DE3000979A1 - Neue dipyridamol-retardformen und verfahren zu ihrer herstellung - Google Patents

Neue dipyridamol-retardformen und verfahren zu ihrer herstellung

Info

Publication number
DE3000979A1
DE3000979A1 DE19803000979 DE3000979A DE3000979A1 DE 3000979 A1 DE3000979 A1 DE 3000979A1 DE 19803000979 DE19803000979 DE 19803000979 DE 3000979 A DE3000979 A DE 3000979A DE 3000979 A1 DE3000979 A1 DE 3000979A1
Authority
DE
Germany
Prior art keywords
dipyridamole
acid
forms according
release
methacrylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803000979
Other languages
German (de)
English (en)
Inventor
Dipl.-Chem. Dr. Gerhard 7950 Biberach Bozler
Dipl.-Chem. Dr. Rolf 7951 Warthausen Brickl
Dipl.-Chem. Dr. Peter 7950 Biberach Gruber
Dipl.-Chem. Dr. Herbert 6507 Ingelheim Stricker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19803000979 priority Critical patent/DE3000979A1/de
Priority to IN896/DEL/80A priority patent/IN155158B/en
Priority to EP80107963A priority patent/EP0032562B1/de
Priority to AT80107963T priority patent/ATE6585T1/de
Priority to DE8080107963T priority patent/DE3067058D1/de
Priority to US06/221,834 priority patent/US4367217A/en
Priority to PL1981229157A priority patent/PL129290B1/pl
Priority to FI810058A priority patent/FI78835C/fi
Priority to IE40/81A priority patent/IE50807B1/en
Priority to CA000368242A priority patent/CA1148084A/en
Priority to DK009481A priority patent/DK158539C/da
Priority to GR63825A priority patent/GR73102B/el
Priority to YU39/81A priority patent/YU42549B/xx
Priority to DD81226911A priority patent/DD156943A5/de
Priority to NO810061A priority patent/NO157369C/no
Priority to PT72330A priority patent/PT72330B/pt
Priority to IL61887A priority patent/IL61887A/xx
Priority to NZ195994A priority patent/NZ195994A/en
Priority to ES498393A priority patent/ES498393A0/es
Priority to GB8100632A priority patent/GB2067073B/en
Priority to HU8168A priority patent/HU184366B/hu
Priority to MA19241A priority patent/MA19040A1/fr
Priority to AU66156/81A priority patent/AU539618B2/en
Priority to ZA008101661A priority patent/ZA811661B/xx
Priority to CS81232A priority patent/CS232713B2/cs
Priority to JP303881A priority patent/JPS56103111A/ja
Priority to OA57296A priority patent/OA06720A/xx
Priority to PH25080A priority patent/PH17063A/en
Priority to AR283919A priority patent/AR221983A1/es
Publication of DE3000979A1 publication Critical patent/DE3000979A1/de
Priority to SG281/84A priority patent/SG28184G/en
Priority to KE3402A priority patent/KE3402A/xx
Priority to HK621/84A priority patent/HK62184A/xx
Priority to MY559/85A priority patent/MY8500559A/xx
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19803000979 1980-01-12 1980-01-12 Neue dipyridamol-retardformen und verfahren zu ihrer herstellung Withdrawn DE3000979A1 (de)

Priority Applications (33)

