DE2819094A1 - Cyclosporin-derivate, ihre verwendung und herstellung - Google Patents

Cyclosporin-derivate, ihre verwendung und herstellung

Info

Publication number
DE2819094A1
DE2819094A1 DE19782819094 DE2819094A DE2819094A1 DE 2819094 A1 DE2819094 A1 DE 2819094A1 DE 19782819094 DE19782819094 DE 19782819094 DE 2819094 A DE2819094 A DE 2819094A DE 2819094 A1 DE2819094 A1 DE 2819094A1
Authority
DE
Germany
Prior art keywords
cyclosporin
dihydro
iso
hereinafter referred
cyclosporine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19782819094
Other languages
German (de)
English (en)
Other versions
DE2819094C2 (enExample
Inventor
Eugen Dr Haerri
Hans Hofmann
Max Kuhn
Rene P Dr Traber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH582377A external-priority patent/CH628023A5/de
Priority claimed from CH582277A external-priority patent/CH628022A5/de
Priority claimed from CH745777A external-priority patent/CH632010A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE2819094A1 publication Critical patent/DE2819094A1/de
Application granted granted Critical
Publication of DE2819094C2 publication Critical patent/DE2819094C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/945—Trichoderma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE19782819094 1977-05-10 1978-04-29 Cyclosporin-derivate, ihre verwendung und herstellung Granted DE2819094A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH582377A CH628023A5 (en) 1977-05-10 1977-05-10 Process for the preparation of an antibiotic derivative
CH582277A CH628022A5 (en) 1977-05-10 1977-05-10 Process for the preparation of an antibiotic derivative
CH745777A CH632010A5 (en) 1977-06-17 1977-06-17 Process for the preparation of a novel antibiotic

Publications (2)

Publication Number Publication Date
DE2819094A1 true DE2819094A1 (de) 1978-11-23
DE2819094C2 DE2819094C2 (enExample) 1988-11-03

Family

ID=27175344

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782819094 Granted DE2819094A1 (de) 1977-05-10 1978-04-29 Cyclosporin-derivate, ihre verwendung und herstellung

Country Status (17)

Country Link
US (2) US4220641A (enExample)
JP (1) JPS53139789A (enExample)
AU (1) AU526582B2 (enExample)
CA (1) CA1117046A (enExample)
DE (1) DE2819094A1 (enExample)
DK (1) DK148751C (enExample)
ES (1) ES469567A1 (enExample)
FI (1) FI59814C (enExample)
FR (1) FR2390420A1 (enExample)
GB (1) GB1591934A (enExample)
IE (1) IE46883B1 (enExample)
IL (1) IL54666A (enExample)
IT (1) IT1104195B (enExample)
NL (1) NL7804846A (enExample)
PH (1) PH13973A (enExample)
PT (1) PT68013B (enExample)
SE (3) SE438860B (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079341A (en) * 1987-07-22 1992-01-07 Galpin Ian J Cyclosporins
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
IE54936B1 (en) * 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0056782B1 (en) * 1981-01-09 1984-08-01 Sandoz Ag Novel cyclosporins
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
DE3580717D1 (de) * 1984-08-02 1991-01-10 Sandoz Ag Pharmazeutische anwendung von (nva)2-cyclosporine.
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
ATE92501T1 (de) 1984-10-04 1993-08-15 Sandoz Ag Monoklonale antikoerper gegen zyklosporine.
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
US5239057A (en) * 1987-03-27 1993-08-24 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US5427960A (en) * 1987-03-27 1995-06-27 Abbott Laboratories Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
DE3851268T2 (de) * 1987-06-19 1995-01-26 Sandoz Ag Zyklische Peptolide.
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
ATE109970T1 (de) * 1987-09-03 1994-09-15 Univ Georgia Res Found Cyclosporin-augenmittel.
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
ES2084069T3 (es) * 1990-08-15 1996-05-01 Abbott Lab Reactivos de inmunoensayo y metodo para la determinacion de ciclosporina.
WO1992013094A1 (en) * 1991-01-25 1992-08-06 Fujisawa Pharmaceutical Co., Ltd. Process for producing cyclosporin a and/or c
ATE127528T1 (de) * 1991-04-06 1995-09-15 Dresden Arzneimittel Verfahren zur fermentativen herstellung und isolierung von cyclosporin a sowie neue cyclosporin- bildende stämme.
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
CN1079837C (zh) * 1995-02-28 2002-02-27 国家研究发展公司 从分枝层壁菌制备环胞多肽a的方法
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
ATE275963T1 (de) 1997-01-30 2004-10-15 Novartis Pharma Gmbh Ölfreie pharmazeutische zusammensetzung welche cyclosporin enthält
IN188719B (enExample) * 1997-09-08 2002-11-02 Panacea Biotec Ltd
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DE69840586D1 (de) 1997-10-08 2009-04-02 Isotechnika Inc Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien
DE69928938T2 (de) 1998-07-01 2006-08-17 Debiopharm S.A. Neues cyclosporin mit verbesserter wirkung
US7060672B2 (en) * 2001-10-19 2006-06-13 Isotechnika, Inc. Cyclosporin analog formulations
CN100334106C (zh) * 2001-10-19 2007-08-29 伊索泰克尼卡股份有限公司 环孢菌素类似物的合成
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US20080206287A1 (en) * 2006-09-18 2008-08-28 Reed John C Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2010088573A1 (en) * 2009-01-30 2010-08-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) * 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) * 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
PL2651965T3 (pl) 2010-12-15 2019-04-30 Contravir Pharmaceuticals Inc Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3
HUE065915T2 (hu) 2011-03-11 2024-06-28 Beth Israel Deaconess Medical Ct Inc Anti-CD40 antitestek és alkalmazásaik
WO2012145427A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
WO2015031381A1 (en) 2013-08-26 2015-03-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
EP3307322B1 (en) 2015-09-04 2021-02-17 Primatope Therapeutics Inc. Humanized anti-cd40 antibodies and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4838877B1 (enExample) * 1970-06-30 1973-11-20 Toyo Jozo Kk
CH614931A5 (enExample) * 1975-11-04 1979-12-28 Sandoz Ag
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Helvetica Chimica Acta, 59, 1076 (1976) *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079341A (en) * 1987-07-22 1992-01-07 Galpin Ian J Cyclosporins
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7632807B2 (en) 2004-10-06 2009-12-15 Albany Molecular Research, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders

Also Published As

Publication number Publication date
IE46883B1 (en) 1983-10-19
DK148751C (da) 1986-02-24
IE780932L (en) 1978-11-10
IT1104195B (it) 1985-10-21
AU526582B2 (en) 1983-01-20
IT7849208A0 (it) 1978-05-05
US4220641A (en) 1980-09-02
SE438860B (sv) 1985-05-13
AU3594778A (en) 1979-11-15
SE7805055L (sv) 1978-11-11
JPS53139789A (en) 1978-12-06
GB1591934A (en) 1981-07-01
NL7804846A (nl) 1978-11-14
FR2390420A1 (fr) 1978-12-08
IL54666A (en) 1980-12-31
PT68013A (fr) 1978-06-01
DK148751B (da) 1985-09-16
US4289851A (en) 1981-09-15
PH13973A (en) 1980-11-20
JPS6252760B2 (enExample) 1987-11-06
FR2390420B1 (enExample) 1980-10-31
CA1117046A (en) 1982-01-26
SE8401135D0 (sv) 1984-03-01
SE8401134L (sv) 1984-03-01
FI59814C (fi) 1981-10-12
FI59814B (fi) 1981-06-30
ES469567A1 (es) 1980-01-01
PT68013B (fr) 1980-03-05
SE8401134D0 (sv) 1984-03-01
FI781348A7 (fi) 1978-11-11
DE2819094C2 (enExample) 1988-11-03
SE8401135L (sv) 1984-03-01
DK188778A (da) 1978-11-11
IL54666A0 (en) 1978-07-31

Similar Documents

Publication Publication Date Title
DE2819094A1 (de) Cyclosporin-derivate, ihre verwendung und herstellung
DE2941080C2 (enExample)
DE3887820T2 (de) Antibiotika, Benanomicine A und B und Dexylosylbenanomicin B, ihre Herstellung und Verwendung.
DE2743654C3 (enExample)
DE2920890C2 (de) Esterastin-Derivate und Verfahren zu deren Herstellung
DE1917874C3 (de) 14-Halogendaunomycine, Verfahren zu ihrer Herstellung und deren Verwendung zur Herstellung von Adriamycin
DE68905644T2 (de) Antibiotische Substanz mit Antitumorwirkung.
DE2911353C2 (enExample)
DE2459616B2 (de) la-Acylmitomycin C-Verbindungen, Verfahren zu ihrer Herstellung und Arzneimittel
DE3132475C2 (enExample)
CH630061A5 (en) Process for the preparation of an antibiotic derivative
CH630062A5 (en) Process for the preparation of an antibiotic derivative
CH640520A5 (en) Cyclosporin derivatives
DE3247175A1 (de) Dihydro- und tetrahydromonacolin l, ihre metallsalze und alkylester sowie verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE69009923T2 (de) Antifungales Antibiotikum und seine Herstellung und Verwendung.
DD202047A5 (de) Verfahren zur herstellung des makrolids 20-dihydro-20,23-dideoxytylonolid
EP0660825B1 (de) Entzündungshemmende makrolactame (cyclamenol)
AT381101B (de) Verfahren zur herstellung von neuem dihydrocyclosporin g
DE2316429A1 (de) Verfahren zur herstellung eines neuen metaboliten
DE69206858T2 (de) Verbindung UCA1064-B
EP0339442A2 (de) Neue Angucyclinone aus Streptomyceten, Verfahren zu ihrer Herstellung und ihre Vewendung
DE2746252A1 (de) Antibiotikum c-15003 enthaltendes arzneimittel zur behandlung von tumore aufweisenden warmbluetern
AT276628B (de) Verfahren zur Herstellung der neuen entzündungswidrigen Substanz Zygosporin A
AT216685B (de) Verfahren zur Herstellung von Steroiden der Δ<1,4>-Pregnadienreihe
DE888918C (de) Verfahren zur Gewinnung eines antibiotischen Wirkstoffes

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition