939A (enExample) |
| EP (1) | EP0059265B1 (enExample) |
| JP (1) | JPS57153645A (enExample) |
| AT (1) | ATE15143T1 (enExample) |
| CA (1) | CA1181689A (enExample) |
| CS (1) | CS241502B2 (enExample) |
| DD (1) | DD206936A1 (enExample) |
| DE (3) | DE3105624A1 (enExample) |
| EG (1) | EG15603A (enExample) |
| GR (1) | GR75042B (enExample) |
| HU (1) | HU183823B (enExample) |
| ZA (1) | ZA82123B (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3212412A1 (de) * | 1982-04-02 | 1983-10-13 | Dr. Ruhland Nachfolger GmbH, 8425 Neustadt | Gewebeverklebbare kollagene wundauflage |
| DE3214337A1 (de) * | 1982-04-19 | 1983-10-27 | Serapharm - Michael Stroetmann, 4400 Münster | Resorbierbares flachmaterial zum abdichten und heilen von wunden und verfahren zu dessen herstellung |
| US5318782A (en) * | 1986-10-03 | 1994-06-07 | Weis Fogh Ulla S | Method for preparing tissue repair promoting substances |
| DE4313724A1 (de) * | 1993-04-27 | 1994-11-03 | Nycomed Arzneimittel Gmbh | Vorrichtung zum gleichmäßigen Auftragen einer Suspension auf einen Kollagenträger |
| US5883078A (en) * | 1995-06-12 | 1999-03-16 | Immuno Aktiengesellschaft | Hemostyptic and tissue adhesive |
| DE10135507A1 (de) * | 2001-07-20 | 2003-02-06 | Henkel Kgaa | Blutstillendes Hautpflaster |
| DE102007045066A1 (de) | 2007-09-20 | 2009-04-02 | Mike Ehrlich | Material zur Blutstillung enthaltend synthetische Peptide oder Polysaccharide |
Families Citing this family (186)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3175003D1 (en) * | 1981-06-25 | 1986-08-28 | Serapharm Gmbh & Co Kg | Enriched plasma derivative for promoting wound sealing and wound healing |
| JPS58180162A (ja) * | 1982-04-19 | 1983-10-21 | 株式会社高研 | 抗血栓性医用材料 |
| SE446688C (sv) * | 1982-09-14 | 1989-10-16 | Magnus Hoeoek | Medel foer avlaegsnande av mikroorganismer fraan vaevnader, vilket bestaar av ett protein som kan bindas till mikroorganismerna |
| US4515637A (en) * | 1983-11-16 | 1985-05-07 | Seton Company | Collagen-thrombin compositions |
| US4738849A (en) * | 1984-06-28 | 1988-04-19 | Interface Biomedical Laboratories Corp. | Composite medical articles for application to wounds and method for producing same |
| US4606910A (en) * | 1984-06-28 | 1986-08-19 | Interface Biomedical Laboratories | Composite hemostatic article including a hemostatic agent onlay and methods for preparing the same |
| US4600533A (en) * | 1984-12-24 | 1986-07-15 | Collagen Corporation | Collagen membranes for medical use |
| JPH0617311B2 (ja) * | 1985-01-24 | 1994-03-09 | 株式会社生体科学研究所 | 正常組織生物活性亢進剤 |
| JPS62205711A (ja) * | 1986-03-03 | 1987-09-10 | 株式会社クボタ | 田植機の植付装置姿勢制御構造 |
| US4894328A (en) * | 1986-03-26 | 1990-01-16 | Board Of Regents, The University Of Texas System | Immunodiagnostic test for syphilis and other treponemal infections |
| US4760131A (en) * | 1986-04-23 | 1988-07-26 | Collagen Corporation | Wound-healing composition |
| CA1294546C (en) * | 1986-04-23 | 1992-01-21 | John S. Sundsmo | Wound healing composition containing collagen |
| WO1987007153A1 (en) * | 1986-05-29 | 1987-12-03 | Interface Biomedical Laboratories Corporation | Composite hemostatic article including a hemostatic agent onlay and methods for preparing the same |
| DE3622642A1 (de) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
| JPS649514U (enExample) * | 1987-07-03 | 1989-01-19 | ||
| AT407834B (de) * | 1987-10-08 | 2001-06-25 | Aventis Behring Gmbh | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
| JPH0199565A (ja) * | 1987-10-12 | 1989-04-18 | Green Cross Corp:The | フィブリン糊調製用キット |
| US4961707A (en) * | 1987-12-22 | 1990-10-09 | University Of Florida | Guided periodontal tissue regeneration |
| US4973466A (en) * | 1988-06-21 | 1990-11-27 | Chiron Ophthalmics, Inc. | Wound-healing dressings and methods |