Application Number Priority Date Filing Date Title
DE19803000979 DE3000979A1 (de) 1980-01-12 1980-01-12 Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
IN896/DEL/80A IN155158B (enExample) 1980-01-12 1980-12-12
EP80107963A EP0032562B1 (de) 1980-01-12 1980-12-17 Neue Dipyridamol-Retardformen und Verfahren zu ihrer Herstellung
AT80107963T ATE6585T1 (de) 1980-01-12 1980-12-17 Neue dipyridamol-retardformen und verfahren zu ihrer herstellung.
DE8080107963T DE3067058D1 (en) 1980-01-12 1980-12-17 Dipyridamol retard-forms and process for their preparation
US06/221,834 US4367217A (en) 1980-01-12 1980-12-31 Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof
NZ195994A NZ195994A (en) 1980-01-12 1981-01-09 Dipyridamole substained release fomulations
FI810058A FI78835C (fi) 1980-01-12 1981-01-09 Foerfarande foer framstaellning av en ny dipyridamol-retardform.
IE40/81A IE50807B1 (en) 1980-01-12 1981-01-09 Dipyridamole sustained release formulations and processes for their preparation
CA000368242A CA1148084A (en) 1980-01-12 1981-01-09 Dipyridamol sustained release forms and processes for the preparation thereof
DK009481A DK158539C (da) 1980-01-12 1981-01-09 Dipyridamol-retardformer og fremgangsmaade til fremstilling heraf
GR63825A GR73102B (enExample) 1980-01-12 1981-01-09
YU39/81A YU42549B (en) 1980-01-12 1981-01-09 Process for obtaining a new retardanded form of dipyridamol
DD81226911A DD156943A5 (de) 1980-01-12 1981-01-09 Verfahren zur herstellung einer neuen dipyridamol-retardform
NO810061A NO157369C (no) 1980-01-12 1981-01-09 Fremgangsmaate for fremstilling av en dipyridamol-retardform.
PT72330A PT72330B (de) 1980-01-12 1981-01-09 Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
IL61887A IL61887A (en) 1980-01-12 1981-01-09 Dipyridamole sustained release pharmaceutical compositions and their preparation
PL1981229157A PL129290B1 (en) 1980-01-12 1981-01-09 Method of obtaining new forms of dipyridamole exhibiting prolonged action
ES498393A ES498393A0 (es) 1980-01-12 1981-01-09 Procedimiento para la preparacion de una nueva forma de ac- cion retardada a base de dipiridamol
GB8100632A GB2067073B (en) 1980-01-12 1981-01-09 Dipyridamole sustained release formulations
PH25080A PH17063A (en) 1980-01-12 1981-01-12 Dipyridamole sustained release forms comprising lacquer coated particles and the preparation thereof
HU8168A HU184366B (en) 1980-01-12 1981-01-12 Process for producing petarde pharmaceutical compositions containing 2,6-bis-bracket-diethanol-mino-bracket-4,8-dipiperidine-py-pyrimido-square bracket-5,4-d-square bracket closed-pyrimidine
AU66156/81A AU539618B2 (en) 1980-01-12 1981-01-12 Sustained release dipyridamole compositions
ZA008101661A ZA811661B (en) 1980-01-12 1981-01-12 Dipyridamole sustained release formulations and processes for their preparation
CS81232A CS232713B2 (en) 1980-01-12 1981-01-12 Production method of new delayed forms of dipyridamole
JP303881A JPS56103111A (en) 1980-01-12 1981-01-12 Sustained release medicine containing dipyridamole and its manufacture
OA57296A OA06720A (fr) 1980-01-12 1981-01-12 Nouvelles formes de retard du dipyridamole et procédé pour leur préparation.
MA19241A MA19040A1 (fr) 1980-01-12 1981-01-12 Nouvelles formes retard du dipyridamole et procede pour leur preparation .
AR283919A AR221983A1 (es) 1980-01-12 1981-01-12 Procedimiento para producir una nueva forma farmaceutica de dipiridamol,de accion retardada
SG281/84A SG28184G (en) 1980-01-12 1984-04-04 Dipyridamole sustained release formulations and processes for their preparation
KE3402A KE3402A (en) 1980-01-12 1984-04-12 Dipyridamole sustained release formulatins and processes for their preparation
HK621/84A HK62184A (en) 1980-01-12 1984-08-09 Dipyridamole sustained release formulations and processes for their preparation
MY559/85A MY8500559A (en) 1980-01-12 1985-12-30 Dipyridamole sustained release formulatins and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803000979 DE3000979A1 (de) 1980-01-12 1980-01-12 Neue dipyridamol-retardformen und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE3000979A1 true DE3000979A1 (de) 1981-07-23

