CN104470475B - 用于提供卷绕的胶原蛋白载体的设备和工艺 - Google Patents
用于提供卷绕的胶原蛋白载体的设备和工艺 Download PDFInfo
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- CN104470475B CN104470475B CN201380039414.9A CN201380039414A CN104470475B CN 104470475 B CN104470475 B CN 104470475B CN 201380039414 A CN201380039414 A CN 201380039414A CN 104470475 B CN104470475 B CN 104470475B
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/36—Surgical swabs, e.g. for absorbency or packing body cavities during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/38—Swabs having a stick-type handle, e.g. cotton tips
- A61F13/385—Apparatus or processes of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C53/00—Shaping by bending, folding, twisting, straightening or flattening; Apparatus therefor
- B29C53/80—Component parts, details or accessories; Auxiliary operations
- B29C53/8008—Component parts, details or accessories; Auxiliary operations specially adapted for winding and joining
- B29C53/8016—Storing, feeding or applying winding materials, e.g. reels, thread guides, tensioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C53/00—Shaping by bending, folding, twisting, straightening or flattening; Apparatus therefor
- B29C53/36—Bending and joining, e.g. for making hollow articles
- B29C53/38—Bending and joining, e.g. for making hollow articles by bending sheets or strips at right angles to the longitudinal axis of the article being formed and joining the edges
- B29C53/48—Bending and joining, e.g. for making hollow articles by bending sheets or strips at right angles to the longitudinal axis of the article being formed and joining the edges for articles of indefinite length, i.e. bending a strip progressively
- B29C53/52—Bending and joining, e.g. for making hollow articles by bending sheets or strips at right angles to the longitudinal axis of the article being formed and joining the edges for articles of indefinite length, i.e. bending a strip progressively using external forming surfaces, e.g. sleeves
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Manufacturing & Machinery (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Compression Or Coding Systems Of Tv Signals (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (32)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DK2012/050178 WO2012159635A1 (en) | 2011-05-24 | 2012-05-24 | Rolled collagen carrier |
DKPCT/DK2012/050178 | 2012-05-24 | ||
EP12194089 | 2012-11-23 | ||
EP12194089.4 | 2012-11-23 | ||
PCT/EP2013/060532 WO2013174874A1 (en) | 2012-05-24 | 2013-05-22 | Apparatus and process for providing a coiled collagen carrier |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104470475A CN104470475A (zh) | 2015-03-25 |
CN104470475B true CN104470475B (zh) | 2017-04-19 |
Family
ID=47257571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380039414.9A Expired - Fee Related CN104470475B (zh) | 2012-05-24 | 2013-05-22 | 用于提供卷绕的胶原蛋白载体的设备和工艺 |
Country Status (13)
Country | Link |
---|---|
US (2) | US10213345B2 (zh) |
EP (1) | EP2854735B1 (zh) |
JP (1) | JP6242873B2 (zh) |
KR (1) | KR102162416B1 (zh) |
CN (1) | CN104470475B (zh) |
BR (1) | BR112014028594B1 (zh) |
CA (1) | CA2871697C (zh) |
DK (1) | DK2854735T3 (zh) |
ES (1) | ES2724233T3 (zh) |
HK (1) | HK1207554A1 (zh) |
IL (1) | IL235760B (zh) |
RU (1) | RU2670746C9 (zh) |
WO (1) | WO2013174874A1 (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002058750A2 (en) * | 2001-01-25 | 2002-08-01 | Nycomed Pharma As | A suspension comprising fibrinogen, thrombin and alcohol and a method of coating a carrier with the same |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE404337A (zh) | 1933-02-11 | 1900-01-01 | ||
GB423017A (en) | 1934-05-24 | 1935-01-23 | Koninklijke Pharma Fab Nv | A process and apparatus for the manufacture of threads, strings, bands, films and the like from animal fibres |
GB487258A (en) | 1936-02-07 | 1938-06-17 | Koninklijke Pharma Fab Nv | Tampons and other porous articles, such as sheaths and bandages, and a process for producing same |
US3759375A (en) | 1971-05-21 | 1973-09-18 | J Nappi | Disposable swab-type applicator package |
DE2207217A1 (de) * | 1972-02-16 | 1973-08-23 | Becker & Co Naturinwerk | Kranzdarm aus kollagen fuer rohwurst |
DE3105624A1 (de) | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
US5147387A (en) | 1990-10-10 | 1992-09-15 | W. L. Gore & Associates, Inc. | Process of implanting a prosthetic sheet repair material |
US5290310A (en) | 1991-10-30 | 1994-03-01 | Howmedica, Inc. | Hemostatic implant introducer |
RU2018540C1 (ru) * | 1992-11-23 | 1994-08-30 | Товарищество с ограниченной ответственностью Фирма "Копримекс" | Способ получения коллагенсодержащего материала |
US5334216A (en) | 1992-12-10 | 1994-08-02 | Howmedica Inc. | Hemostatic plug |
US5942278A (en) | 1993-03-31 | 1999-08-24 | Nycomed Arzneimittel Gmbh | Process for the production of a material for sealing and healing wounds |
US6177126B1 (en) | 1993-03-31 | 2001-01-23 | Nycomed Arzneimittel Gmbh | Process for the production of a material for sealing and healing wounds |
DE19515517C2 (de) * | 1995-04-27 | 1997-08-14 | Johnson & Johnson Gmbh | Verfahren und Vorrichtung zur kontinuierlichen Herstellung von Längenabschnitten aus einem Strang Flüssigkeit absorbierenden Materials sowie dessen Verwendung |
AT402683B (de) | 1995-05-16 | 1997-07-25 | Hafslund Nycomed Pharma | Gerät für endoskopische oder laparoskopische applikation von chirurgischem material |
DE19546435A1 (de) | 1995-12-13 | 1997-06-19 | Nycomed Arzneimittel Gmbh | Vorrichtung zum Einbringen von wundheilendem oder wundversiegelnden Material in den Körper |
ATE196413T1 (de) | 1995-12-13 | 2000-10-15 | Nycomed Arzneimittel Gmbh | Applikator für chirurgisches material |
IT1286223B1 (it) * | 1996-09-18 | 1998-07-08 | Awax Progettazione | Apparato per il confezionamento di prodotti in atmosfera modificata e controllata, con film estensibile ed impermeabile al gas |
RU2118176C1 (ru) * | 1996-09-27 | 1998-08-27 | Истранов Леонид Прокофьевич | Способ получения коллагеновых пластинок |
TW501934B (en) * | 1996-11-20 | 2002-09-11 | Tapic Int Co Ltd | Collagen material and process for making the same |
EP1009291B8 (en) | 1997-03-20 | 2006-01-11 | Genzyme Corporation | Biodegradable tissue retractor |
FR2777284B1 (fr) * | 1998-04-10 | 2000-05-26 | Hamza Mansour | Procede de sterilisation d'un collagene natif en milieu liquide, collagene natif sterile obtenu, compositions le contenant et applications |
JP3726280B2 (ja) * | 1998-09-18 | 2005-12-14 | ニプロ株式会社 | 医療用コラーゲン膜 |
DE19922078A1 (de) | 1999-05-15 | 2000-11-23 | Weitzel Kage Doris | Gewebekonstrukt für die Transplantationschirurgie |
US20020164322A1 (en) | 2001-01-25 | 2002-11-07 | Alfred Schaufler | Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such a suspension, a method for coating a carrier with such a suspension, a method of drying a coating of a carrier, and a coated collagen sponge |
US7052713B2 (en) * | 2001-02-13 | 2006-05-30 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
WO2002083021A1 (en) | 2001-04-13 | 2002-10-24 | I-Flow Corporation | Sterile container for medical applications |
US8465516B2 (en) | 2001-07-26 | 2013-06-18 | Oregon Health Science University | Bodily lumen closure apparatus and method |
EP1408847B1 (en) | 2001-07-26 | 2005-05-04 | Oregon Health Sciences University | Vessel closure member and delivery apparatus |
WO2003065877A2 (en) | 2002-02-04 | 2003-08-14 | Damage Control Surgical Technologies, Inc. | Method and apparatus for improved hemostasis and damage control operations |
US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
JP4581318B2 (ja) * | 2002-08-09 | 2010-11-17 | ニプロ株式会社 | 生分解性筒状体およびそれを用いた生体組織または器官再生器具 |
JP4168740B2 (ja) * | 2002-12-12 | 2008-10-22 | ニプロ株式会社 | コラーゲン製人工血管 |
RU2235539C1 (ru) * | 2003-04-25 | 2004-09-10 | Филатов Владимир Николаевич | Способ получения порошкообразного материала для остановки кровотечений |
US20050208095A1 (en) | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Polymer compositions and methods for their use |
US8133500B2 (en) * | 2003-12-04 | 2012-03-13 | Kensey Nash Bvf Technology, Llc | Compressed high density fibrous polymers suitable for implant |
CN1231633C (zh) * | 2004-05-17 | 2005-12-14 | 陕西科技大学 | 一种利用胶原纤维与植物纤维复合生活用纸的方法 |
GB0415080D0 (en) | 2004-07-05 | 2004-08-04 | Ucl Biomedica Plc | Methods for preparing tissue equivalent implants and products thereof |
DK1809343T3 (da) | 2004-10-20 | 2012-11-26 | Ethicon Inc | Forstærket absorberbar hæmostatisk flerlagssårforbinding samt fremstillingsfremgangsmåde |
CA2606445C (en) | 2005-04-29 | 2014-09-16 | Cook Biotech Incorporated | Volumetric grafts for treatment of fistulae and related methods and systems |
JP4765602B2 (ja) * | 2005-12-14 | 2011-09-07 | ニプロ株式会社 | 再生医療用器具の包装体及び再生医療用器具用の処理方法 |
US8795709B2 (en) | 2006-03-29 | 2014-08-05 | Incept Llc | Superabsorbent, freeze dried hydrogels for medical applications |
DE202006009712U1 (de) | 2006-06-22 | 2007-10-25 | Groninger & Co. Gmbh | Umverpackung für Magazinkästen |
AU2009220808B2 (en) | 2008-03-03 | 2014-01-16 | Omrix Biopharmaceuticals Ltd. | A gelatin sponge comprising an active ingredient, its preparation and use |
US9399082B2 (en) | 2008-04-11 | 2016-07-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Electrospun dextran fibers and devices formed therefrom |
WO2009134417A2 (en) | 2008-04-30 | 2009-11-05 | Alexander Poltorak | Mutli-tier quality of service wireless communications networks |
WO2009134991A2 (en) | 2008-04-30 | 2009-11-05 | Ethicon, Inc. | Tissue engineered blood vessel |
CN102076364B (zh) | 2008-05-02 | 2014-07-02 | 普罗维登斯医疗卫生系统-俄勒冈州D/B/A普罗维登斯圣文森特医疗中心 | 创伤敷裹装置和方法 |
JP5157689B2 (ja) | 2008-07-07 | 2013-03-06 | ニプロ株式会社 | 内視鏡下手術用デバイス |
US9061464B2 (en) | 2008-09-03 | 2015-06-23 | Collagen Matrix, Inc. | Re-rollable wrapping implant |
EP2163230B1 (de) | 2008-09-12 | 2013-03-27 | NOBA Verbandmittel Danz GmbH u. Co. KG | Packung für chirurgische Hilfsmittel, insbesondere für Präpariertupfer |
WO2010053737A1 (en) | 2008-10-29 | 2010-05-14 | Wilson-Cook Medical, Inc. | Endoscopic sheet delivery |
FR2940620B1 (fr) * | 2008-12-26 | 2012-03-30 | Hoya Corp | Os artificiel pouvant etre resorbe et remplace par un os autogene, et procede pour sa production |
US8926552B2 (en) | 2009-08-12 | 2015-01-06 | Medtronic, Inc. | Particle delivery |
ES2606042T3 (es) | 2009-10-29 | 2017-03-17 | Prosidyan, Inc. | Material de injerto óseo bioactivo dinámico y métodos para su manipulación |
EP2515138A1 (en) * | 2011-04-19 | 2012-10-24 | Koninklijke Philips Electronics N.V. | Motion triggered MR imaging using APT/CEST |
UA113959C2 (xx) | 2011-05-24 | 2017-04-10 | Закручений колагеновий носій |
-
2013
- 2013-05-22 EP EP13724814.2A patent/EP2854735B1/en active Active
- 2013-05-22 RU RU2014150941A patent/RU2670746C9/ru active
- 2013-05-22 KR KR1020147035485A patent/KR102162416B1/ko active IP Right Grant
- 2013-05-22 CA CA2871697A patent/CA2871697C/en not_active Expired - Fee Related
- 2013-05-22 US US14/401,702 patent/US10213345B2/en active Active
- 2013-05-22 ES ES13724814T patent/ES2724233T3/es active Active
- 2013-05-22 DK DK13724814.2T patent/DK2854735T3/da active
- 2013-05-22 CN CN201380039414.9A patent/CN104470475B/zh not_active Expired - Fee Related
- 2013-05-22 JP JP2015513158A patent/JP6242873B2/ja active Active
- 2013-05-22 BR BR112014028594-2A patent/BR112014028594B1/pt not_active IP Right Cessation
- 2013-05-22 WO PCT/EP2013/060532 patent/WO2013174874A1/en active Application Filing
-
2014
- 2014-11-18 IL IL235760A patent/IL235760B/en active IP Right Grant
-
2015
- 2015-08-21 HK HK15108106.7A patent/HK1207554A1/zh not_active IP Right Cessation
-
2019
- 2019-01-04 US US16/240,143 patent/US11000985B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002058750A2 (en) * | 2001-01-25 | 2002-08-01 | Nycomed Pharma As | A suspension comprising fibrinogen, thrombin and alcohol and a method of coating a carrier with the same |
WO2002058749A2 (en) * | 2001-01-25 | 2002-08-01 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
WO2002070594A2 (en) * | 2001-01-25 | 2002-09-12 | Nycomed Pharma As | A method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
Also Published As
Publication number | Publication date |
---|---|
EP2854735B1 (en) | 2019-02-13 |
DK2854735T3 (da) | 2019-05-13 |
US20190201246A1 (en) | 2019-07-04 |
CA2871697A1 (en) | 2013-11-28 |
US10213345B2 (en) | 2019-02-26 |
CA2871697C (en) | 2020-08-25 |
KR102162416B1 (ko) | 2020-10-07 |
RU2014150941A (ru) | 2016-07-10 |
IL235760A0 (en) | 2015-01-29 |
RU2670746C9 (ru) | 2018-12-20 |
JP6242873B2 (ja) | 2017-12-06 |
BR112014028594B1 (pt) | 2021-11-30 |
ES2724233T3 (es) | 2019-09-09 |
US20150130112A1 (en) | 2015-05-14 |
JP2015526108A (ja) | 2015-09-10 |
KR20150015510A (ko) | 2015-02-10 |
US11000985B2 (en) | 2021-05-11 |
EP2854735A1 (en) | 2015-04-08 |
WO2013174874A1 (en) | 2013-11-28 |
IL235760B (en) | 2020-11-30 |
RU2670746C2 (ru) | 2018-10-25 |
HK1207554A1 (zh) | 2016-02-05 |
CN104470475A (zh) | 2015-03-25 |
BR112014028594A2 (pt) | 2017-06-27 |
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