| US4863668A (en) * | 1988-09-22 | 1989-09-05 | University Of Utah | Method of forming fibrin-collagen nerve and body tissue repair material |
| US5700479A (en) * | 1988-12-23 | 1997-12-23 | Guidor Ab | Surgical element and method for selective tissue regeneration |
| US5196185A (en) * | 1989-09-11 | 1993-03-23 | Micro-Collagen Pharmaceutics, Ltd. | Collagen-based wound dressing and method for applying same |
| US5219328A (en) * | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
| US5318524A (en) * | 1990-01-03 | 1994-06-07 | Cryolife, Inc. | Fibrin sealant delivery kit |
| US5030215A (en) * | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
| US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
| US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US6117425A (en) * | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| US7208179B1 (en) | 1990-11-27 | 2007-04-24 | The American National Red Cross | Methods for treating disease and forming a supplemented fibrin matrix |
| US5219895A (en) * | 1991-01-29 | 1993-06-15 | Autogenesis Technologies, Inc. | Collagen-based adhesives and sealants and methods of preparation and use thereof |
| US5792835A (en) * | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
| IL105529A0 (en) * | 1992-05-01 | 1993-08-18 | Amgen Inc | Collagen-containing sponges as drug delivery for proteins |
| US5330974A (en) * | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
| US5942278A (en) * | 1993-03-31 | 1999-08-24 | Nycomed Arzneimittel Gmbh | Process for the production of a material for sealing and healing wounds |
| AT502891B1 (de) * | 1993-03-31 | 2008-04-15 | Nycomed Austria Gmbh | Verfahren und vorrichtung zum gleichmässigen auftragen einer suspension auf einen kollagenträger |
| US6177126B1 (en) | 1993-03-31 | 2001-01-23 | Nycomed Arzneimittel Gmbh | Process for the production of a material for sealing and healing wounds |
| AT410754B (de) * | 1993-03-31 | 2003-07-25 | Nycomed Austria Gmbh | Vorrichtung zum gleichmässigen auftragen einer suspension auf einen kollagenträger |
| EP0726749B1 (en) * | 1993-11-03 | 2004-08-11 | Clarion Pharmaceuticals, Inc. | Hemostatic patch |
| US5931165A (en) * | 1994-09-06 | 1999-08-03 | Fusion Medical Technologies, Inc. | Films having improved characteristics and methods for their preparation and use |
| US5660873A (en) * | 1994-09-09 | 1997-08-26 | Bioseal, Limited Liability Corporaton | Coating intraluminal stents |
| US5585007A (en) | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
| US5643192A (en) * | 1995-04-06 | 1997-07-01 | Hamilton Civic Hospitals Research Development, Inc. | Autologous fibrin glue and methods for its preparation and use |
| US20030105007A1 (en) * | 1995-06-07 | 2003-06-05 | Andre Beaulieu | PDGF-betabeta and fibronectin combined in a solid wound dressing for the treatment of wounds |
| CZ292389B6 (cs) * | 1995-12-13 | 2003-09-17 | Nycomed Austria Gmbh | Nástroj pro aplikaci chirurgického materiálu |
| WO1997028832A1 (en) * | 1996-02-06 | 1997-08-14 | New Generation Medical Corporation | Composition for sealing wounds |
| GB2311027B (en) * | 1996-03-15 | 1999-10-27 | Johnson & Johnson Medical | Coated bioabsorbable beads for wound treatment |
| HUP9903586A3 (en) * | 1996-04-04 | 2003-02-28 | Baxter Ag | Hemostatic sponge based on collagen |
| WO2000062828A1 (en) * | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
| US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
| US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
| US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
| US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| US6063061A (en) * | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| WO1998016165A1 (en) * | 1996-10-16 | 1998-04-23 | Fusion Medical Technologies, Inc. | Films having improved characteristics and methods for their preparation and use |
| US6762336B1 (en) | 1998-01-19 | 2004-07-13 | The American National Red Cross | Hemostatic sandwich bandage |
| AU2596999A (en) * | 1998-02-18 | 1999-09-06 | Research Foundation Of The State University Of New York, The | Galactosaminoglycan-based extracellular matrix for wound healing |
| US6194378B1 (en) | 1998-02-18 | 2001-02-27 | The Research Foundation Of State University Of New York | Fibronectin peptides-based extracellular matrix for wound healing |
| US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
| DE19841698A1 (de) * | 1998-09-11 | 2000-03-16 | Curative Technologies Gmbh | Wachstumsfaktor-enthaltende Zusammensetzung zur Heilung von Gewebeschäden |
| DE19851334C2 (de) * | 1998-11-06 | 2000-09-28 | Aventis Behring Gmbh | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
| DE59913287D1 (de) | 1998-11-18 | 2006-05-18 | Zlb Behring Gmbh | Stabilisierte proteinzubereitungen für einen gewebekleber |
| US7276235B2 (en) * | 1998-11-18 | 2007-10-02 | Zlb Behring Gmbh | Tissue glue with improved antiadhesive properties |
| US7572769B2 (en) | 1998-12-23 | 2009-08-11 | Csl Behring Gmbh | Fibrin adhesive granulate and method for its preparation |
| DE59902496D1 (de) * | 1998-12-23 | 2002-10-02 | Aventis Behring Gmbh | Fibrinklebergranulat und verfahren zu dessen herstellung |
| US6946140B1 (en) * | 1999-02-09 | 2005-09-20 | The Research Foundation Of State University Of New York | Methods and compositions for enhancing fibroblast migration |
| WO2000047148A1 (en) * | 1999-02-09 | 2000-08-17 | The Research Foundation Of State University Of New York | Methods and compositions for enhancing fibroblast migration |
| JP4771594B2 (ja) * | 1999-02-12 | 2011-09-14 | バクスター アクチェンゲゼルシャフト | フィブリノーゲンおよびフィブロネクチンをベースとする製剤を生成するための方法ならびにこの方法により入手可能なタンパク質組成物 |
| DE60027695T2 (de) * | 1999-02-12 | 2007-04-26 | Baxter Ag | Verfahren zur herstellung von fibrinogen und fibronectin sowie proteinzusammesetzungen, welche damit herstellbar sind |
| US6472162B1 (en) | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
| US6183498B1 (en) | 1999-09-20 | 2001-02-06 | Devore Dale P. | Methods and products for sealing a fluid leak in a tissue |
| US20030095993A1 (en) * | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
| DE60137489D1 (de) * | 2000-02-03 | 2009-03-12 | Tissuemed Ltd | Gerät zum verschliessen einer chirurgischen punktionswunde |
| US20070009586A1 (en) * | 2000-02-29 | 2007-01-11 | Cohen Kelman I | Wound dressings containing complexes of transition metals and alginate for elastase sequestering |
| US6627785B1 (en) | 2000-02-29 | 2003-09-30 | Virginia Commwealth University | Wound dressings with protease-lowering activity |
| WO2004087227A1 (en) * | 2003-04-04 | 2004-10-14 | Tissuemed Limited | Tissue-adhesive formulations |
| US6309454B1 (en) | 2000-05-12 | 2001-10-30 | Johnson & Johnson Medical Limited | Freeze-dried composite materials and processes for the production thereof |
| US6447799B1 (en) * | 2000-07-24 | 2002-09-10 | Joseph M. Ullman | Thromboplastic system |
| DE60108258T2 (de) * | 2000-10-23 | 2006-03-16 | Tissuemed Ltd. | Selbstklebende, hydratierbare matrix für therapeutische anwendungen |
| US6648911B1 (en) | 2000-11-20 | 2003-11-18 | Avantec Vascular Corporation | Method and device for the treatment of vulnerable tissue site |
| US20020164322A1 (en) * | 2001-01-25 | 2002-11-07 | Alfred Schaufler | Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such a suspension, a method for coating a carrier with such a suspension, a method of drying a coating of a carrier, and a coated collagen sponge |
| US7098315B2 (en) | 2001-01-25 | 2006-08-29 | Nycomed Pharma As | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
| BRPI0206708B8 (pt) * | 2001-01-25 | 2021-06-22 | Nycomed Pharma As | composição sólida, composição para hemostasia, vedação de tecido e colagem de tecido, e, usos de um veículo de colágeno |
| US6733774B2 (en) | 2001-01-25 | 2004-05-11 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
| US7052713B2 (en) | 2001-02-13 | 2006-05-30 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
| US6656488B2 (en) * | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
| WO2004010913A1 (en) * | 2001-07-25 | 2004-02-05 | Us Army Medical Research & Materiel Command | Fibrinogen bandages and methods |
| US7374678B2 (en) | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US7179391B2 (en) | 2002-05-24 | 2007-02-20 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| JP4777650B2 (ja) * | 2002-09-10 | 2011-09-21 | アメリカン ナショナル レッド クロス | 止血用包帯 |
| EP1588722A4 (en) * | 2003-01-20 | 2011-03-02 | Chemo Sero Therapeut Res Inst | HEMOSTATIC MATERIALS |
| US20040243044A1 (en) * | 2003-06-02 | 2004-12-02 | Penegor Stephen A. | Hemostatic wound dressing |
| US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
| US7927626B2 (en) * | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| US7824711B2 (en) | 2003-12-11 | 2010-11-02 | Isto Technologies, Inc. | Particulate cartilage system |
| KR20070026578A (ko) * | 2004-05-21 | 2007-03-08 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 조직 봉합제 |
| WO2006013337A2 (en) * | 2004-08-03 | 2006-02-09 | Tissuemed Limited | Tissue-adhesive materials |
| JP2008510476A (ja) * | 2004-08-27 | 2008-04-10 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 生物学的材料からのｘｉｉｉ因子ポリペプチドの精製 |
| JPWO2006033433A1 (ja) * | 2004-09-24 | 2008-05-15 | 財団法人化学及血清療法研究所 | 創傷治癒剤 |
| US20060258995A1 (en) * | 2004-10-20 | 2006-11-16 | Pendharkar Sanyog M | Method for making a reinforced absorbable multilayered fabric for use in medical devices |
| US9358318B2 (en) * | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
| AU2005295365B2 (en) | 2004-10-20 | 2010-08-05 | Ethicon, Inc. | Absorbable hemostat |
| JP5086093B2 (ja) * | 2004-11-23 | 2012-11-28 | ジモジェネティクス、インコーポレイテッド | 組換え型ヒトｘｉｉｉ因子の精製 |
| EP2666494B1 (en) | 2005-02-07 | 2018-01-17 | Hanuman LLC | Platelet rich plasma concentrate apparatus and method |
| WO2006086201A2 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| EP1916964A4 (en) | 2005-08-26 | 2015-11-04 | Zimmer Inc | IMPLANTS AND METHODS FOR THE REPAIR, REPLACEMENT AND TREATMENT OF JOINT DISEASES |
| US20070083972A1 (en) * | 2005-09-26 | 2007-04-19 | Peter Francis | Rebel office shirt |
| US8277837B2 (en) | 2006-01-11 | 2012-10-02 | Entegrion, Inc. | Hemostatic textile |
| WO2007088402A2 (en) | 2006-02-03 | 2007-08-09 | Tissuemed Limited | Tissue-adhesive materials |
| US20090018575A1 (en) * | 2006-03-01 | 2009-01-15 | Tissuemed Limited | Tissue-adhesive formulations |
| US20070224251A1 (en) * | 2006-03-22 | 2007-09-27 | Masao Tanihara | Hemostatic material |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| AU2007267338B2 (en) * | 2006-05-31 | 2013-04-04 | Baxter Healthcare S.A. | Method for directed cell in-growth and controlled tissue regeneration in spinal surgery |
| TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
| US20080033332A1 (en) * | 2006-08-04 | 2008-02-07 | Macphee Martin | Solid dressing for treating wounded tissue |
| US20160106883A1 (en) * | 2014-10-15 | 2016-04-21 | Stb, Ltd. | Processes For Mixing Fibrinogen and Thrombin Under Conditions That Minimize Fibrin Formation While Preserving Fibrin-forming Ability, Compositions Produced by These Processes, and the Use Thereof |
| US20080138387A1 (en) * | 2006-12-07 | 2008-06-12 | Machiraju Venkat R | Hemostatic sponge and article |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| JP5479319B2 (ja) | 2007-04-12 | 2014-04-23 | バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー | ブイ式懸濁液分画システム |
| AU2008240191B2 (en) | 2007-04-12 | 2013-09-19 | Zimmer, Inc. | Compositions and methods for tissue repair |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US20100239560A1 (en) * | 2007-04-20 | 2010-09-23 | Jens Hassingboe | Multi component non-woven |
| WO2009020612A1 (en) * | 2007-08-06 | 2009-02-12 | Stb Lifesaving Technologies, Inc. | Methods and dressing for sealing internal injuries |
| GB0715514D0 (en) * | 2007-08-10 | 2007-09-19 | Tissuemed Ltd | Coated medical devices |
| CL2008003219A1 (es) | 2007-10-30 | 2009-10-09 | Baxter Int | Uso de una biomatriz de colageno biofuncional, multicapas y no porosa, que dirige el crecimiento celular dentro de los intersticios de la biomatriz de colageno, para tratar un defecto de una membrana visceral o parietal; y biomatriz utilizada. |
| EP2567692B1 (en) | 2008-02-27 | 2016-04-06 | Biomet Biologics, LLC | Use of a device for obtaining interleukin-1 receptor antagonist rich solutions |
| US8642831B2 (en) | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| US8337711B2 (en) | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
| EP2269594B1 (en) | 2008-04-16 | 2016-03-02 | The Chemo-Sero-Therapeutic Research Institute | Method of producing thrombin-immobilized bioabsorbable sheet preparation |
| US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
| CA2765117C (en) * | 2009-06-16 | 2017-07-11 | Joris Hoefinghoff | Hemostatic sponge |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| WO2011035020A1 (en) * | 2009-09-18 | 2011-03-24 | Bioinspire Technologies, Inc. | Free-standing biodegradable patch |
| US9271925B2 (en) | 2013-03-11 | 2016-03-01 | Bioinspire Technologies, Inc. | Multi-layer biodegradable device having adjustable drug release profile |
| JP2013514093A (ja) | 2009-12-16 | 2013-04-25 | バクスター・インターナショナル・インコーポレイテッド | 止血スポンジ |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| WO2011151386A1 (en) | 2010-06-01 | 2011-12-08 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
| WO2011151384A1 (en) | 2010-06-01 | 2011-12-08 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
| JP6289096B2 (ja) | 2010-06-01 | 2018-03-07 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 乾燥した安定な止血組成物を作製するためのプロセス |
| US9427360B2 (en) | 2010-11-04 | 2016-08-30 | W. Jerry Mezger | Hemostatic fabric |
| MY185054A (en) | 2011-05-24 | 2021-04-30 | Takeda As | Rolled collagen carrier |
| RU2013155713A (ru) | 2011-07-06 | 2015-08-20 | Профибрикс Бв | Составы для лечения ран |
| WO2013048787A1 (en) | 2011-09-26 | 2013-04-04 | Yes, Inc. | Novel hemostatic compositions and dressings for bleeding |
| ES2938568T3 (es) | 2011-10-11 | 2023-04-12 | Baxter Int | Composiciones hemostaticas |
| EP2766058B1 (en) | 2011-10-11 | 2022-11-23 | Baxter International Inc. | Hemostatic compositions |
| WO2013056116A1 (en) * | 2011-10-12 | 2013-04-18 | The Trustees Of Columbia University In The City Of New York | Hemostatic dressing for arterial bleeding |
| SG11201401878SA (en) | 2011-10-27 | 2014-09-26 | Baxter Int | Hemostatic compositions |
| CA2865349C (en) | 2012-03-06 | 2021-07-06 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
| JP5844894B2 (ja) | 2012-05-14 | 2016-01-20 | 帝人株式会社 | シート成形体および止血材 |
| KR102107257B1 (ko) | 2012-05-24 | 2020-05-07 | 다케다 에이에스 | 포장재 |
| KR102162416B1 (ko) | 2012-05-24 | 2020-10-07 | 다케다 에이에스 | 코일링된 콜라겐 캐리어를 제공하기 위한 장치 및 방법 |
| EP2825216B1 (en) | 2012-06-12 | 2015-08-19 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| AU2014283170B2 (en) | 2013-06-21 | 2017-11-02 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
| US10765774B2 (en) | 2013-07-09 | 2020-09-08 | Ethicon, Inc. | Hemostatic pad assembly kit and method |
| RU2678592C1 (ru) | 2013-12-11 | 2019-01-30 | Ферросан Медикал Дивайсиз А/С | Сухая композиция, содержащая компонент, улучшающий экструзию |
| US10406255B2 (en) | 2014-05-28 | 2019-09-10 | Highland Industries, Inc. | Hemostatic textile |
| BR112017007466B1 (pt) | 2014-10-13 | 2021-03-02 | Ferrosan Medical Devices A/S | método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca |
| BR112017013565B1 (pt) | 2014-12-24 | 2021-12-28 | Ferrosan Medical Devices A/S | Seringa para retenção e mistura de primeira e segunda substâncias |
| JP6810052B2 (ja) | 2015-03-27 | 2021-01-06 | スリーエム イノベイティブ プロパティズ カンパニー | フィブリン組成物、方法及び創傷物品 |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| RU2717356C2 (ru) | 2015-07-03 | 2020-03-23 | Ферросан Медикал Дивайсиз А/С | Шприц для удерживания вакуума в состоянии хранения |
| EP3522942B1 (en) | 2016-10-05 | 2023-12-27 | 3M Innovative Properties Company | Fibrin composition comprising carrier material, method and wound articles |
| WO2018067622A1 (en) | 2016-10-05 | 2018-04-12 | 3M Innovative Properties Company | Fibrinogen composition, method and wound articles |
| US20190255116A1 (en) | 2016-10-18 | 2019-08-22 | Osaka University | Kit for preparing disease-treating agent, disease-treating agent and method for preparing disease-treating agent |
| KR20210008479A (ko) | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
| EP3895890B1 (en) | 2018-12-14 | 2024-07-03 | Bmg Incorporated | Two-reactant sheet-form tissue-adhesive-reinforcing material |
| US12285540B2 (en) | 2020-07-21 | 2025-04-29 | Ethicon, Inc. | Hemostatic composite aggregate materials having surface enriched with hemostatis-promoting agents |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2914822A1 (de) * | 1978-04-12 | 1979-10-18 | Unitika Ltd | Material zum heilen von wunden |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB704517A (en) * | 1951-08-07 | 1954-02-24 | Schering Ag | Improvements relating to media for stopping the flow of blood |
| FR6652M (enExample) * | 1966-12-28 | 1969-01-27 | ||
| AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
-
1981
- 1981-02-16 DE DE19813105624 patent/DE3105624A1/de not_active Withdrawn
- 1981-12-14 EP EP81110421A patent/EP0059265B1/de not_active Expired
- 1981-12-14 DE DE2001199040 patent/DE10199040I2/de active Active
- 1981-12-14 DE DE8181110421T patent/DE3172087D1/de not_active Expired
- 1981-12-14 AT AT81110421T patent/ATE15143T1/de active
- 1981-12-15 GR GR66787A patent/GR75042B/el unknown
-
1982
- 1982-01-08 ZA ZA82123A patent/ZA82123B/xx unknown
- 1982-01-13 CA CA000394076A patent/CA1181689A/en not_active Expired
- 1982-02-08 DD DD82237263A patent/DD206936A1/de not_active IP Right Cessation
- 1982-02-11 US US06/347,817 patent/US4453939A/en not_active Expired - Lifetime
- 1982-02-11 CS CS82938A patent/CS241502B2/cs unknown
- 1982-02-12 EG EG72/82A patent/EG15603A/xx active
- 1982-02-15 HU HU82451A patent/HU183823B/hu unknown
- 1982-02-16 JP JP57022153A patent/JPS57153645A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2914822A1 (de) * | 1978-04-12 | 1979-10-18 | Unitika Ltd | Material zum heilen von wunden |
Non-Patent Citations (1)
| Title |
|---|
| AT-Z: Wiener Medizinische Wochenschrift, Nr. 7, Seiten 86 bis 89 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3212412A1 (de) * | 1982-04-02 | 1983-10-13 | Dr. Ruhland Nachfolger GmbH, 8425 Neustadt | Gewebeverklebbare kollagene wundauflage |
| DE3214337A1 (de) * | 1982-04-19 | 1983-10-27 | Serapharm - Michael Stroetmann, 4400 Münster | Resorbierbares flachmaterial zum abdichten und heilen von wunden und verfahren zu dessen herstellung |
| US5318782A (en) * | 1986-10-03 | 1994-06-07 | Weis Fogh Ulla S | Method for preparing tissue repair promoting substances |
| DE4313724A1 (de) * | 1993-04-27 | 1994-11-03 | Nycomed Arzneimittel Gmbh | Vorrichtung zum gleichmäßigen Auftragen einer Suspension auf einen Kollagenträger |
| DE4313724C2 (de) * | 1993-04-27 | 2003-12-11 | Nycomed Austria Gmbh Linz | Vorrichtung zum gleichmäßigen Auftragen einer Suspension auf einen Kollagenträger |
| US5883078A (en) * | 1995-06-12 | 1999-03-16 | Immuno Aktiengesellschaft | Hemostyptic and tissue adhesive |
| DE10135507A1 (de) * | 2001-07-20 | 2003-02-06 | Henkel Kgaa | Blutstillendes Hautpflaster |
| DE102007045066A1 (de) | 2007-09-20 | 2009-04-02 | Mike Ehrlich | Material zur Blutstillung enthaltend synthetische Peptide oder Polysaccharide |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA82123B (en) | 1982-11-24 |
| US4453939A (en) | 1984-06-12 |
| CS241502B2 (en) | 1986-03-13 |
| DE10199040I1 (de) | 2001-11-22 |
| GR75042B (enExample) | 1984-07-12 |
| ATE15143T1 (de) | 1985-09-15 |
| DE10199040I2 (de) | 2003-01-09 |
| HU183823B (en) | 1984-06-28 |
| EG15603A (en) | 1986-09-30 |
| EP0059265A1 (de) | 1982-09-08 |
| DE3172087D1 (en) | 1985-10-03 |
| JPS57153645A (en) | 1982-09-22 |
| JPS6134830B2 (enExample) | 1986-08-09 |
| EP0059265B1 (de) | 1985-08-28 |
| DD206936A1 (de) | 1984-02-15 |
| CA1181689A (en) | 1985-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0059265B1 (de) | Material zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung | |
| EP0090997B1 (de) | Gewebeverklebbare kollagene Wundauflage | |
| DE19521324C1 (de) | Gewebeklebstoff und Verwendung desselben als Hämostyptikum | |
| DE915973C (de) | Verfahren zur Herstellung von haemostatisch wirkenden Pfropfen und Verbaenden | |
| DE69329875T2 (de) | Verfahren zur herstellung eines mit plättchenfaktoren angereicherten biologischen klebstoffes und seine verwendung | |
| EP0068048B1 (de) | Angereichertes Plasmaderivat zur Unterstützung von Wundverschluss und Wundabdeckung | |
| DE60203364T2 (de) | Träger mit festem fibrinogen und thrombin | |
| DE19851334C2 (de) | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung | |
| DE69333286T2 (de) | Eine thrombin-blutfraktion zur verwendung in einem medizinischen verfahren | |
| EP0092200B1 (de) | Resorbierbares Flachmaterial zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung | |
| DE69724243T2 (de) | Blutstillender schwamm auf kollagenbasis | |
| EP0049469B1 (de) | Kollagene Wundauflage | |
| DE69004098T2 (de) | Medizinisches spendesystem für gewebeklebstoffkomponenten. | |
| DE60101956T2 (de) | Schaumbildender wundverband | |
| DE3740728A1 (de) | Klebstoff | |
| EP2143771B1 (de) | Klebstoffzusammensetzung, insbesondere zur verwendung in der chirurgischen medizin | |
| DE3042860A1 (de) | Kollagenpraeparate, verfahren zu ihrer herstellung und ihre verwendung in der human- und veterinaermedizin | |
| EP0321442B1 (de) | Biologisch resorbierbares Implantationsmaterial sowie Verfahren zur Herstellung desselben | |
| EP2812037A1 (de) | Biodegradierbares vlies für medizinische zwecke | |
| EP2147687B1 (de) | Flächiges Implantat | |
| EP2098255B1 (de) | Verfahren zur Herstellung von Kollagen-material | |
| DE60121826T2 (de) | Fibrinmaterial und verfahren zu seiner herstellung und verwendung | |
| DE102008033378A1 (de) | Klebstoffzusammensetzung, insbesondere zur Verwendung in der chirurgischen Medizin | |
| DE19858463A1 (de) | Verwendung eines Fibrinklebers zur Regeneration des Lebergewebes | |
| DE1960614A1 (de) | Schaumstoff fuer medizinische,insbesondere zahnmedizinische Zwecke |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OM8 | Search report available as to paragraph 43 lit. 1 sentence 1 patent law | ||
| 8130 | Withdrawal |