Family

ID=6091926

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19803000979 Withdrawn DE3000979A1 (de) 1980-01-12 1980-01-12 Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
DE8080107963T Expired DE3067058D1 (en) 1980-01-12 1980-12-17 Dipyridamol retard-forms and process for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8080107963T Expired DE3067058D1 (en) 1980-01-12 1980-12-17 Dipyridamol retard-forms and process for their preparation

Country Status (32)

Country Link
US (1) US4367217A (enExample)
EP (1) EP0032562B1 (enExample)
JP (1) JPS56103111A (enExample)
AR (1) AR221983A1 (enExample)
AT (1) ATE6585T1 (enExample)
AU (1) AU539618B2 (enExample)
CA (1) CA1148084A (enExample)
CS (1) CS232713B2 (enExample)
DD (1) DD156943A5 (enExample)
DE (2) DE3000979A1 (enExample)
DK (1) DK158539C (enExample)
ES (1) ES498393A0 (enExample)
FI (1) FI78835C (enExample)
GB (1) GB2067073B (enExample)
GR (1) GR73102B (enExample)
HK (1) HK62184A (enExample)
HU (1) HU184366B (enExample)
IE (1) IE50807B1 (enExample)
IL (1) IL61887A (enExample)
IN (1) IN155158B (enExample)
KE (1) KE3402A (enExample)
MA (1) MA19040A1 (enExample)
MY (1) MY8500559A (enExample)
NO (1) NO157369C (enExample)
NZ (1) NZ195994A (enExample)
OA (1) OA06720A (enExample)
PH (1) PH17063A (enExample)
PL (1) PL129290B1 (enExample)
PT (1) PT72330B (enExample)
SG (1) SG28184G (enExample)
YU (1) YU42549B (enExample)
ZA (1) ZA811661B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103387A3 (en) * 1982-08-12 1984-12-12 Pfizer Inc. Long-acting matrix tablet formulations
US6015577A (en) * 1986-08-13 2000-01-18 Dr. Karl Thomae GmbH Pharmaceutical compositions containing dipyridamole or mopidamol and acetylsalicylic acid or the physiologically acceptable salts thereof, processes for preparing them and their use in treating clot formation

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470599A1 (fr) * 1979-12-07 1981-06-12 Panoz Donald Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus
DE3264867D1 (en) * 1981-04-27 1985-08-29 Haessle Ab New pharmaceutical preparation
DE3124090A1 (de) * 1981-06-19 1983-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale dipyridamolformen
DE3126703A1 (de) * 1981-07-07 1983-01-27 Dr. Karl Thomae Gmbh, 7950 Biberach Bromhexin-retardform und verfahren zu ihrer herstellung
IE54171B1 (en) * 1982-06-22 1989-07-05 Univ Glasgow Device for introducing nutrients and/or therapeutic materials into ruminant animals
DE3237575A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale mopidamolformen
DK58983D0 (da) * 1983-02-11 1983-02-11 Leo Pharm Prod Ltd Farmaceutisk praeparat
DE3306250A1 (de) * 1983-02-23 1984-08-23 Basf Ag, 6700 Ludwigshafen Sphaerische einkristalle fuer pharmazeutische zwecke
IE55745B1 (en) * 1983-04-06 1991-01-02 Elan Corp Plc Sustained absorption pharmaceutical composition
HU191542B (en) * 1983-04-08 1987-03-30 Boehringer Ingelheim Ltd Process for production of pastiles containing dipyridamel independent from ph with regulated output of the active substance
JPS6051106A (ja) * 1983-08-31 1985-03-22 Yamanouchi Pharmaceut Co Ltd 塩酸アモスラロ−ル持続性製剤
IE56459B1 (en) * 1983-12-21 1991-08-14 Elan Corp Ltd Controlled absorption pharmaceutical formulation
GB8414221D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Unit dosage form
GB8414220D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Medicaments in unit dose form
US4867984A (en) * 1984-11-06 1989-09-19 Nagin K. Patel Drug in bead form and process for preparing same
SE460947B (sv) * 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
WO1988002629A1 (en) * 1986-10-16 1988-04-21 American Health Products Corporation 2',3'-didesoxyadenosine composition
US5811128A (en) * 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
IL84599A0 (en) * 1986-12-09 1988-04-29 Byk Gulden Lomberg Chem Fab Pharmaceutical composition containing urapidil and process for the preparation thereof
DE3812799A1 (de) * 1988-04-16 1989-10-26 Sanol Arznei Schwarz Gmbh Oral zu verabreichende pharmazeutische zubereitung mit kontrollierter wirkstofffreisetzung und verfahren zu deren herstellung
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5196203A (en) * 1989-01-06 1993-03-23 F. H. Faulding & Co. Limited Theophylline dosage form
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
AT397345B (de) * 1990-04-04 1994-03-25 Chemiefaser Lenzing Ag Pharmazeutisches präparat mit verzögerter wirkstofffreisetzung auf basis von hemicellulosen
ATE120089T1 (de) * 1991-05-20 1995-04-15 Marion Laboratories Inc Mehrschichtige zubereitung mit kontrollierter freisetzung.
ATE217188T1 (de) * 1992-08-05 2002-05-15 Faulding F H & Co Ltd Granulierte pharmazeutische zusammensetzung
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US20060263428A1 (en) * 1993-09-20 2006-11-23 Eugenio Cefali Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
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JP2000159692A (ja) * 1998-09-25 2000-06-13 Sankyo Co Ltd ＨＭＧ―ＣｏＡレダクタ―ゼ阻害薬含有製剤
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DE10149674A1 (de) 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
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US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
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EP1594503A2 (en) * 2003-02-07 2005-11-16 Boehringer Ingelheim International GmbH Use of dipyridamole or mopidamole for treatment and prevention of mmp-9-dependent disorders
DE10306179A1 (de) 2003-02-13 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Dipyridamol in Kombination mit Acetylsalicylsäure und einem Angiotensin II-Antagonisten zur Schlaganfall-Prophylaxe
RU2005136383A (ru) 2003-04-24 2007-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Применение дипиридамола или мопидамола для лечения и предупреждения тромбоэмболических заболеваний и нарушений, вызываемыхизбыточным образованием и/или повышенным уровнем экспрессии тромбиновых рецепторов
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US20050112199A1 (en) * 2003-09-24 2005-05-26 Mahesh Padval Therapeutic regimens for administering drug combinations
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
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ATE6585T1 (de) 1984-03-15
IN155158B (enExample) 1985-01-05
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CA1148084A (en) 1983-06-14
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AU539618B2 (en) 1984-10-11
FI78835B (fi) 1989-06-30
ES498393A0 (es) 1982-09-16
AU6615681A (en) 1981-07-16
NO157369C (no) 1988-03-16
DE3067058D1 (en) 1984-04-19
KE3402A (en) 1984-06-08
DK158539B (da) 1990-06-05
CS232713B2 (en) 1985-02-14
CS23281A2 (en) 1984-06-18
IE50807B1 (en) 1986-07-23
PT72330A (de) 1981-02-01
HU184366B (en) 1984-08-28
GB2067073A (en) 1981-07-22
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DD156943A5 (de) 1982-10-06
SG28184G (en) 1985-02-15
YU42549B (en) 1988-10-31
IE810040L (en) 1981-07-12
US4367217A (en) 1983-01-04
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OA06720A (fr) 1982-06-30
EP0032562A1 (de) 1981-07-29
MA19040A1 (fr) 1981-10-01
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PT72330B (de) 1982-07-23
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YU3981A (en) 1983-09-30
DK158539C (da) 1990-11-05

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